Results for the protein: P46734

Results for the Protein: P46734

24638466

5606

MAP2K3

NCBI, UniProt

MP2K3_HUMAN RecName: Full=Dual specificity mitogen-activated protein kinase kinase 3; Short=MAP kinase kinase 3; Short=MAPKK 3; AltName: Full=MAPK/ERK kinase 3; Short=MEK 3; AltName: Full=Stress-activated protein kinase kinase 2; Short=SAPK kinase 2; Short=SAPKK-2; Short=SAPKK2

			0 13 0 2 11

Tips:

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Swiss-Prot Protein: P46734

Identical to: NP_659731

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK1	cd05622	0.00018	16	347
STKc_ROCK	cd05596	0.00019	24	347
STKc_JNK1	cd07875	0.00041	30	346
STKc_TAO1	cd06635	2.7e-08	38	345
STKc_PAK1	cd06654	1.8e-09	39	346
PTKc_DDR2	cd05095	0.00018	41	321
STKc_MAP4K4_6	cd06636	2.9e-25	42	325
STKc_PAK4	cd06657	3.3e-08	42	344
STKc_JNK2	cd07876	5.1e-05	42	346
PTKc_PDGFR	cd05055	0.0002	43	327
STKc_myosinIIIB	cd06639	4.2e-19	43	326
STKc_JNK3	cd07874	0.00011	45	344
STKc_myosinIIIA	cd06638	6.1e-16	46	325
STKc_JNK	cd07850	3.5e-06	46	346
PTKc_FGFR1	cd05098	0.00011	47	334
STKc_TAO3	cd06633	1.4e-06	47	345
STKc_PAK_I	cd06647	3.9e-15	47	344
STKc_PAK2	cd06655	9.1e-10	47	347
STKc_PAK3	cd06656	5.8e-10	47	347
STKc_p38alpha_MAPK14	cd07877	0.0001	47	347
PTKc_FGFR2	cd05101	6.4e-05	48	334
PKc_MKK7	cd06618	2e-126	49	345
STKc_p38	cd07851	8.9e-09	49	347
STKc_p38gamma_MAPK12	cd07880	4.2e-05	49	347
STKc_TAO2	cd06634	2.5e-09	51	346
STKc_PAK5	cd06658	5.7e-08	51	343
STKc_STK10_LOK	cd06644	3.7e-28	52	346
STKc_PAK6	cd06659	2.3e-13	52	347
STKc_Sty1_Hog1	cd07856	3.1e-06	52	346
STKc_CDK9	cd07865	4.9e-07	53	325
PTKc_FGFR	cd05053	2.1e-06	54	328
PTKc_FGFR4	cd05099	1.7e-05	54	345
STKc_PAK	cd06614	1.5e-24	54	339
STKc_MAP4K3	cd06645	3.7e-16	54	324
STKc_MAP4K5	cd06646	2.5e-12	54	324
STKc_PAK_II	cd06648	1.1e-13	54	343
STKc_ASK	cd06624	9.5e-19	55	325
STKc_CDC2L1	cd07843	1.2e-09	55	325
STKc_Nek7	cd08229	1.6e-15	55	326
PTKc_EGFR_like	cd05057	3.2e-06	56	338
PTKc_VEGFR3	cd05102	0.00061	56	330
PTKc_VEGFR2	cd05103	0.00014	56	330
STKc_MSK1_N	cd05613	9e-07	56	345
PTKc_InsR_like	cd05032	1.7e-09	57	323
PTKc_Src_like	cd05034	7.7e-09	57	324
PTKc_ALK_LTK	cd05036	1.3e-06	57	326
PTKc_Abl	cd05052	4.1e-08	57	324
PTKc_Csk_like	cd05039	0.001	57	326
PTKc_FAK	cd05056	1.1e-07	57	335
PTKc_InsR	cd05061	1.6e-07	57	330
PTKc_IGF-1R	cd05062	2.6e-07	57	325
PTKc_Lck_Blk	cd05067	2.8e-05	57	347
PTKc_Frk_like	cd05068	1.5e-10	57	324
PTKc_Yes	cd05069	9.8e-07	57	320
PTKc_Fyn_Yrk	cd05070	2.1e-06	57	324
PTKc_Src	cd05071	1.1e-06	57	326
PTKc_Lyn	cd05072	7.3e-07	57	324
PTKc_Hck	cd05073	1.1e-06	57	324
PTKc_Csk	cd05082	5.5e-06	57	326
