Results for the protein: NP

Results for the Protein: NP_001165603

287326753

3055

HCK

NCBI

tyrosine-protein kinase HCK isoform e [Homo sapiens]

			0 2 0 2 0

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RefSeq Protein: NP_001165603

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
SH2	cd00173	5.1e-38	123	221
PTKc_CSF-1R	cd05106	6.5e-37	193	496
PTKc_PDGFR_alpha	cd05105	5.2e-17	196	497
PTKc_PDGFR	cd05055	5.4e-30	202	495
PTKc_PDGFR_beta	cd05107	2.9e-18	203	496
PTKc_Kit	cd05104	3.7e-23	206	495
STKc_PAK_I	cd06647	0.00026	210	503
STKc_myosinIIIB	cd06639	2.6e-05	212	497
STKc_PAK5	cd06658	0.00079	216	503
STKc_TAO1	cd06635	0.00021	218	505
STKc_PAK6	cd06659	8.7e-06	219	505
PTK_Tyk2_rpt1	cd05076	8.4e-07	221	492
STKc_TAO	cd06607	5.8e-05	223	505
PTKc_FGFR1	cd05098	1.5e-49	224	502
STKc_PAK	cd06614	5e-13	224	505
STKc_myosinIIIA	cd06638	4.6e-07	224	492
STKc_MAP4K4_6	cd06636	7.8e-05	225	491
STKc_PAK1	cd06654	0.00011	225	505
PTKc_FGFR3	cd05100	1.9e-33	226	505
STKc_PAK2	cd06655	0.00012	226	506
STKc_PAK3	cd06656	0.00019	226	506
PTKc_FGFR4	cd05099	1.7e-52	229	505
STKc_STK10_LOK	cd06644	1.4e-05	230	502
PTKc_FGFR	cd05053	2.8e-62	231	496
PTKc_FGFR2	cd05101	1.8e-44	231	502
PKc_MKK7	cd06618	1.2e-08	231	504
STKc_TAO2	cd06634	2.5e-05	231	505
STKc_p38	cd07851	1.1e-05	231	506
STKc_CDK9	cd07865	3.6e-07	231	495
STKc_PFTAIRE1	cd07869	0.00015	231	499
STKc_SLK_like	cd06611	4.4e-08	232	497
STKc_PAK_II	cd06648	2e-07	232	491
STKc_ASK	cd06624	1.3e-09	233	495
PTKc_VEGFR	cd05054	7.4e-32	234	498
PTKc_EGFR_like	cd05057	1.6e-58	234	499
PTKc_VEGFR3	cd05102	4e-34	234	498
PTKc_VEGFR2	cd05103	1.1e-30	234	498
PTK_HER3	cd05111	2.1e-38	234	505
STKc_MAP4K3	cd06645	2.2e-05	234	491
STKc_Sty1_Hog1	cd07856	3.2e-05	234	504
STKc_PCTAIRE2	cd07872	0.00011	234	505
PTKc_InsR_like	cd05032	7.7e-73	235	493
PTKc_Src_like	cd05034	2.5e-220	235	494
PTKc_ALK_LTK	cd05036	1.1e-61	235	493
PTKc_Csk_like	cd05039	2.6e-97	235	494
PTKc_Abl	cd05052	9e-111	235	495
PTKc_FAK	cd05056	2.3e-85	235	499
PTKc_InsR	cd05061	6.5e-54	235	502
PTKc_Lck_Blk	cd05067	1.2e-190	235	494
PTKc_Frk_like	cd05068	1.1e-149	235	494
PTKc_Yes	cd05069	4.4e-169	235	494
PTKc_Fyn_Yrk	cd05070	2.7e-170	235	494
PTKc_Src	cd05071	1.1e-165	235	496
PTKc_Lyn	cd05072	1e-203	235	494
PTKc_Hck	cd05073	2e-232	235	494
PTKc_Csk	cd05082	6.4e-83	235	494
PTKc_Chk	cd05083	8.4e-84	235	494
PTKc_IGF-1R	cd05062	2.6e-55	235	492
PTKc_EGFR	cd05108	1.2e-27	235	506
PTKc_HER2	cd05109	8.3e-38	235	505
PTKc_HER4	cd05110	6.5e-30	235	503
PTKc_Srm_Brk	cd05148	2e-129	235	494
STKc_TNIK	cd06637	2.3e-06	235	495
STKc_ERK1_2_like	cd07849	3.2e-06	235	504
STKc_MAPK4_6	cd07854	0.00025	235	506
STKc_CDK12	cd07864	2.5e-09	235	503
STKc_PFTAIRE2	cd07870	1.5e-05	235	506
PTK_CCK4	cd05046	7e-34	236	493
PTKc_Ror	cd05048	6.4e-43	236	494
PTKc_Trk	cd05049	1.5e-47	236	493
PTKc_Musk	cd05050	9.8e-56	236	493
PTKc_DDR	cd05051	5.6e-38	236	493
PTKc_EphR_A2	cd05063	2.4e-78	236	495
