Results for the protein: Q07912

Results for the Protein: Q07912

229462980

10188

TNK2

NCBI, UniProt

ACK1_HUMAN RecName: Full=Activated CDC42 kinase 1; Short=ACK-1; AltName: Full=Tyrosine kinase non-receptor protein 2

Known Diseases associated with this Protein:
VARIANT OF UNKNOWN SIGNIFICANCE

1

13

1

2

11

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

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Swiss-Prot Protein: Q07912

Identical to: NP_005772

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_PDGFR_alpha	cd05105	1.7e-13	5	391
PTKc_PDGFR_beta	cd05107	1.6e-08	5	387
PTKc_Kit	cd05104	5.5e-13	11	390
PTKc_VEGFR	cd05054	1.6e-26	20	392
PTKc_VEGFR3	cd05102	1.5e-17	59	392
PTKc_VEGFR2	cd05103	4.9e-14	60	389
STKc_TAO1	cd06635	2.9e-05	101	415
STKc_TAO3	cd06633	0.00056	107	424
PTKc_FGFR1	cd05098	9.7e-31	109	398
STKc_PAK1	cd06654	0.00016	109	410
STKc_PAK6	cd06659	0.00019	109	410
STKc_PAK	cd06614	2.9e-11	110	397
PKc_MKK7	cd06618	7.2e-07	110	398
STKc_PAK_I	cd06647	0.00012	110	408
STKc_PAK_II	cd06648	2.4e-05	110	397
STKc_PAK2	cd06655	0.00075	110	411
STKc_PAK3	cd06656	0.00032	110	412
PTKc_FGFR2	cd05101	4.7e-29	111	401
STKc_TAO2	cd06634	3.5e-07	111	417
STKc_myosinIIIB	cd06639	7.4e-06	112	388
STKc_CDK10	cd07845	1.1e-06	112	409
PTKc_FGFR4	cd05099	1.5e-40	113	403
PTKc_FGFR3	cd05100	2e-25	113	427
STKc_myosinIIIA	cd06638	2.8e-06	113	385
PTKc_PDGFR	cd05055	2.4e-15	114	389
STKc_STK10_LOK	cd06644	6.6e-07	114	407
PTK_Tyk2_rpt1	cd05076	3.7e-07	115	385
STKc_TAO	cd06607	1.3e-05	115	424
STKc_ASK	cd06624	4.6e-09	115	386
STKc_MAP4K4_6	cd06636	0.00058	115	387
STKc_p38	cd07851	0.00075	115	417
STKc_CDK9	cd07865	0.0001	115	399
STKc_MAP4K3	cd06645	0.00025	116	386
STKc_MAP4K5	cd06646	0.00029	116	386
PTKc_EGFR_like	cd05057	1.5e-81	118	399
PTKc_EGFR	cd05108	1.5e-54	118	426
PTKc_HER2	cd05109	7.8e-57	118	397
PTKc_HER4	cd05110	9.8e-51	118	432
PTK_HER3	cd05111	1.8e-61	118	397
STKc_Sty1_Hog1	cd07856	0.00014	118	417
PTKc_ALK_LTK	cd05036	3.8e-36	119	387
PTKc_Chk	cd05083	3.9e-61	119	388
PTKc_FAK	cd05056	1.3e-80	119	393
PTKc_Tie2	cd05088	1e-25	119	409
PTKc_Csk_like	cd05039	7.6e-37	120	388
PTK_Ryk	cd05043	8.3e-21	120	388
PTK_CCK4	cd05046	2.7e-19	120	387
PTKc_Ror	cd05048	4.8e-37	120	384
PTKc_Trk	cd05049	7.3e-54	120	387
PTKc_DDR	cd05051	4.6e-37	120	387
STKc_SLK	cd06643	9.8e-07	120	390
PTKc_InsR_like	cd05032	2.1e-43	121	387
PTKc_EphR	cd05033	7.6e-57	121	389
PTKc_Src_like	cd05034	3e-75	121	388
