Results for the protein: Q8IVH8

Results for the Protein: Q8IVH8

29427817

8491

MAP4K3

NCBI, UniProt

M4K3_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase kinase 3; AltName: Full=Germinal center kinase-related protein kinase; Short=GLK; AltName: Full=MAPK/ERK kinase kinase kinase 3; Short=MEK kinase kinase 3; Short=MEKKK 3

			0 3 0 0 3

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Swiss-Prot Protein: Q8IVH8

Identical to: NP_003609

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_FGFR1	cd05098	1e-05	1	282
STKc_ROCK	cd05596	1.8e-06	1	321
STKc_ROCK2	cd05621	5.4e-07	1	328
STKc_TAO3	cd06633	7.3e-55	1	301
STKc_TAO1	cd06635	1.5e-53	1	301
STKc_myosinIIIB	cd06639	3.4e-65	1	274
STKc_PAK5	cd06658	7.8e-52	1	290
STKc_PAK6	cd06659	6.9e-57	1	296
STKc_Sty1_Hog1	cd07856	2e-08	1	335
STKc_JNK2	cd07876	6.8e-05	1	310
STKc_p38beta_MAPK11	cd07878	6.3e-06	1	340
STKc_p38gamma_MAPK12	cd07880	1.3e-07	1	340
STKc_TAO	cd06607	1.9e-67	2	301
STKc_PAK	cd06614	8.3e-96	2	286
STKc_TAO2	cd06634	3.4e-56	2	302
STKc_ROCK1	cd05622	6.5e-06	3	330
STKc_CDK9	cd07865	4.7e-13	3	301
STKc_p38alpha_MAPK14	cd07877	1.7e-06	3	340
PTKc_FGFR4	cd05099	3.4e-07	4	297
PTKc_FGFR2	cd05101	1.2e-06	4	284
STKc_MAP4K4_6	cd06636	3.5e-94	4	273
STKc_PAK4	cd06657	6.9e-51	4	292
STKc_JNK	cd07850	2.9e-06	4	319
PTKc_Abl	cd05052	7.3e-09	5	268
PTKc_FAK	cd05056	3.2e-08	5	278
STKc_myosinIIIA	cd06638	1.3e-74	5	273
STKc_STK10_LOK	cd06644	5.5e-84	5	289
STKc_ERK1_2_like	cd07849	5.4e-10	5	338
STKc_p38	cd07851	6.3e-09	5	324
STKc_TEY_MAPK_plant	cd07858	2.1e-09	5	340
STKc_ERK5	cd07855	2.7e-10	5	304
STKc_p38delta_MAPK13	cd07879	2.7e-05	5	340
STKc_MAPK4_6	cd07854	2.3e-05	5	303
PTKc_FGFR	cd05053	7.6e-08	6	282
PTKc_TrkB	cd05093	0.00015	6	287
PTKc_TrkC	cd05094	0.00052	6	309
PKc_MKK7	cd06618	6.3e-18	6	291
PKc_MAPKK_Byr1_like	cd06620	2.1e-18	6	282
STKc_MAP4K3	cd06645	6.3e-252	6	272
STKc_MAP4K5	cd06646	4.8e-218	6	272
STKc_PAK_I	cd06647	1.1e-67	7	297
STKc_PAK_II	cd06648	8.4e-64	7	286
STKc_PAK1	cd06654	7.4e-59	7	291
STKc_PAK2	cd06655	1.1e-57	7	297
STKc_PAK3	cd06656	1.3e-58	7	294
STKc_JNK3	cd07874	3.6e-05	7	372
STKc_JNK1	cd07875	0.00045	7	339
PTKc_EGFR_like	cd05057	7e-06	8	284
PTKc_HER2	cd05109	0.00019	8	284
PTK_HER3	cd05111	5.5e-07	8	284
STKc_CDK10	cd07845	2.6e-15	8	283
SPS1	COG0515	1.3e-62	8	462
PTKc_ALK_LTK	cd05036	1.3e-08	9	274
PTKc_EGFR	cd05108	4.4e-05	9	298
PTKc_HER4	cd05110	2.6e-05	9	304
STKc_ASK	cd06624	4.5e-44	9	273
STKc_TNIK	cd06637	8.1e-93	9	273
PTKc_Ror	cd05048	3.4e-06	10	242
PTKc_Musk	cd05050	3.5e-08	10	270
PTKc_InsR	cd05061	9.1e-07	10	286
