Results for the protein: P45985

Results for the Protein: P45985

1170596

6416

MAP2K4

NCBI, UniProt

MP2K4_HUMAN RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4; Short=MAP kinase kinase 4; Short=MAPKK 4; AltName: Full=JNK-activating kinase 1; AltName: Full=MAPK/ERK kinase 4; Short=MEK 4; AltName: Full=SAPK/ERK kinase 1; Short=SEK1; AltName: Full=Stress-activated protein kinase kinase 1; Short=SAPK kinase 1; Short=SAPKK-1; Short=SAPKK1; AltName: Full=c-Jun N-terminal kinase kinase 1; Short=JNKK

			0 6 0 0 6

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Swiss-Prot Protein: P45985

Identical to: NP_003001

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK	cd05596	4.1e-05	60	399
STKc_ROCK2	cd05621	3.9e-06	60	399
PTKc_Kit	cd05104	0.00053	67	369
STKc_PAK1	cd06654	9.8e-12	68	394
STKc_PAK_I	cd06647	2.9e-17	69	392
STKc_PAK2	cd06655	2.4e-13	69	395
STKc_PAK3	cd06656	1.6e-12	69	396
PTKc_PDGFR	cd05055	0.00016	75	369
STKc_PAK5	cd06658	4.6e-14	75	388
STKc_myosinIIIB	cd06639	8.7e-21	78	368
STKc_PAK6	cd06659	1e-11	78	394
STKc_TAO1	cd06635	2e-10	79	399
STKc_myosinIIIA	cd06638	1.2e-25	81	367
PTKc_FGFR1	cd05098	0.0002	83	376
STKc_TAO3	cd06633	1.1e-07	83	387
STKc_JNK2	cd07876	0.00088	83	390
PKc_MKK7	cd06618	4.8e-157	85	387
PTKc_FGFR2	cd05101	4e-05	86	373
STKc_STK10_LOK	cd06644	1.1e-24	86	384
STKc_p38	cd07851	9.5e-07	86	389
PTKc_EGFR_like	cd05057	2.3e-07	87	378
STKc_PAK	cd06614	1.4e-22	87	381
STKc_JNK	cd07850	0.00022	88	396
STKc_p38alpha_MAPK14	cd07877	0.00032	88	392
PTKc_FGFR	cd05053	3.9e-08	89	369
PTKc_FGFR4	cd05099	4e-05	89	396
STKc_SLK_like	cd06611	5.5e-21	89	383
STKc_SLK	cd06643	9.6e-28	89	384
STKc_TAO	cd06607	3.1e-12	90	399
STKc_TAO2	cd06634	3e-10	90	388
PTKc_Tie2	cd05088	2.5e-05	91	392
STKc_CDK9	cd07865	4.6e-06	91	367
STKc_MAP4K4_6	cd06636	5.8e-22	92	367
STKc_MAP4K3	cd06645	6.3e-20	92	366
STKc_MAP4K5	cd06646	1.7e-14	92	366
STKc_p38gamma_MAPK12	cd07880	2e-05	92	395
STKc_ASK	cd06624	6.5e-16	93	367
STKc_PAK4	cd06657	2.3e-11	93	375
PTKc_VEGFR3	cd05102	0.00021	94	372
PTKc_VEGFR2	cd05103	0.00017	94	372
STKc_PAK_II	cd06648	1.1e-14	94	380
STKc_BUR1	cd07866	2.8e-05	94	367
PTKc_InsR_like	cd05032	2.7e-09	95	364
PTKc_Src_like	cd05034	7e-08	95	370
PTKc_ALK_LTK	cd05036	3.4e-07	95	349
PTKc_Csk_like	cd05039	1.7e-07	95	368
PTKc_Abl	cd05052	2.6e-09	95	369
PTKc_FAK	cd05056	5.9e-09	95	373
PTKc_InsR	cd05061	8.3e-06	95	375
PTKc_IGF-1R	cd05062	3.3e-05	95	364
PTKc_Lck_Blk	cd05067	0.0001	95	365
