Results for the protein: O75582

Results for the Protein: O75582

37999482

9252

RPS6KA5

NCBI, UniProt

KS6A5_HUMAN RecName: Full=Ribosomal protein S6 kinase alpha-5; Short=S6K-alpha-5; AltName: Full=90 kDa ribosomal protein S6 kinase 5; AltName: Full=Nuclear mitogen- and stress-activated protein kinase 1; AltName: Full=RSK-like protein kinase; Short=RSKL

			0 4 0 0 4

Tips:

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Swiss-Prot Protein: O75582

Identical to: NP_004746

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621	1.6e-28	20	379
STKc_ROCK1	cd05622	9e-31	20	380
STKc_TAO1	cd06635	2.7e-05	20	354
STKc_PAK1	cd06654	3.8e-08	21	342
STKc_PAK3	cd06656	8.1e-08	22	344
STKc_myosinIIIB	cd06639	3.3e-09	26	319
STKc_PAK_I	cd06647	1.1e-07	27	333
STKc_PAK2	cd06655	4.2e-08	27	336
STKc_PAK5	cd06658	4e-07	27	343
STKc_PAK6	cd06659	1.3e-09	28	341
STKc_TAO2	cd06634	5.4e-06	29	354
STKc_PAK4	cd06657	4e-07	29	340
STKc_MAP4K4_6	cd06636	3.4e-07	30	318
STKc_TAO	cd06607	1.2e-05	31	357
PKc_MKK7	cd06618	1.7e-11	34	341
STKc_myosinIIIA	cd06638	1.5e-09	37	318
STKc_STK10_LOK	cd06644	1.1e-09	39	339
STKc_MAP4K3	cd06645	4.8e-09	39	317
STKc_MAP4K5	cd06646	1.8e-08	39	317
STKc_ASK	cd06624	6.5e-17	40	318
STKc_TNIK	cd06637	5e-08	40	318
PTKc_EGFR_like	cd05057	1.6e-05	41	305
PTKc_EGFR	cd05108	3.1e-06	41	361
PTK_HER3	cd05111	3.8e-06	41	296
PTKc_FAK	cd05056	7e-07	42	326
PTKc_Ror	cd05048	1.9e-05	43	305
PTKc_Trk	cd05049	1.8e-05	43	304
PTKc_Frk_like	cd05068	5.1e-06	43	315
PTKc_Yes	cd05069	2.5e-05	43	316
PTKc_Fyn_Yrk	cd05070	0.0002	43	309
PTKc_Src	cd05071	0.00018	43	318
PTKc_Csk	cd05082	0.00038	43	316
PTKc_Ror2	cd05091	0.00072	43	305
PTKc_TrkA	cd05092	0.00028	43	318
PTKc_TrkB	cd05093	0.00094	43	336
PTKc_Ror1	cd05090	5e-05	43	305
STKc_SLK	cd06643	1.6e-09	43	331
PKc_MEK2	cd06649	6.9e-07	43	365
PKc_MEK1	cd06650	1.8e-05	43	362
STKc_TEY_MAPK_plant	cd07858	2.3e-07	43	361
PTKc_EphR_B	cd05065	0.00023	44	319
PTKc_Btk_Bmx	cd05113	2.5e-07	44	313
STKc_MST1_2	cd06612	4.3e-13	45	318
STKc_MAP4K3_like	cd06613	3e-14	45	317
STKc_PCTAIRE_like	cd07844	1.5e-07	45	348
PTKc_Jak1_rpt2	cd05079	7.1e-05	46	317
PTKc_HER4	cd05110	0.00026	46	343
PTKc_Tec_Rlk	cd05114	2.4e-06	46	316
PTKc_HER2	cd05109	2.4e-06	46	332
STKc_MASTL	cd05610	2.9e-05	46	662
STKc_SLK_like	cd06611	3.5e-13	46	329
STKc_Nek6_Nek7	cd08224	9.9e-11	46	314
STKc_Nek6	cd08228	6.2e-09	46	316
STKc_Nek7	cd08229	5.7e-11	46	318
STKc_ROCK_NDR_like	cd05573	1.9e-82	47	378
STKc_phototropin_lik	cd05574	5.5e-79	47	344
STKc_PKA	cd05580	5e-116	47	351
STKc_PDK1	cd05581	7e-78	47	318
STKc_LATS	cd05598	2.7e-47	47	384
STKc_NDR_like	cd05599	5.9e-26	47	388
