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Results for the Protein: Q9Y6R4
296434576

M3K4_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase 4; AltName: Full=MAP three kinase 1; AltName: Full=MAPK/ERK kinase kinase 4; Short=MEK kinase 4; Short=MEKK 4
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

STKc_ROCK2 - cd05621
STKc_ROCK - cd05596
STKc_ROCK1 - cd05622
STKc_TAO1 - cd06635
STKc_Sty1_Hog1 - cd07856
STKc_PAK6 - cd06659
STKc_TAO3 - cd06633
STKc_JNK1 - cd07875
STKc_TAO2 - cd06634
STKc_myosinIIIA - cd06638
STKc_p38alpha_MAPK14 - cd07877
STKc_JNK2 - cd07876
STKc_JNK - cd07850
STKc_MAP4K4_6 - cd06636
STKc_PAK4 - cd06657
STKc_myosinIIIB - cd06639
PTKc_FGFR - cd05053
PTKc_FGFR2 - cd05101
STKc_p38gamma_MAPK12 - cd07880
STKc_PAK1 - cd06654
PTKc_EGFR_like - cd05057
STKc_STK10_LOK - cd06644
STKc_PAK_I - cd06647
STKc_JNK3 - cd07874
STKc_PAK3 - cd06656
STKc_PAK2 - cd06655
STKc_PAK - cd06614
STKc_PAK_II - cd06648
STKc_CDK9 - cd07865
PTKc_DDR - cd05051
STKc_PAK5 - cd06658
STKc_p38 - cd07851
PKc_MKK7 - cd06618
PTKc_HER2 - cd05109
STKc_MAPK4_6 - cd07854
PTKc_Chk - cd05083
STKc_ERK5 - cd07855
PTKc_EphR_B - cd05065
PTKc_Abl - cd05052
PTKc_InsR - cd05061
PTKc_Csk_like - cd05039
PTKc_IGF-1R - cd05062
STKc_TAO - cd06607
PTKc_TrkA - cd05092
STKc_MAP4K3 - cd06645
STKc_MAP4K5 - cd06646
PTKc_DDR2 - cd05095
STKc_BUR1 - cd07866
PTKc_TrkC - cd05094
PTKc_EphR_A2 - cd05063
PTKc_Ror - cd05048
PTKc_Ror1 - cd05090
PTKc_Trk - cd05049
PTKc_Ror2 - cd05091
PTKc_TrkB - cd05093
PTKc_HER4 - cd05110
PTKc_Btk_Bmx - cd05113
STKc_CDK10 - cd07845
PTKc_Hck - cd05073
PTKc_Tec_Rlk - cd05114
PTKc_FAK - cd05056
PTKc_Csk - cd05082
PTKc_Jak_rpt2 - cd05038
PTKc_Frk_like - cd05068
PTKc_Lyn - cd05072
PTKc_Lck_Blk - cd05067
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE1 - cd07873
STKc_CDK12 - cd07864
PKc_MEK2 - cd06649
PKc_MAPKK_Byr1_like - cd06620
PTKc_EphR_A10 - cd05064
STKc_myosinIII_like - cd06608
STKc_SLK - cd06643
STKc_TNIK - cd06637
STKc_PCTAIRE3 - cd07871
PTKc_EphR_A - cd05066
PTK_HER3 - cd05111
PTKc_Jak1_rpt2 - cd05079
PTKc_Tyk2_rpt2 - cd05080
PTKc_InsR_like - cd05032
STKc_MAPK15 - cd07852
STKc_CDC2L1 - cd07843
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_ALK_LTK - cd05036
STKc_ASK - cd06624
STKc_TEY_MAPK_plant - cd07858
STKc_STK25-YSK1 - cd06642
STKc_ERK1_2_like - cd07849
PTKc_Yes - cd05069
PTKc_Src_like - cd05034
PTKc_Src - cd05071
STKc_PCTAIRE_like - cd07844
STKc_MAP4K3_like - cd06613
STKc_PFTAIRE2 - cd07870
PTKc_EphR - cd05033
PTK_Ryk - cd05043
STKc_PDK1 - cd05581
STKc_CDK8 - cd07868
