Results for the protein: NP

Results for the Protein: NP_001005735

54112407

11200

CHEK2

NCBI

serine/threonine-protein kinase Chk2 isoform c [Homo sapiens]

Known Diseases associated with this Protein:
  BREAST CANCER, SUSCEPTIBILITY TO
  CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
  COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;
  LI-FRAUMENI SYNDROME 2
  OSTEOSARCOMA, SOMATIC
  PROSTATE CANCER, SOMATIC

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Tips:

The Domains on the Default View are decided by the Domain's E-Value.

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To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

RefSeq Protein: NP_001005735

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621	4.4e-11	215	586
STKc_ROCK1	cd05622	6.2e-09	215	586
STKc_ROCK	cd05596	1.1e-09	224	585
STKc_TAO1	cd06635	6.6e-07	228	557
STKc_PAK5	cd06658	7.9e-11	235	546
STKc_myosinIIIA	cd06638	4.3e-11	236	529
STKc_PAK6	cd06659	2.5e-15	236	552
STKc_JNK1	cd07875	1.8e-09	236	558
STKc_PAK4	cd06657	5.3e-10	237	548
STKc_JNK2	cd07876	2.6e-10	238	556
STKc_TAO3	cd06633	1.4e-05	240	557
STKc_myosinIIIB	cd06639	2.6e-11	241	530
STKc_p38	cd07851	1.2e-15	242	565
STKc_p38alpha_MAPK14	cd07877	2e-10	242	558
STKc_JNK	cd07850	7.1e-12	243	570
STKc_PAK	cd06614	9.8e-23	244	542
STKc_JNK3	cd07874	4.6e-10	244	582
STKc_p38gamma_MAPK12	cd07880	2.2e-12	244	565
STKc_p38beta_MAPK11	cd07878	1.2e-09	245	564
STKc_p38delta_MAPK13	cd07879	2.9e-09	245	565
STKc_TAO	cd06607	2.9e-07	246	557
PKc_MKK7	cd06618	1.3e-09	246	544
STKc_MAP4K4_6	cd06636	9.8e-07	248	529
STKc_PAK_II	cd06648	2.9e-14	250	542
STKc_PAK1	cd06654	3.7e-09	250	552
STKc_TAO2	cd06634	1.7e-08	251	567
STKc_PAK_I	cd06647	1.9e-16	251	550
STKc_PAK3	cd06656	2.1e-09	251	554
STKc_CDK9	cd07865	1.7e-12	251	529
PTKc_Jak1_rpt2	cd05079	0.00021	252	549
PTKc_EGFR_like	cd05057	7.9e-06	253	557
STKc_MAP4K3	cd06645	2.4e-09	253	528
STKc_MAP4K5	cd06646	4.3e-09	253	528
STKc_Sty1_Hog1	cd07856	2.8e-12	253	560
STKc_MAPK15	cd07852	1.2e-17	254	546
STKc_BUR1	cd07866	1.7e-14	254	529
PTKc_Tie2	cd05088	8.4e-05	255	553
STKc_STK10_LOK	cd06644	4.1e-11	255	549
STKc_CDK12	cd07864	5.7e-12	255	529
STKc_PFTAIRE1	cd07869	2.2e-05	255	543
PTKc_ALK_LTK	cd05036	5.2e-10	256	511
PTK_HER3	cd05111	2.5e-05	256	541
PTKc_Trk	cd05049	1.1e-05	257	526
PTKc_Abl	cd05052	7.4e-07	257	528
PTKc_InsR	cd05061	0.00028	257	543
PTKc_IGF-1R	cd05062	0.00097	257	531
PTKc_Lck_Blk	cd05067	1.1e-05	257	548
PTKc_Frk_like	cd05068	3e-06	257	534
PTKc_Yes	cd05069	6.1e-05	257	532
PTKc_Fyn_Yrk	cd05070	0.0004	257	532
PTKc_Src	cd05071	0.00052	257	534
PTKc_Lyn	cd05072	7.2e-06	257	513
PTKc_Hck	cd05073	4.9e-06	257	515