PTKc_Chk	cd05083	3.1e-06	57	330
PTKc_Tie2	cd05088	4.2e-07	57	347
STKc_ERK1_2_like	cd07849	5e-09	57	344
STKc_ERK5	cd07855	1.4e-09	57	346
STKc_TEY_MAPK_plant	cd07858	1.9e-07	57	347
STKc_CDK12	cd07864	4.6e-07	57	325
STKc_CDC2L6	cd07867	0.00078	57	344
PTKc_Trk	cd05049	5.1e-07	58	329
PTKc_Musk	cd05050	1e-06	58	322
PTKc_EphR_A2	cd05063	7.2e-05	58	327
PTKc_EphR_A10	cd05064	1.2e-05	58	327
PTKc_Ror1	cd05090	0.00051	58	326
PTKc_TrkA	cd05092	2.2e-05	58	333
PTKc_TrkB	cd05093	0.00055	58	336
PTKc_DDR_like	cd05097	0.00086	58	326
STKc_TAO	cd06607	1.1e-09	58	345
PKc_MAPKK_Byr1_like	cd06620	9.4e-70	58	339
STKc_SLK	cd06643	1.1e-18	58	344
PKc_MEK2	cd06649	3.3e-49	58	347
PKc_MEK1	cd06650	4.9e-51	58	347
PTKc_EphR	cd05033	8.6e-07	59	321
PTKc_Jak_rpt2	cd05038	7.7e-10	59	328
PTKc_Tec_like	cd05059	5.1e-10	59	324
PTKc_EphR_A	cd05066	1.1e-05	59	331
PTKc_Jak1_rpt2	cd05079	6.5e-05	59	328
PTKc_Jak2_Jak3_rpt2	cd05081	1.1e-06	59	327
PTKc_EGFR	cd05108	4.8e-05	59	345
PTKc_HER2	cd05109	3.6e-06	59	338
PTK_HER3	cd05111	0.00036	59	340
PTKc_Itk	cd05112	4e-08	59	324
PTKc_Btk_Bmx	cd05113	1.5e-09	59	324
PTKc_Tec_Rlk	cd05114	1.2e-08	59	324
PTKc_HER4	cd05110	0.00015	59	347
STKc_MST1_2	cd06612	4.8e-26	59	325
STKc_myosinIII_like	cd06608	3.9e-20	60	325
STKc_MAP4K3_like	cd06613	2.7e-30	60	324
PKc_MKK4	cd06616	1.6e-162	60	343
STKc_MST4	cd06640	7e-19	60	346
STKc_MST3	cd06641	8.5e-15	60	347
STKc_STK25-YSK1	cd06642	1e-18	60	347
STKc_PCTAIRE_like	cd07844	2.1e-06	60	325
STKc_PFTAIRE2	cd07870	0.00022	60	325
STKc_PCTAIRE3	cd07871	2.6e-05	60	343
STKc_PCTAIRE2	cd07872	1.3e-05	60	341
STKc_PCTAIRE1	cd07873	0.0002	60	337
STKc_TNIK	cd06637	4.8e-24	61	325
STKc_MEKK3_like_1	cd06653	2.3e-08	61	325
STKc_MEKK2	cd06652	1.3e-07	61	326
STKc_MAPK15	cd07852	1.2e-09	61	342
STKc_Nek6_Nek7	cd08224	8.1e-12	61	329
STKc_Nek6	cd08228	2.4e-13	61	326
PTKc_Tie1	cd05089	1.3e-05	62	346
STKc_ROCK_NDR_like	cd05573	9.2e-11	62	347
STKc_phototropin_lik	cd05574	1.9e-06	62	334
STKc_PKA	cd05580	1.6e-09	62	341
STKc_PDK1	cd05581	4.3e-13	62	325
STKc_DMPK_like	cd05597	8.5e-05	62	347
STKc_NDR_like	cd05599	9.2e-07	62	307
STKc_LATS	cd05598	0.00014	62	347
STKc_Sid2p_Dbf2p	cd05600	0.00049	62	344
STKc_CRIK	cd05601	4.7e-09	62	347
STKc_MAST	cd05609	1.4e-08	62	347
STKc_MRCK_alpha	cd05623	0.0001	62	347
STKc_MRCK_beta	cd05624	0.0003	62	347
STKc_NDR1	cd05628	0.00029	62	347
STKc_PRKX_like	cd05612	1.3e-06	62	341
PKc_MAPKK	cd06605	4e-170	62	330
STKc_MST3_like	cd06609	7.6e-21	62	343
STKc_OSR1_SPAK	cd06610	7.1e-17	62	325
PKc_MEK	cd06615	4.8e-71	62	343
PKc_MKK3_6	cd06617	1.7e-239	62	344
PKc_MKK5	cd06619	8.7e-67	62	347
