Results for the protein: NP

Results for the Protein: NP_001244316

383792178

11200

CHEK2

NCBI

serine/threonine-protein kinase Chk2 isoform d [Homo sapiens]

Known Diseases associated with this Protein:
BREAST CANCER, SUSCEPTIBILITY TO

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1

0

0

Tips:

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RefSeq Protein: NP_001244316

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_EphR	cd05033	1.7e-05	1	246
PTKc_Src_like	cd05034	3.3e-06	1	242
PTKc_Axl_like	cd05035	0.00042	1	260
PTKc_ALK_LTK	cd05036	3.5e-09	1	247
PTKc_Jak_rpt2	cd05038	2.6e-08	1	249
PTKc_Csk_like	cd05039	0.00096	1	216
PTKc_RET	cd05045	0.00058	1	249
PTKc_Trk	cd05049	5.4e-05	1	262
PTKc_Abl	cd05052	5.6e-06	1	264
PTKc_FGFR	cd05053	0.00057	1	246
PTKc_FAK	cd05056	5.9e-07	1	269
PTKc_EGFR_like	cd05057	3e-05	1	293
PTKc_Tec_like	cd05059	2e-06	1	246
PTKc_Ror	cd05048	0.00079	1	248
PTKc_Lck_Blk	cd05067	4.3e-05	1	284
PTKc_Frk_like	cd05068	1.3e-05	1	270
PTKc_Yes	cd05069	0.00021	1	268
PTKc_Lyn	cd05072	2.9e-05	1	249
PTKc_Tyro3	cd05074	0.00052	1	264
PTKc_Tyk2_rpt2	cd05080	1.3e-05	1	279
PTKc_Hck	cd05073	1.8e-05	1	251
PTKc_Csk	cd05082	7.3e-05	1	268
PTKc_Chk	cd05083	0.00067	1	268
PTKc_Tie2	cd05088	0.00074	1	289
PTKc_Tie1	cd05089	0.00064	1	288
PTK_HER3	cd05111	0.00013	1	277
PTKc_Itk	cd05112	2.9e-06	1	264
PTKc_Btk_Bmx	cd05113	6e-06	1	264
PTKc_EGFR	cd05108	0.00013	1	315
PTKc_Tec_Rlk	cd05114	3.4e-06	1	264
PTKc_Srm_Brk	cd05148	4.5e-07	1	242
STKc_Yank1	cd05578	5.6e-32	1	265
STKc_cPKC	cd05587	1.9e-12	1	321
STKc_PKN	cd05589	2.2e-12	1	312
STKc_MSK_N	cd05583	2.4e-23	1	288
STKc_ROCK	cd05596	8.3e-08	1	321
STKc_DMPK_like	cd05597	7.5e-09	1	322
STKc_CRIK	cd05601	3.6e-11	1	322
STKc_MAST	cd05609	9e-22	1	300
STKc_MSK1_N	cd05613	1.2e-18	1	288
STKc_MSK2_N	cd05614	8.3e-16	1	310
STKc_PRKX_like	cd05612	4.9e-33	1	303
STKc_cPKC_alpha	cd05615	5.9e-09	1	318
STKc_GRK4_like	cd05605	2.4e-13	1	303
STKc_cPKC_beta	cd05616	8.6e-08	1	313
STKc_ROCK2	cd05621	5.9e-09	1	322
STKc_ROCK1	cd05622	9.5e-07	1	322
STKc_MRCK_alpha	cd05623	1.9e-08	1	321
STKc_MRCK_beta	cd05624	9.6e-08	1	322
PKc_MAPKK	cd06605	3.3e-12	1	270
STKc_MAPKKK	cd06606	2.1e-46	1	265
STKc_myosinIII_like	cd06608	1.4e-13	1	265
