Results for the protein: NP

Results for the Protein: NP_001036064

110825958

2066

ERBB4

NCBI

receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-2 precursor [Homo sapiens]

Known Diseases associated with this Protein:
AMYOTROPHIC LATERAL SCLEROSIS 19

2

0

2

0

0

Tips:

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RefSeq Protein: NP_001036064

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
FU	cd00064	3.7e-10	502	553
FU	cd00064	1.5e-13	554	615
PTKc_VEGFR	cd05054	1.2e-20	579	981
PTKc_Kit	cd05104	2.7e-11	615	978
PTKc_PDGFR_beta	cd05107	1.3e-08	615	979
PTKc_VEGFR3	cd05102	3.1e-15	646	981
STKc_ROCK	cd05596	0.00093	668	1039
PTKc_CSF-1R	cd05106	1.9e-15	682	979
PTKc_PDGFR_alpha	cd05105	1.7e-12	690	980
STKc_PAK1	cd06654	6.6e-06	691	996
STKc_PAK2	cd06655	9.3e-06	691	997
STKc_PAK3	cd06656	8.2e-07	691	998
STKc_JNK	cd07850	0.00057	699	1060
STKc_JNK2	cd07876	0.00032	699	1055
PTKc_FGFR1	cd05098	4.1e-36	702	982
PKc_MKK7	cd06618	2.1e-09	702	1010
STKc_myosinIIIB	cd06639	0.00027	702	976
PTKc_FGFR2	cd05101	2.5e-37	703	982
STKc_PAK	cd06614	2.3e-10	703	988
STKc_MAP4K4_6	cd06636	0.00047	703	977
STKc_PAK_I	cd06647	1.3e-06	703	994
PTKc_FGFR3	cd05100	1.2e-35	704	1016
PTKc_FGFR4	cd05099	3.1e-47	704	997
STKc_TAO	cd06607	0.00039	704	1010
STKc_TAO2	cd06634	0.00053	704	1010
STKc_myosinIIIA	cd06638	1.3e-05	704	975
PTKc_DDR	cd05051	2.3e-38	706	972
STKc_STK10_LOK	cd06644	1.1e-05	706	993
STKc_CDK9	cd07865	0.0003	706	1004
PTKc_PDGFR	cd05055	2.7e-17	707	978
STKc_p38	cd07851	1.8e-06	707	1005
STKc_MAP4K5	cd06646	4.8e-05	708	974
STKc_CDK10	cd07845	5.2e-05	708	981
STKc_MAPK15	cd07852	4.5e-06	708	1012
PTK_Ryk	cd05043	2.3e-24	710	978
PTKc_EGFR_like	cd05057	9.2e-221	710	988
PTKc_Lck_Blk	cd05067	9.9e-55	710	977
PTKc_Fyn_Yrk	cd05070	1.2e-51	710	977
PTKc_Src	cd05071	7.7e-49	710	979
PTKc_Lyn	cd05072	2.9e-49	710	977
PTKc_Hck	cd05073	3.6e-48	710	977
PTKc_Tie2	cd05088	7.6e-36	710	1000
PTKc_EGFR	cd05108	7.7e-230	710	1025
PTKc_HER2	cd05109	6.1e-206	710	988
PTKc_HER4	cd05110	8.7e-292	710	1012
PTK_HER3	cd05111	2.6e-168	710	988
PTKc_Yes	cd05069	6.1e-45	710	977
STKc_ASK	cd06624	9.1e-08	710	976
PTKc_ALK_LTK	cd05036	2.2e-51	711	976
PTKc_Ror	cd05048	1e-39	711	977
PTKc_FAK	cd05056	3.1e-90	711	982
STKc_MAP4K3	cd06645	5.3e-05	711	982
PTKc_InsR_like	cd05032	2.2e-52	712	976
PTKc_Src_like	cd05034	4.8e-73	712	977
PTK_CCK4	cd05046	4.3e-20	712	976
