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Results for the Protein: NP_001005735
54112407

serine/threonine-protein kinase Chk2 isoform c [Homo sapiens]

Known Diseases associated with this Protein:
  BREAST CANCER, SUSCEPTIBILITY TO
  CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
  COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;
  LI-FRAUMENI SYNDROME 2
  OSTEOSARCOMA, SOMATIC
  PROSTATE CANCER, SOMATIC
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

FHA - cd00060
FHA - pfam00498
STKc_ROCK2 - cd05621
STKc_ROCK1 - cd05622
STKc_ROCK - cd05596
STKc_TAO1 - cd06635
STKc_PAK5 - cd06658
STKc_JNK1 - cd07875
STKc_myosinIIIA - cd06638
STKc_PAK6 - cd06659
STKc_PAK4 - cd06657
STKc_JNK2 - cd07876
STKc_TAO3 - cd06633
STKc_myosinIIIB - cd06639
STKc_p38 - cd07851
STKc_p38alpha_MAPK14 - cd07877
STKc_JNK - cd07850
STKc_p38gamma_MAPK12 - cd07880
STKc_JNK3 - cd07874
STKc_PAK - cd06614
STKc_p38beta_MAPK11 - cd07878
STKc_p38delta_MAPK13 - cd07879
STKc_TAO - cd06607
PKc_MKK7 - cd06618
STKc_MAP4K4_6 - cd06636
STKc_PAK1 - cd06654
STKc_PAK_II - cd06648
STKc_CDK9 - cd07865
STKc_TAO2 - cd06634
STKc_PAK_I - cd06647
STKc_PAK3 - cd06656
PTKc_Jak1_rpt2 - cd05079
STKc_Sty1_Hog1 - cd07856
STKc_MAP4K5 - cd06646
PTKc_EGFR_like - cd05057
STKc_MAP4K3 - cd06645
STKc_BUR1 - cd07866
STKc_MAPK15 - cd07852
STKc_CDK12 - cd07864
STKc_PFTAIRE1 - cd07869
STKc_STK10_LOK - cd06644
PTKc_Tie2 - cd05088
PTKc_ALK_LTK - cd05036
PTK_HER3 - cd05111
PTKc_EGFR - cd05108
PTKc_TrkB - cd05093
PTKc_HER2 - cd05109
PTKc_DDR2 - cd05095
STKc_CDK10 - cd07845
PTKc_TrkA - cd05092
STKc_MAPK4_6 - cd07854
STKc_SLK - cd06643
PTKc_HER4 - cd05110
PTKc_FAK - cd05056
PTKc_IGF-1R - cd05062
PTKc_InsR - cd05061
PTKc_Abl - cd05052
PTKc_Hck - cd05073
PTKc_Lck_Blk - cd05067
PTKc_Frk_like - cd05068
PTKc_Lyn - cd05072
PTKc_Src - cd05071
PTKc_Trk - cd05049
PTKc_Yes - cd05069
PTKc_Fyn_Yrk - cd05070
STKc_PFTAIRE2 - cd07870
STKc_TEY_MAPK_plant - cd07858
PTKc_Csk - cd05082
STKc_ERK5 - cd07855
PKc_MEK2 - cd06649
STKc_PCTAIRE_like - cd07844
PKc_MAPKK_Byr1_like - cd06620
STKc_ASK - cd06624
STKc_MAP4K3_like - cd06613
STKc_ERK1_2_like - cd07849
STKc_TNIK - cd06637
PTKc_Jak_rpt2 - cd05038
PTKc_InsR_like - cd05032
STKc_MST1_2 - cd06612
PTKc_EphR - cd05033
STKc_myosinIII_like - cd06608
PTKc_Tyk2_rpt2 - cd05080
STKc_MST4 - cd06640
STKc_STK25-YSK1 - cd06642
STKc_MST3 - cd06641
STKc_Nek6_Nek7 - cd08224
STKc_SLK_like - cd06611
STKc_MEKK3_like_1 - cd06653
STKc_MEKK2 - cd06652
PTKc_Btk_Bmx - cd05113