PTKc_IGF-1R	cd05062	4.5e-05	10	273
PTKc_DDR_like	cd05097	0.0005	10	275
PTKc_Ror1	cd05090	1.6e-05	10	253
STKc_myosinIII_like	cd06608	4.7e-117	10	273
STKc_SLK_like	cd06611	4.2e-101	10	288
STKc_SLK	cd06643	4.3e-80	10	291
STKc_MAPK15	cd07852	1.7e-11	10	300
STKc_CDK12	cd07864	3.7e-13	10	273
PTKc_Jak_rpt2	cd05038	5.5e-10	11	277
PTKc_Tie2	cd05088	3.3e-06	11	302
PTKc_Itk	cd05112	3.4e-08	11	272
PTKc_Tec_Rlk	cd05114	3.1e-07	11	272
STKc_MST4	cd06640	3.9e-90	11	293
STKc_MST3	cd06641	1.2e-87	11	293
STKc_STK25-YSK1	cd06642	4.8e-94	11	293
STKc_PCTAIRE_like	cd07844	5.6e-14	11	300
STKc_PFTAIRE2	cd07870	5.7e-08	11	273
PTKc_EphR	cd05033	5e-05	12	273
PTKc_Src_like	cd05034	1.7e-10	12	272
PTKc_InsR_like	cd05032	5.2e-08	12	270
PTKc_Trk	cd05049	4.4e-07	12	252
PTKc_Frk_like	cd05068	9.3e-12	12	272
PTKc_Yes	cd05069	9.4e-08	12	276
PTKc_Fyn_Yrk	cd05070	4.6e-06	12	276
PTKc_Src	cd05071	6.3e-07	12	278
PTKc_Lyn	cd05072	7.8e-07	12	272
PTKc_Hck	cd05073	5.6e-07	12	272
PTKc_Lck_Blk	cd05067	6.1e-06	12	294
PTKc_Btk_Bmx	cd05113	3.4e-09	12	272
PTKc_Csk_like	cd05039	3.9e-08	12	274
PTKc_Srm_Brk	cd05148	4.7e-08	12	270
STKc_MST1_2	cd06612	4.1e-127	12	273
STKc_MAP4K3_like	cd06613	1.7e-223	12	272
PTKc_Tec_like	cd05059	2.7e-06	13	274
PTK_Ryk	cd05043	0.0003	13	276
PTKc_EphR_A	cd05066	0.00037	13	278
PTKc_Csk	cd05082	8.2e-06	13	271
PTKc_EphR_A2	cd05063	0.00086	13	268
PTKc_TrkA	cd05092	3.8e-05	13	279
PKc_MKK4	cd06616	4.2e-16	13	290
PKc_MEK2	cd06649	6.1e-11	13	296
PKc_MEK1	cd06650	4.1e-11	13	297
STKc_MEKK2	cd06652	1.1e-30	13	274
STKc_MEKK3_like_1	cd06653	7.1e-40	13	273
STKc_BUR1	cd07866	4.3e-12	13	273
STKc_PFTAIRE1	cd07869	1.1e-06	13	287
STKc_Nek6_Nek7	cd08224	9.7e-18	13	276
PK_STRAD	cd08216	2.2e-16	13	291
PTKc_Chk	cd05083	3.6e-06	14	271
PTKc_Tie1	cd05089	6e-06	14	301
STKc_ROCK_NDR_like	cd05573	3.1e-14	14	339
STKc_phototropin_lik	cd05574	1e-09	14	294
STKc_PKA	cd05580	2.8e-12	14	300
STKc_PDK1	cd05581	6.1e-17	14	273
STKc_DMPK_like	cd05597	1.4e-08	14	332
STKc_LATS	cd05598	1.2e-08	14	338
STKc_CRIK	cd05601	5.8e-12	14	336
STKc_NDR_like	cd05599	1.7e-07	14	325
STKc_Sid2p_Dbf2p	cd05600	2.3e-09	14	335
STKc_MAST	cd05609	1.6e-13	14	299
STKc_PRKX_like	cd05612	9.8e-11	14	301
STKc_MRCK_alpha	cd05623	6.1e-08	14	330
STKc_MRCK_beta	cd05624	3.2e-07	14	332
STKc_NDR2	cd05627	2.1e-07	14	359
STKc_NDR1	cd05628	6.3e-09	14	339
STKc_NDR_like_fungal	cd05629	1e-06	14	339
STKc_LATS2	cd05626	7e-06	14	337
STKc_MST3_like	cd06609	3.8e-119	14	293
STKc_OSR1_SPAK	cd06610	8.4e-87	14	273
PKc_MAPKK	cd06605	6.9e-52	14	278
PKc_MEK	cd06615	2.8e-18	14	293
PKc_MKK3_6	cd06617	1e-19	14	287
