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Results for the Protein:
NP_001059
19913408
7155
TOP2B
NCBI
DNA topoisomerase 2-beta [Homo sapiens]
0
3
0
3
0
Tips:
The Domains on the Default View are decided by the Domain's E-Value.
Clicking a check box will display or hide the correlated domain.
To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.
Default View:
GyrB - COG0187
HATPase_c - pfam02518
HATPase_c - smart00387
TOP2c - smart00433
HATPase_c - cd00075
TopoIIA_Trans_ScTopo - cd03481
DNA_gyraseB - pfam00204
TopoII_MutL_Trans - cd00329
TOPRIM_TopoIIA_like - cd01030
TOPRIM - cd00188
TOPRIM_TopoIIA - cd03365
TOPRIM_TopoIIA_GyrB - cd03366
GyrA - COG0188
TOP4c - smart00434
TOP4c - cd00187
DNA_topoisoIV - pfam00521
DTHCT - pfam08070
RefSeq Protein:
NP_001059
Default View:
Domains
found on the Protein
Domain ↕
CD Accession ↕
E-Value ↕
Start ↕
End ↕
HATPase_c
cd00075
7.7e-07
97
237
TopoIIA_Trans_ScTopo
cd03481
5.6e-101
281
433
TopoII_MutL_Trans
cd00329
5.6e-20
283
398
TOPRIM
cd00188
2e-13
471
586
TOPRIM_TopoIIA_like
cd01030
5.1e-77
471
591
TOPRIM_TopoIIA
cd03365
1.5e-91
471
591
TOPRIM_TopoIIA_GyrB
cd03366
4.3e-24
471
593
GyrA
COG0188
7.7e-11
705
1531
TOP4c
cd00187
8e-231
727
1187
HATPase_c
pfam02518
7.2e-17
92
240
DNA_gyraseB
pfam00204
3.1e-49
282
446
DNA_topoisoIV
pfam00521
1.4e-185
729
1185
HATPase_c
smart00387
6.8e-05
96
240
TOP2c
smart00433
96
686
TOP4c
smart00434
1.3e-230
709
1182
DTHCT
pfam08070
4.1e-56
1503
1606
Table of Mutations found on the Protein
Source ↕
Mut_ID ↕
Class ↕
HGVS ↕
Disease ↕
dbSNP
rs61739570
Polymorphism
p.GLU1612ASP
N/A
dbSNP
rs17016875
Polymorphism
p.THR1314ALA
N/A
dbSNP
rs17016865
Polymorphism
p.THR1563ALA
N/A
Please Cite:
Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.
DMDM_info@umbc.edu
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