Results for the protein: NP

Results for the Protein: NP_006171

21361306

4915

NTRK2

NCBI

BDNF/NT-3 growth factors receptor isoform a precursor [Homo sapiens]

Known Diseases associated with this Protein:
OBESITY, HYPERPHAGIA, AND DEVELOPMENTAL DELAY

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RefSeq Protein: NP_006171

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
Ig3_Contactin-1	cd05851	0.0007	196	284
Ig3_Contactin_like	cd04968	5.7e-05	197	284
Ig_TrkABC_d4	cd04972	1.9e-10	198	283
Ig5_NCAM-1_like	cd05732	0.00058	202	283
Ig2_FGFR_like	cd05729	0.00067	203	283
Ig3_Peroxidasin	cd05745	0.00011	210	283
Ig_2	cd05764	3.1e-05	211	283
Ig	cd00096	3.1e-08	214	280
Ig3_Robo	cd05725	1.7e-05	214	283
Ig_TrKABC_d5	cd04971	8.3e-57	301	379
Ig_TrkB_d5	cd05855	1.1e-57	301	379
PTKc_CSF-1R	cd05106	3e-37	516	828
PTKc_Kit	cd05104	1.9e-25	519	827
PTKc_PDGFR_alpha	cd05105	3.9e-17	522	829
PTKc_PDGFR_beta	cd05107	3e-19	522	828
PTKc_PDGFR	cd05055	6.3e-24	523	827
STKc_myosinIIIB	cd06639	4.2e-05	532	828
STKc_myosinIIIA	cd06638	5.6e-06	533	823
STKc_ERK5	cd07855	0.00074	533	834
PTKc_FGFR1	cd05098	4.8e-57	534	833
STKc_PAK6	cd06659	1.5e-05	535	832
PTKc_FGFR2	cd05101	1.5e-53	537	827
PTKc_EGFR_like	cd05057	9.8e-57	538	837
STKc_PAK_I	cd06647	0.00092	538	838
STKc_PAK4	cd06657	0.00091	538	818
PKc_MKK7	cd06618	1.2e-05	539	835
STKc_CDK9	cd07865	1.3e-05	539	837
PTKc_FGFR	cd05053	5.8e-64	540	827
STKc_SLK	cd06643	9.7e-08	540	829
STKc_TAO2	cd06634	0.00021	541	836
PTKc_FGFR4	cd05099	6.8e-60	542	836
PTKc_FGFR3	cd05100	1.8e-41	542	836
STKc_PAK_II	cd06648	1.7e-07	542	837
PTK_Tyk2_rpt1	cd05076	1.1e-06	544	827
STKc_PAK	cd06614	1.1e-12	544	837
STKc_CDK10	cd07845	5.7e-07	544	835
STKc_Sty1_Hog1	cd07856	0.00022	544	835
STKc_ASK	cd06624	3.4e-07	545	828
STKc_p38	cd07851	6.5e-05	545	828
STKc_CDK12	cd07864	2.7e-08	545	837
STKc_BUR1	cd07866	4.3e-10	545	815
PTKc_Tie2	cd05088	1.9e-44	546	836
PTKc_EGFR	cd05108	5.5e-22	546	838
PTKc_HER2	cd05109	3.3e-39	546	837
PTKc_HER4	cd05110	9.2e-24	546	838
PTK_HER3	cd05111	7.3e-38	546	837
STKc_SLK_like	cd06611	1.8e-09	546	825
STKc_STK10_LOK	cd06644	8.7e-07	546	833
PTKc_ALK_LTK	cd05036	9.5e-87	547	825
PTKc_FAK	cd05056	2.2e-78	547	831
STKc_MAPK15	cd07852	5.5e-06	547	836