PTKc_Frk_like	cd05068	2.4e-08	95	369
PTKc_Yes	cd05069	7.3e-06	95	370
PTKc_Fyn_Yrk	cd05070	5.6e-06	95	370
PTKc_Lyn	cd05072	3.3e-06	95	366
PTKc_Hck	cd05073	1.4e-05	95	366
PTKc_Csk	cd05082	1.1e-07	95	365
PTKc_Chk	cd05083	1.8e-07	95	371
PTKc_Src	cd05071	7.2e-06	95	367
PTKc_Srm_Brk	cd05148	2.4e-06	95	367
STKc_MAPK4_6	cd07854	0.00014	95	399
STKc_TEY_MAPK_plant	cd07858	1.9e-05	95	399
STKc_CDK12	cd07864	3e-08	95	367
PTKc_Trk	cd05049	2.6e-05	96	364
PTKc_Musk	cd05050	7.4e-06	96	364
PTKc_EphR_A2	cd05063	0.0001	96	369
PTKc_EphR_A10	cd05064	0.00042	96	369
PTKc_EphR_B	cd05065	4.1e-05	96	369
PTKc_DDR_like	cd05097	0.00019	96	369
PKc_MAPKK_Byr1_like	cd06620	3.9e-61	96	381
PKc_MEK2	cd06649	1.7e-52	96	393
PKc_MEK1	cd06650	4.9e-51	96	397
STKc_CNK2-like	cd08530	6.9e-11	96	367
PTKc_EphR	cd05033	1.4e-06	97	367
PTKc_Jak_rpt2	cd05038	1.1e-08	97	369
PTKc_EphR_A	cd05066	9.5e-05	97	369
PTKc_Tec_like	cd05059	2.2e-08	97	366
PTKc_Jak1_rpt2	cd05079	0.001	97	369
PTKc_Tyk2_rpt2	cd05080	8.8e-05	97	371
PTKc_Jak2_Jak3_rpt2	cd05081	7.2e-07	97	369
PTKc_EGFR	cd05108	4.8e-06	97	399
PTKc_HER2	cd05109	5e-08	97	380
PTKc_HER4	cd05110	2.6e-05	97	399
PTK_HER3	cd05111	2.1e-07	97	378
PTKc_Itk	cd05112	7.5e-08	97	366
PTKc_Btk_Bmx	cd05113	7.4e-08	97	366
PTKc_Tec_Rlk	cd05114	1.6e-06	97	366
PKc_MKK4	cd06616	4.2e-246	97	385
STKc_ERK5	cd07855	7.9e-06	97	392
STKc_MAP4K3_like	cd06613	7.9e-39	98	366
STKc_MST4	cd06640	3.7e-29	98	392
STKc_MST3	cd06641	1.1e-30	98	392
STKc_STK25-YSK1	cd06642	3.9e-31	98	392
STKc_MEKK2	cd06652	4.8e-08	98	368
STKc_CDK10	cd07845	1.2e-05	98	392
STKc_Sty1_Hog1	cd07856	2.1e-05	98	399
STKc_PCTAIRE_like	cd07844	6.1e-06	98	385
STKc_PCTAIRE3	cd07871	8.6e-05	98	367
STKc_PCTAIRE2	cd07872	0.00039	98	383
STKc_PCTAIRE1	cd07873	0.00019	98	379
STKc_MST1_2	cd06612	5.8e-32	99	367
STKc_TNIK	cd06637	7.5e-20	99	367
STKc_MEKK3_like_1	cd06653	1.3e-09	99	367
STKc_ERK1_2_like	cd07849	8.3e-07	99	397
STKc_Nek6_Nek7	cd08224	1.6e-10	99	370
STKc_Nek6	cd08228	1.1e-08	99	370
STKc_Nek7	cd08229	9.3e-11	99	367
PTKc_Tie1	cd05089	1.1e-05	100	391
STKc_phototropin_lik	cd05574	1.2e-06	100	375
STKc_ROCK_NDR_like	cd05573	5e-09	100	398
STKc_PKA	cd05580	1.3e-08	100	396
STKc_PDK1	cd05581	9.9e-13	100	367
STKc_DMPK_like	cd05597	1.5e-05	100	398
STKc_NDR_like	cd05599	8.4e-06	100	399
STKc_Sid2p_Dbf2p	cd05600	0.00068	100	364
STKc_CRIK	cd05601	1.3e-08	100	398
STKc_MAST	cd05609	8.6e-07	100	399
STKc_PRKX_like	cd05612	6.7e-06	100	398
STKc_MRCK_alpha	cd05623	4.7e-05	100	399
STKc_MRCK_beta	cd05624	6e-05	100	398