STKc_Sid2p_Dbf2p	cd05600	5.4e-22	47	386
STKc_CRIK	cd05601	4.1e-46	47	378
STKc_MAST	cd05609	1e-52	47	349
STKc_PRKX_like	cd05612	1.1e-86	47	353
STKc_DMPK_like	cd05597	1.8e-66	47	387
STKc_MRCK_alpha	cd05623	9.6e-49	47	388
STKc_MRCK_beta	cd05624	1.4e-55	47	387
STKc_LATS1	cd05625	1.3e-26	47	381
STKc_NDR2	cd05627	4.3e-45	47	409
STKc_NDR1	cd05628	1.4e-44	47	388
STKc_LATS2	cd05626	9.2e-30	47	383
STKc_NDR_like_fungal	cd05629	4.3e-49	47	388
PKc_MAPKK	cd06605	6.7e-16	47	323
STKc_MST3_like	cd06609	1.7e-16	47	331
STKc_OSR1_SPAK	cd06610	2.4e-14	47	318
STKc_myosinIII_like	cd06608	2.3e-12	47	318
PKc_MEK	cd06615	5.8e-10	47	335
PKc_MKK3_6	cd06617	7.4e-11	47	333
PKc_MKK5	cd06619	2.1e-06	47	343
PKc_MAPKK_Byr1_like	cd06620	1.1e-11	47	330
PKc_MAPKK_Pek1_like	cd06621	5.4e-10	47	322
PKc_MAPKK_PBS2_like	cd06622	1.5e-10	47	356
PKc_MAPKK_plant_like	cd06623	9.6e-20	47	323
STKc_MEKK3_like	cd06625	1.8e-14	47	318
STKc_MST4	cd06640	5.1e-08	47	339
STKc_MST3	cd06641	1.3e-07	47	339
STKc_STK25-YSK1	cd06642	4.4e-08	47	339
STKc_MEKK2	cd06652	6.6e-08	47	319
STKc_MEKK3_like_1	cd06653	1.8e-09	47	318
STKc_NAK1_like	cd06917	2e-14	47	322
STKc_CdkB_plant	cd07837	7.2e-13	47	319
STKc_CDKL1_4	cd07847	7.1e-10	47	348
STKc_CDKL5	cd07848	1.2e-06	47	318
SPS1	COG0515	2.9e-63	47	419
PTKc_RET	cd05045	0.00018	48	297
PKc_STE	cd05122	1.2e-29	48	317
STKc_Yank1	cd05578	2.6e-80	48	318
STKc_cPKC	cd05587	9.4e-94	48	379
STKc_GRK4_like	cd05605	6.5e-66	48	339
STKc_MSK1_N	cd05613	1.3e-251	48	337
STKc_MSK2_N	cd05614	8.6e-238	48	380
STKc_cPKC_alpha	cd05615	5.1e-76	48	379
STKc_cPKC_beta	cd05616	1.7e-81	48	379
STKc_MSK_N	cd05583	8.1e-239	48	337
STKc_GRK4	cd05631	5.3e-56	48	339
STKc_GRK5	cd05632	4.9e-57	48	339
STKc_GRK6	cd05630	2.7e-60	48	339
STKc_MAPKKK	cd06606	2.2e-43	48	318
STKc_MEKK3	cd06651	1.9e-11	48	320
STKc_Cdc7_like	cd06627	1.1e-18	48	318
STKc_Pho85	cd07836	1.6e-06	48	318
STKc_CDK2_3	cd07860	4.4e-07	48	318
STKc_CDK1_euk	cd07861	1.9e-06	48	318
STKc_Nek	cd08215	1.2e-41	48	318
STKc_Nek1	cd08218	2.2e-25	48	313
STKc_Nek8	cd08220	2.3e-10	48	313
STKc_Nek11	cd08222	6.5e-11	48	318
STKc_Nek4	cd08223	6.8e-10	48	318
STKc_Nek5	cd08225	1.6e-21	48	318
STKc_Nek2	cd08217	1.1e-14	48	318
STKc_Nek3	cd08219	1.6e-22	48	313
STKc_Nek10	cd08528	1.3e-10	48	310
STKc_CNK2-like	cd08530	2e-14	48	318
STKc_FA2-like	cd08529	2.1e-14	48	302
PTKc_Axl_like	cd05035	0.0002	49	322
PTKc_Tyro3	cd05074	0.00011	49	313
PTKc_Tyk2_rpt2	cd05080	6.5e-05	49	347
PTKc_Jak2_Jak3_rpt2	cd05081	3.7e-07	49	313
STKc_PKN	cd05589	7.3e-112	49	378
STKc_MAPKKK_Bck1_lik	cd06629	1.7e-11	49	318
STKc_CDK1_like	cd07835	2.1e-08	49	318
