Results for the protein: Q02763

Results for the Protein: Q02763

218511853

7010

TEK

NCBI, UniProt

TIE2_HUMAN RecName: Full=Angiopoietin-1 receptor; AltName: Full=Endothelial tyrosine kinase; AltName: Full=Tunica interna endothelial cell kinase; AltName: Full=Tyrosine kinase with Ig and EGF homology domains-2; AltName: Full=Tyrosine-protein kinase receptor TEK; AltName: Full=Tyrosine-protein kinase receptor TIE-2; Short=hTIE2; AltName: Full=p140 TEK; AltName: CD_antigen=CD202b; Flags: Precursor

Known Diseases associated with this Protein:
DOMINANTLY INHERITED VENOUS MALFORMATIONS (VMCM)

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Tips:

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Swiss-Prot Protein: Q02763

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
FN3	cd00063	0.00053	445	538
FN3	cd00063	6.4e-10	543	633
FN3	cd00063	1.2e-15	639	731
PTKc_CSF-1R	cd05106	3.2e-53	793	1097
PTKc_Kit	cd05104	1.9e-45	793	1096
STKc_PAK5	cd06658	0.00055	793	1112
STKc_myosinIIIB	cd06639	3.1e-05	794	1095
STKc_PAK6	cd06659	1.3e-06	794	1118
STKc_PAK_II	cd06648	3.6e-06	795	1107
STKc_PAK_I	cd06647	0.0007	797	1104
PKc_MKK7	cd06618	1.1e-07	799	1113
PTKc_PDGFR_alpha	cd05105	6.6e-28	801	1098
PTKc_PDGFR_beta	cd05107	1.5e-29	801	1097
STKc_myosinIIIA	cd06638	2.3e-05	801	1094
PTKc_FGFR1	cd05098	1.3e-75	805	1103
PTKc_PDGFR	cd05055	2.1e-56	806	1096
PTKc_FGFR2	cd05101	3.4e-80	806	1098
STKc_PAK	cd06614	5.8e-14	808	1107
STKc_MAP4K4_6	cd06636	3.4e-06	808	1094
PTKc_FGFR3	cd05100	4.4e-73	811	1122
STKc_TAO2	cd06634	0.00013	812	1122
STKc_TAO	cd06607	8.9e-05	812	1122
STKc_PAK3	cd06656	0.00047	812	1121
STKc_CDK9	cd07865	5.7e-07	812	1085
STKc_CDK10	cd07845	4.5e-07	813	1122
STKc_MAP4K3	cd06645	6.6e-06	814	1093
STKc_MAP4K5	cd06646	3.4e-05	814	1093
STKc_Sty1_Hog1	cd07856	0.00013	814	1115
PTKc_FGFR	cd05053	9.2e-114	815	1097
STKc_ASK	cd06624	3.6e-06	815	1094
STKc_BUR1	cd07866	3.1e-06	815	1085
PTKc_EGFR_like	cd05057	1e-55	816	1106
PTKc_Tie2	cd05088	2e-282	816	1118
PTKc_FGFR4	cd05099	3.7e-82	816	1114
PTKc_HER2	cd05109	1.2e-43	816	1106
PTKc_HER4	cd05110	8.8e-32	816	1123
PTKc_EGFR	cd05108	2.2e-34	816	1124
STKc_STK10_LOK	cd06644	2.4e-07	816	1107
STKc_p38	cd07851	5.7e-05	816	1110
STKc_PCTAIRE3	cd07871	0.0003	816	1114
PTKc_ALK_LTK	cd05036	1.4e-58	817	1094
PTKc_Csk_like	cd05039	8e-53	818	1095
PTKc_Ror	cd05048	7.9e-55	818	1095
PTK_CCK4	cd05046	2.9e-34	818	1094
PTKc_Trk	cd05049	6.5e-65	818	1094
PTKc_FAK	cd05056	6.7e-59	818	1100
PTKc_Csk	cd05082	2.4e-60	818	1095
PTKc_Chk	cd05083	2.9e-67	818	1095
PTKc_DDR1	cd05096	3.2e-40	818	1094
PTK_HER3	cd05111	7.8e-43	818	1106
STKc_myosinIII_like	cd06608	3.6e-09	818	1090
STKc_TNIK	cd06637	3.1e-07	818	1094
PTKc_InsR_like	cd05032	3.7e-59	819	1094
PTKc_EphR	cd05033	2.3e-63	819	1096
PTKc_Jak_rpt2	cd05038	7.2e-58	819	1096
PTK_Ryk	cd05043	5.4e-34	819	1096
PTKc_Musk	cd05050	8.6e-74	819	1094
PTKc_VEGFR	cd05054	2.8e-48	819	1099
PTKc_Abl	cd05052	1.4e-75	819	1096
PTKc_Tec_like	cd05059	1.3e-52	819	1093
PTKc_InsR	cd05061	3.9e-44	819	1105
PTKc_IGF-1R	cd05062	2.8e-49	819	1094
PTKc_EphR_A2	cd05063	3.8e-54	819	1096
PTKc_EphR_A10	cd05064	1.2e-46	819	1096
PTKc_EphR_B	cd05065	1.7e-57	819	1096
PTKc_EphR_A	cd05066	1.5e-61	819	1096