STKc_OSR1_SPAK	cd06610	8.2e-14	1	265
STKc_MAP4K3_like	cd06613	1.3e-14	1	264
PKc_MEK	cd06615	1e-08	1	282
PKc_MKK7	cd06618	2.4e-08	1	280
PKc_MKK5	cd06619	0.00012	1	282
PKc_MAPKK_Pek1_like	cd06621	4.4e-08	1	278
PKc_MAPKK_plant_like	cd06623	1.7e-22	1	270
STKc_ASK	cd06624	4.9e-20	1	265
STKc_Cdc7_like	cd06627	4.2e-22	1	265
STKc_MAPKKK_Byr2_lik	cd06628	1.4e-22	1	265
STKc_MEKK1_plant	cd06632	4.1e-17	1	265
STKc_MAP4K4_6	cd06636	9e-06	1	265
STKc_TNIK	cd06637	1.6e-07	1	265
STKc_myosinIIIA	cd06638	4.6e-10	1	265
STKc_myosinIIIB	cd06639	5.1e-10	1	266
STKc_STK25-YSK1	cd06642	1.5e-09	1	286
STKc_SLK	cd06643	2.2e-10	1	283
STKc_STK10_LOK	cd06644	2.6e-09	1	285
STKc_MAP4K3	cd06645	1.1e-08	1	264
STKc_MAP4K5	cd06646	5.1e-08	1	264
STKc_PAK_I	cd06647	3.3e-11	1	286
STKc_MEKK3	cd06651	4.1e-19	1	267
STKc_MEKK2	cd06652	1.2e-13	1	266
STKc_MEKK3_like_1	cd06653	3.3e-17	1	265
STKc_PAK2	cd06655	3.7e-09	1	289
STKc_PAK5	cd06658	6.2e-08	1	282
STKc_MAK_like	cd07830	2.5e-18	1	265
STKc_CCRK	cd07832	1.3e-17	1	266
STKc_CDK1_like	cd07835	1e-11	1	265
STKc_CDK5	cd07839	4.7e-10	1	265
STKc_CDK7	cd07841	1.8e-16	1	278
STKc_CDK8_like	cd07842	2.1e-12	1	265
STKc_CDKL2_3	cd07846	2.7e-10	1	265
STKc_CDKL5	cd07848	2.8e-06	1	265
STKc_p38	cd07851	2e-14	1	301
STKc_MAPK15	cd07852	3.2e-17	1	282
STKc_NLK	cd07853	3.6e-11	1	322
STKc_ERK5	cd07855	1.9e-15	1	294
STKc_MPK1	cd07857	2.7e-12	1	295
STKc_TEY_MAPK_plant	cd07858	8.4e-25	1	300
STKc_TDY_MAPK_plant	cd07859	7e-14	1	321
STKc_CDK6	cd07862	0.00028	1	265
STKc_CDK12	cd07864	5.7e-11	1	265
STKc_BUR1	cd07866	5.8e-14	1	265
STKc_PCTAIRE3	cd07871	1.2e-06	1	265
STKc_PCTAIRE2	cd07872	2.1e-05	1	288
STKc_PCTAIRE1	cd07873	2e-05	1	276
STKc_JNK1	cd07875	4.7e-08	1	294
STKc_ERK1_2_like	cd07849	1.1e-14	1	293
STKc_p38alpha_MAPK14	cd07877	1.2e-09	1	294
STKc_p38beta_MAPK11	cd07878	5.5e-09	1	300
STKc_p38delta_MAPK13	cd07879	1.5e-06	1	301
STKc_p38gamma_MAPK12	cd07880	8.7e-11	1	301
PK_STRAD	cd08216	0.00018	1	280
STKc_Nek3	cd08219	6.9e-16	1	265
STKc_Nek11	cd08222	9.9e-26	1	265
STKc_Nek4	cd08223	1.3e-23	1	265
STKc_Nek6_Nek7	cd08224	1.1e-10	1	272
STKc_Nek5	cd08225	3e-19	1	265
STKc_Nek6	cd08228	6.9e-13	1	260
STKc_Nek7	cd08229	1.1e-10	1	263
STKc_Nek10	cd08528	1.1e-13	1	264
STKc_FA2-like	cd08529	8.1e-15	1	265
