Results for the protein: P31751

Results for the Protein: P31751

1170703

208

AKT2

NCBI, UniProt

AKT2_HUMAN RecName: Full=RAC-beta serine/threonine-protein kinase; AltName: Full=Protein kinase Akt-2; AltName: Full=Protein kinase B beta; Short=PKB beta; AltName: Full=RAC-PK-beta

Known Diseases associated with this Protein:
  DIABETES MELLITUS, NON-INSULIN-DEPENDENT (NIDDM)
  DIABETES MELLITUS, TYPE II
  HYPOINSULINEMIC HYPOGLYCEMIA AND HEMIHYPERTROPHY
  HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY (HIHGHH)

4

2

2

0

4

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Swiss-Prot Protein: P31751

Identical to: NP_001617

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PH	cd00821	5.6e-19	8	106
PH-like	cd00900	1.7e-14	8	106
	cd01246	4.1e-05	8	106
PH_AGAP	cd01250	0.00041	8	106
PH_GRP1-like	cd01252	0.0006	8	113
PTKc_VEGFR2	cd05103	0.00064	79	413
STKc_ROCK2	cd05621	1.6e-33	108	477
STKc_ROCK1	cd05622	2.3e-38	115	478
STKc_ROCK	cd05596	5.2e-47	116	477
STKc_TAO1	cd06635	8.3e-07	119	446
STKc_PAK1	cd06654	8.8e-16	128	433
STKc_PAK4	cd06657	3.3e-09	128	423
STKc_PAK5	cd06658	5e-09	128	427
STKc_JNK1	cd07875	0.00065	128	465
STKc_PAK_II	cd06648	1.1e-14	129	422
STKc_PAK3	cd06656	3.5e-13	129	435
STKc_MAP4K4_6	cd06636	1.7e-06	131	409
STKc_JNK2	cd07876	2.4e-05	131	480
PTKc_FGFR1	cd05098	0.00035	132	415
STKc_JNK3	cd07874	6.4e-05	133	480
STKc_p38alpha_MAPK14	cd07877	5e-07	133	464
STKc_myosinIIIB	cd06639	5.8e-07	134	410
STKc_JNK	cd07850	8.9e-07	134	478
PTKc_FGFR2	cd05101	0.00027	135	415
STKc_TAO3	cd06633	0.0002	135	446
STKc_PAK	cd06614	5e-20	136	421
STKc_p38	cd07851	9.5e-11	136	453
STKc_p38beta_MAPK11	cd07878	3.2e-05	136	469
STKc_p38gamma_MAPK12	cd07880	9.6e-09	136	466
PKc_MKK7	cd06618	2.1e-10	137	420
STKc_PAK_I	cd06647	5.5e-22	137	424
STKc_PAK2	cd06655	1.1e-15	137	434
PTK_Ryk	cd05043	4.9e-06	138	373
STKc_PAK6	cd06659	1.6e-15	138	434
PTKc_IGF-1R	cd05062	0.00043	140	402
STKc_myosinIIIA	cd06638	2.2e-08	140	409
STKc_STK10_LOK	cd06644	2.3e-15	140	430
STKc_p38delta_MAPK13	cd07879	9.2e-05	140	466
PTKc_FGFR4	cd05099	3.6e-05	141	429
PTKc_FGFR3	cd05100	0.0004	141	447
STKc_TAO	cd06607	8.7e-07	141	447
STKc_TAO2	cd06634	1.2e-07	141	441
STKc_CDK9	cd07865	3.8e-11	141	409
STKc_MAP4K3	cd06645	6.8e-10	142	408
STKc_MAP4K5	cd06646	3.5e-10	142	408
STKc_ASK	cd06624	2e-18	143	409
PTKc_EGFR_like	cd05057	0.00022	144	413
PTKc_ALK_LTK	cd05036	1.4e-05	145	406
PTKc_FAK	cd05056	2.5e-07	145	408
PTKc_Tie2	cd05088	6.4e-06	145	436
STKc_TNIK	cd06637	1.1e-08	145	409
STKc_CDK10	cd07845	5.4e-11	145	428
STKc_TEY_MAPK_plant	cd07858	1.6e-08	145	472
STKc_CDK12	cd07864	2.2e-10	145	409
PTKc_Ror	cd05048	8.8e-06	146	380
PTKc_Trk	cd05049	1.7e-05	146	406
PTKc_Musk	cd05050	3.7e-06	146	406
PTKc_Abl	cd05052	6.3e-07	146	408
