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Results for the Protein: NP_001073594
122056476
841

caspase-8 isoform G precursor [Homo sapiens]

Known Diseases associated with this Protein:
  BREAST CANCER, PROTECTION AGAINST
  CASPASE 8 DEFICIENCY
2
3
2
3
0
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

DED - smart00031
DED_FADD - cd08336
DED_Caspase_10_repea - cd08341
DED_c-FLIP_repeat2 - cd08340
DED_PEA15 - cd08338
DED_Caspase_8_10_rep - cd08792
DED_Caspase_8_repeat - cd08333
DED - pfam01335
DED_Caspase-like_rep - cd08776
DED - cd00045
DED_c-FLIP_repeat1 - cd08337
DED_Caspase_8_10_rep - cd08334
DED_Caspase_10_repea - cd08814
DED_Caspase_8_repeat - cd08813
DED_Caspase-like_rep - cd08775
CASc - cd00032
CASc - smart00115
Peptidase_C14 - pfam00656




Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
DED_FADDcd083362.1e-1360141
DED_PEA15cd083380.0001460143
DED_c-FLIP_repeat2cd083400.00160137
DED_Caspase_10_repeacd083416.7e-0860142
DEDcd000456.4e-1562138
DED_Caspase_8_repeatcd083333.1e-5462143
DED_Caspase-like_repcd087761.8e-2162138
DED_Caspase_8_10_repcd087929.1e-2662138
DED_c-FLIP_repeat1cd083370.0001863146
DED_Caspase_8_10_repcd083345e-44157239
DED_Caspase_8_repeatcd088132e-62157239
DED_Caspase_10_repeacd088145.3e-09157239
DED_Caspase-like_repcd087757.7e-49158237
CASccd000322.1e-132284536
DEDpfam013351.4e-3462145
DEDpfam013359.5e-27160242
Peptidase_C14pfam006562.3e-94293535
DEDsmart000311.3e-3260139
DEDsmart000313e-27158237
CAScsmart001159.7e-141285537

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs1045485 Polymorphismp.ASP344HISN/A
dbSNPrs3769823 Polymorphismp.LYS14ARGN/A
dbSNPrs3769824 Polymorphismp.MET1THRN/A
OMIM601763.0001 Diseasep.ARG248TRPCASPASE 8 DEFICIENCY
OMIM601763.0003 Diseasep.ASP302HISBREAST CANCER, PROTECTION AGAINST



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