SPS1	COG0515	3.9e-45	1	318
PKc_STE	cd05122	5.5e-31	2	264
STKc_RSK_N	cd05582	3.1e-17	2	321
STKc_p70S6K	cd05584	7.2e-25	2	320
STKc_MST3_like	cd06609	7.9e-15	2	286
STKc_PAK	cd06614	4.1e-21	2	278
STKc_MEKK4	cd06626	2.8e-19	2	265
STKc_CDK4_6_like	cd07838	2.9e-14	2	265
STKc_CDK9	cd07865	3e-11	2	265
PTKc	cd00192	2.2e-09	3	246
PTKc_Ack_like	cd05040	7.7e-08	3	247
PTKc_Fes_like	cd05041	1.2e-08	3	244
PTKc_c-ros	cd05044	1.6e-06	3	248
PTKc_Syk_like	cd05060	5.9e-07	3	251
PTKc_Jak1_rpt2	cd05079	0.00027	3	285
PTKc_Jak2_Jak3_rpt2	cd05081	7.1e-06	3	285
PTKc_Fer	cd05085	6.8e-05	3	265
PTKc_Fes	cd05084	1.2e-05	3	267
PTKc_HER2	cd05109	0.00074	3	258
PTKc_HER4	cd05110	0.00031	3	282
PTKc_Syk	cd05116	1.7e-08	3	265
STKc_CMGC	cd05118	3.5e-22	3	265
STKc_PKC	cd05570	1.5e-15	3	312
STKc_PKB	cd05571	2e-26	3	322
STKc_ROCK_NDR_like	cd05573	2.1e-18	3	313
STKc_phototropin_lik	cd05574	3e-17	3	273
STKc_PKA	cd05580	3.7e-25	3	312
STKc_SGK	cd05575	9.1e-11	3	322
STKc_aPKC	cd05588	2.4e-12	3	313
STKc_nPKC_eta	cd05590	1.1e-11	3	319
STKc_nPKC_theta_delt	cd05592	6.3e-15	3	320
STKc_PKB_gamma	cd05593	7.4e-12	3	310
STKc_PKB_alpha	cd05594	4.1e-13	3	320
STKc_PKB_beta	cd05595	2.6e-14	3	320
STKc_LATS	cd05598	5.7e-10	3	317
STKc_SGK1	cd05602	2e-09	3	318
STKc_SGK2	cd05603	2.8e-12	3	321
STKc_SGK3	cd05604	6.3e-11	3	322
STKc_PDK1	cd05581	2.8e-39	3	265
STKc_Rim15_like	cd05611	1.7e-10	3	267
STKc_aPKC_zeta	cd05617	2.3e-10	3	313
STKc_aPKC_iota	cd05618	3e-09	3	313
STKc_nPKC_theta	cd05619	2.6e-11	3	320
STKc_nPKC_delta	cd05620	6.5e-06	3	315
STKc_LATS1	cd05625	9.4e-07	3	317
STKc_LATS2	cd05626	3.2e-06	3	317
STKc_NDR2	cd05627	5.6e-07	3	316
STKc_NDR1	cd05628	2.4e-09	3	316
STKc_NDR_like_fungal	cd05629	4.3e-07	3	321
STKc_GRK6	cd05630	7.4e-09	3	286
STKc_GRK4	cd05631	2.1e-09	3	290
STKc_GRK5	cd05632	3.4e-10	3	286
STKc_nPKC_epsilon	cd05591	3.8e-13	3	319
STKc_NDR_like	cd05599	1e-12	3	304
STKc_TAO	cd06607	9.3e-07	3	293
PKc_MKK3_6	cd06617	4.9e-08	3	283
PKc_MAPKK_Byr1_like	cd06620	2.4e-07	3	281
PKc_MAPKK_PBS2_like	cd06622	9.8e-10	3	313
STKc_MEKK3_like	cd06625	1.2e-23	3	265
STKc_MEKK1	cd06630	1.4e-10	3	266
STKc_YSK4	cd06631	9.6e-12	3	265
STKc_TAO3	cd06633	0.00015	3	293
STKc_TAO1	cd06635	8.5e-06	3	293
STKc_MST4	cd06640	8.7e-08	3	286