PTKc_Src_like - cd05034
PKc_MAPKK_plant_like - cd06623
PTKc_FGFR - cd05053
PTKc_Csk_like - cd05039
PTKc_Srm_Brk - cd05148
STKc_Sid2p_Dbf2p - cd05600
PKc_MKK4 - cd06616
STKc_PAK2 - cd06655
STKc_CDKL - cd07833
STKc_MEKK3_like - cd06625
PKc_MEK - cd06615
PKc_MKK3_6 - cd06617
STKc_CdkB_plant - cd07837
PKc_MKK5 - cd06619
PKc_MAPKK_Pek1_like - cd06621
PKc_MAPKK_PBS2_like - cd06622
STKc_PCTAIRE3 - cd07871
STKc_Nek7 - cd08229
STKc_Nek6 - cd08228
SPS1 - COG0515
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE1 - cd07873
STKc_CDKL1_4 - cd07847
STKc_CDKL5 - cd07848
STKc_CDK6 - cd07862
STKc_CDKL2_3 - cd07846
STKc_NAK1_like - cd06917
STKc_PKA - cd05580
STKc_PDK1 - cd05581
STKc_DMPK_like - cd05597
STKc_LATS - cd05598
STKc_ROCK_NDR_like - cd05573
PTKc_Tec_Rlk - cd05114
PTKc_Chk - cd05083
PTKc_Tie1 - cd05089
PTKc_Itk - cd05112
STKc_CRIK - cd05601
STKc_OSR1_SPAK - cd06610
STKc_NDR1 - cd05628
STKc_MAST - cd05609
PKc_MAPKK - cd06605
STKc_MST3_like - cd06609
STKc_NDR2 - cd05627
STKc_NDR_like_fungal - cd05629
STKc_LATS2 - cd05626
STKc_PRKX_like - cd05612
STKc_MRCK_alpha - cd05623
STKc_MRCK_beta - cd05624
STKc_CDK4 - cd07863
STKc_CDC2L6 - cd07867
STKc_TDY_MAPK_plant - cd07859
STKc_CDK2_3 - cd07860
STKc_CDK8 - cd07868
STKc_CDK7 - cd07841
STKc_Nek - cd08215
STKc_CDK8_like - cd07842
STKc_NLK - cd07853
STKc_MPK1 - cd07857
STKc_CDK1_euk - cd07861
STKc_Nek11 - cd08222
STKc_Nek5 - cd08225
STKc_Nek10 - cd08528
STKc_FA2-like - cd08529
STKc_CDK5 - cd07839
STKc_Nek4 - cd08223
STKc_Nek9 - cd08221
STKc_Nek1 - cd08218
STKc_Nek3 - cd08219
STKc_Nek8 - cd08220
STKc_Nek2 - cd08217
STKc_CNK2-like - cd08530
STKc_cPKC - cd05587
STKc_MSK_N - cd05583
STKc_GRK4_like - cd05605
STKc_MSK2_N - cd05614
STKc_cPKC_alpha - cd05615
STKc_Yank1 - cd05578
PKc_STE - cd05122
STKc_Pho85 - cd07836
PTKc_RET - cd05045
PTKc_Ror - cd05048
PTKc_Tec_like - cd05059
STKc_cPKC_beta - cd05616
STKc_MSK1_N - cd05613
STKc_GRK6 - cd05630
STKc_MEKK1 - cd06630
STKc_MEKK3 - cd06651
STKc_CCRK - cd07832
STKc_MAPK - cd07834
STKc_Cdc7_like - cd06627
STKc_YSK4 - cd06631
STKc_GRK4 - cd05631
STKc_MAPKKK_Byr2_lik - cd06628
STKc_GRK5 - cd05632
STKc_MAPKKK - cd06606
STKc_CDK9_like - cd07840
STKc_CDK4_6_like - cd07838
STYKc - smart00221
Pkinase - pfam00069
STKc_CDK1_like - cd07835
Pkinase_Tyr - pfam07714
TyrKc - smart00219
STKc_LATS1 - cd05625
STKc_PKN - cd05589
STKc_MOK - cd07831
PTKc_Tyro3 - cd05074
PTKc_Axl_like - cd05035
STKc_CDK_like - cd07829
STKc_CMGC - cd05118
STKc_MAK_like - cd07830
PTKc_Jak2_Jak3_rpt2 - cd05081
PK_STRAD - cd08216
