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Results for the Protein: P08235
126885

MCR_HUMAN RecName: Full=Mineralocorticoid receptor; Short=MR; AltName: Full=Nuclear receptor subfamily 3 group C member 2

Known Diseases associated with this Protein:
  EARLY-ONSET HYPERTENSION WITH SEVERE EXACERBATION IN PREGNANCY (EOHSEP)
  PSEUDOHYPOALDOSTERONISM 1, AUTOSOMAL DOMINANT (PHA1A)
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0
21
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

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Default View:

NR_DBD_LXR - cd07160
NR_DBD_GCNF_like - cd07169
NR_DBD_DHR4_like - cd07168
NR_DBD_VDR - cd06955
NR_DBD_PNR - cd06970
NR_DBD_TLX - cd07163
NR_DBD_ERR - cd07170
NR_DBD_RAR - cd06964
NR_DBD_AR - cd07173
NR_DBD_TR2_like - cd06967
NR_DBD_ER - cd07171
NR_DBD_REV_ERB - cd07166
NR_DBD_GR_PR - cd07172
NR_DBD_ROR - cd06968
NR_DBD_EcR - cd07161
NR_DBD_FXR - cd06962
zf-C4 - pfam00105
2DBD_NR_DBD1 - cd07157
NR_DBD_NGFI-B - cd06969
NR_DBD_RXR - cd06956
NR_DBD_CAR - cd06966
ZnF_C4 - smart00399
NR_DBD_PXR - cd07162
NR_DBD_Ppar - cd06965
NR_DBD_EcR_like - cd06959
NR_DBD_TR - cd06961
NR_DBD_DmE78_like - cd07165
NR_DBD_PNR_like_1 - cd07164
NR_DBD_Lrh-1_like - cd07167
2DBD_NR_DBD2 - cd07179
NR_DBD_Ppar_like - cd07158
NR_DBD_GR_like - cd06963
NR_DBD_PNR_like_2 - cd06957
NR_DBD_like - cd06916
NR_DBD_COUP_TF - cd06958
NR_DBD_HNF4A - cd06960
NR_DBD_PNR_like - cd07154
NR_DBD_VDR_like - cd07156
NR_DBD_ER_like - cd07155
NR_LBD_Nurr1_like - cd06945
NR_LBD_HNF4_like - cd06931
NR_LBD_ER - cd06949
NR_LBD_GR_Like - cd06947
NR_LBD_GR - cd07076
NR_LBD_MR - cd07075
NR_LBD_PR - cd07074
NR_LBD_DHR4_like - cd06953
NR_LBD_RXR_like - cd06943
NR_LBD_ERR - cd06946
NR_LBD_AR - cd07073
NR_LBD_ER_like - cd07068
NR_LBD_F1 - cd06929
NR_LBD_Sex_1_like - cd06942
NR_LBD_F2 - cd06930
NR_LBD - cd06157
HOLI - smart00430
Hormone_recep - pfam00104


Swiss-Prot Protein: P08235
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
NR_DBD_LXRcd071607e-16583683
NR_DBD_VDRcd069559.8e-12595695
NR_DBD_PNRcd069705e-19595681
NR_DBD_DHR4_likecd071685.9e-22595682
NR_DBD_GCNF_likecd071695.3e-23595682
NR_DBD_TLXcd071635.4e-18596684
NR_DBD_RARcd069643.1e-23597677
NR_DBD_ERRcd071703.9e-24597693
NR_DBD_TR2_likecd069674.6e-23598688
NR_DBD_REV_ERBcd071664.4e-16598685
NR_DBD_ERcd071716.8e-30598679
NR_DBD_ARcd071731.8e-49598679
NR_DBD_GR_PRcd071727.6e-59599676
NR_DBD_FXRcd069623.2e-15600683
NR_DBD_RORcd069684.7e-21600693
NR_DBD_EcRcd071618.7e-19600690
NR_DBD_RXRcd069569e-24601677
NR_DBD_CARcd069661.7e-18601692
NR_DBD_NGFI-Bcd069698.4e-26601675
2DBD_NR_DBD1cd071572.5e-13601684
NR_DBD_EcR_likecd069593.3e-21602674
NR_DBD_TRcd069612.5e-24602684
NR_DBD_Pparcd069656.4e-15602689
NR_DBD_PXRcd071624.7e-17602688
NR_DBD_likecd069161e-41603674
NR_DBD_PNR_like_2cd069571.2e-22603683
NR_DBD_COUP_TFcd069581.1e-22603675
NR_DBD_HNF4Acd069603.5e-30603678
NR_DBD_GR_likecd069634.2e-56603675
NR_DBD_PNR_likecd071541.5e-23603674
NR_DBD_ER_likecd071551.3e-26603676
NR_DBD_VDR_likecd071563.4e-23603678
NR_DBD_Ppar_likecd071588.3e-21603674
NR_DBD_PNR_like_1cd071642.4e-24603680
NR_DBD_DmE78_likecd071652.5e-19603683
NR_DBD_Lrh-1_likecd071673.1e-24603691
2DBD_NR_DBD2cd071798.6e-19603676
NR_LBD_Nurr1_likecd069450.00035720970
NR_LBD_HNF4_likecd069310.00074729938
NR_LBD_ERcd069492.5e-09734967
NR_LBD_GR_Likecd069478e-183737982
NR_LBD_PRcd070742.5e-118737984
NR_LBD_MRcd070758.9e-182737984
NR_LBD_GRcd070761.2e-128737984
NR_LBD_DHR4_likecd069533.4e-05738948
NR_LBD_RXR_likecd069432.4e-07739932
NR_LBD_ERRcd069464.3e-10739958
NR_LBD_ER_likecd070681.3e-14739966
NR_LBD_ARcd070733.8e-104739982
NR_LBD_F1cd069291.2e-06763942
NR_LBD_Sex_1_likecd069425.5e-05763961
NR_LBD_F2cd069301.6e-55766934
NR_LBDcd061574.1e-50767934
zf-C4pfam001056.2e-44601670
Hormone_receppfam001042.7e-38797963
ZnF_C4smart003993.8e-35602671
HOLIsmart004304.5e-36773934

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_015625Polymorphismp.ALA241VALN/A
Swiss-ProtVAR_014625Polymorphismp.ARG537GLNN/A
Swiss-ProtVAR_031270Diseasep.ARG659SERPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_031273Diseasep.ASN770LYSPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_014626Polymorphismp.ASN554SERN/A
Swiss-ProtVAR_014624Polymorphismp.ASN444THRN/A
Swiss-ProtVAR_031269Diseasep.CYS645SERPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_031274Diseasep.GLN776ARGPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_031278Diseasep.GLU972GLYPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_031268Diseasep.GLY633ARGPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_036063Polymorphismp.HIS7GLNN/A
Swiss-ProtVAR_014623Polymorphismp.ILE180VALN/A
Swiss-ProtVAR_031272Diseasep.LEU769PROPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_015627Diseasep.LEU924PROPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_031279Diseasep.LEU979PROPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_029311Polymorphismp.PHE826TYRN/A
Swiss-ProtVAR_031271Diseasep.PRO759SERPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_031276Diseasep.SER815ARGPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_015626Diseasep.SER810LEUEarly-onset hypertension with severe exacerbation in pregnancy (EOHSEP)
Swiss-ProtVAR_031277Diseasep.SER818LEUPseudohypoaldosteronism 1, autosomal dominant (PHA1A)
Swiss-ProtVAR_031275Diseasep.SER805PROPseudohypoaldosteronism 1, autosomal dominant (PHA1A)



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