Results for the protein: NP

Results for the Protein: NP_001005862

54792098

2064

ERBB2

NCBI

receptor tyrosine-protein kinase erbB-2 isoform b [Homo sapiens]

Known Diseases associated with this Protein:
  ADENOCARCINOMA OF LUNG, SOMATIC
  GASTRIC CANCER, SOMATIC
  GLIOBLASTOMA, SOMATIC
  OVARIAN CANCER, SOMATIC

4

4

4

4

0

Tips:

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RefSeq Protein: NP_001005862

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
FU	cd00064	2.8e-10	480	531
FU	cd00064	5.2e-14	532	594
PTKc_Kit	cd05104	5e-12	580	950
PTKc_PDGFR_beta	cd05107	3.4e-09	580	951
PTKc_VEGFR	cd05054	4.1e-23	584	953
PTKc_VEGFR3	cd05102	1.4e-21	627	953
PTKc_VEGFR2	cd05103	3.9e-14	631	953
PTKc_CSF-1R	cd05106	8.6e-14	654	951
PTKc_PDGFR_alpha	cd05105	8.2e-12	655	952
STKc_PAK1	cd06654	9.7e-06	662	968
STKc_PAK_I	cd06647	1e-05	663	965
STKc_PAK2	cd06655	2.1e-05	663	968
STKc_PAK3	cd06656	3e-06	663	969
PTKc_FGFR1	cd05098	2.1e-37	671	954
PKc_MKK7	cd06618	4.4e-08	674	962
STKc_myosinIIIB	cd06639	0.00025	674	948
PTK_Tyk2_rpt1	cd05076	3.7e-05	675	947
PTKc_FGFR2	cd05101	6.3e-42	675	963
PTKc_FGFR4	cd05099	1.6e-44	676	967
PTKc_FGFR3	cd05100	3.8e-39	676	987
STKc_myosinIIIA	cd06638	1.8e-05	676	947
STKc_p38	cd07851	3.3e-06	676	983
STKc_TAO	cd06607	0.00056	677	980
STKc_PAK	cd06614	6.5e-10	677	960
PTKc_DDR	cd05051	2.2e-27	678	948
STKc_STK10_LOK	cd06644	0.00012	678	965
STKc_PAK_II	cd06648	0.00049	678	960
PTKc_PDGFR	cd05055	1.3e-17	679	950
STKc_MAP4K5	cd06646	0.00024	680	947
STKc_MAP4K3	cd06645	0.00034	680	946
STKc_CDK10	cd07845	5.6e-05	680	969
PTK_Ryk	cd05043	5e-25	682	950
PTKc_EGFR_like	cd05057	2.4e-216	682	960
PTKc_FAK	cd05056	9.4e-85	682	954
PTKc_Lck_Blk	cd05067	1.5e-48	682	946
PTKc_Yes	cd05069	2.7e-43	682	949
PTKc_Fyn_Yrk	cd05070	3e-48	682	949
PTKc_Src	cd05071	1.5e-46	682	951
PTKc_Hck	cd05073	7.2e-41	682	949
PTKc_Lyn	cd05072	1.2e-41	682	949
PTKc_Tie2	cd05088	2.8e-35	682	972
PTKc_EGFR	cd05108	4.9e-230	682	996
PTKc_HER2	cd05109	4.1e-250	682	960
PTKc_HER4	cd05110	4.6e-209	682	983
PTK_HER3	cd05111	2.3e-158	682	960
STKc_ASK	cd06624	4.5e-07	682	948
STKc_Sty1_Hog1	cd07856	0.00016	682	991
PTKc_ALK_LTK	cd05036	1.6e-55	683	948
PTKc_Ror	cd05048	2.4e-34	683	949
STKc_MAP4K4_6	cd06636	0.00028	683	949
