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Results for the Protein: NP_001005862
54792098

receptor tyrosine-protein kinase erbB-2 isoform b [Homo sapiens]

Known Diseases associated with this Protein:
  ADENOCARCINOMA OF LUNG, SOMATIC
  GASTRIC CANCER, SOMATIC
  GLIOBLASTOMA, SOMATIC
  OVARIAN CANCER, SOMATIC
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

Recep_L_domain - pfam01030
Furin-like - pfam00757
FU - smart00261
FU - cd00064
PTKc_PDGFR_beta - cd05107
PTKc_Kit - cd05104
PTKc_VEGFR - cd05054
PTKc_VEGFR3 - cd05102
PTKc_VEGFR2 - cd05103
PTKc_CSF-1R - cd05106
PTKc_PDGFR_alpha - cd05105
STKc_PAK1 - cd06654
STKc_PAK_I - cd06647
STKc_PAK2 - cd06655
STKc_PAK3 - cd06656
PTKc_FGFR1 - cd05098
STKc_myosinIIIB - cd06639
PKc_MKK7 - cd06618
PTKc_FGFR2 - cd05101
PTK_Tyk2_rpt1 - cd05076
PTKc_FGFR3 - cd05100
PTKc_FGFR4 - cd05099
STKc_myosinIIIA - cd06638
STKc_p38 - cd07851
STKc_TAO - cd06607
STKc_PAK - cd06614
STKc_PAK_II - cd06648
PTKc_DDR - cd05051
STKc_STK10_LOK - cd06644
PTKc_PDGFR - cd05055
STKc_CDK10 - cd07845
STKc_MAP4K3 - cd06645
STKc_MAP4K5 - cd06646
STKc_Sty1_Hog1 - cd07856
STKc_ASK - cd06624
PTKc_FAK - cd05056
PTK_Ryk - cd05043
PTKc_Lck_Blk - cd05067
PTKc_EGFR_like - cd05057
PTK_HER3 - cd05111
PTKc_Tie2 - cd05088
PTKc_Lyn - cd05072
PTKc_Hck - cd05073
PTKc_HER4 - cd05110
PTKc_Fyn_Yrk - cd05070
PTKc_HER2 - cd05109
PTKc_EGFR - cd05108
PTKc_Yes - cd05069
PTKc_Src - cd05071
STKc_MAP4K4_6 - cd06636
PTKc_ALK_LTK - cd05036
PTKc_Ror - cd05048
STKc_SLK - cd06643
PTKc_Csk - cd05082
PTKc_Chk - cd05083
PTK_CCK4 - cd05046
PTKc_Trk - cd05049
PTKc_Csk_like - cd05039
PTKc_Src_like - cd05034
PTKc_InsR_like - cd05032
PTKc_Btk_Bmx - cd05113
PTKc_Itk - cd05112
PTKc_TrkC - cd05094
PTKc_DDR_like - cd05097
PTKc_Tec_Rlk - cd05114
PKc_MEK2 - cd06649
PTKc_DDR1 - cd05096
STKc_TNIK - cd06637
PKc_MAPKK_Byr1_like - cd06620
PKc_MKK4 - cd06616
STKc_myosinIII_like - cd06608
PKc_MEK1 - cd06650
PTKc_Tec_like - cd05059
PTKc_EphR_A2 - cd05063
PTKc_EphR - cd05033
PTKc_FGFR - cd05053
PTKc_Abl - cd05052
PTKc_Musk - cd05050
PTKc_DDR2 - cd05095
PTKc_EphR_A10 - cd05064
PTKc_EphR_B - cd05065
PTKc_Ror1 - cd05090
PTKc_TrkB - cd05093
PTKc_TrkA - cd05092
PTKc_EphR_A - cd05066
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Frk_like - cd05068
PTKc_Jak1_rpt2 - cd05079
PTKc_Jak_rpt2 - cd05038
STKc_OSR1_SPAK - cd06610
STKc_MST1_2 - cd06612
PTKc_Srm_Brk - cd05148
STKc_PFTAIRE2 - cd07870
STKc_MAP4K3_like - cd06613
STKc_PCTAIRE_like - cd07844
STKc_PFTAIRE1 - cd07869
STKc_MEKK3_like_1 - cd06653
STKc_MSK_N - cd05583
PTKc_InsR - cd05061
STKc_MEKK2 - cd06652