STKc_MEKK1_plant - cd06632
STKc_p70S6K - cd05584
STKc_RSK_N - cd05582
STKc_MEKK4 - cd06626
STKc_SGK2 - cd05603
STKc_SGK1 - cd05602
STKc_NDR_like - cd05599
STKc_SGK3 - cd05604
STKc_nPKC_theta_delt - cd05592
STKc_aPKC_iota - cd05618
STKc_PKB_beta - cd05595
STKc_nPKC_delta - cd05620
STKc_nPKC_theta - cd05619
STKc_aPKC_zeta - cd05617
STKc_Rim15_like - cd05611
PTKc_Syk_like - cd05060
STKc_PKB_alpha - cd05594
PTKc - cd00192
PTKc_Syk - cd05116
PTKc_Ack_like - cd05040
PTKc_c-ros - cd05044
PTKc_Fes - cd05084
PTKc_Fes_like - cd05041
STKc_PKC - cd05570
PTKc_Fer - cd05085
STKc_aPKC - cd05588
STKc_nPKC_eta - cd05590
STKc_nPKC_epsilon - cd05591
STKc_PKB_gamma - cd05593
STKc_SGK - cd05575
STKc_phototropin_lik - cd05574
STKc_PKB - cd05571
PTKc_Zap-70 - cd05115
STKc_beta_ARK - cd05606
STKc_GRK3 - cd05633
STKc_GRK1 - cd05608
STKc_GRK7 - cd05607
STKc_AGC - cd05123
STKc_GRK - cd05577
STKc_cGK_PKG - cd05572
PKc - cd00180
STKc_Sck1_like - cd05586
STKc_MAST_like - cd05579
STKc_YPK1_like - cd05585
STKc_MAPKKK_Bck1_lik - cd06629
S_TKc - smart00220
STKc_CDC2L1 - cd07843
KIND - smart00750




Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
FHAcd000604.5e-14133246
STKc_ROCK2cd056214.4e-11215586
STKc_ROCK1cd056226.2e-09215586
STKc_ROCKcd055961.1e-09224585
STKc_TAO1cd066356.6e-07228557
STKc_PAK5cd066587.9e-11235546
STKc_myosinIIIAcd066384.3e-11236529
STKc_PAK6cd066592.5e-15236552
STKc_JNK1cd078751.8e-09236558
STKc_PAK4cd066575.3e-10237548
STKc_JNK2cd078762.6e-10238556
STKc_TAO3cd066331.4e-05240557
STKc_myosinIIIBcd066392.6e-11241530
STKc_p38cd078511.2e-15242565
STKc_p38alpha_MAPK14cd078772e-10242558
STKc_JNKcd078507.1e-12243570
STKc_PAKcd066149.8e-23244542
STKc_JNK3cd078744.6e-10244582
STKc_p38gamma_MAPK12cd078802.2e-12244565
STKc_p38beta_MAPK11cd078781.2e-09245564
STKc_p38delta_MAPK13cd078792.9e-09245565
STKc_TAOcd066072.9e-07246557
PKc_MKK7cd066181.3e-09246544
STKc_MAP4K4_6cd066369.8e-07248529
STKc_PAK_IIcd066482.9e-14250542
STKc_PAK1cd066543.7e-09250552
STKc_TAO2cd066341.7e-08251567
STKc_PAK_Icd066471.9e-16251550
STKc_PAK3cd066562.1e-09251554
STKc_CDK9cd078651.7e-12251529
PTKc_Jak1_rpt2cd050790.00021252549
PTKc_EGFR_likecd050577.9e-06253557
STKc_MAP4K3cd066452.4e-09253528
STKc_MAP4K5cd066464.3e-09253528
STKc_Sty1_Hog1cd078562.8e-12253560
STKc_MAPK15cd078521.2e-17254546
STKc_BUR1cd078661.7e-14254529
PTKc_Tie2cd050888.4e-05255553
STKc_STK10_LOKcd066444.1e-11255549
STKc_CDK12cd078645.7e-12255529
STKc_PFTAIRE1cd078692.2e-05255543
PTKc_ALK_LTKcd050365.2e-10256511