PTKc_Jak_rpt2	cd05038	4.9e-79	121	388
PTKc_Musk	cd05050	1.6e-40	121	387
PTKc_Abl	cd05052	2.2e-69	121	389
PTKc_FGFR	cd05053	2.3e-30	121	391
PTKc_Tec_like	cd05059	4.4e-65	121	386
PTKc_InsR	cd05061	1.7e-37	121	398
PTKc_IGF-1R	cd05062	7.2e-31	121	387
PTKc_EphR_A2	cd05063	1.9e-50	121	386
PTKc_EphR_A10	cd05064	3.8e-41	121	389
PTKc_EphR_B	cd05065	9.1e-46	121	386
PTKc_EphR_A	cd05066	2.8e-54	121	386
PTKc_Lck_Blk	cd05067	2.6e-62	121	388
PTKc_Frk_like	cd05068	5.1e-81	121	389
PTKc_Fyn_Yrk	cd05070	1.2e-59	121	388
PTKc_Src	cd05071	1.1e-55	121	391
PTKc_Hck	cd05073	9.4e-64	121	388
PTKc_Yes	cd05069	9.1e-55	121	388
PTKc_Jak1_rpt2	cd05079	1e-54	121	389
PTKc_Jak2_Jak3_rpt2	cd05081	1.7e-70	121	389
PTKc_Csk	cd05082	5.2e-55	121	388
PTKc_Ror1	cd05090	2.9e-34	121	384
PTKc_Ror2	cd05091	6.2e-29	121	388
PTKc_TrkA	cd05092	4.7e-43	121	387
PTKc_TrkB	cd05093	6.5e-38	121	394
PTKc_DDR1	cd05096	1.1e-31	121	387
PTKc_DDR_like	cd05097	1.8e-41	121	387
PTKc_DDR2	cd05095	2.6e-38	121	387
PTKc_Itk	cd05112	1.7e-60	121	386
PTKc_Btk_Bmx	cd05113	1.7e-67	121	386
PTKc_Lyn	cd05072	1.2e-64	121	388
PTKc_Tec_Rlk	cd05114	9.6e-67	121	386
PTKc_TrkC	cd05094	2.5e-28	121	394
PKc_MKK4	cd06616	3.4e-06	121	396
PKc_MAPKK_Byr1_like	cd06620	2e-07	121	397
STKc_PCTAIRE_like	cd07844	2.5e-06	121	424
STKc_MAPK15	cd07852	1.5e-05	121	426
STKc_MAPK4_6	cd07854	3.1e-06	121	426
STKc_TEY_MAPK_plant	cd07858	2.8e-06	121	467
STKc_BUR1	cd07866	1.2e-05	121	378
STKc_PFTAIRE1	cd07869	0.00087	121	428
STKc_PFTAIRE2	cd07870	9.9e-06	121	424
STKc_PCTAIRE3	cd07871	3e-05	121	416
STKc_PCTAIRE1	cd07873	0.00074	121	435
STKc_MST1_2	cd06612	1.5e-10	122	385
STKc_MAP4K3_like	cd06613	4e-09	122	384
STKc_MST4	cd06640	5.1e-06	122	404
STKc_MST3	cd06641	1.4e-06	122	404
STKc_STK25-YSK1	cd06642	3.9e-07	122	407
STKc_CDK12	cd07864	1e-05	122	405
STKc_TNIK	cd06637	5.1e-05	123	385
STKc_MEKK2	cd06652	3.3e-06	123	380
STKc_MEKK3_like_1	cd06653	1e-07	123	387
STKc_CDKL2_3	cd07846	2.4e-05	123	385
STKc_ERK1_2_like	cd07849	2.8e-05	123	414
PTKc_Tie1	cd05089	2.5e-27	124	408
PTKc_Srm_Brk	cd05148	5.3e-68	124	388
STKc_PKA	cd05580	2e-06	124	399
STKc_PDK1	cd05581	7.5e-11	124	385
STKc_PRKX_like	cd05612	4.4e-05	124	400
PKc_MAPKK	cd06605	1.8e-07	124	390
STKc_MST3_like	cd06609	9.9e-10	124	405
STKc_OSR1_SPAK	cd06610	3.5e-10	124	378
PKc_MEK	cd06615	1.9e-05	124	407
PKc_MKK3_6	cd06617	1.4e-06	124	402
PKc_MKK5	cd06619	1.4e-05	124	403
PKc_MAPKK_Pek1_like	cd06621	2.7e-05	124	397
PKc_MAPKK_PBS2_like	cd06622	6e-06	124	432