PTKc_TrkA	cd05092	0.00053	257	520
PTKc_TrkB	cd05093	0.0003	257	540
PTKc_DDR2	cd05095	0.00066	257	547
PTKc_FAK	cd05056	1.2e-07	257	533
PTKc_EGFR	cd05108	2.5e-05	257	579
PTKc_HER2	cd05109	0.00019	257	522
PTKc_HER4	cd05110	0.00011	257	546
STKc_SLK	cd06643	9.7e-11	257	547
STKc_CDK10	cd07845	5.2e-12	257	539
STKc_MAPK4_6	cd07854	1.6e-12	257	564
PTKc_Csk	cd05082	2e-05	258	532
PKc_MEK2	cd06649	0.00036	258	583
STKc_PCTAIRE_like	cd07844	2.4e-08	258	529
STKc_ERK5	cd07855	2.4e-16	258	558
STKc_TEY_MAPK_plant	cd07858	7.2e-29	258	564
STKc_PFTAIRE2	cd07870	8.7e-08	258	529
PTKc_InsR_like	cd05032	2.7e-05	259	531
PTKc_Jak_rpt2	cd05038	8.8e-09	259	513
PTKc_EphR	cd05033	1e-05	259	510
PTKc_Tyk2_rpt2	cd05080	1.1e-05	259	543
STKc_myosinIII_like	cd06608	5.6e-14	259	529
STKc_MST1_2	cd06612	9.6e-19	259	529
STKc_MAP4K3_like	cd06613	1.5e-15	259	528
PKc_MAPKK_Byr1_like	cd06620	1.7e-07	259	545
STKc_ASK	cd06624	9.5e-24	259	529
STKc_TNIK	cd06637	5.2e-08	259	529
STKc_ERK1_2_like	cd07849	2.1e-15	259	557
PTKc_Src_like	cd05034	8.5e-07	260	506
PTKc_Csk_like	cd05039	0.0008	260	480
PTKc_FGFR	cd05053	0.00019	260	510
PTKc_Btk_Bmx	cd05113	1.4e-06	260	528
PTKc_Srm_Brk	cd05148	9e-08	260	506
STKc_Sid2p_Dbf2p	cd05600	4.2e-11	260	586
PKc_MKK4	cd06616	7.3e-08	260	542
PKc_MAPKK_plant_like	cd06623	2.1e-24	260	534
STKc_SLK_like	cd06611	2.1e-14	260	544
STKc_MST4	cd06640	4.2e-08	260	550
STKc_STK25-YSK1	cd06642	6.4e-10	260	550
STKc_MST3	cd06641	3.5e-08	260	550
STKc_MEKK2	cd06652	1.7e-14	260	530
STKc_MEKK3_like_1	cd06653	2.9e-18	260	529
STKc_Nek6_Nek7	cd08224	3.2e-11	260	536
PTKc_Chk	cd05083	0.00036	261	532
PTKc_Tie1	cd05089	0.00037	261	552
PTKc_Itk	cd05112	6.5e-07	261	528
PTKc_Tec_Rlk	cd05114	1.2e-06	261	528
STKc_ROCK_NDR_like	cd05573	5.7e-19	261	577
STKc_PKA	cd05580	9.6e-29	261	576
STKc_PDK1	cd05581	2.4e-43	261	529
STKc_DMPK_like	cd05597	2.5e-09	261	586
STKc_LATS	cd05598	4e-10	261	581
STKc_CRIK	cd05601	1.8e-11	261	586
STKc_MAST	cd05609	1e-23	261	564
STKc_PRKX_like	cd05612	1.1e-35	261	567
STKc_MRCK_alpha	cd05623	8.6e-09	261	585
STKc_MRCK_beta	cd05624	3.3e-08	261	586
STKc_LATS2	cd05626	1.8e-06	261	581
STKc_NDR2	cd05627	2.3e-07	261	580
STKc_NDR1	cd05628	1.2e-09	261	580
STKc_NDR_like_fungal	cd05629	1.2e-07	261	585
PKc_MAPKK	cd06605	1.6e-12	261	534
STKc_MST3_like	cd06609	1.8e-15	261	550
STKc_OSR1_SPAK	cd06610	1.8e-14	261	529
PKc_MEK	cd06615	3.6e-09	261	546
PKc_MKK3_6	cd06617	1.6e-08	261	547
PKc_MKK5	cd06619	7e-05	261	546
PKc_MAPKK_Pek1_like	cd06621	1e-08	261	542
PKc_MAPKK_PBS2_like	cd06622	1.7e-10	261	577
STKc_MEKK3_like	cd06625	1.1e-23	261	529
STKc_PAK2	cd06655	5.2e-10	261	553
STKc_NAK1_like	cd06917	3.8e-11	261	546
STKc_CDKL	cd07833	6.7e-15	261	529
