Results for the protein: P42685

Results for the Protein: P42685

1169745

2444

FRK

NCBI, UniProt

FRK_HUMAN RecName: Full=Tyrosine-protein kinase FRK; AltName: Full=FYN-related kinase; AltName: Full=Nuclear tyrosine protein kinase RAK; AltName: Full=Protein-tyrosine kinase 5

			0 3 0 1 2

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Swiss-Prot Protein: P42685

Identical to: NP_002022

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
SH2	cd00173	2.2e-37	115	208
PTKc_VEGFR	cd05054	2e-23	127	494
PTKc_PDGFR_beta	cd05107	1.5e-10	193	492
PTKc_Kit	cd05104	6.2e-22	193	491
PTKc_CSF-1R	cd05106	5.5e-30	206	492
PTKc_PDGFR	cd05055	2.7e-21	211	491
PTKc_PDGFR_alpha	cd05105	2.6e-16	211	493
STKc_TAO3	cd06633	0.00063	211	504
STKc_PAK6	cd06659	3.1e-05	213	497
STKc_TAO2	cd06634	3.4e-06	214	505
STKc_PAK_I	cd06647	0.00023	214	505
STKc_PAK5	cd06658	0.00042	215	505
STKc_myosinIIIB	cd06639	0.00064	216	493
STKc_myosinIIIA	cd06638	3.7e-05	217	492
STKc_PAK_II	cd06648	1.8e-06	217	501
STKc_MAPK4_6	cd07854	0.00064	217	504
PTKc_FGFR1	cd05098	5.7e-53	218	498
PTKc_FGFR2	cd05101	1.1e-48	218	499
STKc_TAO	cd06607	1.9e-05	218	504
PTKc_FGFR4	cd05099	2.6e-57	219	500
STKc_TAO1	cd06635	0.00014	220	504
STKc_MAP4K4_6	cd06636	0.00013	220	492
STKc_PAK1	cd06654	0.00088	220	502
STKc_PAK2	cd06655	0.00078	220	505
STKc_PAK4	cd06657	0.0009	220	505
PTKc_FGFR3	cd05100	5.7e-42	221	504
PKc_MKK7	cd06618	6.9e-08	221	505
STKc_STK10_LOK	cd06644	4.3e-06	221	504
STKc_SLK	cd06643	6.2e-06	221	502
STKc_p38	cd07851	4e-05	221	505
STKc_CDK9	cd07865	1.5e-06	222	491
STKc_Sty1_Hog1	cd07856	0.00018	223	499
STKc_PAK	cd06614	9e-14	224	504
PTKc_FGFR	cd05053	2.7e-69	225	492
STKc_ASK	cd06624	4.1e-07	225	492
PTKc_EGFR_like	cd05057	2.8e-65	226	501
PTKc_VEGFR3	cd05102	1.6e-25	226	494
PTKc_VEGFR2	cd05103	2.2e-21	226	494
PTKc_InsR_like	cd05032	2e-73	227	489
PTKc_Src_like	cd05034	6.8e-213	227	490
PTKc_ALK_LTK	cd05036	1.6e-61	227	489
PTKc_Csk_like	cd05039	6.4e-85	227	490
PTKc_Abl	cd05052	4.7e-114	227	491
PTKc_InsR	cd05061	2.3e-55	227	496
PTKc_IGF-1R	cd05062	6.9e-51	227	489
PTKc_FAK	cd05056	1.7e-83	227	495
PTKc_Lck_Blk	cd05067	1.3e-126	227	490
PTKc_Frk_like	cd05068	1.4e-185	227	490
PTKc_Yes	cd05069	4.3e-117	227	490
PTKc_Fyn_Yrk	cd05070	3.8e-127	227	490
PTKc_Src	cd05071	2.8e-124	227	492
