Results for the protein: O14965

Results for the Protein: O14965

27923855

6790

AURKA

NCBI, UniProt

AURKA_HUMAN RecName: Full=Aurora kinase A; AltName: Full=Aurora 2; AltName: Full=Aurora/IPL1-related kinase 1; Short=ARK-1; Short=Aurora-related kinase 1; Short=hARK1; AltName: Full=Breast tumor-amplified kinase; AltName: Full=Serine/threonine-protein kinase 15; AltName: Full=Serine/threonine-protein kinase 6; AltName: Full=Serine/threonine-protein kinase aurora-A

			0 8 0 0 8

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Swiss-Prot Protein: O14965

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621	7.3e-10	94	402
STKc_ROCK1	cd05622	5.7e-09	94	401
STKc_TAO3	cd06633	1.5e-06	99	402
STKc_PAK1	cd06654	9.7e-10	106	402
STKc_PAK3	cd06656	4.6e-10	107	401
STKc_PAK5	cd06658	1.1e-08	107	401
PTKc_DDR2	cd05095	8.9e-05	108	401
STKc_JNK2	cd07876	1.7e-05	108	402
STKc_PAK4	cd06657	1.1e-08	109	398
STKc_PAK	cd06614	4.3e-21	110	398
PTKc_FGFR2	cd05101	1.1e-06	111	388
STKc_TAO	cd06607	1.4e-08	111	402
STKc_TAO2	cd06634	8.3e-09	111	403
STKc_PAK_I	cd06647	8.6e-16	111	400
STKc_PAK_II	cd06648	1.4e-13	111	397
STKc_PAK2	cd06655	8.4e-10	111	403
STKc_PAK6	cd06659	3e-13	111	402
PTKc_FGFR3	cd05100	4.7e-05	114	403
STKc_myosinIIIA	cd06638	8.1e-10	114	383
STKc_myosinIIIB	cd06639	2.3e-10	114	384
PTKc_FGFR1	cd05098	2.9e-06	115	391
STKc_MAP4K4_6	cd06636	4.8e-07	115	383
STKc_JNK3	cd07874	0.0004	115	400
STKc_JNK	cd07850	2.6e-06	116	403
STKc_p38alpha_MAPK14	cd07877	1.5e-05	116	403
STKc_CDK9	cd07865	1.1e-11	118	383
STKc_p38delta_MAPK13	cd07879	0.00015	119	403
STKc_p38beta_MAPK11	cd07878	1.9e-06	120	403
STKc_p38gamma_MAPK12	cd07880	5.1e-07	120	403
PKc_MKK7	cd06618	8.3e-13	122	403
STKc_TAO1	cd06635	3.1e-08	122	402
STKc_STK10_LOK	cd06644	3.3e-15	122	402
STKc_p38	cd07851	2.1e-10	122	401
STKc_JNK1	cd07875	0.00042	122	402
PTKc_Jak_rpt2	cd05038	1.6e-09	123	385
PTKc_FGFR4	cd05099	3.1e-07	123	400
STKc_MAP4K3	cd06645	6.6e-10	123	382
STKc_MAP4K5	cd06646	9e-09	123	382
STKc_ASK	cd06624	5.2e-21	124	383
PTKc_EGFR_like	cd05057	3.6e-06	125	397
PTKc_TrkA	cd05092	6.4e-08	125	389
PTKc_VEGFR2	cd05103	0.001	125	386
PTKc_HER2	cd05109	1e-05	125	394
PTK_HER3	cd05111	2.1e-05	125	397
STKc_CDK10	cd07845	1.5e-13	125	397
PTKc_ALK_LTK	cd05036	1.9e-12	126	385
PTKc_FGFR	cd05053	7.2e-08	126	385
PTKc_FAK	cd05056	8.7e-11	126	389
PTKc_EGFR	cd05108	0.00029	126	403
PTKc_Ror	cd05048	5.2e-07	127	382
PTKc_Trk	cd05049	1.8e-10	127	380
PTKc_DDR	cd05051	0.00043	127	380
PTKc_Musk	cd05050	1.1e-07	127	380
PTKc_EphR_A10	cd05064	0.00051	127	387
PTKc_Ror1	cd05090	2.9e-05	127	382
PTKc_Ror2	cd05091	1.2e-05	127	382
PTKc_TrkB	cd05093	1.5e-06	127	396
PTKc_TrkC	cd05094	0.00019	127	402
PTKc_Tie2	cd05088	6.1e-07	127	393
STKc_MEKK4	cd06626	2.5e-17	127	383