STKc_NDR1	cd05628	0.00023	100	399
STKc_LATS	cd05598	0.00021	100	397
PKc_MAPKK	cd06605	3.7e-193	100	372
STKc_MST3_like	cd06609	4.4e-22	100	385
STKc_OSR1_SPAK	cd06610	2.6e-28	100	367
PKc_MEK	cd06615	4.8e-72	100	385
PKc_MKK3_6	cd06617	7.2e-181	100	386
PKc_MKK5	cd06619	2.7e-65	100	389
PKc_MAPKK_Pek1_like	cd06621	1.8e-50	100	385
PKc_MAPKK_PBS2_like	cd06622	2.9e-97	100	388
PKc_MAPKK_plant_like	cd06623	1.9e-79	100	372
STKc_NAK1_like	cd06917	5e-18	100	378
STKc_CDKL	cd07833	1.2e-11	100	367
STKc_CdkB_plant	cd07837	7.9e-11	100	368
STKc_CDC2L1	cd07843	7.4e-07	100	367
STKc_CDKL2_3	cd07846	3.2e-10	100	367
STKc_CDKL5	cd07848	1.8e-05	100	385
STKc_CDKL1_4	cd07847	4.8e-13	100	367
STKc_CDK6	cd07862	3.7e-05	100	367
SPS1	COG0515	1.1e-28	100	399
PKc_STE	cd05122	5.6e-68	101	366
STKc_MSK_N	cd05583	8.7e-10	101	382
STKc_cPKC	cd05587	0.00053	101	399
STKc_GRK4_like	cd05605	5.9e-09	101	397
STKc_MSK1_N	cd05613	1.1e-07	101	384
STKc_MSK2_N	cd05614	1.9e-06	101	399
STKc_GRK6	cd05630	3.2e-05	101	388
STKc_GRK4	cd05631	1.7e-05	101	388
STKc_GRK5	cd05632	3.7e-06	101	388
STKc_MAPKKK	cd06606	1.6e-33	101	367
STKc_MEKK3	cd06651	3.1e-11	101	369
STKc_CCRK	cd07832	6.3e-12	101	368
STKc_MAPK	cd07834	5e-09	101	399
STKc_Pho85	cd07836	6.6e-06	101	385
STKc_CDK5	cd07839	3.1e-07	101	367
STKc_CDK8_like	cd07842	3.1e-06	101	367
STKc_MPK1	cd07857	7.9e-07	101	398
STKc_TDY_MAPK_plant	cd07859	2.3e-05	101	389
STKc_CDK2_3	cd07860	1.3e-06	101	367
STKc_CDK1_euk	cd07861	6.8e-07	101	367
STKc_CDK4	cd07863	6.8e-07	101	367
STKc_Nek	cd08215	3.7e-21	101	367
STKc_Nek2	cd08217	2e-17	101	367
STKc_Nek1	cd08218	4.5e-13	101	367
STKc_Nek3	cd08219	2.6e-11	101	367
STKc_Nek8	cd08220	3.2e-08	101	367
STKc_Nek4	cd08223	1.4e-08	101	367
STKc_Nek5	cd08225	2.9e-09	101	367
STKc_Nek10	cd08528	3.5e-07	101	364
STKc_FA2-like	cd08529	5.6e-15	101	367
STKc_CMGC	cd05118	3.8e-16	102	367
STKc_RSK_N	cd05582	1.3e-06	102	398
STKc_p70S6K	cd05584	5.7e-05	102	395
STKc_PKN	cd05589	0.00029	102	398
STKc_myosinIII_like	cd06608	1.8e-24	102	367
STKc_YSK4	cd06631	5.4e-14	102	367
STKc_MAK_like	cd07830	1e-08	102	367
STKc_MOK	cd07831	3.7e-10	102	367
STKc_CDK4_6_like	cd07838	2.9e-08	102	367
STKc_CDK9_like	cd07840	3.7e-10	102	367
STKc_CDK7	cd07841	9.6e-07	102	366
STKc_CDK1_like	cd07835	1.8e-07	102	385
PK_STRAD	cd08216	3.4e-09	103	383
PK_STRAD_alpha	cd08227	2.7e-06	103	384
PTKc_Axl_like	cd05035	0.0004	104	369
PTKc_Tie	cd05047	0.00011	104	371
PTKc_RET	cd05045	1.3e-05	104	372
PTKc_Tyro3	cd05074	0.00043	104	369