PKc_MAPKK_Pek1_like	cd06621	4e-55	62	343
PKc_MAPKK_PBS2_like	cd06622	5.4e-90	62	346
PKc_MAPKK_plant_like	cd06623	2.6e-87	62	330
STKc_CdkB_plant	cd07837	9.1e-12	62	326
STKc_CDK10	cd07845	7.3e-07	62	339
STKc_CDKL1_4	cd07847	3.3e-14	62	325
STKc_CDKL5	cd07848	6.7e-05	62	325
STKc_CDKL2_3	cd07846	8.1e-10	62	325
STKc_CDK6	cd07862	5.6e-06	62	325
SPS1	COG0515	3.5e-25	62	347
PTKc_RET	cd05045	0.00013	63	330
PTKc_EphR_B	cd05065	8.2e-06	63	331
PKc_STE	cd05122	3.2e-61	63	324
STKc_MSK_N	cd05583	3.5e-10	63	340
STKc_cPKC	cd05587	0.00054	63	347
STKc_GRK4_like	cd05605	1.3e-08	63	347
STKc_MSK2_N	cd05614	5.6e-07	63	347
STKc_GRK6	cd05630	6.1e-06	63	347
STKc_GRK4	cd05631	2e-05	63	346
STKc_GRK5	cd05632	7.9e-06	63	347
STKc_MAPKKK	cd06606	9.9e-26	63	325
STKc_Cdc7_like	cd06627	4.5e-22	63	325
STKc_MAPKKK_Byr2_lik	cd06628	1.9e-16	63	325
STKc_NAK1_like	cd06917	1.9e-16	63	343
STKc_CCRK	cd07832	8.6e-12	63	326
STKc_MAPK	cd07834	3.5e-13	63	345
STKc_Pho85	cd07836	5.3e-07	63	325
STKc_CDK5	cd07839	3.2e-08	63	325
STKc_CDK7	cd07841	1.6e-12	63	339
STKc_NLK	cd07853	1.3e-05	63	345
STKc_MAPK4_6	cd07854	7.5e-07	63	346
STKc_MPK1	cd07857	1.6e-08	63	346
STKc_CDK2_3	cd07860	3.2e-07	63	325
STKc_CDK1_euk	cd07861	5.5e-09	63	325
STKc_CDK4	cd07863	8e-09	63	325
STKc_Nek	cd08215	1.8e-21	63	325
STKc_Nek2	cd08217	1.5e-14	63	325
STKc_Nek1	cd08218	2.1e-16	63	325
STKc_Nek3	cd08219	9.6e-15	63	325
STKc_Nek8	cd08220	4.1e-09	63	325
STKc_Nek9	cd08221	2e-09	63	325
STKc_Nek4	cd08223	2.3e-13	63	325
STKc_Nek5	cd08225	1.9e-13	63	325
STKc_Nek11	cd08222	6.9e-12	63	325
PK_STRAD_alpha	cd08227	7.5e-05	63	345
STKc_Nek10	cd08528	5.6e-08	63	322
STKc_FA2-like	cd08529	2e-12	63	325
STKc_CNK2-like	cd08530	2.1e-11	63	325
PTKc_Axl_like	cd05035	0.00011	64	327
PTKc_Tyro3	cd05074	0.00012	64	327
PTKc_Axl	cd05075	0.00057	64	327
PTKc_Tyk2_rpt2	cd05080	2.4e-06	64	329
STKc_PKN	cd05589	0.00019	64	347
STKc_YSK4	cd06631	4.5e-12	64	325
STKc_CDK1_like	cd07835	6.2e-09	64	325
STKc_CDK4_6_like	cd07838	1.6e-13	64	325
STKc_MAK_like	cd07830	3.1e-12	64	325
STKc_BUR1	cd07866	5e-06	64	325
STKc_TDY_MAPK_plant	cd07859	3e-05	64	347
PK_STRAD	cd08216	5.8e-10	65	341
STKc_CMGC	cd05118	7.9e-16	66	325
STKc_MOK	cd07831	3.7e-12	66	325
STKc_CDKL	cd07833	2.3e-10	66	325
STKc_CDK8_like	cd07842	1.4e-06	66	325
PTKc_Srm_Brk	cd05148	6e-06	67	326
STKc_RSK_N	cd05582	9.2e-07	67	347
STKc_p70S6K	cd05584	6.7e-05	67	347
STKc_Rim15_like	cd05611	8.3e-05	67	334
STKc_SLK_like	cd06611	1.7e-20	67	341
STKc_CDK_like	cd07829	5.9e-15	67	325
STKc_CDK9_like	cd07840	5.7e-09	67	325
PTKc	cd00192	6.5e-14	68	324
PTKc_Ack_like	cd05040	1.6e-08	68	325
PTKc_Fes_like	cd05041	8.2e-09	68	325
