Results for the protein: NP

Results for the Protein: NP_665861

22209009

11200

CHEK2

NCBI

serine/threonine-protein kinase Chk2 isoform b [Homo sapiens]

Known Diseases associated with this Protein:
  BREAST CANCER, SUSCEPTIBILITY TO
  CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
  COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;
  LI-FRAUMENI SYNDROME 2
  OSTEOSARCOMA, SOMATIC
  PROSTATE CANCER, SOMATIC

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Tips:

The Domains on the Default View are decided by the Domain's E-Value.

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RefSeq Protein: NP_665861

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621	5.3e-07	172	514
STKc_ROCK1	cd05622	2.6e-05	172	514
STKc_ROCK	cd05596	2.6e-06	181	513
STKc_PAK5	cd06658	5.3e-05	192	474
STKc_myosinIIIA	cd06638	2.7e-06	193	457
STKc_PAK6	cd06659	4.7e-08	193	480
STKc_JNK1	cd07875	0.00013	193	486
STKc_PAK4	cd06657	1.4e-05	194	476
STKc_JNK2	cd07876	7.2e-05	195	484
STKc_myosinIIIB	cd06639	2.4e-06	198	458
STKc_p38	cd07851	2.8e-11	199	493
STKc_p38alpha_MAPK14	cd07877	1.3e-05	199	486
STKc_JNK	cd07850	6.7e-07	200	498
STKc_PAK	cd06614	3.9e-17	201	470
STKc_JNK3	cd07874	9.7e-05	201	510
STKc_p38gamma_MAPK12	cd07880	1.2e-06	201	493
STKc_p38beta_MAPK11	cd07878	0.00012	202	492
PKc_MKK7	cd06618	1.3e-05	203	472
STKc_PAK_II	cd06648	9.2e-10	207	470
STKc_PAK1	cd06654	8.9e-05	207	480
STKc_PAK_I	cd06647	1.6e-05	208	478
STKc_TAO2	cd06634	0.00067	208	495
STKc_PAK3	cd06656	4.4e-05	208	482
STKc_CDK9	cd07865	7.9e-08	208	457
STKc_MAP4K3	cd06645	4.3e-05	210	456
STKc_MAP4K5	cd06646	6.7e-05	210	456
STKc_Sty1_Hog1	cd07856	2.3e-07	210	488
STKc_MAPK15	cd07852	2.4e-11	211	474
STKc_BUR1	cd07866	1e-09	211	457
STKc_STK10_LOK	cd06644	3.7e-05	212	477
STKc_CDK12	cd07864	1.5e-07	212	457
PTKc_ALK_LTK	cd05036	3.3e-05	213	439
PTKc_FAK	cd05056	0.00091	214	461
STKc_SLK	cd06643	2e-05	214	475
STKc_CDK10	cd07845	8.4e-08	214	467
STKc_MAPK4_6	cd07854	3.7e-08	214	492
STKc_ERK5	cd07855	9e-12	215	486
STKc_TEY_MAPK_plant	cd07858	3.2e-08	215	492
PTKc_Jak_rpt2	cd05038	8.2e-05	216	441
STKc_myosinIII_like	cd06608	3.9e-09	216	457
STKc_MST1_2	cd06612	1.7e-12	216	457
STKc_MAP4K3_like	cd06613	5.7e-11	216	456
PKc_MAPKK_Byr1_like	cd06620	0.0003	216	473
STKc_ASK	cd06624	6.6e-07	216	457
STKc_ERK1_2_like	cd07849	3e-11	216	485
PTKc_Srm_Brk	cd05148	0.00035	217	434
STKc_Sid2p_Dbf2p	cd05600	7e-07	217	514
STKc_SLK_like	cd06611	7.8e-10	217	472
PKc_MAPKK_plant_like	cd06623	1.1e-14	217	462
STKc_MST4	cd06640	0.00018	217	478
STKc_MST3	cd06641	0.00089	217	478
STKc_STK25-YSK1	cd06642	3.7e-05	217	478
STKc_MEKK2	cd06652	3e-06	217	458
PKc_MKK4	cd06616	0.00065	217	470
STKc_MEKK3_like_1	cd06653	2.9e-07	217	457
