Home News About DMDM Database Statistics Research Publications Contact  

Results for the Protein: NP_665861
22209009

serine/threonine-protein kinase Chk2 isoform b [Homo sapiens]

Known Diseases associated with this Protein:
  BREAST CANCER, SUSCEPTIBILITY TO
  CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
  COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;
  LI-FRAUMENI SYNDROME 2
  OSTEOSARCOMA, SOMATIC
  PROSTATE CANCER, SOMATIC
10
0
10
0
0
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

FHA - cd00060
FHA - pfam00498
STKc_ROCK2 - cd05621
STKc_ROCK1 - cd05622
STKc_ROCK - cd05596
STKc_PAK5 - cd06658
STKc_JNK1 - cd07875
STKc_PAK6 - cd06659
STKc_myosinIIIA - cd06638
STKc_PAK4 - cd06657
STKc_JNK2 - cd07876
STKc_myosinIIIB - cd06639
STKc_p38 - cd07851
STKc_p38alpha_MAPK14 - cd07877
STKc_JNK - cd07850
STKc_JNK3 - cd07874
STKc_p38gamma_MAPK12 - cd07880
STKc_PAK - cd06614
STKc_p38beta_MAPK11 - cd07878
PKc_MKK7 - cd06618
STKc_PAK1 - cd06654
STKc_PAK_II - cd06648
STKc_CDK9 - cd07865
STKc_PAK3 - cd06656
STKc_PAK_I - cd06647
STKc_TAO2 - cd06634
STKc_Sty1_Hog1 - cd07856
STKc_MAP4K3 - cd06645
STKc_MAP4K5 - cd06646
STKc_MAPK15 - cd07852
STKc_BUR1 - cd07866
STKc_CDK12 - cd07864
STKc_STK10_LOK - cd06644
PTKc_ALK_LTK - cd05036
STKc_MAPK4_6 - cd07854
STKc_CDK10 - cd07845
PTKc_FAK - cd05056
STKc_SLK - cd06643
STKc_TEY_MAPK_plant - cd07858
STKc_ERK5 - cd07855
STKc_ASK - cd06624
STKc_ERK1_2_like - cd07849
PKc_MAPKK_Byr1_like - cd06620
PTKc_Jak_rpt2 - cd05038
STKc_MAP4K3_like - cd06613
STKc_myosinIII_like - cd06608
STKc_MST1_2 - cd06612
PKc_MKK4 - cd06616
STKc_MEKK3_like_1 - cd06653
STKc_STK25-YSK1 - cd06642
STKc_Nek6_Nek7 - cd08224
STKc_MEKK2 - cd06652
STKc_SLK_like - cd06611
STKc_MST3 - cd06641
PKc_MAPKK_plant_like - cd06623
STKc_Sid2p_Dbf2p - cd05600
STKc_MST4 - cd06640
PTKc_Srm_Brk - cd05148
STKc_PAK2 - cd06655
STKc_NAK1_like - cd06917
STKc_MEKK3_like - cd06625
PKc_MAPKK_Pek1_like - cd06621
PKc_MKK3_6 - cd06617
PKc_MAPKK_PBS2_like - cd06622
STKc_CDKL1_4 - cd07847
STKc_Nek7 - cd08229
SPS1 - COG0515
STKc_Nek6 - cd08228
PKc_MEK - cd06615
STKc_CDKL2_3 - cd07846
STKc_CdkB_plant - cd07837
STKc_CDKL - cd07833
STKc_LATS - cd05598
STKc_CRIK - cd05601
STKc_DMPK_like - cd05597
STKc_PKA - cd05580
STKc_OSR1_SPAK - cd06610
STKc_ROCK_NDR_like - cd05573