PTKc_InsR	cd05061	8.5e-05	146	419
PTKc_EphR_A2	cd05063	0.0008	146	408
PTKc_EphR_A10	cd05064	0.00018	146	408
PTKc_Lck_Blk	cd05067	0.00037	146	426
PTKc_Frk_like	cd05068	5.2e-07	146	409
PTKc_Fyn_Yrk	cd05070	0.00073	146	400
PTKc_Lyn	cd05072	0.00017	146	408
PTKc_Hck	cd05073	0.00032	146	407
PTKc_Ror1	cd05090	0.00011	146	409
PTKc_TrkA	cd05092	1.3e-05	146	406
PTKc_TrkB	cd05093	3.1e-05	146	421
PTKc_DDR2	cd05095	9.9e-05	146	411
PTKc_DDR_like	cd05097	0.00044	146	411
PTKc_Csk	cd05082	1.3e-06	146	407
PKc_MEK2	cd06649	7.8e-07	146	477
PKc_MEK1	cd06650	1.3e-05	146	472
STKc_ERK5	cd07855	5.3e-08	146	451
PTKc_InsR_like	cd05032	7e-06	147	406
PTKc_EphR	cd05033	0.00038	147	385
PTKc_Src_like	cd05034	9e-06	147	407
PTKc_FGFR	cd05053	0.0003	147	411
PTKc_Tec_like	cd05059	1.5e-07	147	385
PTKc_EphR_A	cd05066	0.00063	147	409
PTKc_Csk_like	cd05039	4.9e-07	147	361
PTKc_EGFR	cd05108	0.00028	147	424
PTKc_Itk	cd05112	1.8e-07	147	407
PTKc_Btk_Bmx	cd05113	3.7e-09	147	407
PTKc_Tec_Rlk	cd05114	4.5e-07	147	407
PKc_MAPKK_Byr1_like	cd06620	1.6e-08	147	423
STKc_MAP4K3_like	cd06613	1.9e-17	148	408
PKc_MKK4	cd06616	4.3e-08	148	422
STKc_PCTAIRE_like	cd07844	1.2e-09	148	409
STKc_Sty1_Hog1	cd07856	6.7e-08	148	455
STKc_BUR1	cd07866	3.7e-11	148	409
STKc_PFTAIRE1	cd07869	3.1e-05	148	416
STKc_PCTAIRE3	cd07871	4.7e-09	148	439
STKc_PCTAIRE2	cd07872	3.1e-08	148	429
PTKc_Chk	cd05083	8e-06	149	407
PTKc_Tie1	cd05089	0.00011	149	435
STKc_SLK	cd06643	2.3e-10	149	428
STKc_Nek6_Nek7	cd08224	6.3e-10	149	405
STKc_Nek6	cd08228	3.3e-11	149	412
STKc_Nek7	cd08229	1.5e-11	149	405
PTKc_Jak_rpt2	cd05038	4.8e-08	150	434
PTKc_Srm_Brk	cd05148	6.4e-06	150	396
STKc_ROCK_NDR_like	cd05573	4.8e-76	150	476
STKc_phototropin_lik	cd05574	3.2e-69	150	435
STKc_PKA	cd05580	3.4e-129	150	442
STKc_PDK1	cd05581	2.1e-73	150	409
STKc_DMPK_like	cd05597	5.3e-64	150	478
STKc_LATS	cd05598	4.2e-42	150	470
STKc_NDR_like	cd05599	1.2e-24	150	479
STKc_Sid2p_Dbf2p	cd05600	2.7e-23	150	477
STKc_CRIK	cd05601	5.8e-50	150	476
STKc_MAST	cd05609	1.3e-73	150	440
STKc_PRKX_like	cd05612	8.9e-110	150	443
STKc_MRCK_alpha	cd05623	2.1e-46	150	477
STKc_LATS1	cd05625	4e-31	150	470
STKc_NDR2	cd05627	2.4e-29	150	479
STKc_NDR1	cd05628	2.1e-26	150	479
STKc_MRCK_beta	cd05624	3.8e-54	150	476
STKc_NDR_like_fungal	cd05629	1.9e-48	150	481
STKc_LATS2	cd05626	6.1e-30	150	479
PKc_MAPKK	cd06605	6.8e-15	150	414
STKc_myosinIII_like	cd06608	5.7e-13	150	409
STKc_MST3_like	cd06609	4.1e-15	150	430
STKc_OSR1_SPAK	cd06610	1.6e-13	150	409
STKc_MST1_2	cd06612	5.3e-16	150	409
PKc_MEK	cd06615	1.3e-10	150	422
PKc_MKK3_6	cd06617	7.9e-09	150	428
PKc_MKK5	cd06619	1.6e-06	150	430
PKc_MAPKK_Pek1_like	cd06621	2.2e-10	150	423
PKc_MAPKK_PBS2_like	cd06622	2.4e-08	150	467
PKc_MAPKK_plant_like	cd06623	7.9e-20	150	416