PTKc_Csk_like	cd05039	3.2e-46	712	977
PTKc_Trk	cd05049	2.8e-40	712	976
PTKc_Csk	cd05082	3.4e-54	712	977
PTKc_Chk	cd05083	7.4e-58	712	977
STKc_SLK	cd06643	2.3e-07	712	991
STKc_Sty1_Hog1	cd07856	7.9e-06	712	1020
PTKc_EphR	cd05033	1.3e-75	713	978
PTKc_Jak_rpt2	cd05038	3.6e-83	713	978
PTKc_Abl	cd05052	3e-76	713	978
PTKc_FGFR	cd05053	6.1e-45	713	979
PTKc_Tec_like	cd05059	4.7e-65	713	975
PTKc_EphR_A10	cd05064	5.6e-49	713	978
PTKc_EphR_B	cd05065	5.5e-60	713	978
PTKc_EphR_A	cd05066	3.8e-66	713	978
PTKc_Frk_like	cd05068	1.6e-78	713	977
PTKc_Jak1_rpt2	cd05079	4.9e-54	713	978
PTKc_Jak2_Jak3_rpt2	cd05081	1.6e-57	713	978
PTKc_TrkB	cd05093	1.4e-34	713	986
PTKc_TrkC	cd05094	1.3e-17	713	986
PTKc_DDR2	cd05095	7.1e-31	713	976
PTKc_DDR1	cd05096	1.8e-24	713	976
PTKc_DDR_like	cd05097	2.3e-29	713	976
PTKc_VEGFR2	cd05103	1.7e-13	713	981
PTKc_Itk	cd05112	9.3e-68	713	975
PTKc_EphR_A2	cd05063	5.6e-67	713	978
PTKc_Btk_Bmx	cd05113	1e-68	713	975
PTKc_Tec_Rlk	cd05114	1.4e-69	713	975
PKc_MKK4	cd06616	6.9e-08	713	993
PKc_MAPKK_Byr1_like	cd06620	6.4e-06	713	985
STKc_TNIK	cd06637	0.00029	713	975
STKc_myosinIII_like	cd06608	2.1e-07	713	975
PKc_MEK1	cd06650	0.00034	713	1040
PKc_MEK2	cd06649	0.00036	713	1026
PTKc_Srm_Brk	cd05148	7.8e-57	714	977
STKc_MAP4K3_like	cd06613	2.7e-08	714	974
STKc_MST1_2	cd06612	6.5e-09	714	944
STKc_PCTAIRE_like	cd07844	3.3e-06	714	1004
STKc_PFTAIRE2	cd07870	3.3e-06	714	1028
STKc_PFTAIRE1	cd07869	0.00071	714	1025
PTKc_Ror1	cd05090	5.7e-38	715	977
PTKc_Ror2	cd05091	1.2e-30	715	977
STKc_MST4	cd06640	1.2e-05	715	997
STKc_MST3	cd06641	2.7e-06	715	994
STKc_STK25-YSK1	cd06642	1.3e-07	715	994
STKc_MEKK3	cd06651	1.2e-07	715	977
STKc_MEKK2	cd06652	0.0001	715	976
STKc_MEKK3_like_1	cd06653	0.00012	715	976
STKc_ERK1_2_like	cd07849	9.8e-05	715	1023
STKc_TEY_MAPK_plant	cd07858	5.4e-05	715	1043
STKc_PCTAIRE3	cd07871	0.00097	715	1004
STKc_PCTAIRE1	cd07873	0.00031	715	1018
PTKc_Tie1	cd05089	4.5e-37	716	999
STKc_PKA	cd05580	8.3e-06	716	977
STKc_PDK1	cd05581	2.3e-09	716	974
STKc_DMPK_like	cd05597	0.00058	716	1071
STKc_CRIK	cd05601	0.00063	716	1030
STKc_PRKX_like	cd05612	3.7e-05	716	1008
PKc_MAPKK	cd06605	9e-10	716	980
STKc_MST3_like	cd06609	3.8e-08	716	994
STKc_OSR1_SPAK	cd06610	1.2e-08	716	974
PKc_MEK	cd06615	8.4e-06	716	1017
PKc_MKK3_6	cd06617	3.4e-07	716	991
PKc_MKK5	cd06619	0.00017	716	993
PKc_MAPKK_Pek1_like	cd06621	0.0005	716	984
PKc_MAPKK_PBS2_like	cd06622	2.3e-05	716	1011