PKc_MEK2	cd06649	1.7e-06	127	394
PKc_MEK1	cd06650	9e-06	127	398
STKc_CDK8_like	cd07842	3e-10	127	383
STKc_TEY_MAPK_plant	cd07858	1.9e-06	127	402
STKc_CDK12	cd07864	9.3e-16	127	383
PTKc_InsR_like	cd05032	2.5e-07	128	380
PTKc_EphR	cd05033	1e-05	128	383
PTKc_Csk_like	cd05039	2.7e-07	128	381
PTKc_Abl	cd05052	4.3e-10	128	382
PTKc_InsR	cd05061	1.7e-05	128	388
PTKc_IGF-1R	cd05062	0.00012	128	385
PTKc_EphR_A	cd05066	3e-05	128	383
PTKc_Lck_Blk	cd05067	1.3e-05	128	381
PTKc_Frk_like	cd05068	2.5e-09	128	381
PTKc_Yes	cd05069	8.2e-06	128	381
PTKc_Fyn_Yrk	cd05070	7.2e-05	128	381
PTKc_Src	cd05071	0.00022	128	383
PTKc_Lyn	cd05072	4.8e-08	128	381
PTKc_Hck	cd05073	5.8e-07	128	381
PTKc_Csk	cd05082	2.3e-07	128	381
PTKc_Chk	cd05083	6.9e-06	128	381
PTKc_Btk_Bmx	cd05113	1.8e-11	128	382
PTKc_Srm_Brk	cd05148	4.7e-10	128	381
PKc_MKK4	cd06616	1.5e-08	128	399
STKc_SLK	cd06643	3.8e-11	128	400
STKc_ERK5	cd07855	1.3e-09	128	402
PTKc_EphR_A2	cd05063	4.4e-05	129	383
PTKc_EphR_B	cd05065	5.3e-05	129	385
PTKc_HER4	cd05110	0.00084	129	398
PTKc_Itk	cd05112	6.9e-10	129	382
STKc_MAP4K3_like	cd06613	2.1e-18	129	382
STKc_PCTAIRE_like	cd07844	2.7e-18	129	383
STKc_BUR1	cd07866	1.6e-12	129	383
STKc_PFTAIRE1	cd07869	3.4e-06	129	395
STKc_PFTAIRE2	cd07870	4.9e-09	129	383
STKc_PCTAIRE3	cd07871	4.8e-10	129	383
STKc_PCTAIRE2	cd07872	1.1e-08	129	403
STKc_PCTAIRE1	cd07873	1.9e-08	129	395
PTKc_Tie1	cd05089	4.2e-07	130	399
PTKc_Tec_Rlk	cd05114	4e-12	130	382
STKc_TNIK	cd06637	2.7e-09	130	383
STKc_MAPK15	cd07852	1.4e-10	130	403
STKc_CDC2L6	cd07867	1.2e-05	130	383
STKc_CDK8	cd07868	3.6e-05	130	383
STKc_Nek6_Nek7	cd08224	3e-22	130	386
STKc_Nek6	cd08228	5.4e-17	130	386
STKc_Nek7	cd08229	1.9e-16	130	386
PTKc_Src_like	cd05034	1.9e-09	131	381
STKc_phototropin_lik	cd05574	3.3e-20	131	391
STKc_ROCK_NDR_like	cd05573	2.7e-20	131	403
STKc_PKA	cd05580	7.8e-42	131	390
STKc_PDK1	cd05581	9.5e-64	131	383
STKc_DMPK_like	cd05597	2.1e-09	131	403
STKc_LATS	cd05598	4.1e-10	131	403
STKc_NDR_like	cd05599	6.8e-13	131	401
STKc_Sid2p_Dbf2p	cd05600	2.4e-13	131	403
STKc_CRIK	cd05601	7.8e-15	131	403
STKc_MAST	cd05609	7e-19	131	403
STKc_PRKX_like	cd05612	3.4e-43	131	400
STKc_MRCK_alpha	cd05623	4.8e-10	131	403
STKc_MRCK_beta	cd05624	6.8e-10	131	403
STKc_LATS2	cd05626	2.9e-05	131	403
STKc_NDR2	cd05627	5.4e-08	131	403
STKc_NDR_like_fungal	cd05629	2.7e-07	131	403
STKc_NDR1	cd05628	4.6e-11	131	403
PKc_MAPKK	cd06605	9.7e-15	131	388
STKc_myosinIII_like	cd06608	1.3e-15	131	383
STKc_MST3_like	cd06609	2.5e-21	131	403
STKc_OSR1_SPAK	cd06610	5.9e-17	131	383
STKc_SLK_like	cd06611	2e-13	131	397
STKc_MST1_2	cd06612	1.8e-16	131	383
PKc_MEK	cd06615	1.4e-12	131	396
PKc_MKK3_6	cd06617	5.9e-14	131	398
PKc_MKK5	cd06619	8.7e-07	131	400
PKc_MAPKK_Byr1_like	cd06620	2.5e-11	131	399