STKc_MEKK3_like_1 - cd06653
STKc_CDC2L6 - cd07867
STKc_CDK8_like - cd07842
STKc_MEKK2 - cd06652
STKc_CNK2-like - cd08530
STKc_Nek6_Nek7 - cd08224
PK_STRAD - cd08216
STKc_Nek4 - cd08223
STKc_Yank1 - cd05578
PTKc_DDR_like - cd05097
PKc_MEK1 - cd06650
STKc_GRK6 - cd05630
STKc_MSK_N - cd05583
STKc_MEKK3 - cd06651
STKc_GRK4 - cd05631
STKc_GRK4_like - cd05605
STKc_GRK5 - cd05632
STKc_MAPKKK_Bck1_lik - cd06629
STKc_NAK1_like - cd06917
SPS1 - COG0515
PKc_MKK4 - cd06616
STKc_MEKK3_like - cd06625
STKc_MAST - cd05609
PKc_MKK5 - cd06619
STKc_ROCK_NDR_like - cd05573
STKc_PRKX_like - cd05612
STKc_MST3_like - cd06609
STKc_TDY_MAPK_plant - cd07859
STKc_CDK2_3 - cd07860
STKc_CDK6 - cd07862
STKc_CDK4 - cd07863
STKc_MPK1 - cd07857
STKc_CDK1_euk - cd07861
STKc_CDKL1_4 - cd07847
STKc_PFTAIRE1 - cd07869
STKc_CCRK - cd07832
STKc_CDKL2_3 - cd07846
STKc_CDKL5 - cd07848
STKc_NLK - cd07853
STKc_Nek10 - cd08528
STKc_Nek5 - cd08225
STKc_Nek11 - cd08222
STKc_Nek9 - cd08221
STKc_FA2-like - cd08529
STKc_CDK7 - cd07841
STKc_Nek7 - cd08229
STKc_Nek6 - cd08228
STKc_Nek2 - cd08217
STKc_Nek1 - cd08218
STKc_Nek3 - cd08219
STKc_Nek8 - cd08220
STKc_Nek - cd08215
PTKc_RET - cd05045
STKc_MSK1_N - cd05613
STKc_LATS - cd05598
STKc_cPKC_alpha - cd05615
STKc_cPKC_beta - cd05616
STKc_NDR1 - cd05628
STKc_DMPK_like - cd05597
STKc_cPKC - cd05587
STKc_MAPK - cd07834
PTKc_Musk - cd05050
PTKc_Itk - cd05112
PKc_STE - cd05122
STKc_MRCK_alpha - cd05623
STKc_MSK2_N - cd05614
PKc_MEK - cd06615
STKc_MEKK1_plant - cd06632
STKc_MAPKKK - cd06606
STKc_CdkB_plant - cd07837
STKc_CDK5 - cd07839
STKc_YSK4 - cd06631
STKc_Pho85 - cd07836
STKc_MEKK1 - cd06630
STKc_MEKK4 - cd06626
STKc_Cdc7_like - cd06627
STKc_MAPKKK_Byr2_lik - cd06628
STKc_CDK9_like - cd07840
STKc_CDK4_6_like - cd07838
STKc_CDK1_like - cd07835
STKc_MAK_like - cd07830
Pkinase_Tyr - pfam07714
STKc_MOK - cd07831
Pkinase - pfam00069
STYKc - smart00221
TyrKc - smart00219
STKc_SLK_like - cd06611
PTKc_Tyro3 - cd05074
PTKc_Fyn_Yrk - cd05070
STKc_CDK_like - cd07829
PTKc_Axl_like - cd05035
STKc_CMGC - cd05118
PTKc_Srm_Brk - cd05148
STKc_PKN - cd05589
STKc_MST4 - cd06640
STKc_MST3 - cd06641
PKc_MKK3_6 - cd06617
STKc_PKA - cd05580
PKc_MAPKK_plant_like - cd06623
STKc_p70S6K - cd05584
STKc_SGK2 - cd05603
STKc_aPKC_zeta - cd05617
STKc_PKB_beta - cd05595
STKc_PKB_gamma - cd05593
STKc_aPKC_iota - cd05618
STKc_PKB_alpha - cd05594
STKc_CRIK - cd05601
STKc_CDKL - cd07833
STKc_OSR1_SPAK - cd06610
STKc_nPKC_theta_delt - cd05592
PKc_MAPKK_PBS2_like - cd06622
PKc_MAPKK_Pek1_like - cd06621
PKc_MAPKK - cd06605