PTKc_Aatyk	cd05042	1.3e-05	68	316
PTKc_Met_Ron	cd05058	0.00024	68	329
PTKc_Syk_like	cd05060	1.2e-05	68	307
PTK_Jak2_Jak3_rpt1	cd05078	8.9e-05	68	318
PTKc_Fes	cd05084	1.9e-07	68	325
PTKc_Aatyk2	cd05086	0.00043	68	327
PTKc_Aatyk1_Aatyk3	cd05087	0.0005	68	327
PTKc_Syk	cd05116	7e-07	68	326
STKc_SGK	cd05575	0.00058	68	347
STKc_aPKC	cd05588	2.8e-05	68	347
STKc_nPKC_eta	cd05590	0.00037	68	347
STKc_nPKC_theta_delt	cd05592	0.00011	68	347
STKc_SGK2	cd05603	0.00051	68	340
STKc_nPKC_theta	cd05619	1e-05	68	347
PK_STRAD_beta	cd08226	4.1e-05	68	341
PTKc_Zap-70	cd05115	2.4e-06	69	328
STKc_MAPKKK_Bck1_lik	cd06629	6.5e-10	69	325
PKc	cd00180	3.5e-54	70	323
PTKc_c-ros	cd05044	2.7e-05	70	329
PTKc_Tie	cd05047	1.5e-05	70	328
PTKc_Fer	cd05085	2.1e-06	70	325
STKc_AGC	cd05123	1.4e-17	70	325
STKc_PKC	cd05570	1.2e-07	70	339
STKc_PKB	cd05571	1.6e-06	70	347
STKc_cGK_PKG	cd05572	1.1e-12	70	332
STKc_GRK	cd05577	2.7e-11	70	341
STKc_MAST_like	cd05579	3.8e-13	70	326
STKc_YPK1_like	cd05585	6.8e-06	70	347
STKc_nPKC_epsilon	cd05591	0.00026	70	347
STKc_Sck1_like	cd05586	7.6e-06	70	347
STKc_PKB_gamma	cd05593	0.00011	70	346
STKc_PKB_alpha	cd05594	1.6e-05	70	347
STKc_PKB_beta	cd05595	7.1e-05	70	347
STKc_beta_ARK	cd05606	1.8e-08	70	345
STKc_GRK7	cd05607	7.4e-08	70	346
STKc_GRK1	cd05608	3.9e-11	70	345
STKc_aPKC_zeta	cd05617	0.00099	70	344
STKc_aPKC_iota	cd05618	0.00057	70	347
STKc_GRK3	cd05633	2.9e-07	70	338
STKc_MEKK3_like	cd06625	1.9e-14	70	325
STKc_MEKK4	cd06626	6.2e-15	70	325
STKc_MEKK1_plant	cd06632	1.9e-15	70	325
STKc_MEKK3	cd06651	4.1e-10	70	327
STKc_MEKK1	cd06630	4.6e-10	70	326
STKc_Yank1	cd05578	1.7e-15	71	325
PTK_Ryk	cd05043	0.00019	90	289
Pkinase	pfam00069	1e-53	64	325
Pkinase_Tyr	pfam07714	1.1e-16	64	325
TyrKc	smart00219	6.5e-15	64	325
STYKc	smart00221	7.7e-62	64	325
S_TKc	smart00220	2.3e-68	74	325
KIND	smart00750	2.6e-06	159	333

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs2305873	Polymorphism	p.ALA84THR	N/A
Swiss-Prot	VAR_046068	Polymorphism	p.ARG293HIS	N/A
Swiss-Prot	VAR_046066	Polymorphism	p.ARG94LEU	N/A
Swiss-Prot	VAR_040817	Polymorphism	p.ARG26THR	N/A
Swiss-Prot	VAR_061742	Polymorphism	p.ARG55THR	N/A
Swiss-Prot	VAR_014208	Polymorphism	p.ARG175TRP	N/A
Swiss-Prot	VAR_046067	Polymorphism	p.ARG96TRP	N/A
Swiss-Prot	VAR_014209	Polymorphism	p.LEU215VAL	N/A
Swiss-Prot	VAR_046065	Polymorphism	p.MET90ILE	N/A
Swiss-Prot	VAR_046062	Polymorphism	p.PRO40THR	N/A
Swiss-Prot	VAR_046063	Polymorphism	p.SER68PRO	N/A
dbSNP	rs58609466	Polymorphism	p.THR222MET	N/A
Swiss-Prot	VAR_046069	Polymorphism	p.VAL339MET	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258