STKc_MST4 - cd06640
PTKc_Ror2 - cd05091
STKc_STK25-YSK1 - cd06642
STKc_MST3 - cd06641
STKc_MEKK3 - cd06651
STKc_CDK12 - cd07864
STKc_CDKL1_4 - cd07847
STKc_CDKL2_3 - cd07846
STKc_Nek6_Nek7 - cd08224
STKc_CdkB_plant - cd07837
SPS1 - COG0515
STKc_Nek7 - cd08229
STKc_Nek6 - cd08228
PKc_MEK - cd06615
PKc_MAPKK - cd06605
STKc_MST3_like - cd06609
STKc_PRKX_like - cd05612
STKc_MAST - cd05609
STKc_PKA - cd05580
STKc_NAK1_like - cd06917
PTKc_Tie1 - cd05089
PKc_MKK3_6 - cd06617
STKc_MEKK3_like - cd06625
PKc_MAPKK_PBS2_like - cd06622
PKc_MAPKK_plant_like - cd06623
PKc_MAPKK_Pek1_like - cd06621
PKc_MKK5 - cd06619
STKc_CDK2_3 - cd07860
STKc_Nek3 - cd08219
STKc_CDK4 - cd07863
STKc_CDK7 - cd07841
STKc_Nek8 - cd08220
STKc_NLK - cd07853
STKc_TDY_MAPK_plant - cd07859
STKc_Nek2 - cd08217
STKc_Nek10 - cd08528
STKc_CDK5 - cd07839
STKc_Nek1 - cd08218
STKc_Nek5 - cd08225
STKc_Nek4 - cd08223
STKc_Nek9 - cd08221
STKc_MAPK - cd07834
STKc_GRK4_like - cd05605
STKc_MSK1_N - cd05613
STKc_MSK2_N - cd05614
STKc_Pho85 - cd07836
STKc_cPKC - cd05587
STKc_Yank1 - cd05578
PTKc_RET - cd05045
PTKc_IGF-1R - cd05062
PKc_STE - cd05122
STKc_GRK6 - cd05630
STKc_cPKC_alpha - cd05615
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MEKK1 - cd06630
STKc_YSK4 - cd06631
STKc_CCRK - cd07832
STKc_GRK4 - cd05631
STKc_Cdc7_like - cd06627
STKc_MAPKKK - cd06606
STKc_GRK5 - cd05632
STKc_CDK4_6_like - cd07838
STYKc - smart00221
TyrKc - smart00219
Pkinase_Tyr - pfam07714
Pkinase - pfam00069
STKc_CDK9_like - cd07840
STKc_CMGC - cd05118
PTKc_Tyk2_rpt2 - cd05080
PTKc_Tyro3 - cd05074
STKc_PKN - cd05589
STKc_MAPKKK_Bck1_lik - cd06629
STKc_CDK1_like - cd07835
STKc_MOK - cd07831
STKc_CDK_like - cd07829
PTKc_Axl_like - cd05035
PTKc_Axl - cd05075
STKc_Nek11 - cd08222
STKc_Nek - cd08215
STKc_MEKK1_plant - cd06632
STKc_MEKK4 - cd06626
STKc_FA2-like - cd08529
STKc_CDK8_like - cd07842
STKc_MAK_like - cd07830
STKc_PDK1 - cd05581
STKc_p70S6K - cd05584
STKc_CNK2-like - cd08530
STKc_RSK_N - cd05582
STKc_nPKC_theta_delt - cd05592
STKc_PKB - cd05571
PTKc_Syk - cd05116
STKc_nPKC_theta - cd05619
STKc_SGK2 - cd05603
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_c-ros - cd05044
PTKc_Tie - cd05047
PTKc_Met_Ron - cd05058
PTKc_Syk_like - cd05060
PTKc_Aatyk - cd05042
PTKc_Fes_like - cd05041
PTKc - cd00192
PTK_Jak_rpt1 - cd05037
PTKc_Ack_like - cd05040
PTKc_Fer - cd05085
PTK_Jak1_rpt1 - cd05077
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc_Fes - cd05084
PTKc_Aatyk2 - cd05086
PKc - cd00180
STKc_GRK1 - cd05608
PTKc_Zap-70 - cd05115
STKc_MAST_like - cd05579
STKc_AGC - cd05123