PTKc_Lyn	cd05072	2.4e-129	227	490
PTKc_Hck	cd05073	1.5e-126	227	490
PTKc_Csk	cd05082	1.7e-75	227	490
PTKc_Chk	cd05083	1.5e-75	227	490
PTKc_Tie1	cd05089	1.2e-41	227	505
PTKc_Srm_Brk	cd05148	1.4e-146	227	490
STKc_ERK1_2_like	cd07849	4.3e-05	227	502
STKc_CDK12	cd07864	2.3e-07	227	504
PTK_CCK4	cd05046	3.2e-41	228	489
PTKc_Ror	cd05048	6.7e-61	228	490
PTKc_Trk	cd05049	2.7e-53	228	489
PTKc_Musk	cd05050	1.5e-62	228	489
PTKc_EphR_A10	cd05064	1.4e-60	228	491
PTKc_EphR_A2	cd05063	4.1e-73	228	491
PTKc_DDR	cd05051	7.8e-46	228	489
PTKc_Ror2	cd05091	3.1e-47	228	490
PTKc_Ror1	cd05090	1.2e-47	228	490
PTKc_TrkA	cd05092	4.8e-55	228	489
PTKc_TrkB	cd05093	8.7e-55	228	499
PTKc_TrkC	cd05094	7.6e-39	228	499
PTKc_DDR2	cd05095	3.5e-55	228	489
PTKc_DDR1	cd05096	1.5e-40	228	489
PTKc_DDR_like	cd05097	3.1e-53	228	489
PKc_MAPKK_Byr1_like	cd06620	1.1e-07	228	504
STKc_TNIK	cd06637	1.2e-05	228	492
STKc_MAP4K3	cd06645	2.2e-06	228	491
STKc_MAP4K5	cd06646	1.1e-06	228	491
PTKc_EphR	cd05033	7e-102	229	491
PTKc_Jak_rpt2	cd05038	2.3e-69	229	491
PTK_Ryk	cd05043	3.3e-34	229	494
PTKc_Tec_like	cd05059	3.9e-104	229	488
PTKc_EphR_B	cd05065	1.8e-74	229	491
PTKc_EphR_A	cd05066	8.5e-77	229	491
PTKc_Jak1_rpt2	cd05079	5.6e-58	229	491
PTKc_Tyk2_rpt2	cd05080	1.2e-42	229	492
PTKc_Jak2_Jak3_rpt2	cd05081	7.8e-54	229	491
PTKc_Tie2	cd05088	7.9e-38	229	505
PTKc_EGFR	cd05108	5.8e-35	229	505
PTKc_HER2	cd05109	5e-48	229	501
PTKc_HER4	cd05110	3.5e-39	229	499
PTK_HER3	cd05111	3.4e-39	229	501
PTKc_Itk	cd05112	2.7e-90	229	488
PTKc_Btk_Bmx	cd05113	1.7e-93	229	488
PTKc_Tec_Rlk	cd05114	9.1e-90	229	488
STKc_SLK_like	cd06611	3.4e-08	229	502
PKc_MKK4	cd06616	8.5e-07	229	505
STKc_MAPK15	cd07852	2.1e-06	229	500
STKc_MAP4K3_like	cd06613	2e-11	230	491
STKc_MST4	cd06640	9.5e-08	230	505
STKc_MST3	cd06641	3.1e-08	230	505
STKc_PCTAIRE_like	cd07844	9.7e-07	230	504
STKc_PFTAIRE2	cd07870	1.1e-05	230	504
STKc_PCTAIRE1	cd07873	0.00019	230	499
STKc_PCTAIRE2	cd07872	3.3e-05	230	500
STKc_STK25-YSK1	cd06642	1.2e-08	231	505
STKc_MEKK2	cd06652	1.2e-05	231	489
STKc_MEKK3_like_1	cd06653	1.5e-07	231	492
STKc_Nek6_Nek7	cd08224	1.2e-09	231	492
STKc_Nek11	cd08222	1.7e-09	231	488
STKc_ROCK_NDR_like	cd05573	8.6e-05	232	505
STKc_phototropin_lik	cd05574	4.1e-05	232	500
STKc_PKA	cd05580	2e-06	232	501
