Results for the protein: NP

Results for the Protein: NP_001177730

299829215

10733

PLK4

NCBI

serine/threonine-protein kinase PLK4 isoform 3 [Homo sapiens]

			0 3 0 3 0

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RefSeq Protein: NP_001177730

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_Tie	cd05047	5.4e-05	1	220
PTKc_Ror	cd05048	0.00014	1	179
PTKc_Abl	cd05052	0.00014	1	223
PTKc_EphR_A2	cd05063	0.00067	1	223
PTKc_EphR_B	cd05065	0.00091	1	223
PTKc_EphR_A	cd05066	0.0005	1	223
PTKc_Fyn_Yrk	cd05070	0.00062	1	222
PTKc_Src	cd05071	0.00038	1	224
PTKc_Lyn	cd05072	5.3e-05	1	222
PTKc_Trk	cd05049	5.3e-05	1	221
PTKc_Hck	cd05073	0.00034	1	222
PTKc_Musk	cd05050	0.00062	1	226
PTKc_Tyk2_rpt2	cd05080	0.00059	1	227
PTKc_Fes	cd05084	3.6e-05	1	224
PTKc_Fer	cd05085	8.3e-06	1	224
PTKc_Tie2	cd05088	8.5e-05	1	241
PTKc_Tie1	cd05089	0.00019	1	247
PTKc_Tec_Rlk	cd05114	7.1e-05	1	223
PKc_STE	cd05122	4.8e-16	1	223
STKc_AGC	cd05123	2.8e-44	1	224
STKc_PKC	cd05570	2.2e-15	1	272
STKc_PKB	cd05571	3.7e-13	1	298
STKc_SGK	cd05575	1.7e-08	1	278
STKc_Yank1	cd05578	4.2e-18	1	224
STKc_RSK_N	cd05582	4.6e-18	1	272
STKc_p70S6K	cd05584	2.8e-21	1	298
STKc_Sck1_like	cd05586	3.6e-07	1	353
STKc_cPKC	cd05587	2.3e-11	1	300
STKc_aPKC	cd05588	1e-09	1	300
STKc_PKN	cd05589	6e-11	1	296
STKc_nPKC_eta	cd05590	1e-08	1	297
STKc_nPKC_epsilon	cd05591	2.6e-10	1	288
STKc_nPKC_theta_delt	cd05592	2e-12	1	298
STKc_PKB_alpha	cd05594	1.6e-10	1	302
STKc_PKB_beta	cd05595	1.1e-09	1	292
STKc_DMPK_like	cd05597	7.8e-07	1	285
STKc_Sid2p_Dbf2p	cd05600	5.5e-09	1	268
STKc_PKB_gamma	cd05593	1.9e-09	1	317
STKc_SGK2	cd05603	8.3e-09	1	304
STKc_SGK3	cd05604	7.2e-06	1	280
STKc_GRK4_like	cd05605	3e-08	1	246
STKc_beta_ARK	cd05606	1e-06	1	244
STKc_GRK7	cd05607	5.7e-07	1	249
STKc_GRK1	cd05608	2.5e-08	1	244
STKc_SGK1	cd05602	1.2e-06	1	305
STKc_PRKX_like	cd05612	3.4e-17	1	251
STKc_cPKC_alpha	cd05615	1.2e-09	1	273
STKc_cPKC_beta	cd05616	1.1e-07	1	304
STKc_aPKC_zeta	cd05617	2.5e-09	1	300
STKc_aPKC_iota	cd05618	1.6e-07	1	300
STKc_nPKC_theta	cd05619	7e-11	1	301
STKc_ROCK1	cd05622	8.6e-05	1	287
STKc_MRCK_beta	cd05624	5.8e-06	1	274
STKc_LATS1	cd05625	1.9e-05	1	303
STKc_LATS2	cd05626	4.7e-05	1	272
STKc_NDR2	cd05627	0.00014	1	307
STKc_NDR1	cd05628	8.5e-06	1	309
STKc_MSK1_N	cd05613	1.8e-08	1	244
STKc_GRK6	cd05630	6.3e-05	1	246
STKc_GRK4	cd05631	8.2e-06	1	246
STKc_GRK3	cd05633	6.6e-06	1	253
STKc_GRK5	cd05632	7.3e-07	1	246
STKc_PDK1	cd05581	5.2e-29	1	224
STKc_MAST	cd05609	9.4e-10	1	297
STKc_NDR_like_fungal	cd05629	6.2e-06	1	312
PKc_MAPKK	cd06605	2.7e-09	1	229
STKc_MAPKKK	cd06606	7.1e-22	1	224
STKc_TAO	cd06607	1e-05	1	267
STKc_OSR1_SPAK	cd06610	1.1e-10	1	224
STKc_PAK	cd06614	2.5e-15	1	238
PKc_MEK	cd06615	6.1e-08	1	242
PKc_MKK3_6	cd06617	2.3e-06	1	243