PTKc_InsR_like	cd05032	1.2e-55	684	948
PTKc_Src_like	cd05034	9.6e-62	684	949
PTKc_Csk_like	cd05039	3.7e-39	684	949
PTK_CCK4	cd05046	7.5e-19	684	948
PTKc_Trk	cd05049	1.3e-35	684	948
PTKc_Csk	cd05082	9.9e-52	684	949
PTKc_Chk	cd05083	1.1e-52	684	949
STKc_SLK	cd06643	1.6e-05	684	963
PTKc_EphR	cd05033	3.7e-64	685	950
PTKc_Jak_rpt2	cd05038	5.9e-66	685	950
PTKc_Musk	cd05050	2.6e-36	685	948
PTKc_Abl	cd05052	6.7e-69	685	950
PTKc_FGFR	cd05053	3.1e-49	685	951
PTKc_Tec_like	cd05059	7.1e-52	685	947
PTKc_EphR_A2	cd05063	6.3e-63	685	950
PTKc_EphR_A10	cd05064	3.9e-45	685	950
PTKc_EphR_B	cd05065	1.4e-60	685	950
PTKc_Frk_like	cd05068	4.8e-71	685	949
PTKc_Jak1_rpt2	cd05079	1e-42	685	950
PTKc_Jak2_Jak3_rpt2	cd05081	2e-52	685	950
PTKc_EphR_A	cd05066	2.9e-62	685	950
PTKc_Ror1	cd05090	3.6e-34	685	949
PTKc_TrkB	cd05093	2.3e-28	685	958
PTKc_TrkA	cd05092	2.9e-33	685	956
PTKc_DDR2	cd05095	5.7e-28	685	948
PTKc_DDR1	cd05096	1.6e-21	685	948
PTKc_DDR_like	cd05097	7.2e-29	685	948
PTKc_TrkC	cd05094	2.6e-12	685	958
PTKc_Itk	cd05112	1.5e-62	685	947
PTKc_Btk_Bmx	cd05113	8.8e-60	685	947
PTKc_Tec_Rlk	cd05114	7.4e-62	685	947
STKc_myosinIII_like	cd06608	9.2e-07	685	947
PKc_MKK4	cd06616	1.5e-06	685	965
PKc_MAPKK_Byr1_like	cd06620	1.4e-07	685	957
STKc_TNIK	cd06637	9.1e-05	685	947
PKc_MEK2	cd06649	6.6e-05	685	1000
PKc_MEK1	cd06650	9.6e-06	685	1011
PTKc_Srm_Brk	cd05148	1.8e-50	686	949
STKc_OSR1_SPAK	cd06610	8.3e-09	686	946
STKc_MST1_2	cd06612	2.3e-09	686	916
STKc_MAP4K3_like	cd06613	6.2e-08	686	946
STKc_PCTAIRE_like	cd07844	1.9e-05	686	975
STKc_PFTAIRE1	cd07869	0.00054	686	996
STKc_PFTAIRE2	cd07870	3e-06	686	1001
PTKc_InsR	cd05061	4.9e-41	687	959
PTKc_Ror2	cd05091	2.7e-24	687	949
STKc_MSK_N	cd05583	1.6e-05	687	996
STKc_MST4	cd06640	9.6e-07	687	978
STKc_STK25-YSK1	cd06642	2.7e-08	687	968
STKc_MST3	cd06641	9.3e-07	687	967
STKc_MEKK3	cd06651	6e-09	687	949
STKc_MEKK2	cd06652	2.3e-05	687	948
STKc_MEKK3_like_1	cd06653	2.7e-05	687	948
PTKc_Tie1	cd05089	1e-35	688	971
STKc_PKA	cd05580	4.3e-05	688	949
STKc_MAST	cd05609	0.00037	688	1002
STKc_PRKX_like	cd05612	7.1e-05	688	991
PKc_MAPKK	cd06605	3e-09	688	952
STKc_MST3_like	cd06609	1.9e-08	688	928
PKc_MEK	cd06615	1.6e-05	688	959
PKc_MKK3_6	cd06617	2.2e-07	688	962
PKc_MKK5	cd06619	6.2e-05	688	982