STKc_nPKC_theta - cd05619
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc_Met_Ron - cd05058
PTKc_Syk_like - cd05060
PTKc_Fes - cd05084
PTKc - cd00192
STKc_nPKC_epsilon - cd05591
PTKc_Aatyk - cd05042
PTKc_Fes_like - cd05041
PTKc_Ack_like - cd05040
PTKc_Fer - cd05085
PTKc_c-ros - cd05044
STKc_SGK - cd05575
STKc_RSK_N - cd05582
STKc_aPKC - cd05588
STKc_nPKC_eta - cd05590
PTKc_Aatyk2 - cd05086
STKc_PKB - cd05571
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_Syk - cd05116
STKc_phototropin_lik - cd05574
STKc_Sid2p_Dbf2p - cd05600
STKc_MST1_2 - cd06612
PTKc_Zap-70 - cd05115
STKc_Rim15_like - cd05611
STKc_Sck1_like - cd05586
STKc_NDR_like - cd05599
STKc_GRK1 - cd05608
STKc_GRK3 - cd05633
STKc_AGC - cd05123
STKc_cGK_PKG - cd05572
STKc_PKC - cd05570
PKc - cd00180
STKc_GRK7 - cd05607
STKc_GRK - cd05577
STKc_beta_ARK - cd05606
STKc_YPK1_like - cd05585
STKc_MAST_like - cd05579
S_TKc - smart00220
PTKc_Tec_like - cd05059
KIND - smart00750


Swiss-Prot Protein: Q9Y6R4
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
STKc_ROCK2cd056213.4e-0512981607
STKc_ROCKcd055961.3e-0512991608
STKc_ROCK1cd056227.7e-0513021608
STKc_TAO1cd066352e-0913131606
STKc_Sty1_Hog1cd078563.9e-0713171608
STKc_TAO3cd066331.4e-0713211606
STKc_PAK6cd066591.2e-1613211608
STKc_JNK1cd078750.0002813221608
STKc_myosinIIIAcd066381.3e-2013241601
STKc_TAO2cd066341.4e-1013241607
STKc_JNK2cd078762.2e-0513251608
STKc_p38alpha_MAPK14cd078770.0007813251608
STKc_MAP4K4_6cd066363.3e-2113261601
STKc_JNKcd078508.3e-0613261608
PTKc_FGFRcd050530.0005813271601
PTKc_FGFR2cd051010.0002813271608
STKc_myosinIIIBcd066392.2e-1813271602
STKc_PAK4cd066571.3e-1013271606
PTKc_EGFR_likecd050571.4e-0613281607
STKc_STK10_LOKcd066441.3e-2713281608
STKc_PAK1cd066544.8e-2413281608
STKc_p38gamma_MAPK12cd078804.1e-0513281608
STKc_PAKcd066147.7e-2913291608
STKc_PAK_IIcd066487.4e-2213291608
STKc_PAK2cd066552.9e-2613291607
STKc_PAK3cd066569.2e-2413291607
STKc_PAK_Icd066471.5e-3413291606
STKc_JNK3cd078740.0006613291608
PTKc_DDRcd050510.0004113301603
STKc_PAK5cd066582.5e-1113301608
STKc_CDK9cd078652.4e-1113301601
PKc_MKK7cd066181e-1413311608
STKc_p38cd078517.3e-0813311608
PTKc_Csk_likecd050391.3e-0613321602
PTKc_Ablcd050524.6e-0913321600
PTKc_InsRcd050613.4e-0513321605
PTKc_IGF-1Rcd050620.0003313321603
PTKc_EphR_Bcd050652e-0613321604
PTKc_Chkcd050832.2e-0713321602
PTKc_HER2cd051097.9e-0613321604
STKc_MAPK4_6cd078542.5e-0613321608
STKc_ERK5cd078557e-0713321608
PTKc_Rorcd050482.4e-0513331604
PTKc_Trkcd050492.6e-0813331598
PTKc_EphR_A2cd050633.8e-0513331600