STKc_CdkB_plant	cd07837	6.9e-14	261	530
STKc_CDKL2_3	cd07846	9.4e-11	261	529
STKc_CDKL1_4	cd07847	3.2e-13	261	529
STKc_CDKL5	cd07848	1.6e-06	261	529
STKc_CDK6	cd07862	0.00011	261	529
STKc_PCTAIRE3	cd07871	4.1e-07	261	529
STKc_PCTAIRE1	cd07873	4.6e-06	261	540
STKc_PCTAIRE2	cd07872	6.2e-06	261	552
STKc_Nek7	cd08229	5.4e-11	261	527
STKc_Nek6	cd08228	1.5e-14	261	524
SPS1	COG0515	5e-50	261	582
PTKc_RET	cd05045	0.00039	262	513
PTKc_Ror	cd05048	0.00043	262	512
PTKc_Tec_like	cd05059	1.3e-06	262	510
PKc_STE	cd05122	4.6e-33	262	528
STKc_Yank1	cd05578	8.8e-35	262	529
STKc_MSK_N	cd05583	1.2e-24	262	552
STKc_cPKC	cd05587	8.7e-14	262	585
STKc_GRK4_like	cd05605	4.1e-14	262	567
STKc_MSK1_N	cd05613	1.2e-19	262	552
STKc_MSK2_N	cd05614	4.3e-17	262	574
STKc_cPKC_alpha	cd05615	3e-09	262	582
STKc_cPKC_beta	cd05616	5e-08	262	577
STKc_GRK6	cd05630	5.2e-09	262	550
STKc_GRK4	cd05631	1.5e-09	262	554
STKc_GRK5	cd05632	2.3e-10	262	550
STKc_MAPKKK	cd06606	2.7e-50	262	529
STKc_MAPKKK_Byr2_lik	cd06628	8e-25	262	529
STKc_Cdc7_like	cd06627	5.7e-23	262	529
STKc_MEKK1	cd06630	1.2e-10	262	530
STKc_YSK4	cd06631	5.4e-12	262	529
STKc_MEKK3	cd06651	6.1e-20	262	531
STKc_CCRK	cd07832	3.4e-18	262	530
STKc_MAPK	cd07834	4.8e-19	262	563
STKc_Pho85	cd07836	2.7e-18	262	529
STKc_CDK5	cd07839	2.9e-10	262	529
STKc_CDK7	cd07841	2.6e-17	262	542
STKc_CDK8_like	cd07842	1e-12	262	529
STKc_NLK	cd07853	2.1e-11	262	586
STKc_MPK1	cd07857	1e-12	262	559
STKc_CDK1_euk	cd07861	2.7e-19	262	529
STKc_CDK4	cd07863	6.8e-09	262	529
STKc_CDC2L6	cd07867	6.8e-07	262	529
STKc_CDK8	cd07868	2.8e-06	262	529
STKc_CDK2_3	cd07860	7.7e-13	262	529
STKc_TDY_MAPK_plant	cd07859	6.8e-16	262	585
STKc_Nek	cd08215	7.9e-43	262	529
STKc_Nek2	cd08217	3.1e-16	262	529
STKc_Nek1	cd08218	7.8e-24	262	529
STKc_Nek3	cd08219	2.4e-18	262	529
STKc_Nek8	cd08220	1e-26	262	529
STKc_Nek9	cd08221	1.7e-14	262	529
STKc_Nek11	cd08222	1.2e-28	262	529
STKc_Nek4	cd08223	6.7e-27	262	529
STKc_Nek5	cd08225	4.2e-21	262	529
STKc_Nek10	cd08528	2.3e-16	262	528
STKc_FA2-like	cd08529	1.2e-15	262	529
STKc_CNK2-like	cd08530	8.8e-15	262	529
PTKc_Axl_like	cd05035	0.00028	263	524
PTKc_Tyro3	cd05074	0.00034	263	528
STKc_CMGC	cd05118	2.2e-23	263	529
STKc_PKN	cd05589	3.7e-13	263	576
STKc_LATS1	cd05625	5.9e-07	263	581
STKc_CDK_like	cd07829	8.1e-21	263	529
STKc_MAK_like	cd07830	7.3e-19	263	529
STKc_MOK	cd07831	1.4e-16	263	529
STKc_CDK1_like	cd07835	2.7e-13	263	529
STKc_CDK4_6_like	cd07838	9.2e-15	263	529
STKc_CDK9_like	cd07840	9.8e-18	263	529
PTKc_Jak2_Jak3_rpt2	cd05081	6.2e-06	264	549
PK_STRAD	cd08216	0.0001	264	544
STKc_MEKK1_plant	cd06632	4.1e-17	265	529
STKc_RSK_N	cd05582	3.1e-17	266	585
STKc_p70S6K	cd05584	7.2e-25	266	584
