Results for the protein: P11388

Results for the Protein: P11388

13959709

7153

TOP2A

NCBI, UniProt

TOP2A_HUMAN RecName: Full=DNA topoisomerase 2-alpha; AltName: Full=DNA topoisomerase II, alpha isozyme

Known Diseases associated with this Protein:
DNA TOPOISOMERASE II, RESISTANCE TO INHIBITION OF, BY AMSACRINE

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Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Default View: GyrB - COG0187 HATPase_c - pfam02518 HATPase_c - smart00387 TOP2c - smart00433 HATPase_c - cd00075 TopoIIA_Trans_ScTopo - cd03481 DNA_gyraseB - pfam00204 TopoII_MutL_Trans - cd00329 TOPRIM_TopoIIA_like - cd01030 TOPRIM - cd00188 TOPRIM_TopoIIA - cd03365 TOPRIM_TopoIIA_GyrB - cd03366 GyrA - COG0188 TOP4c - smart00434 TOP4c - cd00187 DNA_topoisoIV - pfam00521 DTHCT - pfam08070	Swiss-Prot Protein: P11388 Identical to: NP_001058 Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
HATPase_c	cd00075	1.2e-07	81	221
TopoIIA_Trans_ScTopo	cd03481	8e-108	265	417
TopoII_MutL_Trans	cd00329	3.7e-21	267	382
TOPRIM	cd00188	2.8e-14	455	572
TOPRIM_TopoIIA_like	cd01030	1.7e-76	455	575
TOPRIM_TopoIIA	cd03365	4e-91	455	575
TOPRIM_TopoIIA_GyrB	cd03366	2.8e-23	455	577
GyrA	COG0188	3e-11	674	1492
TOP4c	cd00187	4.1e-232	711	1174
HATPase_c	pfam02518	4.8e-19	76	224
DNA_gyraseB	pfam00204	2.4e-51	266	430
DNA_topoisoIV	pfam00521	2.7e-201	713	1172
HATPase_c	smart00387	1.1e-05	76	224
TOP2c	smart00433		80	670
TOP4c	smart00434	2e-232	693	1169
DTHCT	pfam08070	3e-50	1435	1523

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs11540720	Polymorphism	p.ALA1515SER	N/A
Swiss-Prot	VAR_007532	Polymorphism	p.ARG450GLN	N/A
Swiss-Prot	VAR_007533	Polymorphism	p.ARG487LYS	N/A
dbSNP	rs34300454	Polymorphism	p.GLY1386ASP	N/A
dbSNP	rs11656816	Polymorphism	p.SER654ILE	N/A
Swiss-Prot	VAR_029245	Polymorphism	p.THR1324LYS	N/A
OMIM	126430.0001	Disease	p.ARG486LYS	DNA TOPOISOMERASE II, RESISTANCE TO INHIBITION OF, BY AMSACRINE

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