PTKc_Frk_like	cd05068	9.1e-69	819	1095
PTKc_Yes	cd05069	3e-37	819	1095
PTKc_Fyn_Yrk	cd05070	8.6e-37	819	1095
PTKc_Src	cd05071	1.4e-36	819	1097
PTKc_Lyn	cd05072	2e-46	819	1095
PTKc_Jak1_rpt2	cd05079	8.4e-35	819	1096
PTKc_Jak2_Jak3_rpt2	cd05081	8.3e-43	819	1096
PTKc_Lck_Blk	cd05067	8.4e-48	819	1095
PTKc_Ror1	cd05090	4.3e-50	819	1095
PTKc_Ror2	cd05091	9.1e-42	819	1095
PTKc_TrkA	cd05092	2e-54	819	1102
PTKc_TrkB	cd05093	1.5e-48	819	1104
PTKc_DDR2	cd05095	3.4e-46	819	1094
PTKc_VEGFR3	cd05102	3.9e-52	819	1099
PTKc_DDR_like	cd05097	9.5e-43	819	1094
PTKc_Hck	cd05073	4.6e-48	819	1095
PTKc_Btk_Bmx	cd05113	4.4e-63	819	1093
PTKc_Tec_Rlk	cd05114	9.9e-56	819	1093
PTKc_Itk	cd05112	2.4e-65	819	1093
STKc_phototropin_lik	cd05574	3.3e-05	819	1102
PKc_MKK4	cd06616	5.4e-08	819	1107
STKc_MEKK3_like	cd06625	6.8e-09	819	1094
STKc_MEKK3	cd06651	2.9e-05	819	1088
PTKc_DDR	cd05051	2.6e-39	820	1094
PTKc_VEGFR2	cd05103	2.2e-46	820	1099
STKc_MAPKKK_Byr2_lik	cd06628	3.1e-12	820	1094
STKc_MST4	cd06640	1.5e-06	820	1115
STKc_MST3	cd06641	1.7e-06	820	1115
STKc_STK25-YSK1	cd06642	1.3e-06	820	1115
STKc_PCTAIRE_like	cd07844	0.00019	820	1112
STKc_MPK1	cd07857	7.5e-05	820	1106
STKc_Nek8	cd08220	1e-06	820	1093
PTKc_Src_like	cd05034	2e-64	821	1095
PTKc_Tie1	cd05089	3.8e-237	821	1117
PTKc_Srm_Brk	cd05148	6.2e-53	821	1095
STKc_SLK_like	cd06611	2.1e-08	821	1109
STKc_SLK	cd06643	6.9e-07	821	1105
STKc_CDK12	cd07864	2e-06	821	1112
STKc_Nek6	cd08228	1.3e-05	821	1097
STKc_Nek7	cd08229	9.9e-07	821	1097
STKc_Nek6_Nek7	cd08224	1.1e-07	821	1097
STKc_ROCK_NDR_like	cd05573	6.5e-05	822	1114
STKc_PKA	cd05580	1.5e-07	822	1102
STKc_PDK1	cd05581	8e-16	822	1089
STKc_Sid2p_Dbf2p	cd05600	0.00067	822	1115
STKc_CRIK	cd05601	6.2e-05	822	1119
STKc_PRKX_like	cd05612	5.9e-07	822	1109
STKc_MRCK_alpha	cd05623	0.001	822	1115
PKc_MAPKK	cd06605	1.5e-09	822	1097
STKc_MST3_like	cd06609	8.8e-10	822	1103
STKc_OSR1_SPAK	cd06610	1.7e-08	822	1095
STKc_MST1_2	cd06612	1.3e-09	822	1092
PKc_MKK3_6	cd06617	7.7e-08	822	1108
PKc_MEK	cd06615	1e-06	822	1107
PKc_MKK5	cd06619	0.00033	822	1100
PKc_MAPKK_Pek1_like	cd06621	9.9e-08	822	1102
PKc_MAPKK_PBS2_like	cd06622	1.5e-09	822	1110
PKc_MAPKK_plant_like	cd06623	4.7e-13	822	1098
STKc_MEKK3_like_1	cd06653	0.0006	822	1094
STKc_MAP4K3_like	cd06613	5.1e-11	822	1093
STKc_CDKL	cd07833	4.9e-10	822	1089
STKc_CdkB_plant	cd07837	7.7e-07	822	1097
STKc_CDK9_like	cd07840	3.1e-10	822	1112
STKc_CDC2L1	cd07843	3.7e-05	822	1085
STKc_CDKL2_3	cd07846	4.7e-08	822	1094
STKc_ERK1_2_like	cd07849	2e-05	822	1118
SPS1	COG0515	4.4e-11	822	1124
PTKc_RET	cd05045	2.7e-89	823	1099
PTKc_TrkC	cd05094	2.7e-29	823	1104
STKc_Yank1	cd05578	3.5e-06	823	1095
STKc_MSK_N	cd05583	0.00059	823	1118
STKc_cPKC	cd05587	0.00034	823	1115
STKc_GRK4_like	cd05605	0.00011	823	1124
STKc_cPKC_alpha	cd05615	9.3e-05	823	1115
STKc_GRK4	cd05631	0.00067	823	1121
STKc_cPKC_beta	cd05616	0.00031	823	1104
STKc_MAPKKK	cd06606	3.5e-18	823	1095
PKc_MAPKK_Byr1_like	cd06620	0.00017	823	1114
STKc_Cdc7_like	cd06627	1e-12	823	1090
STKc_CCRK	cd07832	2.2e-07	823	1093
STKc_Pho85	cd07836	0.0002	823	1112
STKc_NLK	cd07853	0.0004	823	1111
STKc_CDK1_euk	cd07861	0.00041	823	1114
STKc_MAPK	cd07834	4.2e-06	823	1109