PTK_HER3cd051112.5e-05256541
PTKc_Trkcd050491.1e-05257526
PTKc_Ablcd050527.4e-07257528
PTKc_InsRcd050610.00028257543
PTKc_IGF-1Rcd050620.00097257531
PTKc_Lck_Blkcd050671.1e-05257548
PTKc_Frk_likecd050683e-06257534
PTKc_Yescd050696.1e-05257532
PTKc_Fyn_Yrkcd050700.0004257532
PTKc_Srccd050710.00052257534
PTKc_Lyncd050727.2e-06257513
PTKc_Hckcd050734.9e-06257515
PTKc_TrkAcd050920.00053257520
PTKc_TrkBcd050930.0003257540
PTKc_DDR2cd050950.00066257547
PTKc_FAKcd050561.2e-07257533
PTKc_EGFRcd051082.5e-05257579
PTKc_HER2cd051090.00019257522
PTKc_HER4cd051100.00011257546
STKc_SLKcd066439.7e-11257547
STKc_CDK10cd078455.2e-12257539
STKc_MAPK4_6cd078541.6e-12257564
PTKc_Cskcd050822e-05258532
PKc_MEK2cd066490.00036258583
STKc_PCTAIRE_likecd078442.4e-08258529
STKc_ERK5cd078552.4e-16258558
STKc_TEY_MAPK_plantcd078587.2e-29258564
STKc_PFTAIRE2cd078708.7e-08258529
PTKc_InsR_likecd050322.7e-05259531
PTKc_Jak_rpt2cd050388.8e-09259513
PTKc_EphRcd050331e-05259510
PTKc_Tyk2_rpt2cd050801.1e-05259543
STKc_myosinIII_likecd066085.6e-14259529
STKc_MST1_2cd066129.6e-19259529
STKc_MAP4K3_likecd066131.5e-15259528
PKc_MAPKK_Byr1_likecd066201.7e-07259545
STKc_ASKcd066249.5e-24259529
STKc_TNIKcd066375.2e-08259529
STKc_ERK1_2_likecd078492.1e-15259557
PTKc_Src_likecd050348.5e-07260506
PTKc_Csk_likecd050390.0008260480
PTKc_FGFRcd050530.00019260510
PTKc_Btk_Bmxcd051131.4e-06260528
PTKc_Srm_Brkcd051489e-08260506
STKc_Sid2p_Dbf2pcd056004.2e-11260586
PKc_MKK4cd066167.3e-08260542
PKc_MAPKK_plant_likecd066232.1e-24260534
STKc_SLK_likecd066112.1e-14260544
STKc_MST4cd066404.2e-08260550
STKc_STK25-YSK1cd066426.4e-10260550
STKc_MST3cd066413.5e-08260550
STKc_MEKK2cd066521.7e-14260530
STKc_MEKK3_like_1cd066532.9e-18260529
STKc_Nek6_Nek7cd082243.2e-11260536
PTKc_Chkcd050830.00036261532
PTKc_Tie1cd050890.00037261552
PTKc_Itkcd051126.5e-07261528
PTKc_Tec_Rlkcd051141.2e-06261528
STKc_ROCK_NDR_likecd055735.7e-19261577
STKc_PKAcd055809.6e-29261576
STKc_PDK1cd055812.4e-43261529
STKc_DMPK_likecd055972.5e-09261586
STKc_LATScd055984e-10261581
STKc_CRIKcd056011.8e-11261586
STKc_MASTcd056091e-23261564
STKc_PRKX_likecd056121.1e-35261567
STKc_MRCK_alphacd056238.6e-09261585
STKc_MRCK_betacd056243.3e-08261586
STKc_LATS2cd056261.8e-06261581
STKc_NDR2cd056272.3e-07261580
STKc_NDR1cd056281.2e-09261580
STKc_NDR_like_fungalcd056291.2e-07261585
PKc_MAPKKcd066051.6e-12261534
STKc_MST3_likecd066091.8e-15261550
STKc_OSR1_SPAKcd066101.8e-14261529
PKc_MEKcd066153.6e-09261546
PKc_MKK3_6cd066171.6e-08261547
PKc_MKK5cd066197e-05261546