PKc_MAPKK_Pek1_like	cd06621	8.6e-05	688	959
PKc_MAPKK_PBS2_like	cd06622	3.8e-06	688	997
PKc_MAPKK_plant_like	cd06623	7.8e-12	688	952
STKc_MEKK3_like	cd06625	5.5e-10	688	948
STKc_NAK1_like	cd06917	6.6e-07	688	947
STKc_CdkB_plant	cd07837	4.1e-06	688	976
STKc_CDKL2_3	cd07846	0.00095	688	947
STKc_CDKL1_4	cd07847	1.3e-05	688	984
STKc_CDK12	cd07864	0.00012	688	975
STKc_Nek6_Nek7	cd08224	1.3e-06	688	955
STKc_Nek6	cd08228	6.2e-05	688	952
STKc_Nek7	cd08229	8.7e-07	688	951
SPS1	COG0515	2.5e-27	688	1146
PTKc_RET	cd05045	7.1e-51	689	953
PTKc_IGF-1R	cd05062	5.8e-38	689	948
PKc_STE	cd05122	7e-12	689	946
STKc_Yank1	cd05578	1.9e-06	689	949
STKc_cPKC	cd05587	9.4e-05	689	1017
STKc_GRK4_like	cd05605	8.1e-06	689	983
STKc_MSK1_N	cd05613	1.7e-05	689	976
STKc_MSK2_N	cd05614	7e-06	689	1022
STKc_cPKC_alpha	cd05615	0.00021	689	1004
STKc_GRK6	cd05630	0.0006	689	972
STKc_GRK4	cd05631	0.00061	689	1005
STKc_GRK5	cd05632	0.00067	689	978
STKc_MAPKKK	cd06606	1.9e-15	689	947
STKc_Cdc7_like	cd06627	5.3e-12	689	943
STKc_MAPKKK_Byr2_lik	cd06628	2.3e-08	689	948
STKc_MEKK1	cd06630	8.8e-08	689	947
STKc_YSK4	cd06631	4e-09	689	947
STKc_CCRK	cd07832	2e-07	689	940
STKc_MAPK	cd07834	4.6e-06	689	982
STKc_Pho85	cd07836	0.00013	689	1001
STKc_CDK5	cd07839	0.00014	689	975
STKc_CDK7	cd07841	4.2e-06	689	943
STKc_NLK	cd07853	0.00069	689	1013
STKc_TDY_MAPK_plant	cd07859	0.00071	689	1018
STKc_CDK2_3	cd07860	0.00033	689	975
STKc_CDK4	cd07863	0.00031	689	975
STKc_Nek3	cd08219	3.3e-08	689	948
STKc_Nek8	cd08220	9.9e-06	689	948
STKc_Nek9	cd08221	3.9e-05	689	948
STKc_Nek4	cd08223	2e-05	689	948
STKc_Nek5	cd08225	3.1e-05	689	948
STKc_Nek2	cd08217	1.4e-06	689	949
STKc_Nek1	cd08218	3.9e-05	689	948
STKc_Nek10	cd08528	0.00021	689	948
PTKc_Axl_like	cd05035	1.6e-55	690	950
PTKc_Axl	cd05075	4.2e-42	690	950
PTKc_Tyro3	cd05074	2.7e-49	690	950
PTKc_Tyk2_rpt2	cd05080	1.5e-27	690	951
STKc_CMGC	cd05118	1.2e-07	690	939
STKc_PKN	cd05589	0.00022	690	1001
STKc_MAPKKK_Bck1_lik	cd06629	5.8e-07	690	947
STKc_CDK_like	cd07829	2.5e-06	690	947
STKc_MOK	cd07831	1.4e-05	690	946
STKc_CDK1_like	cd07835	1.9e-06	690	975
STKc_CDK9_like	cd07840	9.8e-08	690	956
STKc_CDK4_6_like	cd07838	2.1e-05	690	894
STKc_MEKK1_plant	cd06632	8.9e-08	691	943
STKc_Nek	cd08215	9.1e-12	691	948
