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Results for the Protein: NP_001245210
384871702

DNA mismatch repair protein Msh2 isoform 2 [Homo sapiens]

Known Diseases associated with this Protein:
  COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1
  COLORECTAL CANCER, HEREDITARY, NONPOLYPOSIS, TYPE 1
  MUIR-TORRE SYNDROME
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

MutS - COG0249
MutS_II - pfam05188
MutS_III - pfam05192
MUTSd - smart00533
COG1193 - COG1193
MutS_IV - pfam05190
MutS_V - pfam00488
ABC_MSH3_euk - cd03287
ABC_MSH2_euk - cd03285
ABC_MSH5_euk - cd03281
ABC_MSH6_euk - cd03286
ABC_MutS_homologs - cd03243
ABC_Class2 - cd03227
ABC_MSH4_euk - cd03282
ABC_MutS2 - cd03280
ABC_MutS1 - cd03284
ABC_MutS-like - cd03283
ABC_ATPase - cd00267
MUTSac - smart00534




Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
COG1193COG11936.9e-05288866
ABC_MSH3_eukcd032873.9e-80566778
ABC_Class2cd032271e-19567750
ABC_MutS_homologscd032431.5e-96567770
ABC_MSH4_eukcd032821.4e-61567770
ABC_MutS2cd032808e-17567770
ABC_MutS-likecd032832.4e-19567770
ABC_MutS1cd032842.5e-109567782
ABC_MSH6_eukcd032864.3e-63567778
ABC_MSH2_eukcd032858.9e-180567786
ABC_MSH5_eukcd032813.4e-48567770
ABC_ATPasecd002676.3e-07570750
MutS_IIpfam051888.4e-3377224
MutS_IVpfam051906.4e-29407503
MutS_Vpfam004881.3e-161553788
MutS_IIIpfam051923.6e-119231548
MUTSdsmart005337.9e-110257579
MUTSacsmart005343.6e-127598782

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
OMIM609309.0012 Diseasep.ALA570PROCOLORECTAL CANCER, HEREDITARY, NONPOLYPOSIS, TYPE 1
OMIM609309.0007 Diseasep.ARG458PROCOLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1
OMIM609309.0003 Diseasep.ARG340TERCOLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1
OMIM609309.0006 Diseasep.GLN535TERMUIR-TORRE SYNDROME
OMIM609309.0004 Diseasep.HIS573TYRCOLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1
OMIM609309.0001 Diseasep.PRO556LEUCOLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1



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