STKc_MAST - cd05609
STKc_PDK1 - cd05581
STKc_PRKX_like - cd05612
STKc_MST3_like - cd06609
PKc_MAPKK - cd06605
STKc_NDR1 - cd05628
STKc_MRCK_beta - cd05624
STKc_MRCK_alpha - cd05623
STKc_NDR2 - cd05627
STKc_MPK1 - cd07857
STKc_CDK1_euk - cd07861
STKc_Nek - cd08215
STKc_CDK2_3 - cd07860
STKc_Nek2 - cd08217
STKc_CDK8_like - cd07842
STKc_Nek1 - cd08218
STKc_CDK7 - cd07841
STKc_NLK - cd07853
STKc_TDY_MAPK_plant - cd07859
STKc_FA2-like - cd08529
STKc_CDK5 - cd07839
STKc_CNK2-like - cd08530
STKc_Nek10 - cd08528
STKc_Nek5 - cd08225
STKc_Nek4 - cd08223
STKc_Nek8 - cd08220
STKc_Nek9 - cd08221
STKc_Nek11 - cd08222
STKc_Nek3 - cd08219
STKc_GRK4_like - cd05605
STKc_MSK1_N - cd05613
STKc_MSK2_N - cd05614
STKc_cPKC_alpha - cd05615
STKc_GRK6 - cd05630
STKc_cPKC - cd05587
STKc_MSK_N - cd05583
PKc_STE - cd05122
STKc_Pho85 - cd07836
STKc_Yank1 - cd05578
STKc_GRK4 - cd05631
STKc_cPKC_beta - cd05616
STKc_GRK5 - cd05632
STKc_MEKK3 - cd06651
STKc_CCRK - cd07832
STKc_MAPK - cd07834
STKc_MEKK1 - cd06630
STKc_YSK4 - cd06631
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MAPKKK - cd06606
STKc_Cdc7_like - cd06627
STYKc - smart00221
TyrKc - smart00219
STKc_CDK1_like - cd07835
Pkinase - pfam00069
Pkinase_Tyr - pfam07714
STKc_MAK_like - cd07830
STKc_MOK - cd07831
STKc_CDK_like - cd07829
STKc_CDK9_like - cd07840
STKc_CMGC - cd05118
STKc_CDK4_6_like - cd07838
STKc_PKN - cd05589
STKc_MEKK1_plant - cd06632
STKc_MEKK4 - cd06626
STKc_RSK_N - cd05582
STKc_p70S6K - cd05584
STKc_SGK3 - cd05604
STKc_SGK1 - cd05602
STKc_SGK2 - cd05603
STKc_Rim15_like - cd05611
STKc_nPKC_theta - cd05619
STKc_NDR_like - cd05599
STKc_PKB - cd05571
STKc_aPKC_iota - cd05618
STKc_aPKC_zeta - cd05617
STKc_phototropin_lik - cd05574
PTKc_Syk - cd05116
STKc_PKC - cd05570
PTKc - cd00192
PTKc_Fes_like - cd05041
PTKc_Syk_like - cd05060
STKc_SGK - cd05575
STKc_aPKC - cd05588
STKc_PKB_alpha - cd05594
STKc_PKB_beta - cd05595
STKc_PKB_gamma - cd05593
STKc_nPKC_epsilon - cd05591
STKc_nPKC_eta - cd05590
STKc_nPKC_theta_delt - cd05592
STKc_beta_ARK - cd05606
STKc_GRK3 - cd05633
STKc_GRK - cd05577
STKc_GRK1 - cd05608
STKc_MAST_like - cd05579
STKc_cGK_PKG - cd05572
STKc_AGC - cd05123
PKc - cd00180
STKc_GRK7 - cd05607
STKc_YPK1_like - cd05585
STKc_Sck1_like - cd05586
STKc_MAPKKK_Bck1_lik - cd06629
S_TKc - smart00220
STKc_CDC2L1 - cd07843