STKc_Nek6_Nek7	cd08224	7e-08	217	464
STKc_ROCK_NDR_like	cd05573	1e-14	218	505
STKc_PKA	cd05580	2.5e-17	218	504
STKc_PDK1	cd05581	1.7e-19	218	457
STKc_DMPK_like	cd05597	4e-05	218	514
STKc_LATS	cd05598	7.2e-06	218	509
STKc_CRIK	cd05601	1.3e-07	218	514
STKc_MAST	cd05609	2.5e-07	218	492
STKc_PRKX_like	cd05612	1.7e-11	218	495
STKc_MRCK_alpha	cd05623	3.5e-05	218	513
STKc_MRCK_beta	cd05624	0.00023	218	514
STKc_NDR2	cd05627	0.0009	218	508
STKc_NDR1	cd05628	3.2e-05	218	508
PKc_MAPKK	cd06605	8.9e-07	218	462
STKc_MST3_like	cd06609	1.2e-09	218	478
STKc_OSR1_SPAK	cd06610	1e-09	218	457
PKc_MEK	cd06615	0.0003	218	474
PKc_MKK3_6	cd06617	0.00034	218	475
PKc_MAPKK_Pek1_like	cd06621	0.00017	218	470
PKc_MAPKK_PBS2_like	cd06622	1.6e-06	218	505
STKc_MEKK3_like	cd06625	3.7e-11	218	457
STKc_PAK2	cd06655	1.2e-05	218	481
STKc_NAK1_like	cd06917	8.5e-06	218	474
STKc_CDKL	cd07833	1.1e-09	218	457
STKc_CdkB_plant	cd07837	3.1e-07	218	458
STKc_CDKL2_3	cd07846	5.9e-06	218	457
STKc_CDKL1_4	cd07847	0.00055	218	457
STKc_Nek6	cd08228	1.2e-06	218	452
STKc_Nek7	cd08229	1.5e-06	218	455
SPS1	COG0515	1.9e-15	218	510
PKc_STE	cd05122	1.7e-13	219	456
STKc_Yank1	cd05578	1e-16	219	457
STKc_MSK_N	cd05583	2.1e-10	219	480
STKc_cPKC	cd05587	2.7e-05	219	513
STKc_GRK4_like	cd05605	7.5e-07	219	495
STKc_MSK1_N	cd05613	1.7e-08	219	480
STKc_MSK2_N	cd05614	1.5e-08	219	502
STKc_cPKC_alpha	cd05615	0.00025	219	510
STKc_cPKC_beta	cd05616	0.00042	219	505
STKc_GRK6	cd05630	8.8e-05	219	478
STKc_GRK4	cd05631	1.9e-05	219	482
STKc_GRK5	cd05632	1.3e-05	219	478
STKc_MAPKKK	cd06606	4.2e-19	219	457
STKc_Cdc7_like	cd06627	1.6e-16	219	457
STKc_MAPKKK_Byr2_lik	cd06628	2.8e-07	219	457
STKc_MEKK1	cd06630	3.2e-06	219	458
STKc_YSK4	cd06631	1.1e-06	219	457
STKc_MEKK3	cd06651	2e-09	219	459
STKc_CCRK	cd07832	4e-12	219	458
STKc_MAPK	cd07834	8.8e-13	219	491
STKc_Pho85	cd07836	0.00016	219	457
STKc_CDK5	cd07839	2.6e-06	219	457
STKc_CDK7	cd07841	7e-12	219	470
STKc_CDK8_like	cd07842	1.1e-06	219	457
STKc_NLK	cd07853	1.5e-06	219	514
STKc_TDY_MAPK_plant	cd07859	7.6e-07	219	513
STKc_CDK2_3	cd07860	0.0003	219	457
STKc_MPK1	cd07857	3.8e-08	219	487
STKc_CDK1_euk	cd07861	4.5e-05	219	457
STKc_Nek	cd08215	6.3e-19	219	457
STKc_Nek2	cd08217	3.7e-11	219	457
STKc_Nek1	cd08218	8.6e-07	219	457
STKc_Nek3	cd08219	1.3e-08	219	457
STKc_Nek8	cd08220	2.4e-09	219	457
STKc_Nek9	cd08221	5.4e-10	219	457
STKc_Nek11	cd08222	7.1e-08	219	457
STKc_Nek4	cd08223	4.4e-07	219	457
STKc_Nek5	cd08225	8.5e-06	219	457
STKc_FA2-like	cd08529	2e-11	219	457
STKc_CNK2-like	cd08530	5.8e-10	219	457
STKc_Nek10	cd08528	1e-07	219	456
STKc_CMGC	cd05118	5.2e-14	220	457
STKc_PKN	cd05589	1.1e-07	220	504
STKc_CDK_like	cd07829	4.2e-13	220	457
STKc_MAK_like	cd07830	9.2e-13	220	457