STKc_MEKK3_like	cd06625	1.3e-22	150	409
STKc_MST4	cd06640	8.1e-15	150	430
STKc_MST3	cd06641	3.1e-11	150	430
STKc_STK25-YSK1	cd06642	1.3e-11	150	430
STKc_MEKK2	cd06652	6.3e-09	150	410
STKc_MEKK3_like_1	cd06653	5.6e-10	150	409
STKc_NAK1_like	cd06917	9.1e-15	150	422
STKc_CDKL	cd07833	1.1e-13	150	409
STKc_CdkB_plant	cd07837	1.3e-09	150	410
STKc_CDKL2_3	cd07846	4e-10	150	409
STKc_CDC2L1	cd07843	8.9e-08	150	409
STKc_CDKL1_4	cd07847	6.2e-12	150	409
STKc_CDKL5	cd07848	1.3e-06	150	409
STKc_ERK1_2_like	cd07849	2.7e-06	150	475
STKc_CDK6	cd07862	2.1e-05	150	439
STKc_PFTAIRE2	cd07870	2.9e-07	150	409
SPS1	COG0515	1.4e-60	150	481
PTKc_RET	cd05045	3.1e-05	151	407
PTKc_EphR_B	cd05065	0.00017	151	410
PTKc_Jak1_rpt2	cd05079	4.6e-05	151	430
PKc_STE	cd05122	1.5e-31	151	408
STKc_Yank1	cd05578	4e-80	151	409
STKc_MSK_N	cd05583	3.3e-110	151	428
STKc_cPKC	cd05587	9.9e-128	151	477
STKc_GRK4_like	cd05605	4.1e-70	151	430
STKc_MSK1_N	cd05613	3.7e-92	151	428
STKc_MSK2_N	cd05614	6.9e-93	151	478
STKc_cPKC_alpha	cd05615	9.7e-114	151	477
STKc_cPKC_beta	cd05616	9.3e-115	151	477
STKc_GRK6	cd05630	3.4e-65	151	430
STKc_GRK4	cd05631	2.2e-62	151	430
STKc_GRK5	cd05632	2.9e-63	151	430
STKc_MAPKKK	cd06606	3.4e-42	151	409
STKc_Cdc7_like	cd06627	9.2e-20	151	409
STKc_MEKK3	cd06651	1.4e-12	151	411
STKc_CCRK	cd07832	3e-14	151	410
STKc_MAPK	cd07834	2.8e-10	151	433
STKc_Pho85	cd07836	1.5e-09	151	409
STKc_CDK5	cd07839	6.3e-08	151	409
STKc_CDK7	cd07841	1.1e-13	151	424
STKc_CDK8_like	cd07842	2.1e-07	151	409
STKc_NLK	cd07853	2.1e-06	151	473
STKc_MPK1	cd07857	1.4e-07	151	434
STKc_TDY_MAPK_plant	cd07859	4e-08	151	471
STKc_CDK2_3	cd07860	1.1e-11	151	409
STKc_CDK1_euk	cd07861	2.7e-12	151	439
STKc_CDK4	cd07863	3.3e-06	151	409
STKc_Nek	cd08215	1.3e-53	151	409
STKc_Nek2	cd08217	1e-15	151	409
STKc_Nek1	cd08218	1e-33	151	409
STKc_Nek3	cd08219	1.2e-31	151	404
STKc_Nek8	cd08220	1.4e-14	151	409
STKc_Nek4	cd08223	2.7e-23	151	409
STKc_Nek5	cd08225	5.4e-26	151	409
STKc_Nek10	cd08528	4.6e-10	151	387
STKc_FA2-like	cd08529	2.1e-16	151	399
STKc_CNK2-like	cd08530	6.6e-15	151	399
PTKc_Axl_like	cd05035	9.1e-06	152	408
PTKc_Tyro3	cd05074	2.3e-07	152	410
PTKc_Tyk2_rpt2	cd05080	4.8e-07	152	431
PTKc_Jak2_Jak3_rpt2	cd05081	2.1e-08	152	438
STKc_CMGC	cd05118	2e-16	152	409
STKc_PKN	cd05589	1.8e-147	152	476
STKc_MAPKKK_Bck1_lik	cd06629	4.2e-12	152	409
STKc_CDK_like	cd07829	1.5e-18	152	409
STKc_MAK_like	cd07830	1.9e-14	152	409
STKc_MOK	cd07831	1.2e-12	152	409
STKc_CDK1_like	cd07835	2.5e-08	152	409
STKc_CDK4_6_like	cd07838	1e-11	152	409
STKc_CDK9_like	cd07840	2.4e-14	152	409
STKc_MAPK4_6	cd07854	6.9e-05	152	452
STKc_CDC2L6	cd07867	0.00056	152	439
STKc_CDK8	cd07868	0.00092	152	439
STKc_MAPKKK_Byr2_lik	cd06628	6.5e-22	153	409
STKc_PCTAIRE1	cd07873	1.4e-06	153	425
PK_STRAD	cd08216	2.6e-05	153	428
