Results for the protein: O00444

Results for the Protein: O00444

160113150

10733

PLK4

NCBI, UniProt

PLK4_HUMAN RecName: Full=Serine/threonine-protein kinase PLK4; AltName: Full=Polo-like kinase 4; Short=PLK-4; AltName: Full=Serine/threonine-protein kinase 18; AltName: Full=Serine/threonine-protein kinase Sak

			0 9 0 2 7

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Swiss-Prot Protein: O00444

Identical to: NP_055079

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK	cd05596	5.8e-08	1	329
STKc_ROCK2	cd05621	4.4e-08	1	327
PKc_MKK7	cd06618	1.2e-10	1	285
STKc_TAO3	cd06633	5.7e-07	1	308
STKc_myosinIIIB	cd06639	2.1e-09	1	266
STKc_PAK_I	cd06647	2.7e-16	1	291
STKc_PAK_II	cd06648	4.9e-13	1	277
STKc_PAK2	cd06655	1.8e-09	1	287
STKc_PAK3	cd06656	5.5e-10	1	299
STKc_PAK4	cd06657	1.4e-07	1	284
STKc_PAK6	cd06659	6.1e-12	1	293
STKc_PAK5	cd06658	1.1e-07	1	283
STKc_PAK1	cd06654	6.4e-09	1	293
STKc_p38	cd07851	2e-10	1	299
STKc_Sty1_Hog1	cd07856	2e-10	1	297
STKc_CDK9	cd07865	2.1e-11	1	265
STKc_JNK2	cd07876	9e-05	1	296
STKc_p38alpha_MAPK14	cd07877	2.1e-06	1	327
STKc_p38beta_MAPK11	cd07878	1.8e-06	1	304
STKc_p38delta_MAPK13	cd07879	0.00035	1	306
STKc_p38gamma_MAPK12	cd07880	8.4e-07	1	304
PTKc_FGFR1	cd05098	4.1e-05	2	276
STKc_PAK	cd06614	1.7e-20	2	279
STKc_TAO1	cd06635	8.5e-09	2	308
STKc_STK10_LOK	cd06644	1.8e-14	2	285
STKc_MAP4K3	cd06645	3.4e-11	2	264
STKc_MAP4K5	cd06646	3.1e-09	2	264
STKc_myosinIIIA	cd06638	2.6e-09	2	265
STKc_CDK10	cd07845	1.1e-14	2	276
PTKc_EphR_A2	cd05063	9e-07	3	264
PTKc_FGFR3	cd05100	5.2e-05	3	310
STKc_ASK	cd06624	2.6e-27	3	265
STKc_MAP4K4_6	cd06636	6e-07	3	265
STKc_JNK	cd07850	1.4e-06	3	294
PTKc_EGFR_like	cd05057	1.6e-07	4	257
PTK_Ryk	cd05043	6.9e-05	5	245
PTKc_FAK	cd05056	1.4e-09	5	264
PTKc_PDGFR	cd05055	1.7e-05	5	246
PTKc_DDR2	cd05095	1.2e-05	5	267
STKc_ROCK1	cd05622	5.6e-08	5	328
STKc_TNIK	cd06637	2.1e-09	5	265
STKc_MAPK15	cd07852	7.7e-11	5	290
STKc_MAPK4_6	cd07854	2.2e-10	5	302
STKc_PFTAIRE2	cd07870	4.7e-10	5	265
PTKc_Ror	cd05048	1.2e-07	6	220
STKc_CDK12	cd07864	1.9e-13	6	265
PTKc_ALK_LTK	cd05036	4.1e-08	7	265
PTKc_Jak_rpt2	cd05038	1.4e-08	7	267
PTKc_Jak1_rpt2	cd05079	3.8e-05	7	265
PTKc_FGFR2	cd05101	1.4e-05	7	274
PKc_MAPKK_Pek1_like	cd06621	1.8e-08	7	277
STKc_MST4	cd06640	9.9e-16	7	287
STKc_MST3	cd06641	3.6e-10	7	287
STKc_STK25-YSK1	cd06642	3.1e-13	7	286
STKc_SLK	cd06643	5.4e-14	7	282
STKc_CDK5	cd07839	2e-11	7	265
STKc_TEY_MAPK_plant	cd07858	3.2e-10	7	310
STKc_JNK3	cd07874	8.3e-05	7	320
PTKc_InsR_like	cd05032	8e-08	8	262
PTKc_EphR	cd05033	1.5e-07	8	264
PTKc_Trk	cd05049	3.9e-08	8	262
PTKc_Abl	cd05052	2.6e-08	8	264
PTKc_FGFR	cd05053	3.2e-06	8	246