PKc_MAPKK_plant_like	cd06623	3.1e-12	716	976
STKc_MEKK3_like	cd06625	1.9e-10	716	976
STKc_PAK_II	cd06648	0.00015	716	988
STKc_NAK1_like	cd06917	1.3e-06	716	985
STKc_CdkB_plant	cd07837	3.3e-06	716	1005
STKc_CDKL1_4	cd07847	6e-07	716	1013
STKc_CDK12	cd07864	4.4e-06	716	1004
STKc_BUR1	cd07866	0.00047	716	967
STKc_CDKL2_3	cd07846	1e-05	716	975
STKc_Nek6	cd08228	4.8e-06	716	979
STKc_Nek7	cd08229	3.5e-07	716	979
STKc_Nek6_Nek7	cd08224	1.5e-07	716	979
SPS1	COG0515	2.3e-29	716	1155
PTKc_Musk	cd05050	1.5e-43	717	976
PTKc_IGF-1R	cd05062	1.6e-36	717	976
PTKc_InsR	cd05061	1.4e-38	717	988
PTKc_RET	cd05045	5.3e-45	717	981
PKc_STE	cd05122	5.6e-12	717	974
PTKc_TrkA	cd05092	1.4e-36	717	976
STKc_Yank1	cd05578	3.7e-09	717	977
STKc_MSK_N	cd05583	2.6e-05	717	1025
STKc_cPKC	cd05587	4.7e-06	717	1046
STKc_GRK4_like	cd05605	3.7e-05	717	1033
STKc_MSK2_N	cd05614	4.1e-05	717	1086
STKc_cPKC_alpha	cd05615	2.3e-05	717	1052
STKc_cPKC_beta	cd05616	0.00044	717	1052
STKc_MSK1_N	cd05613	0.00032	717	1001
STKc_MAPKKK	cd06606	4.5e-16	717	975
STKc_Cdc7_like	cd06627	2e-14	717	970
STKc_MAPKKK_Byr2_lik	cd06628	1.6e-12	717	975
STKc_YSK4	cd06631	5.8e-10	717	975
STKc_MEKK1	cd06630	5.6e-09	717	975
STKc_CCRK	cd07832	7.9e-08	717	978
STKc_Pho85	cd07836	3.1e-05	717	1004
STKc_CDK5	cd07839	4e-06	717	1004
STKc_MAPK	cd07834	1.4e-08	717	1020
STKc_NLK	cd07853	0.00011	717	1053
STKc_MPK1	cd07857	0.00037	717	1021
STKc_CDK2_3	cd07860	3e-05	717	1004
STKc_TDY_MAPK_plant	cd07859	8.6e-06	717	1058
STKc_CDK4	cd07863	7.3e-05	717	1004
STKc_CDK7	cd07841	3.1e-07	717	971
STKc_CDK1_euk	cd07861	0.00013	717	1004
STKc_Nek1	cd08218	1.4e-05	717	975
STKc_Nek3	cd08219	1.9e-08	717	976
STKc_Nek8	cd08220	8e-07	717	976
STKc_Nek9	cd08221	4.7e-05	717	976
STKc_Nek2	cd08217	1.7e-06	717	977
STKc_Nek5	cd08225	9.9e-06	717	975
STKc_Nek4	cd08223	1.4e-05	717	975
STKc_Nek10	cd08528	2.1e-06	717	976
STKc_CNK2-like	cd08530	2.8e-07	717	976
PTKc_Axl_like	cd05035	1.2e-64	718	978
PTKc_Axl	cd05075	8.6e-50	718	978
PTKc_Tyro3	cd05074	3.8e-53	718	978
PTKc_Tyk2_rpt2	cd05080	4.6e-41	718	979
STKc_CMGC	cd05118	2.7e-08	718	975
STKc_PKN	cd05589	3.1e-06	718	1056
STKc_MAPKKK_Bck1_lik	cd06629	2e-08	718	975
STKc_CDK_like	cd07829	1.2e-08	718	975
STKc_MOK	cd07831	2.5e-06	718	974
STKc_CDK1_like	cd07835	3.6e-07	718	1004
STKc_MAK_like	cd07830	5.5e-08	718	944
STKc_CDK4_6_like	cd07838	6.9e-06	718	967