PKc_MKK7	cd06618	1.2e-07	1	244
PKc_MKK5	cd06619	0.00041	1	246
PKc_MAPKK_PBS2_like	cd06622	3.2e-07	1	280
STKc_ASK	cd06624	2.6e-08	1	224
PKc_MAPKK_plant_like	cd06623	1.8e-15	1	230
STKc_MEKK3_like	cd06625	9.7e-14	1	224
STKc_MAPKKK_Byr2_lik	cd06628	6.7e-10	1	224
STKc_MEKK1	cd06630	5.6e-10	1	225
STKc_MEKK1_plant	cd06632	2.3e-13	1	224
STKc_TAO2	cd06634	6.1e-05	1	268
STKc_TAO1	cd06635	0.00019	1	267
STKc_TNIK	cd06637	8.8e-06	1	224
STKc_myosinIIIB	cd06639	1.9e-05	1	225
STKc_myosinIIIA	cd06638	2.5e-06	1	224
STKc_STK25-YSK1	cd06642	7.4e-07	1	245
STKc_SLK	cd06643	4.2e-08	1	241
STKc_MAP4K3	cd06645	9.6e-07	1	223
STKc_PAK_II	cd06648	1.2e-09	1	236
STKc_MEKK2	cd06652	2.7e-05	1	225
STKc_PAK1	cd06654	7.5e-05	1	252
STKc_PAK3	cd06656	9.3e-06	1	258
STKc_PAK4	cd06657	4.1e-05	1	243
STKc_PAK5	cd06658	0.00015	1	242
STKc_TAO3	cd06633	0.001	1	267
STKc_PAK6	cd06659	7e-08	1	252
PKc_MAPKK_Pek1_like	cd06621	8.1e-08	1	236
STKc_CDK1_like	cd07835	3.1e-07	1	224
STKc_CDK7	cd07841	1.9e-11	1	236
STKc_CDK8_like	cd07842	4.8e-07	1	224
STKc_MAPK	cd07834	3.3e-11	1	252
STKc_PCTAIRE_like	cd07844	3.3e-06	1	254
STKc_CDKL1_4	cd07847	1.1e-06	1	224
STKc_JNK	cd07850	0.00056	1	253
STKc_TDY_MAPK_plant	cd07859	7.8e-05	1	311
STKc_CDK2_3	cd07860	3.6e-06	1	224
STKc_CDK1_euk	cd07861	4.8e-06	1	224
STKc_TEY_MAPK_plant	cd07858	9.3e-06	1	269
STKc_CDK12	cd07864	1.1e-09	1	224
STKc_PFTAIRE2	cd07870	9.2e-06	1	224
STKc_PCTAIRE3	cd07871	1.5e-06	1	224
STKc_PCTAIRE2	cd07872	2.2e-05	1	252
STKc_PCTAIRE1	cd07873	5.4e-05	1	240
STKc_CDK9	cd07865	1.4e-08	1	224
STKc_Nek	cd08215	9.1e-31	1	224
STKc_Nek1	cd08218	2.7e-28	1	224
STKc_Nek3	cd08219	2.1e-24	1	224
STKc_Nek11	cd08222	2e-12	1	224
STKc_Nek4	cd08223	1.1e-15	1	224
STKc_Nek6_Nek7	cd08224	4.8e-10	1	227
STKc_Nek5	cd08225	4.9e-23	1	224
STKc_Nek6	cd08228	6.6e-07	1	227
STKc_Nek7	cd08229	9.8e-09	1	227
PK_STRAD	cd08216	6.1e-05	1	240
STKc_Nek10	cd08528	7.3e-08	1	221
SPS1	COG0515	1.8e-40	1	384
PTKc_InsR_like	cd05032	6.5e-05	2	221
PTKc_EphR	cd05033	9.3e-05	2	223
PTKc_Src_like	cd05034	3.3e-09	2	222
PTKc_ALK_LTK	cd05036	0.00047	2	224
PTKc_Csk_like	cd05039	2.4e-05	2	222
PTKc_Jak_rpt2	cd05038	1.6e-05	2	226
PTKc_FAK	cd05056	1.9e-05	2	223
PTKc_Tec_like	cd05059	3e-08	2	220
PTKc_Frk_like	cd05068	3.6e-08	2	222
PTKc_Yes	cd05069	0.00014	2	222
PTKc_Jak2_Jak3_rpt2	cd05081	3e-05	2	226
PTKc_Itk	cd05112	1.4e-06	2	223
PTKc_Btk_Bmx	cd05113	3.5e-06	2	219
STKc_GRK	cd05577	5.6e-11	2	240
STKc_cGK_PKG	cd05572	1.6e-18	2	230
STKc_YPK1_like	cd05585	2.2e-09	2	286
STKc_PKA	cd05580	8e-17	2	260
STKc_ROCK	cd05596	3.6e-05	2	288
STKc_LATS	cd05598	2.7e-07	2	272
STKc_Rim15_like	cd05611	1e-07	2	226
STKc_MSK2_N	cd05614	2.5e-10	2	274
STKc_ROCK2	cd05621	0.00015	2	286
STKc_MRCK_alpha	cd05623	4.8e-06	2	305
STKc_myosinIII_like	cd06608	5.5e-10	2	224