PTK_CCK4	cd05046	1.7e-75	548	825
PTKc_Ror	cd05048	4.6e-120	548	826
PTKc_Trk	cd05049	4.1e-238	548	825
PTKc_Musk	cd05050	3.4e-135	548	825
PTKc_VEGFR	cd05054	2.8e-31	548	830
PTKc_DDR	cd05051	1.1e-106	548	825
PTKc_IGF-1R	cd05062	1.5e-80	548	825
PTKc_EphR_A2	cd05063	6.2e-66	548	827
PTKc_InsR	cd05061	2.4e-83	548	836
PTKc_EphR_A10	cd05064	2.3e-59	548	827
PTKc_Abl	cd05052	9.5e-72	548	827
PTKc_Lck_Blk	cd05067	2.1e-52	548	826
PTKc_Frk_like	cd05068	1.8e-76	548	826
PTKc_Yes	cd05069	8.4e-45	548	826
PTKc_Fyn_Yrk	cd05070	6.9e-50	548	826
PTKc_Src	cd05071	1.2e-46	548	828
PTKc_Lyn	cd05072	2.3e-55	548	826
PTKc_Hck	cd05073	1.8e-54	548	826
PTKc_Jak2_Jak3_rpt2	cd05081	1.9e-48	548	827
PTKc_Csk	cd05082	4.1e-49	548	826
PTKc_Tyk2_rpt2	cd05080	3.8e-45	548	828
PTKc_Ror1	cd05090	1e-92	548	826
PTKc_Ror2	cd05091	9.6e-86	548	826
PTKc_TrkA	cd05092	5.4e-205	548	825
PTKc_TrkC	cd05094	1.4e-209	548	835
PTKc_DDR2	cd05095	9.9e-92	548	825
PTKc_DDR1	cd05096	4e-85	548	825
PTKc_DDR_like	cd05097	5.1e-92	548	825
PTKc_TrkB	cd05093	2.3e-279	548	835
PTKc_VEGFR3	cd05102	3.5e-36	548	830
PTKc_VEGFR2	cd05103	4.4e-29	548	830
PKc_MAPKK_Byr1_like	cd06620	4.7e-09	548	838
STKc_MAP4K3	cd06645	5.5e-05	548	827
STKc_MAP4K5	cd06646	0.00032	548	830
STKc_PCTAIRE_like	cd07844	2e-05	548	837
STKc_PCTAIRE3	cd07871	3.3e-05	548	834
STKc_PFTAIRE2	cd07870	0.00028	548	834
PTKc_InsR_like	cd05032	1.3e-103	549	825
PTKc_EphR	cd05033	2.6e-75	549	827
PTKc_Src_like	cd05034	6.8e-69	549	826
PTKc_Jak_rpt2	cd05038	9.9e-67	549	827
PTKc_Csk_like	cd05039	2.7e-35	549	829
PTK_Ryk	cd05043	6.1e-27	549	826
PTKc_Tec_like	cd05059	4.2e-72	549	827
PTKc_EphR_B	cd05065	4.7e-62	549	827
PTKc_EphR_A	cd05066	1.5e-68	549	827
PTKc_Chk	cd05083	9.3e-58	549	826
PTKc_Jak1_rpt2	cd05079	5.3e-42	549	827
PTKc_Itk	cd05112	2.6e-69	549	827
PTKc_Btk_Bmx	cd05113	1.1e-69	549	824
PTKc_Tec_Rlk	cd05114	3.9e-66	549	824
PKc_MKK4	cd06616	7.5e-06	549	837
STKc_MAP4K3_like	cd06613	2.2e-09	550	822
STKc_MST3	cd06641	2.4e-06	550	837
STKc_STK25-YSK1	cd06642	1.7e-06	550	838
STKc_MST4	cd06640	5.8e-06	550	837
STKc_CDKL2_3	cd07846	6.9e-06	550	837
STKc_CDKL1_4	cd07847	4.8e-05	550	837
STKc_PCTAIRE2	cd07872	0.00059	550	832
PTKc_Srm_Brk	cd05148	2.5e-62	551	826