STKc_CDK9_like	cd07840	4.2e-10	718	1004
STKc_MEKK1_plant	cd06632	9.3e-09	719	970
STKc_CDKL	cd07833	0.00046	719	974
STKc_Nek	cd08215	1.5e-14	719	976
STKc_MEKK4	cd06626	1.7e-07	720	975
STKc_CDK8_like	cd07842	1.3e-05	720	1004
STKc_RSK_N	cd05582	1.8e-05	721	1049
STKc_p70S6K	cd05584	3.2e-05	721	1033
STKc_MAPK4_6	cd07854	0.00098	721	1038
STKc_FA2-like	cd08529	1.2e-08	721	976
PTKc	cd00192	7.1e-123	722	975
PTK_Jak_rpt1	cd05037	8.2e-13	722	975
PTKc_Ack_like	cd05040	3e-92	722	976
PTKc_Aatyk	cd05042	1.7e-12	722	976
PTKc_c-ros	cd05044	1.1e-53	722	976
PTKc_Tie	cd05047	1.1e-43	722	979
PTKc_Met_Ron	cd05058	3.7e-73	722	980
PTKc_Syk_like	cd05060	2.8e-99	722	982
PTKc_Fes_like	cd05041	8.2e-51	722	976
PTK_Tyk2_rpt1	cd05076	2.6e-06	722	975
PTK_Jak1_rpt1	cd05077	1.4e-08	722	975
PTK_Jak2_Jak3_rpt1	cd05078	1.1e-13	722	975
PTKc_Fes	cd05084	2.5e-48	722	976
PTKc_Fer	cd05085	9.7e-61	722	976
PTKc_Aatyk1_Aatyk3	cd05087	3.2e-16	722	976
PTKc_Aatyk2	cd05086	2.8e-08	722	976
PTKc_Syk	cd05116	8.8e-69	722	979
STKc_PKB	cd05571	4.4e-06	722	1058
STKc_SGK	cd05575	0.00034	722	1051
STKc_PKC	cd05570	3.1e-06	722	1056
STKc_nPKC_epsilon	cd05591	0.00097	722	1046
STKc_nPKC_theta_delt	cd05592	5.3e-05	722	1033
STKc_PKB_gamma	cd05593	0.00056	722	1056
STKc_PKB_alpha	cd05594	0.0001	722	1054
STKc_aPKC	cd05588	0.00024	722	1052
STKc_SGK2	cd05603	0.00013	722	1052
STKc_SGK1	cd05602	0.00086	722	1060
STKc_nPKC_theta	cd05619	1.3e-05	722	1030
STKc_Nek11	cd08222	4.3e-07	722	975
PKc	cd00180	9e-57	724	974
PTKc_Zap-70	cd05115	1.3e-73	724	979
STKc_AGC	cd05123	5e-07	724	977
STKc_cGK_PKG	cd05572	0.00019	724	1011
STKc_GRK	cd05577	0.0002	724	1026
STKc_GRK1	cd05608	5.7e-05	724	1002
STKc_MAST_like	cd05579	6e-05	724	949
STKc_Sck1_like	cd05586	0.00095	724	1112
STKc_SLK_like	cd06611	1.5e-06	724	988
Recep_L_domain	pfam01030	6.8e-47	55	167
Furin-like	pfam00757	3.4e-74	183	335
Recep_L_domain	pfam01030	1.2e-38	358	478
Pkinase	pfam00069	3.3e-34	718	974
FU	smart00261	1.5e-10	226	268
FU	smart00261	1.2e-12	493	544
FU	smart00261	8e-16	549	599
Pkinase_Tyr	pfam07714	2.4e-140	718	974
TyrKc	smart00219	5e-133	718	974
STYKc	smart00221	9.4e-51	718	1004
S_TKc	smart00220	2.9e-40	728	978

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	600543.0001	Disease	p.ARG927GLN	AMYOTROPHIC LATERAL SCLEROSIS 19
OMIM	600543.0002	Disease	p.ARG1259TRP	AMYOTROPHIC LATERAL SCLEROSIS 19

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258