STKc_Nek	cd08215	5.6e-15	823	1094
STKc_Nek2	cd08217	2.7e-09	823	1094
STKc_Nek3	cd08219	6.4e-11	823	1094
STKc_Nek4	cd08223	1.6e-06	823	1094
STKc_Nek5	cd08225	2.9e-06	823	1094
STKc_Nek10	cd08528	0.00011	823	1092
STKc_FA2-like	cd08529	1.3e-07	823	1092
STKc_CNK2-like	cd08530	2e-09	823	1093
PTKc_Axl_like	cd05035	1.3e-72	824	1096
PTKc_Tyro3	cd05074	2e-64	824	1096
PTKc_Axl	cd05075	1.8e-65	824	1096
PTKc_Tyk2_rpt2	cd05080	3e-31	824	1097
STKc_PKN	cd05589	1.2e-05	824	1114
STKc_NAK1_like	cd06917	1.2e-05	824	1100
PKc_STE	cd05122	7.8e-13	825	1090
STKc_CDK_like	cd07829	1.2e-10	825	1092
STKc_MAK_like	cd07830	1.2e-09	825	1094
STKc_CDK5	cd07839	4.2e-05	825	1094
STKc_CDK7	cd07841	7.8e-11	825	1112
STKc_CDK8_like	cd07842	2.6e-06	825	1085
STKc_CDKL1_4	cd07847	2e-05	825	1094
STKc_CDK2_3	cd07860	0.00011	825	1094
STKc_CDK6	cd07862	0.00013	825	1124
STKc_CDK4	cd07863	6e-05	825	1112
STKc_MOK	cd07831	1.2e-07	825	1089
PK_STRAD	cd08216	0.001	825	1098
STKc_Nek1	cd08218	4.2e-07	825	1094
STKc_CMGC	cd05118	1.8e-12	826	1089
STKc_MAPKKK_Bck1_lik	cd06629	1.9e-07	826	1095
STKc_CDK1_like	cd07835	4.1e-07	826	1094
STKc_CDK4_6_like	cd07838	5.4e-06	826	1085
STKc_Nek11	cd08222	3.1e-06	826	1096
STKc_RSK_N	cd05582	7.5e-05	827	1124
STKc_p70S6K	cd05584	0.00087	827	1116
STKc_MEKK4	cd06626	2.5e-07	827	1090
PTKc	cd00192	2.4e-142	828	1093
PTK_Jak_rpt1	cd05037	2.2e-08	828	1093
PTKc_Ack_like	cd05040	3e-47	828	1094
PTKc_Fes_like	cd05041	2e-70	828	1094
PTKc_Aatyk	cd05042	7.6e-14	828	1092
PTKc_c-ros	cd05044	2.4e-55	828	1094
PTKc_Tie	cd05047	4.9e-246	828	1097
PTKc_Met_Ron	cd05058	2.8e-60	828	1098
PTKc_Syk_like	cd05060	1e-59	828	1097
PTK_Jak1_rpt1	cd05077	3.1e-07	828	1093
PTK_Jak2_Jak3_rpt1	cd05078	5.5e-08	828	1093
PTKc_Fes	cd05084	9e-62	828	1094
PTKc_Fer	cd05085	2.5e-71	828	1094
PTKc_Aatyk1_Aatyk3	cd05087	1.2e-22	828	1094
PTKc_Aatyk2	cd05086	3.8e-09	828	1094
PTKc_Syk	cd05116	2.8e-50	828	1097
STKc_PKC	cd05570	1.7e-07	828	1114
STKc_PKB	cd05571	0.00016	828	1116
STKc_SGK	cd05575	0.00016	828	1114
STKc_nPKC_eta	cd05590	0.00054	828	1115
STKc_nPKC_epsilon	cd05591	0.0009	828	1115
STKc_PKB_gamma	cd05593	0.0002	828	1122
STKc_PKB_alpha	cd05594	0.00084	828	1124
STKc_nPKC_theta_delt	cd05592	1.3e-05	828	1124
STKc_SGK2	cd05603	0.00016	828	1115
STKc_nPKC_theta	cd05619	1.9e-05	828	1116
STKc_MEKK1	cd06630	1.6e-05	828	1094
STKc_YSK4	cd06631	3.2e-06	828	1090
STKc_MEKK1_plant	cd06632	6.6e-09	829	1090
STKc_Nek9	cd08221	6.1e-07	829	1094
PKc	cd00180	1.3e-57	830	1092
PTKc_Zap-70	cd05115	6e-49	830	1097
STKc_AGC	cd05123	2.8e-10	830	1096
STKc_cGK_PKG	cd05572	7.1e-07	830	1092
STKc_GRK	cd05577	0.00053	830	1100
STKc_MAST_like	cd05579	8.1e-06	830	1094
STKc_YPK1_like	cd05585	0.00023	830	1124
STKc_GRK1	cd05608	0.00017	830	1124
STKc_GRK7	cd05607	0.00017	830	1123
PTK_Tyk2_rpt1	cd05076	8.2e-05	833	1093
fn3	pfam00041	4.3e-11	445	531
fn3	pfam00041	8.7e-13	544	626
fn3	pfam00041	5.2e-17	640	726
Pkinase	pfam00069	4.9e-45	824	1092
Ig_Tie2_1	pfam10430	1.4e-73	23	118
EGF	smart00181	0.00018	219	252
FN3	smart00060	0.00035	444	528
FN3	smart00060	5.5e-08	543	625
FN3	smart00060	4.3e-15	639	721
Pkinase_Tyr	pfam07714	7e-139	824	1092
TyrKc	smart00219	1.5e-142	824	1092
STYKc	smart00221	3e-52	824	1094
S_TKc	smart00220	4.6e-46	834	1096