RefSeq Protein: NP_665861
   Default View:





















































































































































































Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
FHAcd000608.8e-1593203
STKc_ROCK2cd056215.3e-07172514
STKc_ROCK1cd056222.6e-05172514
STKc_ROCKcd055962.6e-06181513
STKc_PAK5cd066585.3e-05192474
STKc_myosinIIIAcd066382.7e-06193457
STKc_PAK6cd066594.7e-08193480
STKc_JNK1cd078750.00013193486
STKc_PAK4cd066571.4e-05194476
STKc_JNK2cd078767.2e-05195484
STKc_myosinIIIBcd066392.4e-06198458
STKc_p38cd078512.8e-11199493
STKc_p38alpha_MAPK14cd078771.3e-05199486
STKc_JNKcd078506.7e-07200498
STKc_PAKcd066143.9e-17201470
STKc_JNK3cd078749.7e-05201510
STKc_p38gamma_MAPK12cd078801.2e-06201493
STKc_p38beta_MAPK11cd078780.00012202492
PKc_MKK7cd066181.3e-05203472
STKc_PAK_IIcd066489.2e-10207470
STKc_PAK1cd066548.9e-05207480
STKc_PAK_Icd066471.6e-05208478
STKc_TAO2cd066340.00067208495
STKc_PAK3cd066564.4e-05208482
STKc_CDK9cd078657.9e-08208457
STKc_MAP4K3cd066454.3e-05210456
STKc_MAP4K5cd066466.7e-05210456
STKc_Sty1_Hog1cd078562.3e-07210488
STKc_MAPK15cd078522.4e-11211474
STKc_BUR1cd078661e-09211457
STKc_STK10_LOKcd066443.7e-05212477
STKc_CDK12cd078641.5e-07212457
PTKc_ALK_LTKcd050363.3e-05213439
PTKc_FAKcd050560.00091214461
STKc_SLKcd066432e-05214475
STKc_CDK10cd078458.4e-08214467
STKc_MAPK4_6cd078543.7e-08214492
STKc_ERK5cd078559e-12215486
STKc_TEY_MAPK_plantcd078583.2e-08215492
PTKc_Jak_rpt2cd050388.2e-05216441
STKc_myosinIII_likecd066083.9e-09216457
STKc_MST1_2cd066121.7e-12216457
STKc_MAP4K3_likecd066135.7e-11216456
PKc_MAPKK_Byr1_likecd066200.0003216473
STKc_ASKcd066246.6e-07216457
STKc_ERK1_2_likecd078493e-11216485
PTKc_Srm_Brkcd051480.00035217434
STKc_Sid2p_Dbf2pcd056007e-07217514
STKc_SLK_likecd066117.8e-10217472
PKc_MAPKK_plant_likecd066231.1e-14217462
STKc_MST4cd066400.00018217478
STKc_MST3cd066410.00089217478
STKc_STK25-YSK1cd066423.7e-05217478
STKc_MEKK2cd066523e-06217458
PKc_MKK4cd066160.00065217470
STKc_MEKK3_like_1cd066532.9e-07217457
STKc_Nek6_Nek7cd082247e-08217464
STKc_ROCK_NDR_likecd055731e-14218505
STKc_PKAcd055802.5e-17218504
STKc_PDK1cd055811.7e-19218457
STKc_DMPK_likecd055974e-05218514
STKc_LATScd055987.2e-06218509
STKc_CRIKcd056011.3e-07218514
STKc_MASTcd056092.5e-07218492
STKc_PRKX_likecd056121.7e-11218495
STKc_MRCK_alphacd056233.5e-05218513
STKc_MRCK_betacd056240.00023218514
STKc_NDR2cd056270.0009218508
STKc_NDR1cd056283.2e-05218508
PKc_MAPKKcd066058.9e-07218462
STKc_MST3_likecd066091.2e-09218478
STKc_OSR1_SPAKcd066101e-09218457
PKc_MEKcd066150.0003218474
PKc_MKK3_6cd066170.00034218475
PKc_MAPKK_Pek1_likecd066210.00017218470
PKc_MAPKK_PBS2_likecd066221.6e-06218505
STKc_MEKK3_likecd066253.7e-11218457
STKc_PAK2cd066551.2e-05218481
STKc_NAK1_likecd069178.5e-06218474
STKc_CDKLcd078331.1e-09218457
STKc_CdkB_plantcd078373.1e-07218458
STKc_CDKL2_3cd078465.9e-06218457
STKc_CDKL1_4cd078470.00055218457
STKc_Nek6cd082281.2e-06218452
STKc_Nek7cd082291.5e-06218455
SPS1COG05151.9e-15218510
PKc_STEcd051221.7e-13219456
STKc_Yank1cd055781e-16219457
STKc_MSK_Ncd055832.1e-10219480
STKc_cPKCcd055872.7e-05219513
STKc_GRK4_likecd056057.5e-07219495
STKc_MSK1_Ncd056131.7e-08219480
STKc_MSK2_Ncd056141.5e-08219502
STKc_cPKC_alphacd056150.00025219510
STKc_cPKC_betacd056160.00042219505
STKc_GRK6cd056308.8e-05219478
STKc_GRK4cd056311.9e-05219482
STKc_GRK5cd056321.3e-05219478