PTKc_EphR_A10	cd05064	1.4e-62	236	495
PTKc_Ror1	cd05090	1.6e-40	236	494
PTKc_Ror2	cd05091	7.8e-39	236	494
PTKc_TrkA	cd05092	4e-50	236	493
PTKc_TrkB	cd05093	1.8e-42	236	503
PTKc_TrkC	cd05094	1.3e-29	236	503
PTKc_DDR1	cd05096	7.9e-30	236	493
PTKc_DDR_like	cd05097	2.3e-38	236	493
PTKc_DDR2	cd05095	1.3e-41	236	493
PKc_MAPKK_Byr1_like	cd06620	4.5e-06	236	495
STKc_SLK	cd06643	7.8e-06	236	506
STKc_MAP4K5	cd06646	4.6e-05	236	492
PTKc_EphR	cd05033	3e-95	237	495
PTKc_Jak_rpt2	cd05038	4.7e-63	237	495
PTK_Ryk	cd05043	7.2e-24	237	498
PTKc_Tec_like	cd05059	5.2e-98	237	492
PTKc_EphR_B	cd05065	2e-78	237	495
PTKc_EphR_A	cd05066	3.9e-79	237	495
PTKc_Jak1_rpt2	cd05079	2.9e-46	237	495
PTKc_Tie2	cd05088	1.6e-34	237	502
PTKc_Itk	cd05112	4e-90	237	492
PTKc_Btk_Bmx	cd05113	6.2e-89	237	492
PTKc_Tec_Rlk	cd05114	3.3e-88	237	492
STKc_MAPK15	cd07852	3.7e-06	237	505
STKc_BUR1	cd07866	3.3e-07	237	484
STKc_myosinIII_like	cd06608	5.7e-08	238	487
STKc_MST1_2	cd06612	2.7e-12	238	495
STKc_MAP4K3_like	cd06613	8.9e-11	238	492
STKc_MST3	cd06641	1.2e-06	238	506
STKc_MST4	cd06640	2.3e-06	238	506
STKc_STK25-YSK1	cd06642	4.6e-07	238	506
STKc_PCTAIRE_like	cd07844	1.2e-06	238	503
PKc_MKK4	cd06616	6.3e-06	239	504
PKc_MAPKK_PBS2_like	cd06622	7.8e-06	239	494
STKc_MEKK2	cd06652	3.5e-05	239	486
STKc_MEKK3_like_1	cd06653	1e-07	239	493
STKc_CdkB_plant	cd07837	2.1e-08	239	504
STKc_CDK10	cd07845	4.9e-06	239	506
STKc_Nek6_Nek7	cd08224	3.1e-10	239	496
PTKc_Tie1	cd05089	2.3e-39	240	506
STKc_phototropin_lik	cd05574	2.4e-05	240	499
STKc_PKA	cd05580	2.5e-06	240	487
STKc_PDK1	cd05581	2e-10	240	495
STKc_CRIK	cd05601	0.00029	240	503
STKc_PRKX_like	cd05612	6.4e-05	240	503
STKc_ROCK_NDR_like	cd05573	0.00056	240	503
PKc_MAPKK	cd06605	3.9e-10	240	492
STKc_MST3_like	cd06609	5.4e-11	240	506
STKc_OSR1_SPAK	cd06610	8.3e-12	240	484
PKc_MEK	cd06615	5e-06	240	504
PKc_MKK3_6	cd06617	2e-07	240	496
PKc_MKK5	cd06619	0.00025	240	505
PKc_MAPKK_plant_like	cd06623	4.2e-14	240	492
PKc_MAPKK_Pek1_like	cd06621	4.1e-07	240	491
STKc_Pho85	cd07836	4.4e-05	240	506
STKc_CDK2_3	cd07860	3.4e-05	240	503
STKc_CDK1_euk	cd07861	0.00012	240	506
STKc_Nek1	cd08218	1.2e-09	240	496
STKc_Nek6	cd08228	8.8e-09	240	496
STKc_Nek7	cd08229	1.4e-11	240	496
SPS1	COG0515	1.3e-10	240	506
PTKc_RET	cd05045	2.3e-54	241	498
PKc_STE	cd05122	9e-16	241	486
STKc_MSK_N	cd05583	7.9e-05	241	506
STKc_GRK4_like	cd05605	5.9e-05	241	506
STKc_GRK4	cd05631	0.00072	241	499
STKc_GRK5	cd05632	0.00072	241	506
STKc_MAPKKK	cd06606	1.4e-28	241	485
STKc_Cdc7_like	cd06627	1.7e-18	241	484
STKc_MAPKKK_Byr2_lik	cd06628	1.8e-16	241	495
STKc_MEKK3	cd06651	5.8e-08	241	489
STKc_CCRK	cd07832	1.7e-08	241	496
STKc_MAPK	cd07834	6.2e-07	241	504
STKc_CDK7	cd07841	6.8e-11	241	506
STKc_CDK8_like	cd07842	1.1e-05	241	495
STKc_MPK1	cd07857	2.5e-06	241	494
STKc_NLK	cd07853	0.001	241	505
STKc_Nek	cd08215	7e-16	241	492
STKc_Nek3	cd08219	6e-11	241	491