STKc_GRK - cd05577
STKc_cGK_PKG - cd05572
S_TKc - smart00220
KIND - smart00750




Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
FUcd000641.4e-14205266
FUcd000642.8e-10480531
FUcd000645.2e-14532594
PTKc_Kitcd051045e-12580950
PTKc_PDGFR_betacd051073.4e-09580951
PTKc_VEGFRcd050544.1e-23584953
PTKc_VEGFR3cd051021.4e-21627953
PTKc_VEGFR2cd051033.9e-14631953
PTKc_CSF-1Rcd051068.6e-14654951
PTKc_PDGFR_alphacd051058.2e-12655952
STKc_PAK1cd066549.7e-06662968
STKc_PAK_Icd066471e-05663965
STKc_PAK2cd066552.1e-05663968
STKc_PAK3cd066563e-06663969
PTKc_FGFR1cd050982.1e-37671954
PKc_MKK7cd066184.4e-08674962
STKc_myosinIIIBcd066390.00025674948
PTK_Tyk2_rpt1cd050763.7e-05675947
PTKc_FGFR2cd051016.3e-42675963
PTKc_FGFR4cd050991.6e-44676967
PTKc_FGFR3cd051003.8e-39676987
STKc_myosinIIIAcd066381.8e-05676947
STKc_p38cd078513.3e-06676983
STKc_TAOcd066070.00056677980
STKc_PAKcd066146.5e-10677960
PTKc_DDRcd050512.2e-27678948
STKc_STK10_LOKcd066440.00012678965
STKc_PAK_IIcd066480.00049678960
PTKc_PDGFRcd050551.3e-17679950
STKc_MAP4K5cd066460.00024680947
STKc_MAP4K3cd066450.00034680946
STKc_CDK10cd078455.6e-05680969
PTK_Rykcd050435e-25682950
PTKc_EGFR_likecd050572.4e-216682960
PTKc_FAKcd050569.4e-85682954
PTKc_Lck_Blkcd050671.5e-48682946
PTKc_Yescd050692.7e-43682949
PTKc_Fyn_Yrkcd050703e-48682949
PTKc_Srccd050711.5e-46682951
PTKc_Hckcd050737.2e-41682949
PTKc_Lyncd050721.2e-41682949
PTKc_Tie2cd050882.8e-35682972
PTKc_EGFRcd051084.9e-230682996
PTKc_HER2cd051094.1e-250682960
PTKc_HER4cd051104.6e-209682983
PTK_HER3cd051112.3e-158682960
STKc_ASKcd066244.5e-07682948
STKc_Sty1_Hog1cd078560.00016682991
PTKc_ALK_LTKcd050361.6e-55683948
PTKc_Rorcd050482.4e-34683949
STKc_MAP4K4_6cd066360.00028683949
PTKc_InsR_likecd050321.2e-55684948
PTKc_Src_likecd050349.6e-62684949
PTKc_Csk_likecd050393.7e-39684949
PTK_CCK4cd050467.5e-19684948
PTKc_Trkcd050491.3e-35684948
PTKc_Cskcd050829.9e-52684949
PTKc_Chkcd050831.1e-52684949
STKc_SLKcd066431.6e-05684963
PTKc_EphRcd050333.7e-64685950
PTKc_Jak_rpt2cd050385.9e-66685950
PTKc_Muskcd050502.6e-36685948
PTKc_Ablcd050526.7e-69685950
PTKc_FGFRcd050533.1e-49685951
PTKc_Tec_likecd050597.1e-52685947
PTKc_EphR_A2cd050636.3e-63685950
PTKc_EphR_A10cd050643.9e-45685950
PTKc_EphR_Bcd050651.4e-60685950
PTKc_Frk_likecd050684.8e-71685949
PTKc_Jak1_rpt2cd050791e-42685950
PTKc_Jak2_Jak3_rpt2cd050812e-52685950
PTKc_EphR_Acd050662.9e-62685950
PTKc_Ror1cd050903.6e-34685949
PTKc_TrkBcd050932.3e-28685958
PTKc_TrkAcd050922.9e-33685956
PTKc_DDR2cd050955.7e-28685948
PTKc_DDR1cd050961.6e-21685948
PTKc_DDR_likecd050977.2e-29685948