STKc_MST3	cd06641	7.4e-08	3	286
STKc_PAK_II	cd06648	2.1e-13	3	278
STKc_PAK1	cd06654	4.7e-08	3	288
STKc_PAK3	cd06656	2.6e-08	3	290
STKc_TAO2	cd06634	1.7e-07	3	303
STKc_CDK_like	cd07829	4.7e-20	3	265
STKc_MOK	cd07831	2.6e-16	3	265
STKc_MAPK	cd07834	1.3e-18	3	299
STKc_Pho85	cd07836	3.9e-16	3	265
STKc_CdkB_plant	cd07837	4.6e-13	3	266
STKc_CDK9_like	cd07840	2e-17	3	265
STKc_PCTAIRE_like	cd07844	1.7e-07	3	265
STKc_CDKL1_4	cd07847	1.5e-10	3	265
STKc_JNK	cd07850	1.1e-10	3	306
STKc_MAPK4_6	cd07854	2.9e-12	3	300
STKc_Sty1_Hog1	cd07856	1.2e-11	3	296
STKc_CDK2_3	cd07860	7.8e-12	3	265
STKc_CDK1_euk	cd07861	9.4e-17	3	265
STKc_CDK4	cd07863	1.7e-08	3	265
STKc_PFTAIRE1	cd07869	0.00011	3	279
STKc_PFTAIRE2	cd07870	4.1e-07	3	265
STKc_JNK3	cd07874	8e-09	3	318
STKc_JNK2	cd07876	7.6e-09	3	292
STKc_Nek	cd08215	3.6e-41	3	265
STKc_Nek2	cd08217	6.5e-16	3	265
STKc_Nek1	cd08218	1.9e-21	3	265
STKc_Nek8	cd08220	5.6e-25	3	265
STKc_CNK2-like	cd08530	2e-14	3	265
PTKc_Zap-70	cd05115	1.6e-06	4	265
STKc_beta_ARK	cd05606	5.2e-10	4	285
STKc_GRK3	cd05633	3.6e-08	4	290
PKc_MKK4	cd06616	1.2e-07	4	278
STKc_PAK4	cd06657	1.4e-07	4	284
STKc_PAK6	cd06659	7.2e-11	4	288
STKc_NAK1_like	cd06917	4.9e-11	4	282
STKc_CDKL	cd07833	1.2e-14	4	265
STKc_CDC2L6	cd07867	1.7e-06	4	265
STKc_Nek9	cd08221	5.8e-14	4	265
PKc	cd00180	2.8e-79	5	263
STKc_AGC	cd05123	6.5e-46	5	265
STKc_cGK_PKG	cd05572	6.3e-29	5	272
STKc_GRK	cd05577	4.5e-12	5	279
STKc_MAST_like	cd05579	2.1e-23	5	270
STKc_YPK1_like	cd05585	7.2e-24	5	321
STKc_Sck1_like	cd05586	3e-13	5	322
STKc_Sid2p_Dbf2p	cd05600	5.7e-11	5	322
STKc_GRK7	cd05607	3.5e-09	5	285
STKc_GRK1	cd05608	7.7e-11	5	294
STKc_SLK_like	cd06611	2.3e-14	5	280
STKc_MST1_2	cd06612	2.9e-18	5	265
STKc_MAPKKK_Bck1_lik	cd06629	1.6e-12	6	265
STKc_CDK10	cd07845	6.8e-12	8	275
STKc_CDC2L1	cd07843	4.3e-16	10	265
STKc_CDK8	cd07868	6.1e-06	16	265
Pkinase	pfam00069	2.4e-89	2	265
Pkinase_Tyr	pfam07714	5.3e-16	1	245
TyrKc	smart00219	1.9e-13	1	265
STYKc	smart00221	5.6e-88	1	265
S_TKc	smart00220	4.9e-101	9	265
KIND	smart00750	0.00014	86	273

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	604373.0014	Disease	p.SER164PHE	BREAST CANCER, SUSCEPTIBILITY TO

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258