STKc_Nek11	cd08222	1.1e-05	691	947
STKc_MEKK4	cd06626	1.2e-06	692	947
STKc_CDK8_like	cd07842	0.00031	692	975
STKc_FA2-like	cd08529	9e-08	692	948
STKc_PDK1	cd05581	1.8e-09	693	946
STKc_RSK_N	cd05582	1.4e-05	693	1023
STKc_p70S6K	cd05584	3e-06	693	1005
STKc_MAK_like	cd07830	1.4e-05	693	916
STKc_CNK2-like	cd08530	1e-06	693	948
PTKc	cd00192	1e-121	694	947
PTK_Jak_rpt1	cd05037	1.5e-10	694	947
PTKc_Ack_like	cd05040	2.7e-78	694	948
PTKc_Fes_like	cd05041	1.6e-42	694	948
PTKc_Aatyk	cd05042	2.4e-12	694	945
PTKc_c-ros	cd05044	1.3e-51	694	948
PTKc_Tie	cd05047	8.2e-42	694	951
PTKc_Met_Ron	cd05058	4.8e-71	694	952
PTKc_Syk_like	cd05060	1.9e-90	694	951
PTK_Jak1_rpt1	cd05077	2.2e-07	694	947
PTK_Jak2_Jak3_rpt1	cd05078	9.1e-11	694	947
PTKc_Fes	cd05084	3e-45	694	948
PTKc_Aatyk2	cd05086	2.7e-07	694	948
PTKc_Aatyk1_Aatyk3	cd05087	8.5e-11	694	948
PTKc_Fer	cd05085	6.9e-51	694	948
PTKc_Syk	cd05116	1.3e-62	694	951
STKc_PKB	cd05571	0.00015	694	1028
STKc_nPKC_theta_delt	cd05592	0.00013	694	1005
STKc_SGK2	cd05603	0.00064	694	1007
STKc_nPKC_theta	cd05619	4.5e-05	694	996
PKc	cd00180	3e-53	696	946
PTKc_Zap-70	cd05115	2.7e-63	696	951
STKc_AGC	cd05123	1e-06	696	949
STKc_cGK_PKG	cd05572	0.0004	696	914
STKc_GRK	cd05577	0.00083	696	1004
STKc_MAST_like	cd05579	4.8e-06	696	921
STKc_GRK1	cd05608	7.4e-05	696	977
Recep_L_domain	pfam01030	3.1e-50	22	143
Furin-like	pfam00757	1.5e-69	159	313
Recep_L_domain	pfam01030	1.1e-28	336	456
Pkinase	pfam00069	5.5e-33	690	946
FU	smart00261	2.2e-07	202	246
FU	smart00261	5.5e-09	471	522
FU	smart00261	3.3e-09	527	576
Pkinase_Tyr	pfam07714	1.1e-131	690	946
TyrKc	smart00219	5.9e-128	690	946
STYKc	smart00221	7.1e-47	690	957
S_TKc	smart00220	9.9e-37	700	950
KIND	smart00750	0.00045	777	972

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs28933370	Polymorphism	p.ASN827SER	N/A
dbSNP	rs1136201	Polymorphism	p.ILE625VAL	N/A
dbSNP	rs61552325	Polymorphism	p.PRO1140ALA	N/A
dbSNP	rs4252633	Polymorphism	p.TRP422CYS	N/A
OMIM	164870.0008	Disease	p.ASN827SER	OVARIAN CANCER, SOMATIC
OMIM	164870.0006	Disease	p.GLU884LYS	GLIOBLASTOMA, SOMATIC
OMIM	164870.0007	Disease	p.GLY746SER	GASTRIC CANCER, SOMATIC
OMIM	164870.0005	Disease	p.LEU725PRO	ADENOCARCINOMA OF LUNG, SOMATIC

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258