PTKc_TrkCcd050942.6e-12685958
PTKc_Itkcd051121.5e-62685947
PTKc_Btk_Bmxcd051138.8e-60685947
PTKc_Tec_Rlkcd051147.4e-62685947
STKc_myosinIII_likecd066089.2e-07685947
PKc_MKK4cd066161.5e-06685965
PKc_MAPKK_Byr1_likecd066201.4e-07685957
STKc_TNIKcd066379.1e-05685947
PKc_MEK2cd066496.6e-056851000
PKc_MEK1cd066509.6e-066851011
PTKc_Srm_Brkcd051481.8e-50686949
STKc_OSR1_SPAKcd066108.3e-09686946
STKc_MST1_2cd066122.3e-09686916
STKc_MAP4K3_likecd066136.2e-08686946
STKc_PCTAIRE_likecd078441.9e-05686975
STKc_PFTAIRE1cd078690.00054686996
STKc_PFTAIRE2cd078703e-066861001
PTKc_InsRcd050614.9e-41687959
PTKc_Ror2cd050912.7e-24687949
STKc_MSK_Ncd055831.6e-05687996
STKc_MST4cd066409.6e-07687978
STKc_STK25-YSK1cd066422.7e-08687968
STKc_MST3cd066419.3e-07687967
STKc_MEKK3cd066516e-09687949
STKc_MEKK2cd066522.3e-05687948
STKc_MEKK3_like_1cd066532.7e-05687948
PTKc_Tie1cd050891e-35688971
STKc_PKAcd055804.3e-05688949
STKc_MASTcd056090.000376881002
STKc_PRKX_likecd056127.1e-05688991
PKc_MAPKKcd066053e-09688952
STKc_MST3_likecd066091.9e-08688928
PKc_MEKcd066151.6e-05688959
PKc_MKK3_6cd066172.2e-07688962
PKc_MKK5cd066196.2e-05688982
PKc_MAPKK_Pek1_likecd066218.6e-05688959
PKc_MAPKK_PBS2_likecd066223.8e-06688997
PKc_MAPKK_plant_likecd066237.8e-12688952
STKc_MEKK3_likecd066255.5e-10688948
STKc_NAK1_likecd069176.6e-07688947
STKc_CdkB_plantcd078374.1e-06688976
STKc_CDKL2_3cd078460.00095688947
STKc_CDKL1_4cd078471.3e-05688984
STKc_CDK12cd078640.00012688975
STKc_Nek6_Nek7cd082241.3e-06688955
STKc_Nek6cd082286.2e-05688952
STKc_Nek7cd082298.7e-07688951
SPS1COG05152.5e-276881146
PTKc_RETcd050457.1e-51689953
PTKc_IGF-1Rcd050625.8e-38689948
PKc_STEcd051227e-12689946
STKc_Yank1cd055781.9e-06689949
STKc_cPKCcd055879.4e-056891017
STKc_GRK4_likecd056058.1e-06689983
STKc_MSK1_Ncd056131.7e-05689976
STKc_MSK2_Ncd056147e-066891022
STKc_cPKC_alphacd056150.000216891004
STKc_GRK6cd056300.0006689972
STKc_GRK4cd056310.000616891005
STKc_GRK5cd056320.00067689978
STKc_MAPKKKcd066061.9e-15689947
STKc_Cdc7_likecd066275.3e-12689943
STKc_MAPKKK_Byr2_likcd066282.3e-08689948
STKc_MEKK1cd066308.8e-08689947
STKc_YSK4cd066314e-09689947
STKc_CCRKcd078322e-07689940
STKc_MAPKcd078344.6e-06689982
STKc_Pho85cd078360.000136891001
STKc_CDK5cd078390.00014689975
STKc_CDK7cd078414.2e-06689943
STKc_NLKcd078530.000696891013
STKc_TDY_MAPK_plantcd078590.000716891018
STKc_CDK2_3cd078600.00033689975
STKc_CDK4cd078630.00031689975
STKc_Nek3cd082193.3e-08689948
STKc_Nek8cd082209.9e-06689948
STKc_Nek9cd082213.9e-05689948
STKc_Nek4cd082232e-05689948
STKc_Nek5cd082253.1e-05689948
STKc_Nek2cd082171.4e-06689949