STKc_phototropin_lik	cd05574	0.00013	551	833
STKc_MEKK2	cd06652	7.9e-07	551	824
STKc_MEKK3_like_1	cd06653	3.8e-08	551	828
STKc_CDK5	cd07839	1.1e-06	551	834
STKc_CDK8_like	cd07842	1.7e-05	551	813
STKc_ERK1_2_like	cd07849	0.00013	551	838
STKc_MPK1	cd07857	0.00062	551	836
STKc_CDK4	cd07863	0.00016	551	827
STKc_Nek6_Nek7	cd08224	1.2e-09	551	832
PTKc_Tie1	cd05089	2e-48	552	835
STKc_PKA	cd05580	4.1e-05	552	829
STKc_PDK1	cd05581	8.2e-12	552	823
STKc_PRKX_like	cd05612	2.8e-05	552	834
PKc_MAPKK	cd06605	8.6e-08	552	828
STKc_MST3_like	cd06609	2.6e-09	552	834
PKc_MEK	cd06615	1.2e-05	552	837
PKc_MKK3_6	cd06617	1.1e-05	552	838
PKc_MKK5	cd06619	0.00016	552	838
PKc_MAPKK_Pek1_like	cd06621	2.2e-07	552	820
PKc_MAPKK_PBS2_like	cd06622	1.2e-05	552	837
STKc_MEKK3_like	cd06625	1.4e-12	552	828
STKc_MAPKKK_Bck1_lik	cd06629	7e-11	552	816
PKc_MAPKK_plant_like	cd06623	1e-13	552	821
STKc_MOK	cd07831	4.6e-05	552	838
STKc_CDK1_like	cd07835	2.8e-07	552	834
STKc_Nek6	cd08228	8.9e-08	552	828
STKc_Nek7	cd08229	1.9e-09	552	828
SPS1	COG0515	3.4e-08	552	838
PTKc_RET	cd05045	7e-55	553	830
STKc_Yank1	cd05578	1.9e-08	553	834
STKc_MSK_N	cd05583	3.1e-05	553	835
STKc_GRK4_like	cd05605	9.7e-05	553	836
STKc_MSK1_N	cd05613	0.00025	553	836
STKc_Cdc7_like	cd06627	1.5e-14	553	823
STKc_MAPKKK_Byr2_lik	cd06628	1.3e-14	553	823
STKc_MAPKKK	cd06606	1.7e-19	553	823
STKc_MEKK3	cd06651	2.3e-10	553	825
STKc_CCRK	cd07832	7.3e-10	553	815
STKc_MAPK	cd07834	2.9e-08	553	830
STKc_Pho85	cd07836	4.8e-06	553	833
STKc_CDK7	cd07841	3.8e-09	553	827
STKc_CDK2_3	cd07860	0.00015	553	834
STKc_CDK1_euk	cd07861	3.5e-05	553	834
STKc_Nek1	cd08218	9.8e-08	553	827
STKc_Nek3	cd08219	2.8e-10	553	823
STKc_Nek8	cd08220	9e-07	553	827
STKc_Nek	cd08215	3.4e-17	553	825
STKc_Nek11	cd08222	1.6e-13	553	827
STKc_Nek4	cd08223	3.2e-11	553	827
STKc_Nek5	cd08225	7.7e-09	553	823
STKc_Nek10	cd08528	2.2e-05	553	825
STKc_FA2-like	cd08529	1e-11	553	828
PTKc_Axl_like	cd05035	2.5e-62	554	827
PTKc_Tyro3	cd05074	1e-61	554	827
PTKc_Axl	cd05075	4.9e-55	554	830
STKc_CNK2-like	cd08530	1.2e-09	554	823
STKc_ROCK_NDR_like	cd05573	0.00032	555	838
STKc_MAK_like	cd07830	1.1e-10	555	823
STKc_CDK4_6_like	cd07838	1.8e-06	555	813
STKc_CDK9_like	cd07840	2.6e-12	555	837