STKc_MAPKKKcd066064.2e-19219457
STKc_Cdc7_likecd066271.6e-16219457
STKc_MAPKKK_Byr2_likcd066282.8e-07219457
STKc_MEKK1cd066303.2e-06219458
STKc_YSK4cd066311.1e-06219457
STKc_MEKK3cd066512e-09219459
STKc_CCRKcd078324e-12219458
STKc_MAPKcd078348.8e-13219491
STKc_Pho85cd078360.00016219457
STKc_CDK5cd078392.6e-06219457
STKc_CDK7cd078417e-12219470
STKc_CDK8_likecd078421.1e-06219457
STKc_NLKcd078531.5e-06219514
STKc_TDY_MAPK_plantcd078597.6e-07219513
STKc_CDK2_3cd078600.0003219457
STKc_MPK1cd078573.8e-08219487
STKc_CDK1_eukcd078614.5e-05219457
STKc_Nekcd082156.3e-19219457
STKc_Nek2cd082173.7e-11219457
STKc_Nek1cd082188.6e-07219457
STKc_Nek3cd082191.3e-08219457
STKc_Nek8cd082202.4e-09219457
STKc_Nek9cd082215.4e-10219457
STKc_Nek11cd082227.1e-08219457
STKc_Nek4cd082234.4e-07219457
STKc_Nek5cd082258.5e-06219457
STKc_FA2-likecd085292e-11219457
STKc_CNK2-likecd085305.8e-10219457
STKc_Nek10cd085281e-07219456
STKc_CMGCcd051185.2e-14220457
STKc_PKNcd055891.1e-07220504
STKc_CDK_likecd078294.2e-13220457
STKc_MAK_likecd078309.2e-13220457
STKc_MOKcd078316.4e-11220457
STKc_CDK4_6_likecd078386.7e-09220457
STKc_CDK9_likecd078407.9e-12220457
STKc_CDK1_likecd078350.0004220457
STKc_MEKK1_plantcd066327.1e-13222457
STKc_RSK_Ncd055823.3e-05223513
STKc_p70S6Kcd055841.5e-07223512
STKc_MEKK4cd066269.7e-13223457
PTKccd001928.5e-06224438
PTKc_Fes_likecd050411e-05224436
PTKc_Syk_likecd050600.00023224443
PTKc_Sykcd051160.0006224457
STKc_PKCcd055701.7e-10224504
STKc_phototropin_likcd055744.3e-12224465
STKc_SGKcd055757.7e-07224514
STKc_aPKCcd055883e-06224505
STKc_nPKC_etacd055904.8e-05224511
STKc_nPKC_epsiloncd055912.5e-06224511
STKc_PKB_gammacd055932.2e-07224502
STKc_PKB_alphacd055943.7e-08224512
STKc_PKB_betacd055957.1e-07224512
STKc_nPKC_theta_deltcd055927.5e-06224512
STKc_NDR_likecd055994.8e-09224496
STKc_SGK1cd056023.1e-05224510
STKc_SGK2cd056031.2e-06224513
STKc_SGK3cd056040.0001224514
STKc_Rim15_likecd056111.5e-05224459
STKc_aPKC_zetacd056178.2e-05224505
STKc_aPKC_iotacd056180.00019224505
STKc_nPKC_thetacd056193.4e-06224512
STKc_PKBcd055713.3e-10224514
STKc_beta_ARKcd056061.1e-05225477
STKc_GRK3cd056330.00014225482
PKccd001801.3e-42226455
STKc_AGCcd051236.6e-18226457
STKc_cGK_PKGcd055729.2e-15226464
STKc_MAST_likecd055792.8e-17226462
STKc_YPK1_likecd055851.3e-08226513
STKc_Sck1_likecd055862.2e-06226514
STKc_GRK7cd056070.00016226477
STKc_GRK1cd056087e-05226486
STKc_GRKcd055772e-07226471
STKc_MAPKKK_Bck1_likcd066291.8e-07227457
STKc_CDC2L1cd078439.7e-11231457
FHApfam004983.8e-15113192
Pkinasepfam000693.4e-55220457
Pkinase_Tyrpfam077142.8e-11220437
TyrKcsmart002197.1e-09220457
STYKcsmart002215.4e-63220457
S_TKcsmart002205e-57230457

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
OMIM604373.0006 Diseasep.ALA17SEROSTEOSARCOMA, SOMATIC
OMIM604373.0008 Diseasep.ARG138CYSPROSTATE CANCER, SOMATIC
OMIM604373.0007 Diseasep.ARG137HISPROSTATE CANCER, SOMATIC
OMIM604373.0009 Diseasep.ARG138HISPROSTATE CANCER, SOMATIC
OMIM604373.0003 Diseasep.ARG1TRPLI-FRAUMENI SYNDROME 2
OMIM604373.0011 Diseasep.GLU196LYSPROSTATE CANCER, SOMATIC
OMIM604373.0010 Diseasep.GLU196TERPROSTATE CANCER, SOMATIC
OMIM604373.0002 Diseasep.ILE114THRLI-FRAUMENI SYNDROME 2||COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;||CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
OMIM604373.0005 Diseasep.PRO85LEUOSTEOSARCOMA, SOMATIC
OMIM604373.0014 Diseasep.SER356PHEBREAST CANCER, SUSCEPTIBILITY TO



   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258