STKc_Nek1cd082183.9e-05689948
STKc_Nek10cd085280.00021689948
PTKc_Axl_likecd050351.6e-55690950
PTKc_Axlcd050754.2e-42690950
PTKc_Tyro3cd050742.7e-49690950
PTKc_Tyk2_rpt2cd050801.5e-27690951
STKc_CMGCcd051181.2e-07690939
STKc_PKNcd055890.000226901001
STKc_MAPKKK_Bck1_likcd066295.8e-07690947
STKc_CDK_likecd078292.5e-06690947
STKc_MOKcd078311.4e-05690946
STKc_CDK1_likecd078351.9e-06690975
STKc_CDK9_likecd078409.8e-08690956
STKc_CDK4_6_likecd078382.1e-05690894
STKc_MEKK1_plantcd066328.9e-08691943
STKc_Nekcd082159.1e-12691948
STKc_Nek11cd082221.1e-05691947
STKc_MEKK4cd066261.2e-06692947
STKc_CDK8_likecd078420.00031692975
STKc_FA2-likecd085299e-08692948
STKc_PDK1cd055811.8e-09693946
STKc_RSK_Ncd055821.4e-056931023
STKc_p70S6Kcd055843e-066931005
STKc_MAK_likecd078301.4e-05693916
STKc_CNK2-likecd085301e-06693948
PTKccd001921e-121694947
PTK_Jak_rpt1cd050371.5e-10694947
PTKc_Ack_likecd050402.7e-78694948
PTKc_Fes_likecd050411.6e-42694948
PTKc_Aatykcd050422.4e-12694945
PTKc_c-roscd050441.3e-51694948
PTKc_Tiecd050478.2e-42694951
PTKc_Met_Roncd050584.8e-71694952
PTKc_Syk_likecd050601.9e-90694951
PTK_Jak1_rpt1cd050772.2e-07694947
PTK_Jak2_Jak3_rpt1cd050789.1e-11694947
PTKc_Fescd050843e-45694948
PTKc_Aatyk2cd050862.7e-07694948
PTKc_Aatyk1_Aatyk3cd050878.5e-11694948
PTKc_Fercd050856.9e-51694948
PTKc_Sykcd051161.3e-62694951
STKc_PKBcd055710.000156941028
STKc_nPKC_theta_deltcd055920.000136941005
STKc_SGK2cd056030.000646941007
STKc_nPKC_thetacd056194.5e-05694996
PKccd001803e-53696946
PTKc_Zap-70cd051152.7e-63696951
STKc_AGCcd051231e-06696949
STKc_cGK_PKGcd055720.0004696914
STKc_GRKcd055770.000836961004
STKc_MAST_likecd055794.8e-06696921
STKc_GRK1cd056087.4e-05696977
Recep_L_domainpfam010303.1e-5022143
Furin-likepfam007571.5e-69159313
Recep_L_domainpfam010301.1e-28336456
Pkinasepfam000695.5e-33690946
FUsmart002612.2e-07202246
FUsmart002615.5e-09471522
FUsmart002613.3e-09527576
Pkinase_Tyrpfam077141.1e-131690946
TyrKcsmart002195.9e-128690946
STYKcsmart002217.1e-47690957
S_TKcsmart002209.9e-37700950
KINDsmart007500.00045777972

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs28933370 Polymorphismp.ASN827SERN/A
dbSNPrs1136201 Polymorphismp.ILE625VALN/A
dbSNPrs61552325 Polymorphismp.PRO1140ALAN/A
dbSNPrs4252633 Polymorphismp.TRP422CYSN/A
OMIM164870.0008 Diseasep.ASN827SEROVARIAN CANCER, SOMATIC
OMIM164870.0006 Diseasep.GLU884LYSGLIOBLASTOMA, SOMATIC
OMIM164870.0007 Diseasep.GLY746SERGASTRIC CANCER, SOMATIC
OMIM164870.0005 Diseasep.LEU725PROADENOCARCINOMA OF LUNG, SOMATIC



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