PKc_MAPKK_Pek1_like	cd06621	3.6e-15	131	393
PKc_MAPKK_PBS2_like	cd06622	1e-10	131	402
PKc_MAPKK_plant_like	cd06623	1.4e-33	131	389
STKc_MEKK3_like	cd06625	3.8e-25	131	383
STKc_MST4	cd06640	1.8e-19	131	401
STKc_MST3	cd06641	5.6e-17	131	401
STKc_STK25-YSK1	cd06642	4.5e-19	131	401
STKc_MEKK2	cd06652	1.1e-09	131	384
STKc_MEKK3_like_1	cd06653	4.5e-18	131	383
STKc_CDKL	cd07833	5.7e-14	131	383
STKc_CdkB_plant	cd07837	1.8e-12	131	384
STKc_CDC2L1	cd07843	4.3e-13	131	383
STKc_CDKL2_3	cd07846	2e-11	131	383
STKc_CDKL1_4	cd07847	4.3e-18	131	383
STKc_CDKL5	cd07848	6e-07	131	383
STKc_ERK1_2_like	cd07849	5.9e-09	131	400
STKc_CDK6	cd07862	1.2e-06	131	383
SPS1	COG0515	1e-47	131	403
PTKc_RET	cd05045	8.5e-05	132	387
PTKc_Tec_like	cd05059	4.6e-10	132	384
PKc_STE	cd05122	6.7e-60	132	382
STKc_Yank1	cd05578	6.4e-42	132	383
STKc_MSK_N	cd05583	3.8e-35	132	402
STKc_cPKC	cd05587	6.7e-21	132	403
STKc_MSK1_N	cd05613	4.1e-27	132	402
STKc_MSK2_N	cd05614	2.2e-17	132	401
STKc_cPKC_alpha	cd05615	7.4e-11	132	403
STKc_cPKC_beta	cd05616	8.9e-10	132	403
STKc_GRK4_like	cd05605	1.7e-15	132	396
STKc_GRK4	cd05631	7e-10	132	396
STKc_GRK5	cd05632	1.1e-08	132	396
STKc_GRK6	cd05630	2.5e-08	132	403
STKc_MAPKKK	cd06606	1.5e-50	132	383
STKc_Cdc7_like	cd06627	1.4e-26	132	383
STKc_MAPKKK_Byr2_lik	cd06628	2.8e-35	132	383
STKc_MEKK1	cd06630	2.4e-15	132	384
STKc_YSK4	cd06631	5.5e-12	132	383
STKc_MEKK3	cd06651	2.2e-16	132	385
STKc_CCRK	cd07832	3.8e-18	132	384
STKc_MAPK	cd07834	2.2e-11	132	402
STKc_Pho85	cd07836	1e-20	132	383
STKc_CDK5	cd07839	8.7e-12	132	383
STKc_CDK7	cd07841	5.5e-17	132	394
STKc_NLK	cd07853	2.4e-06	132	403
STKc_MPK1	cd07857	4.3e-10	132	399
STKc_TDY_MAPK_plant	cd07859	4.8e-06	132	403
STKc_CDK1_euk	cd07861	3.9e-24	132	383
STKc_CDK4	cd07863	3.4e-08	132	383
STKc_CDK2_3	cd07860	1e-22	132	383
STKc_Nek	cd08215	1.4e-40	132	383
STKc_Nek2	cd08217	6.7e-20	132	383
STKc_Nek1	cd08218	6.2e-31	132	383
STKc_Nek3	cd08219	1.4e-26	132	383
STKc_Nek8	cd08220	3.8e-27	132	383
STKc_Nek9	cd08221	7.7e-14	132	383
STKc_Nek11	cd08222	3e-22	132	383
STKc_Nek4	cd08223	4.8e-19	132	383
STKc_Nek5	cd08225	2.6e-30	132	383
STKc_Nek10	cd08528	6.6e-14	132	383
STKc_FA2-like	cd08529	1.3e-15	132	383
STKc_CNK2-like	cd08530	9.3e-15	132	383
PTKc_Axl_like	cd05035	1.1e-06	133	382
PTK_Ryk	cd05043	0.00017	133	359
PTKc_Tyro3	cd05074	5.1e-06	133	382
PTKc_Axl	cd05075	3.2e-05	133	382
PTKc_Jak1_rpt2	cd05079	6.4e-05	133	385
PTKc_Tyk2_rpt2	cd05080	1.1e-05	133	386
PTKc_Jak2_Jak3_rpt2	cd05081	8.9e-08	133	403
STKc_CMGC	cd05118	2.9e-19	133	383
STKc_PKN	cd05589	6.7e-22	133	403
STKc_LATS1	cd05625	1.4e-05	133	403
STKc_MAPKKK_Bck1_lik	cd06629	1e-15	133	383
STKc_CDK_like	cd07829	1.7e-22	133	383
STKc_MAK_like	cd07830	1.8e-14	133	383
STKc_CDK1_like	cd07835	1.3e-20	133	383