PTKc_Ror1cd050902.1e-0513331604
PTKc_Ror2cd050910.0008213331604
PTKc_TrkBcd050934.8e-0613331606
PTKc_TrkCcd050940.0008113331606
PTKc_DDR2cd050957.8e-0513331603
PTKc_TrkAcd050927.3e-0713331607
STKc_TAOcd066071e-0913331606
STKc_MAP4K3cd066456.9e-3313331600
STKc_MAP4K5cd066463.6e-3313331600
STKc_BUR1cd078661.2e-1313331601
PTKc_Jak_rpt2cd050384.3e-0813341604
PTKc_FAKcd050569.5e-1113341608
PTKc_Frk_likecd050682.1e-1213341598
PTKc_Lck_Blkcd050673.3e-0513341600
PTKc_Lyncd050729.3e-0813341598
PTKc_Cskcd050824e-0513341599
PTKc_Hckcd050734.9e-0713341598
PTKc_HER4cd051100.0006313341608
PTKc_Btk_Bmxcd051135.2e-0913341600
PTKc_Tec_Rlkcd051144.1e-0713341600
STKc_CDK10cd078455.3e-1213341608
PTKc_EphR_A10cd050641.7e-0613351603
PKc_MAPKK_Byr1_likecd066201.1e-1213351607
PKc_MEK2cd066491.6e-0513351608
STKc_CDK12cd078643.7e-1313351601
STKc_PCTAIRE2cd078721.3e-0613351607
STKc_PCTAIRE1cd078731.3e-0613351606
PTKc_InsR_likecd050321.2e-0613361602
PTKc_Jak1_rpt2cd050794.8e-0613361604
PTKc_Tyk2_rpt2cd050801.1e-0713361605
PTKc_EphR_Acd050662.6e-0513361600
PTK_HER3cd051112e-0513361608
STKc_TNIKcd066371.6e-1613361601
STKc_myosinIII_likecd066083.5e-1813361601
STKc_SLKcd066435.2e-3213361608
STKc_PCTAIRE3cd078712.1e-0813361601
PTKc_ALK_LTKcd050362e-0813371601
PTKc_Jak2_Jak3_rpt2cd050811e-0813371605
STKc_ASKcd066242.4e-5713371601
STKc_CDC2L1cd078433.2e-1113371601
STKc_MAPK15cd078521.6e-0913371608
PTKc_Src_likecd050341.2e-0813381600
PTKc_Srccd050712.1e-0513381601
PTKc_Yescd050697e-0613381598
STKc_STK25-YSK1cd066422.2e-2013381608
STKc_TEY_MAPK_plantcd078588.1e-0513381608
STKc_ERK1_2_likecd078491e-0713381608
PTKc_EphRcd050333.8e-0813391601
PTK_Rykcd050430.00113391601
STKc_PDK1cd055813.1e-1813391601
STKc_MAP4K3_likecd066131.6e-4213391600
STKc_PCTAIRE_likecd078441.3e-1113391601
STKc_PFTAIRE2cd078704.3e-0913391601
PTKc_DDR_likecd050970.0004913401603
STKc_Yank1cd055785.5e-1913401601
STKc_MSK_Ncd055836.3e-1613401608
STKc_GRK6cd056301.2e-0613401607
STKc_GRK4cd056315.9e-0713401607
STKc_GRK5cd056325.7e-0713401607
STKc_GRK4_likecd056051.6e-0913401607
STKc_MEKK3cd066513.6e-5913401603
PKc_MEK1cd066507.7e-0613401608
STKc_MEKK2cd066523.6e-4813401602
STKc_MEKK3_like_1cd066535.2e-5113401601
STKc_CDK8_likecd078427.1e-1213401601
STKc_CDK8cd078680.0002513401601
STKc_CDC2L6cd078670.0001513401601
PK_STRADcd082166.6e-0913401606
STKc_Nek4cd082232.1e-2413401601
STKc_Nek6_Nek7cd082249.6e-2213401604
STKc_CNK2-likecd085301.2e-1513401601
STKc_ROCK_NDR_likecd055733.3e-1013411608
STKc_MASTcd056098.9e-0813411606
STKc_PRKX_likecd056126.4e-1013411608