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_066610	Disease	p.ALA925SER	Dominantly inherited venous malformations (VMCM)
Swiss-Prot	VAR_041860	Polymorphism	p.ALA724THR	N/A
Swiss-Prot	VAR_041862	Polymorphism	p.ALA1124VAL	N/A
Swiss-Prot	VAR_041856	Polymorphism	p.ALA226VAL	N/A
Swiss-Prot	VAR_066608	Disease	p.ARG918CYS	Dominantly inherited venous malformations (VMCM)
Swiss-Prot	VAR_066607	Disease	p.ARG915HIS	Dominantly inherited venous malformations (VMCM)
Swiss-Prot	VAR_006352	Disease	p.ARG849TRP	Dominantly inherited venous malformations (VMCM)
Swiss-Prot	VAR_048002	Polymorphism	p.GLN346PRO	N/A
Swiss-Prot	VAR_041855	Polymorphism	p.ILE148THR	N/A
Swiss-Prot	VAR_041858	Polymorphism	p.LEU634PHE	N/A
Swiss-Prot	VAR_066611	Disease	p.LYS1100ASN	Dominantly inherited venous malformations (VMCM)
Swiss-Prot	VAR_035714	Polymorphism	p.LYS117ASN	N/A
Swiss-Prot	VAR_041861	Polymorphism	p.PRO883ALA	N/A
Swiss-Prot	VAR_048003	Polymorphism	p.THR391ILE	N/A
Swiss-Prot	VAR_066606	Disease	p.TYR897CYS	Dominantly inherited venous malformations (VMCM)
Swiss-Prot	VAR_008716	Disease	p.TYR897SER	Dominantly inherited venous malformations (VMCM)
Swiss-Prot	VAR_024578	Polymorphism	p.VAL486ILE	N/A
Swiss-Prot	VAR_041859	Polymorphism	p.VAL676ILE	N/A
Swiss-Prot	VAR_041857	Polymorphism	p.VAL600LEU	N/A
Swiss-Prot	VAR_066609	Disease	p.VAL919LEU	Dominantly inherited venous malformations (VMCM)

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258