STKc_MAPKKK_Bck1_lik	cd06629	1.8e-09	2	224
STKc_MAP4K4_6	cd06636	0.00025	2	224
STKc_MST4	cd06640	8.3e-07	2	246
STKc_MST3	cd06641	1.1e-05	2	246
STKc_STK10_LOK	cd06644	2.4e-07	2	244
STKc_MAP4K5	cd06646	1.8e-05	2	223
STKc_MEKK3	cd06651	2.1e-08	2	226
STKc_MEKK3_like_1	cd06653	9.2e-06	2	224
STKc_CdkB_plant	cd07837	4.6e-10	2	225
STKc_CDK5	cd07839	2.7e-09	2	224
STKc_ERK1_2_like	cd07849	3.3e-07	2	255
STKc_MAPK15	cd07852	8.2e-10	2	249
STKc_NLK	cd07853	3.5e-09	2	296
STKc_MAPK4_6	cd07854	8.4e-08	2	261
STKc_CDK6	cd07862	0.00033	2	224
STKc_CDK4	cd07863	2.4e-05	2	224
STKc_FA2-like	cd08529	9.3e-13	2	218
PTKc_Syk_like	cd05060	2.3e-05	3	210
PTKc_Srm_Brk	cd05148	5.6e-08	3	222
STKc_ROCK_NDR_like	cd05573	8.9e-14	3	296
STKc_phototropin_lik	cd05574	5.3e-13	3	243
STKc_MSK_N	cd05583	6e-11	3	241
STKc_CRIK	cd05601	4.4e-11	3	278
STKc_PAK_I	cd06647	2e-05	3	250
STKc_PAK2	cd06655	1.8e-05	3	246
STKc_CDKL	cd07833	1.1e-10	3	224
STKc_Pho85	cd07836	5e-06	3	224
STKc_CDK9_like	cd07840	2.9e-15	3	224
STKc_ERK5	cd07855	1.6e-09	3	256
STKc_Nek2	cd08217	1.3e-12	3	224
STKc_Nek8	cd08220	2e-10	3	224
PTKc	cd00192	2.8e-11	4	223
PTKc_Ack_like	cd05040	1.2e-07	4	225
PTKc_Zap-70	cd05115	3.4e-05	4	227
PTKc_Syk	cd05116	2.2e-05	4	224
STKc_MAST_like	cd05579	8.2e-21	4	229
PKc_MAPKK_Byr1_like	cd06620	1.9e-05	4	239
STKc_Cdc7_like	cd06627	1.2e-18	4	224
STKc_CDK_like	cd07829	8.5e-19	4	224
STKc_MAK_like	cd07830	3.4e-12	4	224
STKc_Sty1_Hog1	cd07856	1.5e-07	4	256
STKc_BUR1	cd07866	4.1e-10	4	224
PTKc_Fes_like	cd05041	3.6e-08	5	224
STKc_CMGC	cd05118	7.7e-15	5	224
STKc_nPKC_delta	cd05620	1.3e-06	5	305
STKc_NDR_like	cd05599	2.4e-09	5	309
STKc_MST3_like	cd06609	2.2e-13	5	243
STKc_MST1_2	cd06612	2.6e-13	5	224
STKc_MOK	cd07831	5.1e-11	5	224
STKc_MAP4K3_like	cd06613	1.4e-11	6	223
STKc_NAK1_like	cd06917	1.1e-09	6	240
STKc_CDKL2_3	cd07846	2.1e-08	6	224
PTKc_Aatyk	cd05042	4.8e-06	7	207
STKc_YSK4	cd06631	2.1e-10	7	224
STKc_p38	cd07851	1.8e-07	7	258
STKc_MPK1	cd07857	9.7e-08	7	253
STKc_Nek9	cd08221	6.7e-13	7	224
STKc_SLK_like	cd06611	2.9e-12	8	241
STKc_CCRK	cd07832	4.4e-13	8	225
STKc_CDK4_6_like	cd07838	5.7e-12	8	224
STKc_MEKK4	cd06626	1.5e-11	11	224
STKc_CDK10	cd07845	1.8e-11	11	235
STKc_CNK2-like	cd08530	2.8e-13	11	224
STKc_CDC2L1	cd07843	2.3e-11	13	224
PKc_MKK4	cd06616	0.00011	38	243
Pkinase	pfam00069	8.4e-58	4	224
POLO_box	pfam00659	1e-14	851	915
Pkinase_Tyr	pfam07714	1.5e-14	1	224
TyrKc	smart00219	3.9e-11	1	224
S_TKc	smart00220	7.5e-80	1	224
STYKc	smart00221	1.8e-58	1	224
KIND	smart00750	8.1e-06	60	232

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs17012739	Polymorphism	p.GLU789ASP	N/A
dbSNP	rs3811740	Polymorphism	p.SER191THR	N/A
dbSNP	rs61735390	Polymorphism	p.THR787MET	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258