STKc_Nek9	cd08221	6.2e-13	153	409
STKc_Nek11	cd08222	2.2e-21	153	409
STKc_RSK_N	cd05582	3e-100	155	476
STKc_p70S6K	cd05584	6.1e-115	155	478
STKc_Rim15_like	cd05611	7.1e-20	155	415
STKc_MEKK4	cd06626	9.6e-18	155	409
PTKc	cd00192	2.4e-12	156	405
PTKc_Fes_like	cd05041	4.6e-08	156	406
PTKc_Aatyk	cd05042	0.00012	156	412
PTKc_c-ros	cd05044	0.00019	156	406
PTKc_Tie	cd05047	4.8e-05	156	411
PTKc_Ack_like	cd05040	1.6e-07	156	390
PTKc_Met_Ron	cd05058	7.8e-05	156	412
PTKc_Syk_like	cd05060	0.00012	156	390
PTKc_Fes	cd05084	3.5e-07	156	404
PTKc_Fer	cd05085	2.6e-05	156	406
PTKc_Syk	cd05116	6.6e-07	156	409
STKc_PKC	cd05570	5.4e-159	156	476
STKc_PKB	cd05571	7.9e-247	156	478
STKc_SGK	cd05575	5.8e-146	156	476
STKc_aPKC	cd05588	4.1e-114	156	477
STKc_nPKC_eta	cd05590	2.2e-127	156	477
STKc_nPKC_epsilon	cd05591	2e-127	156	477
STKc_PKB_gamma	cd05593	1.2e-257	156	481
STKc_PKB_alpha	cd05594	2.5e-264	156	479
STKc_PKB_beta	cd05595	1.2e-287	156	478
STKc_nPKC_theta_delt	cd05592	5.3e-123	156	478
STKc_SGK1	cd05602	2.1e-117	156	478
STKc_SGK2	cd05603	1.1e-124	156	477
STKc_aPKC_zeta	cd05617	1.6e-106	156	477
STKc_aPKC_iota	cd05618	1.1e-105	156	477
STKc_nPKC_theta	cd05619	3.6e-104	156	478
STKc_nPKC_delta	cd05620	4e-97	156	478
STKc_SGK3	cd05604	1.7e-122	156	478
STKc_MEKK1	cd06630	1.1e-10	156	410
STKc_MEKK1_plant	cd06632	2.5e-16	156	409
STKc_YSK4	cd06631	1.2e-11	156	409
STKc_beta_ARK	cd05606	5.5e-64	157	429
STKc_GRK3	cd05633	4.9e-59	157	430
PKc	cd00180	4.3e-78	158	407
PTKc_Zap-70	cd05115	7.4e-06	158	409
STKc_AGC	cd05123	9.5e-164	158	409
STKc_GRK	cd05577	3.5e-75	158	429
STKc_cGK_PKG	cd05572	4.3e-82	158	416
STKc_MAST_like	cd05579	2.2e-63	158	414
STKc_YPK1_like	cd05585	2e-116	158	475
STKc_Sck1_like	cd05586	4.8e-105	158	475
STKc_GRK7	cd05607	4.8e-55	158	429
STKc_GRK1	cd05608	1.4e-67	158	429
STKc_SLK_like	cd06611	1.3e-13	158	420
STKc_MAPK15	cd07852	4.8e-07	199	441
PH	pfam00169	1.5e-24	6	108
Pkinase	pfam00069	5e-110	152	409
Pkinase_C	pfam00433	1.4e-11	429	479
PH	smart00233	1.4e-23	6	108
Pkinase_Tyr	pfam07714	7.3e-17	152	409
TyrKc	smart00219	3.1e-13	152	409
STYKc	smart00221	2.3e-96	152	409
S_TKc	smart00220	8.3e-114	162	409
KIND	smart00750	1.1e-05	241	417
S_TK_X	smart00133	5.8e-16	410	477

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_067310	Disease	p.ARG274HIS	Diabetes mellitus, non-insulin-dependent (NIDDM)
Swiss-Prot	VAR_040357	Polymorphism	p.ARG208LYS	N/A
Swiss-Prot	VAR_067309	Disease	p.GLU17LYS	Hypoinsulinemic hypoglycemia with hemihypertrophy (HIHGHH)
Swiss-Prot	VAR_040356	Polymorphism	p.ILE188VAL	N/A
OMIM	164731.0001	Disease	p.ARG274HIS	DIABETES MELLITUS, TYPE II
OMIM	164731.0002	Disease	p.GLU17LYS	HYPOINSULINEMIC HYPOGLYCEMIA AND HEMIHYPERTROPHY

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258