PKc_MKK5	cd06619	6.5e-29	14	289
PKc_MAPKK_Pek1_like	cd06621	2.8e-24	14	284
PKc_MAPKK_plant_like	cd06623	5.9e-46	14	279
STKc_MEKK3_like	cd06625	5.2e-52	14	273
PKc_MAPKK_PBS2_like	cd06622	5.6e-24	14	326
STKc_CDKL	cd07833	1.1e-14	14	273
STKc_CdkB_plant	cd07837	1.4e-12	14	274
STKc_CDC2L1	cd07843	7.1e-13	14	273
STKc_CDKL2_3	cd07846	5.8e-13	14	273
STKc_CDKL5	cd07848	5.4e-06	14	273
STKc_CDKL1_4	cd07847	9.8e-28	14	300
STKc_CDK6	cd07862	1.4e-06	14	305
STKc_PCTAIRE3	cd07871	2e-08	14	273
STKc_PCTAIRE1	cd07873	4.7e-07	14	285
STKc_PCTAIRE2	cd07872	1.1e-07	14	321
STKc_Nek6	cd08228	9.4e-19	14	278
STKc_Nek7	cd08229	6e-16	14	279
PTKc_RET	cd05045	0.00059	15	271
PTKc_EphR_B	cd05065	3.3e-05	15	268
PKc_STE	cd05122	2.5e-155	15	272
STKc_Yank1	cd05578	6.7e-16	15	273
STKc_MSK_N	cd05583	4.1e-11	15	292
STKc_cPKC	cd05587	1.5e-21	15	337
STKc_GRK4_like	cd05605	1.8e-10	15	294
STKc_MSK2_N	cd05614	4.4e-09	15	336
STKc_cPKC_alpha	cd05615	1.2e-10	15	332
STKc_cPKC_beta	cd05616	2.9e-09	15	337
STKc_MSK1_N	cd05613	5.8e-09	15	292
STKc_GRK6	cd05630	2.9e-08	15	294
STKc_GRK4	cd05631	2.1e-08	15	294
STKc_GRK5	cd05632	1.6e-09	15	294
STKc_MAPKKK	cd06606	5.3e-84	15	273
STKc_Cdc7_like	cd06627	1.3e-82	15	273
STKc_MEKK3	cd06651	3.5e-33	15	275
STKc_CCRK	cd07832	5.1e-14	15	274
STKc_MAPK	cd07834	4.5e-11	15	325
STKc_Pho85	cd07836	4.4e-18	15	291
STKc_CDK5	cd07839	3.3e-12	15	273
STKc_CDK7	cd07841	2.7e-15	15	286
STKc_CDK8_like	cd07842	9.2e-13	15	273
STKc_NLK	cd07853	5.3e-07	15	345
STKc_MPK1	cd07857	1.6e-08	15	331
STKc_TDY_MAPK_plant	cd07859	1.3e-08	15	340
STKc_CDK2_3	cd07860	5.3e-16	15	291
STKc_CDK4	cd07863	7.6e-09	15	273
STKc_CDK1_euk	cd07861	2e-20	15	300
STKc_Nek	cd08215	7.8e-52	15	273
STKc_Nek2	cd08217	4.9e-19	15	273
STKc_Nek1	cd08218	3.5e-31	15	273
STKc_Nek3	cd08219	1e-28	15	273
STKc_Nek8	cd08220	1.5e-21	15	273
STKc_Nek9	cd08221	5.9e-14	15	273
STKc_Nek11	cd08222	2.4e-22	15	273
STKc_Nek4	cd08223	9.3e-24	15	273
STKc_Nek5	cd08225	3.2e-38	15	273
STKc_Nek10	cd08528	2.4e-11	15	273
STKc_FA2-like	cd08529	9e-18	15	273
STKc_CNK2-like	cd08530	4.8e-15	15	273
PTKc_Axl_like	cd05035	1.9e-05	16	275
PTKc_Tyro3	cd05074	9.8e-06	16	275
PTKc_Jak1_rpt2	cd05079	3e-05	16	276
PTKc_Tyk2_rpt2	cd05080	3.2e-08	16	277
PTKc_Jak2_Jak3_rpt2	cd05081	6.8e-08	16	275
STKc_CMGC	cd05118	7.6e-18	16	273
STKc_PKN	cd05589	1.4e-09	16	336
STKc_LATS1	cd05625	1.1e-06	16	337
STKc_MAPKKK_Bck1_lik	cd06629	2.1e-23	16	273
STKc_CDK_like	cd07829	1.3e-18	16	273
STKc_MAK_like	cd07830	3.4e-18	16	273
STKc_MOK	cd07831	1.7e-12	16	273
STKc_CDK1_like	cd07835	4.8e-14	16	291
STKc_CDK9_like	cd07840	3.7e-16	16	273