STKc_MAPKKK_Byr2_lik	cd06628	2e-21	50	318
STKc_MEKK4	cd06626	2.4e-15	51	318
STKc_RSK_N	cd05582	2.6e-130	52	378
STKc_p70S6K	cd05584	3.6e-142	52	380
STKc_Rim15_like	cd05611	6.8e-21	52	324
PTKc_Met_Ron	cd05058	0.00035	53	315
PTK_Jak2_Jak3_rpt1	cd05078	0.00048	53	310
PTKc_Aatyk2	cd05086	0.00047	53	318
PTKc_Aatyk1_Aatyk3	cd05087	0.0004	53	318
STKc_PKB	cd05571	4.9e-103	53	380
STKc_PKC	cd05570	4.5e-109	53	378
STKc_SGK	cd05575	2.2e-105	53	378
STKc_aPKC	cd05588	3e-90	53	379
STKc_nPKC_eta	cd05590	1.1e-87	53	379
STKc_nPKC_theta_delt	cd05592	2.3e-95	53	380
STKc_PKB_alpha	cd05594	1e-86	53	381
STKc_nPKC_epsilon	cd05591	2.3e-90	53	379
STKc_PKB_beta	cd05595	3.3e-96	53	380
STKc_PKB_gamma	cd05593	1.1e-86	53	383
STKc_SGK1	cd05602	4.9e-85	53	380
STKc_SGK2	cd05603	1.1e-89	53	379
STKc_SGK3	cd05604	3e-88	53	380
STKc_nPKC_delta	cd05620	7.7e-73	53	380
STKc_aPKC_zeta	cd05617	2.8e-77	53	379
STKc_aPKC_iota	cd05618	1e-77	53	379
STKc_nPKC_theta	cd05619	8e-78	53	380
STKc_MEKK1	cd06630	8.3e-11	53	319
STKc_YSK4	cd06631	8.7e-10	53	318
STKc_MEKK1_plant	cd06632	5.9e-16	53	318
STKc_beta_ARK	cd05606	1.1e-70	54	338
STKc_GRK3	cd05633	4.1e-63	54	339
PKc	cd00180	7.7e-73	55	316
PTKc_Zap-70	cd05115	2.3e-05	55	307
STKc_AGC	cd05123	5.6e-160	55	318
STKc_cGK_PKG	cd05572	4e-84	55	325
STKc_GRK	cd05577	6.5e-76	55	338
STKc_MAST_like	cd05579	2.1e-66	55	323
STKc_YPK1_like	cd05585	5.2e-100	55	377
STKc_Sck1_like	cd05586	6.6e-89	55	423
STKc_GRK1	cd05608	4.5e-66	55	338
STKc_GRK7	cd05607	1.3e-47	55	338
STKc_JNK1	cd07875	1.2e-07	400	726
STKc_PAK_I	cd06647	5.7e-06	402	711
STKc_PAK	cd06614	9e-17	403	699
STKc_PAK6	cd06659	7.9e-09	405	714
STKc_myosinIIIA	cd06638	2.3e-08	406	687
STKc_p38alpha_MAPK14	cd07877	2.6e-06	406	727
STKc_JNK3	cd07874	1.8e-08	407	747
STKc_JNK	cd07850	2.1e-09	408	722
STKc_p38beta_MAPK11	cd07878	5.3e-07	408	760
STKc_PAK_II	cd06648	2.9e-11	410	699
STKc_p38gamma_MAPK12	cd07880	2e-08	410	727
PTKc_FGFR4	cd05099	0.00044	413	689
STKc_CDK9	cd07865	4.3e-11	413	687
STKc_JNK2	cd07876	1.2e-08	413	724
STKc_p38delta_MAPK13	cd07879	2.9e-05	413	727
STKc_MAPK15	cd07852	1.1e-10	416	699
STKc_ERK1_2_like	cd07849	3e-10	417	735
STKc_BUR1	cd07866	2.9e-08	417	687
PTKc_ALK_LTK	cd05036	1.3e-06	418	689
PTKc_Tie2	cd05088	2e-05	418	711
PTK_Ryk	cd05043	6.2e-06	419	676
STKc_GRK4_like	cd05605	1.2e-10	419	703
STKc_GRK4	cd05631	2.5e-08	419	703
STKc_ASK	cd06624	4.8e-09	419	687
STKc_ERK5	cd07855	1.1e-09	419	726
STKc_Sty1_Hog1	cd07856	4.9e-09	419	722
STKc_TEY_MAPK_plant	cd07858	7.6e-15	419	727
STKc_Nek10	cd08528	1.3e-10	419	684
PTKc_Jak_rpt2	cd05038	1.6e-07	420	671
PTKc_Abl	cd05052	1.4e-06	420	688
PTKc_Lyn	cd05072	6.7e-05	420	671