PKc_MAPKK_plant_like	cd06623	3.3e-13	124	393
STKc_MEKK3_like	cd06625	4.3e-12	124	387
STKc_NAK1_like	cd06917	2.9e-08	124	389
STKc_CdkB_plant	cd07837	2.2e-07	124	400
STKc_CDC2L1	cd07843	3.8e-05	124	378
STKc_CDK6	cd07862	0.00049	124	410
STKc_CDKL1_4	cd07847	3.5e-07	124	424
STKc_Nek6_Nek7	cd08224	2.8e-09	124	393
STKc_Nek7	cd08229	4.4e-09	124	388
STKc_Nek6	cd08228	7.7e-07	124	390
SPS1	COG0515	2.6e-31	124	585
PTKc_RET	cd05045	2e-30	125	389
PKc_STE	cd05122	2.8e-12	125	384
STKc_Yank1	cd05578	2.5e-06	125	385
STKc_cPKC	cd05587	3.4e-07	125	458
STKc_GRK4_like	cd05605	8.5e-05	125	439
STKc_cPKC_alpha	cd05615	2.8e-05	125	464
STKc_cPKC_beta	cd05616	4.6e-05	125	466
STKc_MAPKKK	cd06606	1.5e-19	125	385
STKc_Cdc7_like	cd06627	2.3e-17	125	379
STKc_MEKK3	cd06651	3.6e-08	125	381
STKc_CCRK	cd07832	2.1e-06	125	410
STKc_MAPK	cd07834	1.3e-05	125	417
STKc_CDK5	cd07839	3.4e-06	125	399
STKc_CDK7	cd07841	3.1e-07	125	397
STKc_CDK8_like	cd07842	1.9e-06	125	386
STKc_NLK	cd07853	5.7e-06	125	452
STKc_MPK1	cd07857	7.8e-05	125	458
STKc_TDY_MAPK_plant	cd07859	4.2e-05	125	472
STKc_CDK2_3	cd07860	3.9e-06	125	424
STKc_CDK1_euk	cd07861	1.2e-05	125	424
STKc_Pho85	cd07836	9.4e-07	125	424
STKc_CDK4	cd07863	0.00027	125	424
STKc_Nek	cd08215	9.2e-13	125	385
STKc_Nek2	cd08217	4.4e-08	125	386
STKc_Nek1	cd08218	2.7e-05	125	386
STKc_Nek3	cd08219	1.3e-07	125	385
STKc_Nek4	cd08223	9.8e-06	125	386
STKc_Nek5	cd08225	5.1e-06	125	385
STKc_Nek10	cd08528	1.2e-07	125	387
STKc_CNK2-like	cd08530	4.1e-09	125	381
STKc_FA2-like	cd08529	1.9e-10	125	386
PTKc_Axl	cd05075	1.5e-43	126	389
PTKc_Tyro3	cd05074	1.3e-51	126	389
PTKc_Tyk2_rpt2	cd05080	3.7e-50	126	390
PTKc_Axl_like	cd05035	5.8e-57	126	389
STKc_CMGC	cd05118	2.7e-09	126	378
STKc_p70S6K	cd05584	0.00022	126	472
STKc_PKN	cd05589	6.2e-06	126	465
STKc_myosinIII_like	cd06608	1.1e-07	126	385
STKc_CDK_like	cd07829	9.4e-11	126	362
STKc_MAK_like	cd07830	1.1e-09	126	386
STKc_MOK	cd07831	7.6e-07	126	378
STKc_CDK1_like	cd07835	8.5e-08	126	424
STKc_CDK4_6_like	cd07838	8.4e-05	126	399
STKc_CDK9_like	cd07840	1e-06	126	399
STKc_SLK_like	cd06611	4.5e-09	128	401
STKc_MEKK4	cd06626	3.4e-11	128	385
STKc_CDKL	cd07833	0.00012	128	385
STKc_Nek11	cd08222	1.4e-06	128	386
STKc_RSK_N	cd05582	5.6e-05	129	463
PTKc	cd00192	3.2e-122	130	386
PTK_Jak_rpt1	cd05037	8.5e-13	130	385
PTKc_Ack_like	cd05040	1.3e-213	130	387
PTKc_Fes_like	cd05041	4.1e-48	130	387
PTKc_Aatyk	cd05042	1.1e-15	130	387
PTKc_c-ros	cd05044	1.5e-44	130	387
PTKc_Syk_like	cd05060	4.5e-99	130	390