PTKc_InsR	cd05061	5.8e-05	8	270
PTKc_IGF-1R	cd05062	5.8e-05	8	261
PTKc_EphR_A10	cd05064	7.9e-06	8	269
PTKc_EphR_B	cd05065	3.7e-07	8	264
PTKc_EphR_A	cd05066	1.8e-06	8	264
PTKc_Frk_like	cd05068	3.1e-20	8	263
PTKc_Fyn_Yrk	cd05070	1e-06	8	263
PTKc_Lyn	cd05072	5.2e-08	8	263
PTKc_Csk	cd05082	6.2e-07	8	263
PTKc_Chk	cd05083	1.4e-06	8	268
PTKc_Tie2	cd05088	4.5e-08	8	282
PTKc_Ror2	cd05091	8.3e-06	8	249
PTKc_TrkB	cd05093	1.3e-06	8	277
PTKc_TrkC	cd05094	6.4e-05	8	323
PTKc_TrkA	cd05092	1.8e-07	8	270
PTKc_EGFR	cd05108	7.5e-07	8	315
PTKc_HER2	cd05109	7.9e-06	8	276
PTKc_HER4	cd05110	1.1e-05	8	281
PTKc_Itk	cd05112	2.2e-10	8	264
PTKc_Btk_Bmx	cd05113	2.6e-10	8	260
PTK_HER3	cd05111	9.3e-07	8	257
PKc_MKK4	cd06616	1.6e-06	8	284
PKc_MAPKK_Byr1_like	cd06620	9.8e-08	8	280
PKc_MEK2	cd06649	6.1e-06	8	292
PKc_MEK1	cd06650	1.1e-05	8	298
STKc_PCTAIRE_like	cd07844	8.6e-22	8	295
STKc_BUR1	cd07866	3.9e-14	8	265
STKc_PFTAIRE1	cd07869	8.4e-07	8	278
STKc_PCTAIRE3	cd07871	4.7e-11	8	265
STKc_PCTAIRE1	cd07873	1.1e-08	8	281
STKc_PCTAIRE2	cd07872	1.6e-09	8	293
STKc_Nek8	cd08220	2.7e-24	8	265
PTKc_Csk_like	cd05039	4e-08	9	263
PTKc_Tie1	cd05089	4.9e-08	9	288
PTKc_Ror1	cd05090	9.9e-05	9	249
PTKc_Tec_Rlk	cd05114	1e-08	9	264
STKc_CDC2L1	cd07843	1e-13	9	265
STKc_Nek6_Nek7	cd08224	3.3e-23	9	268
STKc_Nek6	cd08228	2.6e-18	9	268
STKc_Nek7	cd08229	2e-16	9	268
PTKc_Src_like	cd05034	5.2e-12	10	263
PTKc_Musk	cd05050	1.9e-07	10	267
PTKc_DDR	cd05051	2e-05	10	258
PTKc_Lck_Blk	cd05067	9.5e-06	10	263
PTKc_Yes	cd05069	1e-07	10	263
PTKc_Hck	cd05073	2.8e-07	10	263
PTKc_Src	cd05071	2.6e-07	10	265
PTKc_DDR_like	cd05097	2.5e-05	10	267
PTKc_Srm_Brk	cd05148	4.5e-12	10	263
STKc_ROCK_NDR_like	cd05573	1.2e-17	10	337
STKc_phototropin_lik	cd05574	2.9e-17	10	284
STKc_PKA	cd05580	2.9e-24	10	301
STKc_PDK1	cd05581	8.4e-61	10	265
STKc_DMPK_like	cd05597	1.6e-16	10	326
STKc_LATS	cd05598	1.1e-09	10	313
STKc_NDR_like	cd05599	7.2e-12	10	350
STKc_Sid2p_Dbf2p	cd05600	1.7e-11	10	309
STKc_CRIK	cd05601	1.8e-14	10	319
STKc_MAST	cd05609	2.1e-27	10	338
STKc_PRKX_like	cd05612	3.4e-35	10	292
STKc_MRCK_alpha	cd05623	1.4e-09	10	346
STKc_LATS2	cd05626	1.3e-07	10	313
STKc_NDR2	cd05627	1.2e-07	10	348
STKc_NDR1	cd05628	1.5e-09	10	350
STKc_NDR_like_fungal	cd05629	9.7e-10	10	353
STKc_MRCK_beta	cd05624	2.2e-09	10	315
PKc_MAPKK	cd06605	2e-11	10	270
STKc_myosinIII_like	cd06608	1.5e-13	10	265
STKc_MST3_like	cd06609	4.2e-18	10	284
STKc_OSR1_SPAK	cd06610	4.4e-15	10	265
STKc_MST1_2	cd06612	1.7e-17	10	265
PKc_MEK	cd06615	1.3e-10	10	283
STKc_MAP4K3_like	cd06613	1.1e-16	10	264
PKc_MKK3_6	cd06617	1.9e-08	10	284
PKc_MKK5	cd06619	6.3e-07	10	287
PKc_MAPKK_PBS2_like	cd06622	1.4e-09	10	321