PTKc_Hck	cd05073	8.6e-05	420	690
PTKc_Tec_Rlk	cd05114	3.2e-06	420	686
STKc_CDK4_6_like	cd07838	1.2e-10	420	676
STKc_PCTAIRE_like	cd07844	1.3e-14	420	716
STKc_p38	cd07851	1.6e-12	420	727
STKc_CDK12	cd07864	4.7e-12	420	687
STKc_PFTAIRE2	cd07870	2e-09	420	715
STKc_PFTAIRE1	cd07869	3.2e-06	420	695
STKc_PCTAIRE2	cd07872	1.2e-07	420	724
STKc_PCTAIRE1	cd07873	3e-06	420	698
STKc_PCTAIRE3	cd07871	1.4e-08	420	686
STKc_Nek6_Nek7	cd08224	1.1e-10	420	696
PTKc_InsR_like	cd05032	4.1e-07	421	669
PTKc_Src_like	cd05034	2.1e-06	421	690
PTKc_InsR	cd05061	0.00099	421	700
PTKc_Frk_like	cd05068	5.4e-07	421	690
STKc_CDKL2_3	cd07846	2.4e-10	421	687
STKc_CDKL1_4	cd07847	4e-17	421	723
STKc_CDK6	cd07862	3.7e-05	421	704
PTKc_Musk	cd05050	7.3e-05	422	689
PTKc_EphR_A2	cd05063	0.00016	422	688
PTKc_Lck_Blk	cd05067	0.00027	422	690
PTKc_Tie1	cd05089	0.00014	422	705
PTKc_Itk	cd05112	2.4e-07	422	686
PTKc_Srm_Brk	cd05148	4.9e-08	422	696
STKc_Yank1	cd05578	8.8e-23	422	693
PKc_MKK4	cd06616	7.7e-10	422	704
STKc_MAPK	cd07834	1e-13	422	718
STKc_CDK5	cd07839	1.1e-08	422	686
STKc_MPK1	cd07857	3.8e-09	422	703
STKc_TDY_MAPK_plant	cd07859	6.3e-08	422	734
STKc_Nek	cd08215	6.8e-29	422	687
STKc_Nek11	cd08222	1.6e-07	422	687
STKc_Nek5	cd08225	1.7e-13	422	687
STKc_Nek3	cd08219	2.7e-21	422	687
PTKc_FGFR	cd05053	0.00059	423	669
PTKc_Chk	cd05083	9.3e-06	423	690
STKc_PKA	cd05580	1.4e-18	423	725
STKc_PDK1	cd05581	1.7e-44	423	687
STKc_MAST	cd05609	1.1e-09	423	742
STKc_PRKX_like	cd05612	4.8e-18	423	716
PKc_MAPKK_plant_like	cd06623	6e-19	423	692
STKc_MOK	cd07831	7.2e-17	423	684
STKc_CDK9_like	cd07840	2.6e-16	423	687
STKc_MAPK4_6	cd07854	9.5e-08	423	722
PTKc_EphR_A10	cd05064	9.3e-05	424	687
PKc_STE	cd05122	6.7e-31	424	686
STKc_cPKC	cd05587	7.4e-22	424	734
STKc_MSK1_N	cd05613	6.6e-12	424	721
STKc_MSK2_N	cd05614	9.9e-11	424	739
STKc_DMPK_like	cd05597	1.6e-13	424	752
STKc_cPKC_beta	cd05616	1.7e-10	424	747
STKc_MSK_N	cd05583	5.2e-16	424	701
STKc_MAPKKK	cd06606	4.4e-25	424	687
STKc_Pho85	cd07836	3.1e-10	424	687
STKc_CDK8_like	cd07842	6.9e-09	424	687
STKc_NLK	cd07853	4.3e-10	424	763
SPS1	COG0515	1.4e-54	424	802
PTKc_EphR	cd05033	1.8e-05	425	642
PTKc_Tec_like	cd05059	1.2e-05	425	668
PTKc_EphR_A	cd05066	0.00034	425	688
PTKc_Btk_Bmx	cd05113	3.4e-07	425	671
STKc_CDC2L6	cd07867	4e-05	425	687
STKc_CDK8	cd07868	5.2e-05	425	687
STKc_cPKC_alpha	cd05615	3.6e-11	426	747
STKc_MAPKKK_Byr2_lik	cd06628	4.9e-08	427	687
STKc_CDK_like	cd07829	1.4e-21	427	687
STKc_CDK7	cd07841	6.1e-15	427	682
STKc_CDK1_euk	cd07861	6.9e-13	427	687
PK_STRAD	cd08216	1.3e-05	427	689
STKc_Nek1	cd08218	8.7e-17	427	687