PKc_MAPKK_Pek1_likecd066211e-08261542
PKc_MAPKK_PBS2_likecd066221.7e-10261577
STKc_MEKK3_likecd066251.1e-23261529
STKc_PAK2cd066555.2e-10261553
STKc_NAK1_likecd069173.8e-11261546
STKc_CDKLcd078336.7e-15261529
STKc_CdkB_plantcd078376.9e-14261530
STKc_CDKL2_3cd078469.4e-11261529
STKc_CDKL1_4cd078473.2e-13261529
STKc_CDKL5cd078481.6e-06261529
STKc_CDK6cd078620.00011261529
STKc_PCTAIRE3cd078714.1e-07261529
STKc_PCTAIRE1cd078734.6e-06261540
STKc_PCTAIRE2cd078726.2e-06261552
STKc_Nek7cd082295.4e-11261527
STKc_Nek6cd082281.5e-14261524
SPS1COG05155e-50261582
PTKc_RETcd050450.00039262513
PTKc_Rorcd050480.00043262512
PTKc_Tec_likecd050591.3e-06262510
PKc_STEcd051224.6e-33262528
STKc_Yank1cd055788.8e-35262529
STKc_MSK_Ncd055831.2e-24262552
STKc_cPKCcd055878.7e-14262585
STKc_GRK4_likecd056054.1e-14262567
STKc_MSK1_Ncd056131.2e-19262552
STKc_MSK2_Ncd056144.3e-17262574
STKc_cPKC_alphacd056153e-09262582
STKc_cPKC_betacd056165e-08262577
STKc_GRK6cd056305.2e-09262550
STKc_GRK4cd056311.5e-09262554
STKc_GRK5cd056322.3e-10262550
STKc_MAPKKKcd066062.7e-50262529
STKc_MAPKKK_Byr2_likcd066288e-25262529
STKc_Cdc7_likecd066275.7e-23262529
STKc_MEKK1cd066301.2e-10262530
STKc_YSK4cd066315.4e-12262529
STKc_MEKK3cd066516.1e-20262531
STKc_CCRKcd078323.4e-18262530
STKc_MAPKcd078344.8e-19262563
STKc_Pho85cd078362.7e-18262529
STKc_CDK5cd078392.9e-10262529
STKc_CDK7cd078412.6e-17262542
STKc_CDK8_likecd078421e-12262529
STKc_NLKcd078532.1e-11262586
STKc_MPK1cd078571e-12262559
STKc_CDK1_eukcd078612.7e-19262529
STKc_CDK4cd078636.8e-09262529
STKc_CDC2L6cd078676.8e-07262529
STKc_CDK8cd078682.8e-06262529
STKc_CDK2_3cd078607.7e-13262529
STKc_TDY_MAPK_plantcd078596.8e-16262585
STKc_Nekcd082157.9e-43262529
STKc_Nek2cd082173.1e-16262529
STKc_Nek1cd082187.8e-24262529
STKc_Nek3cd082192.4e-18262529
STKc_Nek8cd082201e-26262529
STKc_Nek9cd082211.7e-14262529
STKc_Nek11cd082221.2e-28262529
STKc_Nek4cd082236.7e-27262529
STKc_Nek5cd082254.2e-21262529
STKc_Nek10cd085282.3e-16262528
STKc_FA2-likecd085291.2e-15262529
STKc_CNK2-likecd085308.8e-15262529
PTKc_Axl_likecd050350.00028263524
PTKc_Tyro3cd050740.00034263528
STKc_CMGCcd051182.2e-23263529
STKc_PKNcd055893.7e-13263576
STKc_LATS1cd056255.9e-07263581
STKc_CDK_likecd078298.1e-21263529
STKc_MAK_likecd078307.3e-19263529
STKc_MOKcd078311.4e-16263529
STKc_CDK1_likecd078352.7e-13263529
STKc_CDK4_6_likecd078389.2e-15263529
STKc_CDK9_likecd078409.8e-18263529
PTKc_Jak2_Jak3_rpt2cd050816.2e-06264549
PK_STRADcd082160.0001264544
STKc_MEKK1_plantcd066324.1e-17265529