STKc_Rim15_like	cd05611	2.2e-05	105	366
STKc_MEKK4	cd06626	8.1e-17	105	367
STKc_Cdc7_like	cd06627	1.4e-19	105	367
STKc_CDK_like	cd07829	5.8e-14	105	367
STKc_MAPK15	cd07852	8e-08	105	388
PTKc	cd00192	4.6e-13	106	366
PTKc_Ack_like	cd05040	8.4e-06	106	363
PTKc_Fes_like	cd05041	1.9e-10	106	367
PTKc_Aatyk	cd05042	7.9e-05	106	364
PTKc_Syk_like	cd05060	1e-05	106	371
PTKc_Fes	cd05084	2.5e-06	106	367
PTKc_Aatyk2	cd05086	7.5e-05	106	370
PTKc_Aatyk1_Aatyk3	cd05087	0.00036	106	370
PTKc_Syk	cd05116	6.8e-07	106	370
STKc_MAPKKK_Bck1_lik	cd06629	1.5e-10	106	367
STKc_MEKK1	cd06630	4e-10	106	368
STKc_MEKK1_plant	cd06632	1.2e-16	106	367
STKc_Nek11	cd08222	1.5e-07	106	367
PTKc_Zap-70	cd05115	5.8e-08	107	370
PK_STRAD_beta	cd08226	7.3e-06	107	390
PKc	cd00180	1.7e-62	108	365
PTKc_c-ros	cd05044	3.7e-05	108	364
PTKc_Met_Ron	cd05058	1.5e-05	108	371
PTKc_Fer	cd05085	7.5e-07	108	367
STKc_AGC	cd05123	8.4e-17	108	367
STKc_PKC	cd05570	1.3e-07	108	381
STKc_PKB	cd05571	2.6e-05	108	399
STKc_cGK_PKG	cd05572	1.4e-10	108	372
STKc_SGK	cd05575	0.00011	108	398
STKc_GRK	cd05577	4.9e-10	108	387
STKc_Yank1	cd05578	9.7e-16	108	367
STKc_MAST_like	cd05579	2.2e-15	108	372
STKc_aPKC	cd05588	1.8e-05	108	399
STKc_Sck1_like	cd05586	2.9e-05	108	397
STKc_nPKC_epsilon	cd05591	0.00026	108	397
STKc_nPKC_theta_delt	cd05592	5.4e-05	108	395
STKc_PKB_alpha	cd05594	0.00014	108	399
STKc_YPK1_like	cd05585	5.5e-06	108	394
STKc_SGK1	cd05602	0.001	108	396
STKc_SGK2	cd05603	5.9e-05	108	399
STKc_beta_ARK	cd05606	2.5e-07	108	387
STKc_GRK7	cd05607	1.9e-08	108	383
STKc_GRK1	cd05608	1.5e-10	108	387
STKc_aPKC_zeta	cd05617	9.9e-05	108	399
STKc_nPKC_theta	cd05619	5.9e-05	108	392
STKc_GRK3	cd05633	9.2e-07	108	388
STKc_MEKK3_like	cd06625	1.4e-16	108	367
STKc_MAPKKK_Byr2_lik	cd06628	3.2e-20	108	367
STKc_Nek9	cd08221	4.8e-09	108	367
Pkinase	pfam00069	2.5e-61	102	367
Pkinase_Tyr	pfam07714	2.5e-15	102	367
TyrKc	smart00219	1.6e-14	102	367
STYKc	smart00221	3.3e-70	102	367
S_TKc	smart00220	2e-74	112	367
KIND	smart00750	5.3e-08	196	375

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040822	Polymorphism	p.ALA279THR	N/A
Swiss-Prot	VAR_040819	Polymorphism	p.ARG154TRP	N/A
Swiss-Prot	VAR_040820	Polymorphism	p.ASN234ILE	N/A
Swiss-Prot	VAR_040818	Polymorphism	p.GLN142LEU	N/A
Swiss-Prot	VAR_062963	Polymorphism	p.SER16ARG	N/A
Swiss-Prot	VAR_040821	Polymorphism	p.SER251ASN	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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