PKc_MAPKK_plant_like	cd06623	6.4e-20	10	271
STKc_MEKK3_like	cd06625	1.2e-30	10	265
STKc_MEKK2	cd06652	6.7e-10	10	266
STKc_MEKK3_like_1	cd06653	4.6e-13	10	265
STKc_NAK1_like	cd06917	5.5e-13	10	281
STKc_CdkB_plant	cd07837	3.6e-14	10	266
STKc_CDKL	cd07833	1e-12	10	265
STKc_CDKL2_3	cd07846	1.2e-10	10	265
STKc_CDKL5	cd07848	3.1e-06	10	265
STKc_ERK1_2_like	cd07849	3.2e-10	10	296
STKc_CDK6	cd07862	1.2e-06	10	265
STKc_CDKL1_4	cd07847	1.2e-13	10	265
SPS1	COG0515	1.1e-69	10	425
PTKc_RET	cd05045	5.8e-05	11	268
PTKc_Tec_like	cd05059	1.4e-09	11	261
PTKc_DDR1	cd05096	0.00081	11	267
PKc_STE	cd05122	3.8e-37	11	264
STKc_Yank1	cd05578	5.3e-32	11	265
STKc_MSK_N	cd05583	4.3e-17	11	282
STKc_cPKC	cd05587	6.4e-32	11	341
STKc_GRK4_like	cd05605	2.4e-17	11	287
STKc_MSK1_N	cd05613	3.4e-11	11	285
STKc_MSK2_N	cd05614	5.8e-18	11	315
STKc_cPKC_alpha	cd05615	2.1e-16	11	314
STKc_cPKC_beta	cd05616	1.9e-13	11	345
STKc_GRK6	cd05630	3.2e-08	11	287
STKc_GRK4	cd05631	2.9e-09	11	287
STKc_GRK5	cd05632	2e-10	11	287
STKc_TAO	cd06607	1.5e-08	11	308
STKc_MAPKKK	cd06606	1.3e-48	11	265
STKc_Cdc7_like	cd06627	6.1e-34	11	265
STKc_MAPKKK_Byr2_lik	cd06628	8.5e-30	11	265
STKc_MEKK1	cd06630	6.4e-13	11	266
STKc_YSK4	cd06631	9.4e-14	11	265
STKc_TAO2	cd06634	4.5e-09	11	309
STKc_MEKK3	cd06651	1e-15	11	267
STKc_CCRK	cd07832	1.5e-15	11	266
STKc_MAPK	cd07834	6.4e-14	11	293
STKc_Pho85	cd07836	2.3e-21	11	265
STKc_CDK7	cd07841	8.6e-16	11	277
STKc_NLK	cd07853	9.9e-11	11	337
STKc_CDK8_like	cd07842	1.3e-09	11	265
STKc_MPK1	cd07857	8.7e-11	11	294
STKc_TDY_MAPK_plant	cd07859	1.1e-09	11	352
STKc_CDK2_3	cd07860	2.9e-17	11	265
STKc_CDK1_euk	cd07861	1.3e-17	11	265
STKc_CDK4	cd07863	2.3e-08	11	265
STKc_Nek	cd08215	2.3e-51	11	265
STKc_Nek1	cd08218	8.3e-40	11	265
STKc_Nek2	cd08217	4.4e-16	11	265
STKc_Nek3	cd08219	3.6e-36	11	265
STKc_Nek11	cd08222	3.5e-24	11	265
STKc_Nek4	cd08223	3.6e-26	11	265
STKc_Nek5	cd08225	3.5e-38	11	265
STKc_Nek10	cd08528	2.5e-11	11	262
STKc_CNK2-like	cd08530	1.5e-19	11	265
STKc_FA2-like	cd08529	5.2e-16	11	259
PTKc_Axl_like	cd05035	1.3e-05	12	264
PTKc_Tyk2_rpt2	cd05080	5.7e-06	12	268
PTKc_Jak2_Jak3_rpt2	cd05081	8.1e-08	12	267
PTKc_Tyro3	cd05074	2.1e-05	12	267
STKc_CMGC	cd05118	1.5e-18	12	265
STKc_PKN	cd05589	3.5e-25	12	337
STKc_LATS1	cd05625	4.9e-08	12	344
STKc_MAPKKK_Bck1_lik	cd06629	3.4e-13	12	265
STKc_CDK_like	cd07829	3e-22	12	265
STKc_MAK_like	cd07830	4.6e-16	12	265
STKc_MOK	cd07831	7.7e-15	12	265
STKc_CDK1_like	cd07835	5e-16	12	265
STKc_CDK4_6_like	cd07838	2.1e-14	12	265
STKc_CDK9_like	cd07840	6.7e-19	12	265
STKc_ERK5	cd07855	9.2e-12	12	297
STKc_MEKK1_plant	cd06632	8.1e-17	13	265
PK_STRAD	cd08216	6.7e-08	13	281