STKc_CDK9_like	cd07840	2.3e-18	133	383
STKc_CDK4_6_like	cd07838	2.9e-14	133	383
STKc_MAPK4_6	cd07854	1.8e-06	133	403
STKc_Sty1_Hog1	cd07856	8.4e-09	133	401
PK_STRAD	cd08216	4.8e-06	134	390
STKc_p70S6K	cd05584	5.2e-26	136	402
STKc_MEKK1_plant	cd06632	8.2e-18	136	383
PTKc	cd00192	7.6e-14	137	382
PTK_Jak_rpt1	cd05037	1.3e-05	137	378
PTKc_Ack_like	cd05040	5.9e-13	137	380
PTKc_Fes_like	cd05041	8e-12	137	383
PTKc_Aatyk	cd05042	3.1e-06	137	380
PTKc_c-ros	cd05044	2.1e-07	137	380
PTKc_Met_Ron	cd05058	2.3e-05	137	387
PTKc_Syk_like	cd05060	5.5e-08	137	379
PTK_Jak2_Jak3_rpt1	cd05078	5.4e-05	137	379
PTKc_Fes	cd05084	9.5e-09	137	383
PTKc_Aatyk1_Aatyk3	cd05087	0.00015	137	385
PTKc_Syk	cd05116	6.4e-08	137	383
STKc_PKC	cd05570	3.8e-19	137	403
STKc_PKB	cd05571	1.4e-20	137	402
STKc_SGK	cd05575	1.1e-14	137	403
STKc_RSK_N	cd05582	3.5e-28	137	403
STKc_aPKC	cd05588	9.9e-09	137	403
STKc_nPKC_eta	cd05590	1.8e-22	137	403
STKc_nPKC_epsilon	cd05591	1.4e-18	137	401
STKc_nPKC_theta_delt	cd05592	2.4e-20	137	403
STKc_PKB_gamma	cd05593	8.8e-12	137	403
STKc_PKB_alpha	cd05594	3.1e-13	137	401
STKc_PKB_beta	cd05595	5.6e-16	137	400
STKc_SGK1	cd05602	2.2e-11	137	403
STKc_SGK2	cd05603	1e-16	137	401
STKc_SGK3	cd05604	2.6e-12	137	403
STKc_aPKC_zeta	cd05617	1.7e-08	137	400
STKc_aPKC_iota	cd05618	6.8e-07	137	403
STKc_nPKC_theta	cd05619	1.4e-16	137	403
STKc_nPKC_delta	cd05620	1.8e-07	137	403
STKc_MOK	cd07831	2.8e-13	137	383
STKc_Rim15_like	cd05611	4.2e-14	138	382
PKc	cd00180	8.2e-85	139	381
PTK_CCK4	cd05046	1.6e-07	139	380
PTKc_Tie	cd05047	1.1e-06	139	379
PTKc_Fer	cd05085	8.1e-09	139	383
PTKc_Zap-70	cd05115	3.9e-07	139	386
STKc_AGC	cd05123	1.1e-70	139	383
STKc_cGK_PKG	cd05572	9.8e-44	139	389
STKc_GRK	cd05577	7.1e-13	139	391
STKc_MAST_like	cd05579	2.1e-34	139	388
STKc_YPK1_like	cd05585	1.8e-26	139	403
STKc_Sck1_like	cd05586	2.9e-10	139	403
STKc_beta_ARK	cd05606	1.1e-09	139	403
STKc_GRK7	cd05607	3.9e-09	139	395
STKc_GRK1	cd05608	1.8e-11	139	403
STKc_GRK3	cd05633	5.1e-08	139	403
STKc_NAK1_like	cd06917	1.4e-16	139	402
Pkinase	pfam00069	8.5e-84	133	383
Pkinase_Tyr	pfam07714	1.6e-18	133	381
TyrKc	smart00219	2.2e-15	133	383
STYKc	smart00221	7.8e-93	133	383
S_TKc	smart00220	7.2e-101	143	383
KIND	smart00750	9.2e-07	216	391

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_030840	Polymorphism	p.GLY11ARG	N/A
Swiss-Prot	VAR_041130	Polymorphism	p.MET373VAL	N/A
Swiss-Prot	VAR_030841	Polymorphism	p.PHE31ILE	N/A
Swiss-Prot	VAR_041127	Polymorphism	p.PRO50LEU	N/A
Swiss-Prot	VAR_041128	Polymorphism	p.SER155ARG	N/A
Swiss-Prot	VAR_061745	Polymorphism	p.SER104LEU	N/A
Swiss-Prot	VAR_030842	Polymorphism	p.VAL57ILE	N/A
Swiss-Prot	VAR_041129	Polymorphism	p.VAL174MET	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258