STKc_PDK1	cd05581	2.5e-12	232	491
STKc_CRIK	cd05601	0.00054	232	504
STKc_PRKX_like	cd05612	0.00014	232	502
PKc_MAPKK	cd06605	2.3e-10	232	493
STKc_myosinIII_like	cd06608	1.3e-06	232	483
STKc_MST3_like	cd06609	2e-11	232	498
STKc_OSR1_SPAK	cd06610	2e-11	232	492
STKc_MST1_2	cd06612	3.1e-11	232	492
PKc_MEK	cd06615	4.3e-06	232	504
PKc_MKK3_6	cd06617	1.7e-07	232	505
PKc_MKK5	cd06619	0.00012	232	505
PKc_MAPKK_Pek1_like	cd06621	1.6e-07	232	505
PKc_MAPKK_PBS2_like	cd06622	2.1e-06	232	505
PKc_MAPKK_plant_like	cd06623	2.5e-12	232	495
STKc_MEKK3_like	cd06625	2.5e-11	232	492
STKc_CdkB_plant	cd07837	2.3e-08	232	492
STKc_CDKL	cd07833	7.5e-07	232	491
STKc_CDC2L1	cd07843	2.7e-06	232	491
STKc_CDKL2_3	cd07846	4.7e-07	232	491
STKc_CDKL1_4	cd07847	6.2e-07	232	491
STKc_CDK6	cd07862	0.00025	232	505
STKc_PCTAIRE3	cd07871	1.6e-06	232	502
STKc_Nek6	cd08228	8.5e-08	232	493
STKc_Nek7	cd08229	2.1e-10	232	493
SPS1	COG0515	4.1e-14	232	505
PTKc_RET	cd05045	7.6e-52	233	494
STKc_MSK_N	cd05583	3.3e-05	233	499
STKc_GRK4_like	cd05605	2.7e-06	233	495
STKc_cPKC_alpha	cd05615	0.00058	233	505
STKc_GRK6	cd05630	0.00038	233	495
STKc_GRK5	cd05632	0.00016	233	495
STKc_MAPKKK	cd06606	3.8e-20	233	492
STKc_Cdc7_like	cd06627	3.3e-17	233	486
STKc_MEKK3	cd06651	5e-08	233	490
STKc_Pho85	cd07836	1.1e-06	233	503
STKc_CDK5	cd07839	3.2e-06	233	503
STKc_MAPK	cd07834	1e-07	233	505
STKc_CDK8_like	cd07842	0.00044	233	491
STKc_NLK	cd07853	0.00073	233	503
STKc_MPK1	cd07857	5.5e-06	233	504
STKc_CDK2_3	cd07860	3.4e-06	233	504
STKc_CDK1_euk	cd07861	5.5e-06	233	503
STKc_CDK4	cd07863	0.00019	233	504
STKc_BUR1	cd07866	2.4e-07	233	480
STKc_Nek	cd08215	2.1e-15	233	492
STKc_Nek1	cd08218	2e-09	233	488
STKc_Nek3	cd08219	3.8e-09	233	487
STKc_Nek8	cd08220	2.4e-05	233	492
STKc_Nek4	cd08223	2.9e-07	233	491
STKc_Nek5	cd08225	2.3e-06	233	487
STKc_Nek10	cd08528	1.7e-07	233	489
PTKc_Axl_like	cd05035	1.7e-63	234	491
PTKc_Tyro3	cd05074	1.3e-58	234	491
PTKc_Axl	cd05075	9.9e-55	234	491
STKc_PKN	cd05589	7.2e-05	234	505
STKc_CDK1_like	cd07835	1.5e-07	234	504
STKc_CMGC	cd05118	1.8e-12	235	491
PKc_STE	cd05122	7.4e-15	235	491
STKc_Yank1	cd05578	1.3e-09	235	491
STKc_MEKK4	cd06626	3.4e-10	235	492
STKc_MAPKKK_Byr2_lik	cd06628	3.2e-17	235	492
STKc_NAK1_like	cd06917	7.7e-11	235	498