STKc_MST3_likecd066095.4e-2613411607
PKc_MKK5cd066193e-0713411608
PKc_MKK4cd066168.3e-1313411608
STKc_MEKK3_likecd066251.3e-7113411601
STKc_MAPKKK_Bck1_likcd066295.6e-3813411601
STKc_NAK1_likecd069171.1e-1913411605
SPS1COG05155.7e-3213411607
PTKc_RETcd050450.0008513421603
PTKc_Muskcd050507e-0713421598
PTKc_Itkcd051124.6e-0813421600
PKc_STEcd051221.5e-7113421600
STKc_cPKCcd055870.0002313421602
STKc_DMPK_likecd055970.0004113421606
STKc_LATScd055981e-0513421607
STKc_MSK1_Ncd056137.7e-1113421607
STKc_MSK2_Ncd056141.1e-0913421605
STKc_cPKC_alphacd056150.0001913421602
STKc_cPKC_betacd056160.0007713421608
STKc_NDR1cd056280.0003313421607
STKc_MRCK_alphacd056230.0002413421607
STKc_MAPKKKcd066065.6e-13213421601
STKc_MEKK4cd066264e-19513421601
STKc_Cdc7_likecd066277.3e-6013421601
STKc_MAPKKK_Byr2_likcd066281.1e-6113421601
STKc_MEKK1cd066305.4e-4913421602
STKc_YSK4cd066317.9e-5013421601
STKc_MEKK1_plantcd066321.5e-8813421601
PKc_MEKcd066152.3e-1313421608
STKc_Pho85cd078363.3e-1813421601
STKc_CdkB_plantcd078371.3e-1313421602
STKc_CDK5cd078391.8e-1213421601
STKc_MAPKcd078346.3e-1013421607
STKc_CDK7cd078413.7e-1613421608
STKc_CCRKcd078321.9e-1613421602
STKc_CDKL2_3cd078467.7e-1513421601
STKc_CDKL1_4cd078476.9e-2913421601
STKc_CDKL5cd078481.1e-0613421601
STKc_NLKcd078530.0001513421608
STKc_MPK1cd078572.5e-0713421608
STKc_TDY_MAPK_plantcd078595.7e-0513421608
STKc_CDK2_3cd078601.1e-2113421601
STKc_CDK1_eukcd078616e-1813421601
STKc_CDK6cd078621.1e-0713421601
STKc_CDK4cd078631.5e-0913421601
STKc_PFTAIRE1cd078696.6e-0613421606
STKc_Nekcd082153.9e-4813421601
STKc_Nek2cd082172.6e-2113421601
STKc_Nek1cd082181.9e-3813421601
STKc_Nek3cd082198.2e-3113421601
STKc_Nek8cd082201.2e-2013421601
STKc_Nek6cd082283.1e-2213421603
STKc_Nek7cd082298.4e-1913421604
STKc_Nek11cd082222.1e-2113421601
STKc_Nek5cd082256.9e-3013421601
STKc_Nek9cd082212.3e-2213421601
STKc_Nek10cd085288.5e-1113421597
STKc_FA2-likecd085292.9e-1713421601
PTKc_Axl_likecd050350.0001113431604
PTKc_Fyn_Yrkcd050707.8e-0613431604
PTKc_Tyro3cd050748.8e-0513431603
STKc_CMGCcd051181.6e-1913431601
PTKc_Srm_Brkcd051488.5e-0613431599
STKc_PKNcd055896e-0613431608
STKc_SLK_likecd066117.1e-2013431608
STKc_MST4cd066402e-1713431608
STKc_MST3cd066414e-1413431602
STKc_CDK_likecd078295.4e-2113431601
STKc_MOKcd078315.1e-1113431601
STKc_CDK1_likecd078355.7e-1913431601
STKc_CDK4_6_likecd078381.5e-1513431601
STKc_CDK9_likecd078401.8e-1613431601
STKc_MAK_likecd078306e-1613431601
STKc_PKAcd055801.2e-1313441603
PKc_MKK3_6cd066175.3e-1513441608
PKc_MAPKK_plant_likecd066239.1e-4513441606