STKc_Nek4	cd08223	3.5e-07	427	687
STKc_Nek6	cd08228	5.4e-10	427	693
STKc_GRK5	cd05632	1.1e-08	428	703
STKc_GRK6	cd05630	1.9e-08	428	703
STKc_CDK1_like	cd07835	1.2e-11	428	687
STKc_CDK10	cd07845	2.4e-13	428	701
STKc_CDK2_3	cd07860	3.5e-10	428	687
STKc_CDK4	cd07863	4.6e-07	428	687
STKc_Nek8	cd08220	1.7e-09	428	687
STKc_p70S6K	cd05584	2.4e-20	429	755
STKc_Nek7	cd08229	7.8e-11	429	690
PTKc	cd00192	7.3e-10	430	682
PTKc_Ack_like	cd05040	1.3e-09	430	689
PTKc_Fes_like	cd05041	1e-08	430	643
PTKc_c-ros	cd05044	0.00014	430	689
PTKc_Syk_like	cd05060	6.8e-07	430	665
PTKc_Fer	cd05085	2.5e-07	430	687
PTKc_Fes	cd05084	1.6e-06	430	688
PTKc_Syk	cd05116	4.5e-06	430	688
STKc_CMGC	cd05118	1.3e-22	430	687
STKc_PKB	cd05571	4.5e-30	430	767
STKc_SGK	cd05575	5.6e-11	430	765
STKc_RSK_N	cd05582	6.9e-27	430	753
STKc_aPKC	cd05588	5.6e-11	430	769
STKc_nPKC_eta	cd05590	2.1e-19	430	753
STKc_nPKC_theta_delt	cd05592	1.5e-20	430	757
STKc_PKB_alpha	cd05594	4.4e-14	430	765
STKc_nPKC_epsilon	cd05591	1.1e-18	430	769
STKc_PKB_beta	cd05595	2.3e-16	430	767
STKc_PKB_gamma	cd05593	1.4e-14	430	770
STKc_SGK1	cd05602	9.4e-10	430	767
STKc_SGK2	cd05603	2.8e-12	430	773
STKc_SGK3	cd05604	1.9e-07	430	735
STKc_nPKC_delta	cd05620	2.4e-07	430	735
STKc_aPKC_zeta	cd05617	3.5e-10	430	734
STKc_aPKC_iota	cd05618	3.5e-08	430	734
STKc_nPKC_theta	cd05619	9.2e-15	430	748
STKc_MAK_like	cd07830	1.9e-16	430	687
PKc	cd00180	5.7e-81	432	685
PTKc_Tie	cd05047	0.00067	432	688
STKc_AGC	cd05123	2.7e-53	432	687
STKc_cGK_PKG	cd05572	1.4e-22	432	690
STKc_YPK1_like	cd05585	2.6e-26	432	753
STKc_Sck1_like	cd05586	1.5e-14	432	797
STKc_PKN	cd05589	6e-10	432	738
STKc_beta_ARK	cd05606	3.4e-11	432	701
STKc_GRK1	cd05608	2.3e-12	432	705
STKc_GRK3	cd05633	7.9e-09	432	702
STKc_GRK7	cd05607	3e-09	432	702
STKc_CDKL	cd07833	1.8e-12	432	687
STKc_CCRK	cd07832	1.4e-16	432	688
STKc_Nek9	cd08221	5.3e-11	432	681
STKc_CDC2L1	cd07843	5.2e-13	440	687
STKc_MAST_like	cd05579	1.8e-19	444	692
Pkinase	pfam00069	9.8e-91	49	318
Pkinase_C	pfam00433	6.2e-12	338	381
Pkinase	pfam00069	8.5e-83	426	687
COG3642	COG3642	0.001	454	617
STYKc	smart00221	1.8e-90	49	318
S_TKc	smart00220	9e-105	59	318
S_TK_X	smart00133	1.1e-16	319	379
Pkinase_Tyr	pfam07714	3.6e-13	425	687
TyrKc	smart00219	1.6e-12	426	686
STYKc	smart00221	1.9e-81	426	687
S_TKc	smart00220	1.8e-95	436	687

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040634	Polymorphism	p.ASP554ASN	N/A
Swiss-Prot	VAR_051634	Polymorphism	p.HIS190ARG	N/A
Swiss-Prot	VAR_040635	Polymorphism	p.PRO574LEU	N/A
Swiss-Prot	VAR_040636	Polymorphism	p.TYR599CYS	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258