STKc_MOK	cd07831	6.4e-11	220	457
STKc_CDK4_6_like	cd07838	6.7e-09	220	457
STKc_CDK9_like	cd07840	7.9e-12	220	457
STKc_CDK1_like	cd07835	0.0004	220	457
STKc_MEKK1_plant	cd06632	7.1e-13	222	457
STKc_RSK_N	cd05582	3.3e-05	223	513
STKc_p70S6K	cd05584	1.5e-07	223	512
STKc_MEKK4	cd06626	9.7e-13	223	457
PTKc	cd00192	8.5e-06	224	438
PTKc_Fes_like	cd05041	1e-05	224	436
PTKc_Syk_like	cd05060	0.00023	224	443
PTKc_Syk	cd05116	0.0006	224	457
STKc_PKC	cd05570	1.7e-10	224	504
STKc_phototropin_lik	cd05574	4.3e-12	224	465
STKc_SGK	cd05575	7.7e-07	224	514
STKc_aPKC	cd05588	3e-06	224	505
STKc_nPKC_eta	cd05590	4.8e-05	224	511
STKc_nPKC_epsilon	cd05591	2.5e-06	224	511
STKc_PKB_gamma	cd05593	2.2e-07	224	502
STKc_PKB_alpha	cd05594	3.7e-08	224	512
STKc_PKB_beta	cd05595	7.1e-07	224	512
STKc_nPKC_theta_delt	cd05592	7.5e-06	224	512
STKc_NDR_like	cd05599	4.8e-09	224	496
STKc_SGK1	cd05602	3.1e-05	224	510
STKc_SGK2	cd05603	1.2e-06	224	513
STKc_SGK3	cd05604	0.0001	224	514
STKc_Rim15_like	cd05611	1.5e-05	224	459
STKc_aPKC_zeta	cd05617	8.2e-05	224	505
STKc_aPKC_iota	cd05618	0.00019	224	505
STKc_nPKC_theta	cd05619	3.4e-06	224	512
STKc_PKB	cd05571	3.3e-10	224	514
STKc_beta_ARK	cd05606	1.1e-05	225	477
STKc_GRK3	cd05633	0.00014	225	482
PKc	cd00180	1.3e-42	226	455
STKc_AGC	cd05123	6.6e-18	226	457
STKc_cGK_PKG	cd05572	9.2e-15	226	464
STKc_MAST_like	cd05579	2.8e-17	226	462
STKc_YPK1_like	cd05585	1.3e-08	226	513
STKc_Sck1_like	cd05586	2.2e-06	226	514
STKc_GRK7	cd05607	0.00016	226	477
STKc_GRK1	cd05608	7e-05	226	486
STKc_GRK	cd05577	2e-07	226	471
STKc_MAPKKK_Bck1_lik	cd06629	1.8e-07	227	457
STKc_CDC2L1	cd07843	9.7e-11	231	457
FHA	pfam00498	3.8e-15	113	192
Pkinase	pfam00069	3.4e-55	220	457
Pkinase_Tyr	pfam07714	2.8e-11	220	437
TyrKc	smart00219	7.1e-09	220	457
STYKc	smart00221	5.4e-63	220	457
S_TKc	smart00220	5e-57	230	457

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	604373.0006	Disease	p.ALA17SER	OSTEOSARCOMA, SOMATIC
OMIM	604373.0008	Disease	p.ARG138CYS	PROSTATE CANCER, SOMATIC
OMIM	604373.0007	Disease	p.ARG137HIS	PROSTATE CANCER, SOMATIC
OMIM	604373.0009	Disease	p.ARG138HIS	PROSTATE CANCER, SOMATIC
OMIM	604373.0003	Disease	p.ARG1TRP	LI-FRAUMENI SYNDROME 2
OMIM	604373.0011	Disease	p.GLU196LYS	PROSTATE CANCER, SOMATIC
OMIM	604373.0010	Disease	p.GLU196TER	PROSTATE CANCER, SOMATIC
OMIM	604373.0002	Disease	p.ILE114THR	LI-FRAUMENI SYNDROME 2\|\|COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;\|\|CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
OMIM	604373.0005	Disease	p.PRO85LEU	OSTEOSARCOMA, SOMATIC
OMIM	604373.0014	Disease	p.SER356PHE	BREAST CANCER, SUSCEPTIBILITY TO

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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