STKc_CDK4_6_like	cd07838	1.1e-15	16	273
STKc_CDC2L6	cd07867	2.1e-06	16	273
STKc_CDK8	cd07868	4e-06	16	273
STKc_MAPKKK_Byr2_lik	cd06628	2.5e-49	17	273
STKc_NAK1_like	cd06917	7.6e-71	17	290
PK_STRAD_beta	cd08226	3.1e-08	17	288
PK_STRAD_alpha	cd08227	8.4e-10	17	292
STKc_YSK4	cd06631	4.3e-43	18	273
STKc_RSK_N	cd05582	5.1e-08	19	322
STKc_p70S6K	cd05584	9e-09	19	340
STKc_Rim15_like	cd05611	4.4e-09	19	339
PTKc	cd00192	8.3e-13	20	272
PTK_Jak_rpt1	cd05037	0.00027	20	272
PTKc_Ack_like	cd05040	1.2e-08	20	269
PTKc_Aatyk	cd05042	6.9e-05	20	270
PTKc_c-ros	cd05044	1.9e-05	20	270
PTKc_Tie	cd05047	2.8e-05	20	275
PTKc_Fes_like	cd05041	2.7e-11	20	242
PTKc_Met_Ron	cd05058	3.4e-05	20	279
PTKc_Syk_like	cd05060	4.1e-05	20	259
PTKc_Fes	cd05084	1.3e-08	20	273
PTKc_Fer	cd05085	1.4e-07	20	273
PTKc_Aatyk2	cd05086	3.3e-05	20	275
PTK_Jak1_rpt1	cd05077	6.3e-05	20	272
PTKc_Aatyk1_Aatyk3	cd05087	0.00042	20	272
PTKc_Syk	cd05116	5.5e-05	20	273
STKc_PKB	cd05571	6.5e-15	20	341
STKc_SGK	cd05575	2.6e-09	20	336
STKc_PKC	cd05570	1.8e-13	20	336
STKc_aPKC	cd05588	9.3e-10	20	337
STKc_nPKC_eta	cd05590	1.1e-08	20	332
STKc_nPKC_epsilon	cd05591	7.2e-11	20	332
STKc_nPKC_theta_delt	cd05592	1e-09	20	341
STKc_PKB_gamma	cd05593	3.1e-09	20	344
STKc_PKB_beta	cd05595	1.2e-08	20	341
STKc_PKB_alpha	cd05594	1.1e-10	20	342
STKc_SGK1	cd05602	1.2e-08	20	341
STKc_SGK2	cd05603	8.9e-10	20	340
STKc_SGK3	cd05604	1.7e-07	20	341
STKc_aPKC_iota	cd05618	6.3e-07	20	337
STKc_nPKC_theta	cd05619	4.1e-11	20	341
STKc_nPKC_delta	cd05620	1.7e-05	20	341
STKc_aPKC_zeta	cd05617	1.1e-08	20	333
STKc_MEKK4	cd06626	6.6e-37	20	273
STKc_MEKK1	cd06630	1.4e-15	20	274
STKc_MEKK1_plant	cd06632	4.6e-66	20	273
PTKc_Zap-70	cd05115	4.5e-05	21	266
PKc	cd00180	2e-74	22	271
STKc_AGC	cd05123	1.2e-17	22	273
STKc_cGK_PKG	cd05572	4.2e-13	22	277
STKc_GRK	cd05577	3e-12	22	293
STKc_MAST_like	cd05579	2.1e-18	22	278
STKc_YPK1_like	cd05585	9.6e-09	22	338
STKc_Sck1_like	cd05586	3.2e-09	22	388
STKc_beta_ARK	cd05606	1.6e-09	22	293
STKc_GRK7	cd05607	6.1e-08	22	293
STKc_GRK1	cd05608	3.5e-11	22	293
STKc_GRK3	cd05633	1.4e-07	22	314
Pkinase	pfam00069	3.1e-82	16	273
CNH	pfam00780	1.7e-99	566	864
Pkinase_Tyr	pfam07714	2.2e-18	16	273
STYKc	smart00221	2.4e-86	16	273
TyrKc	smart00219	2.4e-15	16	271
S_TKc	smart00220	1.9e-91	26	273
KIND	smart00750	7.9e-33	96	281
CNH	smart00036	2.1e-114	561	874

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040744	Polymorphism	p.HIS424GLN	N/A
Swiss-Prot	VAR_040745	Polymorphism	p.THR669SER	N/A
Swiss-Prot	VAR_040743	Polymorphism	p.VAL200LEU	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258