STKc_p70S6Kcd055842e-0713461608
PTKccd001922.6e-1413471600
PTKc_Ack_likecd050403.6e-1213471602
PTKc_Fes_likecd050412.7e-0713471601
PTKc_Aatykcd050421.3e-0513471598
PTKc_c-roscd050441.2e-0513471597
PTKc_Met_Roncd050581.9e-0513471605
PTKc_Syk_likecd050602.7e-0713471606
PTK_Jak2_Jak3_rpt1cd050781.7e-0513471599
PTKc_Fescd050841.4e-0713471601
PTKc_Fercd050856.5e-0613471601
PTKc_Aatyk2cd050863.3e-0513471598
PTKc_Aatyk1_Aatyk3cd050870.0006813471600
PTKc_Sykcd051161.6e-0613471600
STKc_PKBcd055711.2e-0713471608
STKc_SGKcd055751.9e-0513471608
STKc_RSK_Ncd055822.2e-0613471608
STKc_aPKCcd055887e-0713471608
STKc_nPKC_etacd055900.0002913471608
STKc_nPKC_epsiloncd055919.8e-0513471608
STKc_nPKC_theta_deltcd055926.8e-0613471608
STKc_PKB_gammacd055933.6e-0613471608
STKc_PKB_alphacd055943.5e-0713471608
STKc_CRIKcd056018.6e-1013471601
STKc_SGK2cd056034.4e-0513471602
STKc_PKB_betacd055957.3e-0613471608
STKc_aPKC_zetacd056171.6e-0713471608
STKc_aPKC_iotacd056182.6e-0613471608
STKc_nPKC_thetacd056191.1e-0513471608
PKc_MAPKKcd066054.3e-2013471606
PKc_MAPKK_Pek1_likecd066211.1e-1613471608
PKc_MAPKK_PBS2_likecd066223e-1313471607
STKc_OSR1_SPAKcd066102.1e-2113471601
STKc_CDKLcd078333.2e-1713471601
PTKc_Zap-70cd051150.0001213481600
STKc_phototropin_likcd055742.9e-1013481608
STKc_Sid2p_Dbf2pcd056001.3e-0613481602
STKc_MST1_2cd066121.2e-2713481601
PKccd001805.2e-7613491599
STKc_AGCcd051239.5e-2713491601
STKc_PKCcd055703.1e-1213491608
STKc_cGK_PKGcd055723.9e-1513491608
STKc_GRKcd055775.8e-1113491606
STKc_MAST_likecd055791.6e-1813491606
STKc_YPK1_likecd055856.5e-0713491608
STKc_beta_ARKcd056062.5e-0813491608
STKc_GRK7cd056072.9e-0713491603
STKc_GRK1cd056083.3e-0813491608
STKc_Rim15_likecd056117.1e-0713491606
STKc_Sck1_likecd055867.5e-0513491606
STKc_GRK3cd056332.7e-0713491608
STKc_NDR_likecd055990.0001813491605
PTKc_Tec_likecd050591.4e-1013631600
Pkinasepfam000692.2e-7613431601
Pkinase_Tyrpfam077142.1e-1713431601
STYKcsmart002213.1e-8413431601
TyrKcsmart002191.3e-1513431601
S_TKcsmart002201e-9113531601
KINDsmart007507.6e-0814251608

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_040692Polymorphismp.ALA1492VALN/A
Swiss-ProtVAR_059767Polymorphismp.ARG157HISN/A
Swiss-ProtVAR_040688Polymorphismp.ARG566HISN/A
Swiss-ProtVAR_040689Polymorphismp.GLN584HISN/A
Swiss-ProtVAR_040691Polymorphismp.GLU1413GLNN/A
Swiss-ProtVAR_040690Polymorphismp.HIS906PRON/A
Swiss-ProtVAR_040686Polymorphismp.ILE294THRN/A
Swiss-ProtVAR_040687Polymorphismp.VAL335ILEN/A



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