STKc_RSK_Ncd055823.1e-17266585
STKc_p70S6Kcd055847.2e-25266584
STKc_MEKK4cd066262.8e-19266529
PTKccd001922.2e-09267510
PTKc_Ack_likecd050407.7e-08267511
PTKc_c-roscd050441.6e-06267512
PTKc_Fes_likecd050411.2e-08267508
PTKc_Syk_likecd050605.9e-07267515
PTKc_Fescd050841.2e-05267531
PTKc_Fercd050856.8e-05267529
PTKc_Sykcd051161.7e-08267529
STKc_PKCcd055701.5e-15267576
STKc_PKBcd055712e-26267586
STKc_phototropin_likcd055743e-17267537
STKc_SGKcd055759.1e-11267586
STKc_aPKCcd055882.4e-12267577
STKc_nPKC_etacd055901.1e-11267583
STKc_nPKC_epsiloncd055913.8e-13267583
STKc_PKB_gammacd055937.4e-12267574
STKc_PKB_alphacd055944.1e-13267584
STKc_PKB_betacd055952.6e-14267584
STKc_nPKC_theta_deltcd055926.3e-15267584
STKc_NDR_likecd055991e-12267568
STKc_SGK1cd056022e-09267582
STKc_SGK2cd056032.8e-12267585
STKc_SGK3cd056046.3e-11267586
STKc_Rim15_likecd056111.7e-10267531
STKc_aPKC_zetacd056172.3e-10267577
STKc_nPKC_thetacd056192.6e-11267584
STKc_nPKC_deltacd056206.5e-06267579
STKc_aPKC_iotacd056183e-09267577
PTKc_Zap-70cd051151.6e-06268529
STKc_beta_ARKcd056065.2e-10268549
STKc_GRK3cd056333.6e-08268554
PKccd001802.8e-79269527
STKc_AGCcd051236.5e-46269529
STKc_cGK_PKGcd055726.3e-29269536
STKc_GRKcd055774.5e-12269543
STKc_MAST_likecd055792.1e-23269534
STKc_YPK1_likecd055857.2e-24269585
STKc_Sck1_likecd055863e-13269586
STKc_GRK7cd056073.5e-09269549
STKc_GRK1cd056087.7e-11269558
STKc_MAPKKK_Bck1_likcd066291.6e-12270529
STKc_CDC2L1cd078434.3e-16274529
FHApfam004983.8e-15156235
Pkinasepfam000693.4e-92263529
Pkinase_Tyrpfam077141.9e-16263509
TyrKcsmart002196.3e-14263529
STYKcsmart002213.3e-92263529
S_TKcsmart002204.9e-101273529
KINDsmart007500.00014350537

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
OMIM604373.0006 Diseasep.ALA17SEROSTEOSARCOMA, SOMATIC
OMIM604373.0008 Diseasep.ARG181CYSPROSTATE CANCER, SOMATIC
OMIM604373.0007 Diseasep.ARG180HISPROSTATE CANCER, SOMATIC
OMIM604373.0009 Diseasep.ARG181HISPROSTATE CANCER, SOMATIC
OMIM604373.0003 Diseasep.ARG145TRPLI-FRAUMENI SYNDROME 2
OMIM604373.0011 Diseasep.GLU239LYSPROSTATE CANCER, SOMATIC
OMIM604373.0010 Diseasep.GLU239TERPROSTATE CANCER, SOMATIC
OMIM604373.0002 Diseasep.ILE157THRLI-FRAUMENI SYNDROME 2||COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;||CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
OMIM604373.0005 Diseasep.PRO85LEUOSTEOSARCOMA, SOMATIC
OMIM604373.0014 Diseasep.SER428PHEBREAST CANCER, SUSCEPTIBILITY TO



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