PTK_Jak1_rpt1	cd05077	3.5e-08	130	385
PTK_Jak2_Jak3_rpt1	cd05078	5e-13	130	385
PTKc_Fes	cd05084	1.2e-48	130	387
PTKc_Fer	cd05085	1.7e-52	130	387
PTKc_Aatyk2	cd05086	8.7e-17	130	387
PTKc_Tie	cd05047	2.8e-32	130	387
PTKc_Met_Ron	cd05058	9.3e-52	130	391
PTKc_Syk	cd05116	2.8e-64	130	386
PTKc_Aatyk1_Aatyk3	cd05087	9.7e-22	130	387
STKc_PKC	cd05570	6.3e-07	130	426
STKc_PKB	cd05571	3.8e-07	130	467
STKc_nPKC_epsilon	cd05591	7.7e-06	130	453
STKc_nPKC_theta_delt	cd05592	1.2e-06	130	457
STKc_PKB_gamma	cd05593	0.0002	130	468
STKc_PKB_alpha	cd05594	0.00014	130	444
STKc_PKB_beta	cd05595	0.00028	130	465
STKc_SGK2	cd05603	2.1e-05	130	464
STKc_nPKC_theta	cd05619	1e-07	130	451
STKc_nPKC_delta	cd05620	0.00091	130	437
STKc_MAPKKK_Bck1_lik	cd06629	2.6e-10	130	379
STKc_MEKK1	cd06630	3.7e-09	130	382
STKc_YSK4	cd06631	6.7e-10	130	385
STKc_MEKK1_plant	cd06632	3.5e-12	130	379
STKc_Nek8	cd08220	0.00013	130	386
PTKc_Zap-70	cd05115	4e-61	131	390
PKc	cd00180	9.7e-58	132	385
STKc_AGC	cd05123	1.4e-08	132	378
STKc_cGK_PKG	cd05572	5.2e-05	132	388
STKc_YPK1_like	cd05585	0.0007	132	425
STKc_GRK1	cd05608	0.00068	132	403
STKc_MAPKKK_Byr2_lik	cd06628	1.3e-10	132	385
STKc_Nek9	cd08221	2.4e-07	132	386
STKc_MAST_like	cd05579	0.00018	150	378
SH3	cd00174	2.9e-13	377	445
Pkinase	pfam00069	4.3e-36	126	385
Pkinase_Tyr	pfam07714	1.4e-133	126	385
TyrKc	smart00219	2.8e-134	126	385
STYKc	smart00221	2.3e-54	126	387
S_TKc	smart00220	9.5e-42	136	386
KIND	smart00750	8.7e-05	211	393
SH3	smart00326	7.3e-15	374	446
GTPase_binding	pfam09027	3e-44	447	514
Inhibitor_Mig-6	pfam11555	1.8e-34	774	841

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_032801	Polymorphism	p.ARG748GLN	N/A
Swiss-Prot	VAR_032794	Polymorphism	p.ARG99GLN	N/A
Swiss-Prot	VAR_032802	Polymorphism	p.ARG1038HIS	N/A
dbSNP	rs112384084	Polymorphism	p.ARG877HIS	N/A
Swiss-Prot	VAR_032792	Polymorphism	p.ARG34LEU	N/A
dbSNP	rs3747673	Polymorphism	p.ARG99TRP	N/A
Swiss-Prot	VAR_032797	Polymorphism	p.GLU346LYS	N/A
Swiss-Prot	VAR_032793	Polymorphism	p.LYS71ARG	N/A
Swiss-Prot	VAR_032798	Polymorphism	p.MET409ILE	N/A
Swiss-Prot	VAR_032800	Polymorphism	p.PRO725LEU	N/A
Swiss-Prot	VAR_057115	Polymorphism	p.PRO802LEU	N/A
Swiss-Prot	VAR_032799	Polymorphism	p.PRO507SER	N/A
Swiss-Prot	VAR_032796	Polymorphism	p.THR152MET	N/A
OMIM	606994.0001	Disease	p.VAL638MET	VARIANT OF UNKNOWN SIGNIFICANCE

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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