STKc_CDK_like	cd07829	5.3e-14	235	491
STKc_MAK_like	cd07830	8.4e-11	235	491
STKc_MOK	cd07831	4.3e-05	235	491
STKc_CCRK	cd07832	2e-07	235	487
STKc_CDK4_6_like	cd07838	2.4e-05	235	491
STKc_CDK9_like	cd07840	1.3e-10	235	491
STKc_CDK7	cd07841	7.3e-10	235	504
PK_STRAD	cd08216	0.0004	235	493
STKc_Nek2	cd08217	8.2e-08	235	492
STKc_CNK2-like	cd08530	8e-08	235	483
STKc_FA2-like	cd08529	2.3e-09	235	487
STKc_RSK_N	cd05582	0.00031	237	504
STKc_CDK10	cd07845	3.5e-07	237	481
PTKc	cd00192	8.1e-131	238	488
PTK_Jak_rpt1	cd05037	1.4e-12	238	488
PTKc_Fes_like	cd05041	2.3e-88	238	489
PTKc_Aatyk	cd05042	1.7e-15	238	490
PTKc_c-ros	cd05044	1.7e-68	238	489
PTKc_Ack_like	cd05040	3.1e-83	238	489
PTKc_Tie	cd05047	8.5e-49	238	492
PTKc_Met_Ron	cd05058	1.2e-62	238	493
PTKc_Syk_like	cd05060	5.5e-84	238	492
PTK_Tyk2_rpt1	cd05076	5.9e-08	238	488
PTK_Jak1_rpt1	cd05077	6.9e-10	238	488
PTK_Jak2_Jak3_rpt1	cd05078	1.3e-13	238	488
PTKc_Fes	cd05084	3.3e-74	238	489
PTKc_Fer	cd05085	2.3e-75	238	489
PTKc_Aatyk2	cd05086	8.9e-16	238	490
PTKc_Aatyk1_Aatyk3	cd05087	1.1e-25	238	489
PTKc_Syk	cd05116	9.1e-68	238	492
STKc_PKC	cd05570	7.1e-07	238	498
STKc_nPKC_theta_delt	cd05592	0.00052	238	503
STKc_nPKC_theta	cd05619	4.2e-05	238	505
STKc_MEKK1	cd06630	5.6e-07	238	484
STKc_MEKK1_plant	cd06632	5.3e-12	238	483
PTKc_Zap-70	cd05115	2.1e-61	239	492
PKc	cd00180	3.9e-65	240	487
STKc_AGC	cd05123	1.6e-09	240	485
STKc_cGK_PKG	cd05572	4.2e-09	240	487
STKc_GRK	cd05577	1.7e-05	240	494
STKc_MAST_like	cd05579	3.5e-07	240	485
STKc_GRK1	cd05608	3.7e-05	240	499
STKc_YSK4	cd06631	1.7e-09	240	492
STKc_Nek9	cd08221	1.3e-06	240	487
STKc_MAPKKK_Bck1_lik	cd06629	1.4e-10	241	492
SH3_1	pfam00018	3e-14	48	102
SH2	pfam00017	5.1e-38	116	193
Pkinase	pfam00069	1.6e-45	234	487
SH3	smart00326	6.6e-22	43	108
SH3_2	pfam07653	8.2e-10	46	107
SH2	smart00252	6.1e-35	114	199
Pkinase_Tyr	pfam07714	1.1e-144	234	487
TyrKc	smart00219	4e-135	234	487
STYKc	smart00221	3.4e-61	234	489
S_TKc	smart00220	8e-53	244	491

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs3756772	Polymorphism	p.GLY122ARG	N/A
Swiss-Prot	VAR_041702	Polymorphism	p.ILE100VAL	N/A
Swiss-Prot	VAR_041703	Polymorphism	p.SER133LEU	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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