PK_STRAD	cd08216	0.00052	555	829
PKc_STE	cd05122	1.8e-13	556	816
STKc_myosinIII_like	cd06608	3.8e-07	556	802
STKc_OSR1_SPAK	cd06610	2.9e-09	556	816
STKc_MEKK4	cd06626	4.1e-11	556	816
STKc_Nek2	cd08217	2.5e-08	556	823
STKc_RSK_N	cd05582	0.00077	557	836
STKc_NAK1_like	cd06917	1.8e-08	557	834
STKc_CDK_like	cd07829	3.3e-12	557	823
PTKc	cd00192	2.7e-142	558	824
PTK_Jak_rpt1	cd05037	9e-13	558	824
PTKc_Ack_like	cd05040	5.2e-70	558	825
PTKc_Aatyk	cd05042	2.4e-34	558	825
PTKc_c-ros	cd05044	1.7e-90	558	825
PTKc_Met_Ron	cd05058	8.2e-67	558	829
PTKc_Fes_like	cd05041	1.3e-56	558	825
PTKc_Syk_like	cd05060	3.7e-61	558	828
PTK_Jak1_rpt1	cd05077	9.6e-10	558	824
PTK_Jak2_Jak3_rpt1	cd05078	6e-13	558	824
PTKc_Fes	cd05084	4.5e-64	558	825
PTKc_Aatyk2	cd05086	7.8e-40	558	825
PTKc_Aatyk1_Aatyk3	cd05087	3.5e-46	558	825
PTKc_Syk	cd05116	3.1e-52	558	828
STKc_CMGC	cd05118	4.1e-11	558	823
STKc_PKC	cd05570	1.1e-05	558	837
STKc_nPKC_theta_delt	cd05592	0.00032	558	838
STKc_nPKC_theta	cd05619	0.00013	558	831
STKc_MEKK1	cd06630	2.2e-07	558	824
STKc_MEKK1_plant	cd06632	2.3e-12	558	823
STKc_Nek9	cd08221	2.2e-08	558	822
PTKc_Zap-70	cd05115	2.2e-53	559	828
STKc_CDKL	cd07833	1.5e-06	559	823
STKc_CdkB_plant	cd07837	1.2e-07	559	835
STKc_CDC2L1	cd07843	2.1e-06	559	834
PKc	cd00180	3e-62	560	826
PTKc_Tie	cd05047	2.4e-54	560	828
PTKc_Fer	cd05085	3.9e-54	560	825
STKc_AGC	cd05123	4.5e-09	560	833
STKc_GRK	cd05577	0.00087	560	835
STKc_MAST_like	cd05579	7.5e-09	560	821
STKc_cGK_PKG	cd05572	5.6e-08	560	830
STKc_GRK1	cd05608	0.00014	560	835
STKc_MST1_2	cd06612	7.4e-10	560	816
STKc_YSK4	cd06631	3.7e-09	560	823
LRRNT	pfam01462	5.1e-08	31	60
Pkinase	pfam00069	7.9e-43	554	826
LRRNT	smart00013	1.7e-07	31	65
LRRCT	smart00082	9.5e-09	148	195
I-set	pfam07679	6.3e-10	197	283
IG	smart00409	7.9e-14	203	284
IG_like	smart00410	7.9e-14	203	284
V-set	pfam07686	0.0008	205	283
IGc2	smart00408	4.1e-08	210	273
Pkinase_Tyr	pfam07714	1.6e-148	554	823
TyrKc	smart00219	1.1e-137	554	823
STYKc	smart00221	1.8e-59	554	825
S_TKc	smart00220	5.4e-51	564	833

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	600456.0001	Disease	p.TYR722CYS	OBESITY, HYPERPHAGIA, AND DEVELOPMENTAL DELAY

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258