STKc_SLK_like	cd06611	1.8e-14	14	282
STKc_p70S6K	cd05584	2e-34	15	339
STKc_MEKK4	cd06626	5.1e-15	15	265
STKc_CDC2L6	cd07867	0.00011	15	265
STKc_CDK8	cd07868	0.00013	15	294
PTKc	cd00192	1.6e-17	16	264
PTKc_Ack_like	cd05040	4.9e-12	16	266
PTKc_Fes_like	cd05041	3.2e-11	16	265
PTKc_c-ros	cd05044	4.1e-06	16	265
PTKc_Tie	cd05047	1.9e-07	16	261
PTKc_Met_Ron	cd05058	4.2e-06	16	271
PTKc_Syk_like	cd05060	2.7e-08	16	251
PTK_Jak2_Jak3_rpt1	cd05078	0.00019	16	261
PTKc_Fes	cd05084	6.6e-08	16	265
PTKc_Fer	cd05085	7.6e-09	16	265
PTKc_Aatyk2	cd05086	8.8e-05	16	248
PTKc_Aatyk1_Aatyk3	cd05087	6.6e-05	16	267
PTKc_Syk	cd05116	7e-08	16	265
STKc_PKC	cd05570	1.1e-18	16	313
STKc_PKB	cd05571	4e-29	16	339
STKc_SGK	cd05575	2.6e-11	16	319
STKc_RSK_N	cd05582	3.9e-31	16	313
STKc_aPKC	cd05588	3e-19	16	341
STKc_nPKC_eta	cd05590	1.5e-24	16	338
STKc_nPKC_epsilon	cd05591	1.5e-24	16	329
STKc_PKB_gamma	cd05593	1.8e-12	16	358
STKc_PKB_alpha	cd05594	2e-14	16	343
STKc_SGK1	cd05602	2.3e-09	16	346
STKc_SGK3	cd05604	1.4e-11	16	321
STKc_SGK2	cd05603	2.5e-14	16	345
STKc_PKB_beta	cd05595	2.4e-22	16	333
STKc_aPKC_zeta	cd05617	3.3e-12	16	341
STKc_nPKC_theta_delt	cd05592	1.7e-28	16	339
STKc_aPKC_iota	cd05618	3.8e-10	16	341
STKc_nPKC_theta	cd05619	1.2e-21	16	342
STKc_nPKC_delta	cd05620	4.1e-16	16	346
STKc_beta_ARK	cd05606	1.1e-10	17	285
STKc_GRK3	cd05633	3.7e-09	17	294
STKc_Nek9	cd08221	2.7e-16	17	265
PKc	cd00180	1.2e-81	18	263
PTKc_Aatyk	cd05042	4.5e-08	18	248
PTKc_Zap-70	cd05115	6e-08	18	268
STKc_AGC	cd05123	5.3e-64	18	265
STKc_cGK_PKG	cd05572	1.6e-30	18	271
STKc_GRK	cd05577	1.8e-13	18	281
STKc_MAST_like	cd05579	1.1e-26	18	270
STKc_YPK1_like	cd05585	1.2e-18	18	327
STKc_Sck1_like	cd05586	2.9e-10	18	394
STKc_GRK7	cd05607	3e-13	18	290
STKc_GRK1	cd05608	6.6e-14	18	285
STKc_Rim15_like	cd05611	1.5e-09	20	267
Pkinase	pfam00069	6.2e-85	12	265
POLO_box	pfam00659	1e-14	892	956
Pkinase_Tyr	pfam07714	2.8e-19	12	265
TyrKc	smart00219	4.3e-16	12	265
STYKc	smart00221	4.6e-91	12	265
S_TKc	smart00220	9.5e-102	22	265
KIND	smart00750	8.1e-06	101	273

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041029	Polymorphism	p.ALA226THR	N/A
Swiss-Prot	VAR_041028	Polymorphism	p.ARG146HIS	N/A
Swiss-Prot	VAR_041031	Polymorphism	p.ASN449ASP	N/A
dbSNP	rs17012739	Polymorphism	p.GLU830ASP	N/A
Swiss-Prot	VAR_041030	Polymorphism	p.PRO317LEU	N/A
Swiss-Prot	VAR_019632	Polymorphism	p.SER232THR	N/A
dbSNP	rs61735390	Polymorphism	p.THR828MET	N/A
Swiss-Prot	VAR_041032	Polymorphism	p.TRP519SER	N/A
Swiss-Prot	VAR_041027	Polymorphism	p.TYR86CYS	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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