STKc_MEKK4	cd06626	2.8e-19	266	529
PTKc	cd00192	2.2e-09	267	510
PTKc_Ack_like	cd05040	7.7e-08	267	511
PTKc_c-ros	cd05044	1.6e-06	267	512
PTKc_Fes_like	cd05041	1.2e-08	267	508
PTKc_Syk_like	cd05060	5.9e-07	267	515
PTKc_Fes	cd05084	1.2e-05	267	531
PTKc_Fer	cd05085	6.8e-05	267	529
PTKc_Syk	cd05116	1.7e-08	267	529
STKc_PKC	cd05570	1.5e-15	267	576
STKc_PKB	cd05571	2e-26	267	586
STKc_phototropin_lik	cd05574	3e-17	267	537
STKc_SGK	cd05575	9.1e-11	267	586
STKc_aPKC	cd05588	2.4e-12	267	577
STKc_nPKC_eta	cd05590	1.1e-11	267	583
STKc_nPKC_epsilon	cd05591	3.8e-13	267	583
STKc_PKB_gamma	cd05593	7.4e-12	267	574
STKc_PKB_alpha	cd05594	4.1e-13	267	584
STKc_PKB_beta	cd05595	2.6e-14	267	584
STKc_nPKC_theta_delt	cd05592	6.3e-15	267	584
STKc_NDR_like	cd05599	1e-12	267	568
STKc_SGK1	cd05602	2e-09	267	582
STKc_SGK2	cd05603	2.8e-12	267	585
STKc_SGK3	cd05604	6.3e-11	267	586
STKc_Rim15_like	cd05611	1.7e-10	267	531
STKc_aPKC_zeta	cd05617	2.3e-10	267	577
STKc_nPKC_theta	cd05619	2.6e-11	267	584
STKc_nPKC_delta	cd05620	6.5e-06	267	579
STKc_aPKC_iota	cd05618	3e-09	267	577
PTKc_Zap-70	cd05115	1.6e-06	268	529
STKc_beta_ARK	cd05606	5.2e-10	268	549
STKc_GRK3	cd05633	3.6e-08	268	554
PKc	cd00180	2.8e-79	269	527
STKc_AGC	cd05123	6.5e-46	269	529
STKc_cGK_PKG	cd05572	6.3e-29	269	536
STKc_GRK	cd05577	4.5e-12	269	543
STKc_MAST_like	cd05579	2.1e-23	269	534
STKc_YPK1_like	cd05585	7.2e-24	269	585
STKc_Sck1_like	cd05586	3e-13	269	586
STKc_GRK7	cd05607	3.5e-09	269	549
STKc_GRK1	cd05608	7.7e-11	269	558
STKc_MAPKKK_Bck1_lik	cd06629	1.6e-12	270	529
STKc_CDC2L1	cd07843	4.3e-16	274	529
FHA	pfam00498	3.8e-15	156	235
Pkinase	pfam00069	3.4e-92	263	529
Pkinase_Tyr	pfam07714	1.9e-16	263	509
TyrKc	smart00219	6.3e-14	263	529
STYKc	smart00221	3.3e-92	263	529
S_TKc	smart00220	4.9e-101	273	529
KIND	smart00750	0.00014	350	537

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	604373.0006	Disease	p.ALA17SER	OSTEOSARCOMA, SOMATIC
OMIM	604373.0008	Disease	p.ARG181CYS	PROSTATE CANCER, SOMATIC
OMIM	604373.0007	Disease	p.ARG180HIS	PROSTATE CANCER, SOMATIC
OMIM	604373.0009	Disease	p.ARG181HIS	PROSTATE CANCER, SOMATIC
OMIM	604373.0003	Disease	p.ARG145TRP	LI-FRAUMENI SYNDROME 2
OMIM	604373.0011	Disease	p.GLU239LYS	PROSTATE CANCER, SOMATIC
OMIM	604373.0010	Disease	p.GLU239TER	PROSTATE CANCER, SOMATIC
OMIM	604373.0002	Disease	p.ILE157THR	LI-FRAUMENI SYNDROME 2\|\|COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;\|\|CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
OMIM	604373.0005	Disease	p.PRO85LEU	OSTEOSARCOMA, SOMATIC
OMIM	604373.0014	Disease	p.SER428PHE	BREAST CANCER, SUSCEPTIBILITY TO

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258