STKc_Nek4	cd08223	1.9e-09	241	496
STKc_Nek5	cd08225	8.3e-12	241	496
STKc_Nek10	cd08528	9.6e-07	241	493
STKc_FA2-like	cd08529	3.3e-12	241	491
STKc_CNK2-like	cd08530	3.3e-09	241	491
PTKc_Axl_like	cd05035	2.5e-56	242	495
PTKc_Axl	cd05075	4.8e-45	242	495
PTKc_Tyk2_rpt2	cd05080	1.5e-35	242	496
PTKc_Jak2_Jak3_rpt2	cd05081	2.1e-45	242	495
PTKc_Tyro3	cd05074	2e-51	242	495
STKc_PKN	cd05589	1.6e-05	242	503
STKc_CDK_like	cd07829	4.7e-14	242	496
STKc_MAK_like	cd07830	9.5e-14	242	494
STKc_MOK	cd07831	9.4e-07	242	484
STKc_CDK4_6_like	cd07838	5.2e-05	242	487
STKc_Yank1	cd05578	7.1e-08	243	496
STKc_MEKK3_like	cd06625	3e-11	243	493
STKc_MEKK4	cd06626	3.7e-11	243	487
STKc_NAK1_like	cd06917	2.9e-08	243	503
STKc_CDK1_like	cd07835	6.3e-06	243	503
STKc_CDK5	cd07839	6.4e-06	243	503
STKc_CDK9_like	cd07840	9.5e-12	243	487
STKc_CDKL1_4	cd07847	1.4e-05	243	503
STKc_PCTAIRE3	cd07871	8.7e-05	243	503
STKc_PCTAIRE1	cd07873	0.00047	243	499
PK_STRAD	cd08216	0.00018	243	493
STKc_Nek8	cd08220	1.8e-06	243	491
STKc_Nek11	cd08222	7.2e-09	244	496
STKc_RSK_N	cd05582	0.00069	245	506
STKc_CDKL	cd07833	1.2e-06	245	484
STKc_CDC2L1	cd07843	1.8e-06	245	487
STKc_CDKL2_3	cd07846	7.5e-07	245	495
PTKc	cd00192	3.5e-121	246	492
PTK_Jak_rpt1	cd05037	2.9e-10	246	492
PTKc_Ack_like	cd05040	1.4e-77	246	493
PTKc_Fes_like	cd05041	1.8e-88	246	493
PTKc_Aatyk	cd05042	2.8e-14	246	493
PTKc_c-ros	cd05044	2.1e-63	246	493
PTKc_Tie	cd05047	1.6e-45	246	496
PTKc_Met_Ron	cd05058	4e-58	246	497
PTKc_Syk_like	cd05060	2.1e-72	246	496
PTK_Jak1_rpt1	cd05077	1.5e-08	246	492
PTK_Jak2_Jak3_rpt1	cd05078	1.1e-09	246	492
PTKc_Fes	cd05084	5.2e-66	246	493
PTKc_Fer	cd05085	1.1e-76	246	493
PTKc_Aatyk2	cd05086	6.9e-11	246	493
PTKc_Aatyk1_Aatyk3	cd05087	1.4e-17	246	493
PTKc_Syk	cd05116	3.2e-58	246	496
STKc_CMGC	cd05118	1.3e-12	246	487
STKc_PKC	cd05570	5.7e-08	246	496
STKc_nPKC_theta	cd05619	3.5e-05	246	506
STKc_MEKK1	cd06630	1.4e-07	246	485
STKc_MEKK1_plant	cd06632	6.1e-12	246	487
STKc_Nek2	cd08217	2.7e-09	246	490
PTKc_Zap-70	cd05115	3.8e-57	247	496
PKc	cd00180	9e-69	248	491
STKc_AGC	cd05123	5.2e-10	248	495
STKc_cGK_PKG	cd05572	6.1e-09	248	491
STKc_GRK	cd05577	0.00044	248	496
STKc_MAST_like	cd05579	4.6e-08	248	493
STKc_GRK7	cd05607	9.9e-05	248	505
STKc_GRK1	cd05608	0.00041	248	506
STKc_YSK4	cd06631	2.7e-09	248	495
STKc_Nek9	cd08221	7.4e-06	248	491
STKc_MAPKKK_Bck1_lik	cd06629	9.5e-11	249	485
SH3_1	pfam00018	8.5e-22	64	110
SH2	pfam00017	1.1e-42	124	206
Pkinase	pfam00069	1.5e-40	242	491
SH3	smart00326	5.4e-21	59	116
SH3_2	pfam07653	2.2e-06	62	115
SH2	smart00252	1.3e-34	122	212
Pkinase_Tyr	pfam07714	1e-151	242	491
TyrKc	smart00219	6.4e-131	242	491
STYKc	smart00221	1e-57	242	487
S_TKc	smart00220	3.2e-51	252	495

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs114505022	Polymorphism	p.ALA350THR	N/A
dbSNP	rs17093828	Polymorphism	p.PRO482GLN	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258