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Results for the Protein: NP_006715
55956902

mitogen-activated protein kinase kinase kinase 4 isoform b [Homo sapiens]
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

STKc_ROCK2 - cd05621
STKc_ROCK - cd05596
STKc_ROCK1 - cd05622
STKc_TAO1 - cd06635
STKc_Sty1_Hog1 - cd07856
STKc_PAK6 - cd06659
STKc_TAO3 - cd06633
STKc_JNK1 - cd07875
STKc_TAO2 - cd06634
STKc_myosinIIIA - cd06638
STKc_p38alpha_MAPK14 - cd07877
STKc_JNK2 - cd07876
STKc_JNK - cd07850
STKc_MAP4K4_6 - cd06636
STKc_PAK4 - cd06657
STKc_myosinIIIB - cd06639
PTKc_FGFR - cd05053
PTKc_FGFR2 - cd05101
STKc_p38gamma_MAPK12 - cd07880
STKc_PAK1 - cd06654
PTKc_EGFR_like - cd05057
STKc_STK10_LOK - cd06644
STKc_PAK3 - cd06656
STKc_JNK3 - cd07874
STKc_PAK2 - cd06655
STKc_PAK_II - cd06648
STKc_PAK - cd06614
STKc_PAK_I - cd06647
STKc_CDK9 - cd07865
PTKc_DDR - cd05051
STKc_PAK5 - cd06658
STKc_p38 - cd07851
PKc_MKK7 - cd06618
PTKc_HER2 - cd05109
STKc_MAPK4_6 - cd07854
PTKc_Chk - cd05083
STKc_ERK5 - cd07855
PTKc_EphR_B - cd05065
PTKc_Abl - cd05052
PTKc_InsR - cd05061
PTKc_Csk_like - cd05039
PTKc_IGF-1R - cd05062
STKc_TAO - cd06607
PTKc_TrkC - cd05094
STKc_MAP4K3 - cd06645
STKc_MAP4K5 - cd06646
PTKc_Ror2 - cd05091
STKc_BUR1 - cd07866
PTKc_DDR2 - cd05095
PTKc_Ror1 - cd05090
PTKc_Trk - cd05049
PTKc_Ror - cd05048
PTKc_EphR_A2 - cd05063
PTKc_TrkB - cd05093
PTKc_TrkA - cd05092
PTKc_HER4 - cd05110
PTKc_Tec_Rlk - cd05114
STKc_CDK10 - cd07845
PTKc_Csk - cd05082
PTKc_Btk_Bmx - cd05113
PTKc_FAK - cd05056
PTKc_Hck - cd05073
PTKc_Jak_rpt2 - cd05038
PTKc_Lck_Blk - cd05067
PTKc_Lyn - cd05072
PTKc_Frk_like - cd05068
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE1 - cd07873
STKc_CDK12 - cd07864
PKc_MEK2 - cd06649
PKc_MAPKK_Byr1_like - cd06620
PTKc_EphR_A10 - cd05064
STKc_TNIK - cd06637
STKc_SLK - cd06643
STKc_myosinIII_like - cd06608
STKc_PCTAIRE3 - cd07871
PTKc_Tyk2_rpt2 - cd05080
PTK_HER3 - cd05111
PTKc_EphR_A - cd05066
PTKc_Jak1_rpt2 - cd05079
PTKc_InsR_like - cd05032
STKc_MAPK15 - cd07852
STKc_CDC2L1 - cd07843
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_ALK_LTK - cd05036
STKc_ASK - cd06624
STKc_ERK1_2_like - cd07849
STKc_STK25-YSK1 - cd06642
STKc_TEY_MAPK_plant - cd07858
PTKc_Src - cd05071
PTKc_Src_like - cd05034
PTKc_Yes - cd05069
STKc_PCTAIRE_like - cd07844
STKc_MAP4K3_like - cd06613
STKc_PFTAIRE2 - cd07870
PTKc_EphR - cd05033
PTK_Ryk - cd05043
STKc_PDK1 - cd05581
STKc_CDK8 - cd07868
STKc_MEKK3 - cd06651
STKc_CDC2L6 - cd07867
STKc_CDK8_like - cd07842
STKc_MEKK3_like_1 - cd06653
STKc_CNK2-like - cd08530
STKc_Nek6_Nek7 - cd08224
PK_STRAD - cd08216
STKc_Nek4 - cd08223
STKc_Yank1 - cd05578
PTKc_DDR_like - cd05097
STKc_MEKK2 - cd06652
STKc_GRK4_like - cd05605
STKc_MSK_N - cd05583
PKc_MEK1 - cd06650
STKc_GRK6 - cd05630
STKc_GRK5 - cd05632
STKc_GRK4 - cd05631
STKc_MAPKKK_Bck1_lik - cd06629
STKc_NAK1_like - cd06917
SPS1 - COG0515
PKc_MKK5 - cd06619
STKc_MEKK3_like - cd06625
STKc_MAST - cd05609
PKc_MKK4 - cd06616
STKc_ROCK_NDR_like - cd05573
STKc_PRKX_like - cd05612
STKc_MST3_like - cd06609
STKc_CDK1_euk - cd07861
STKc_CDK6 - cd07862
STKc_PFTAIRE1 - cd07869
STKc_NLK - cd07853
STKc_CDK2_3 - cd07860
STKc_CDK4 - cd07863
STKc_MAPK - cd07834
STKc_CDK5 - cd07839
STKc_CDKL1_4 - cd07847
STKc_CDKL5 - cd07848
STKc_MPK1 - cd07857
STKc_TDY_MAPK_plant - cd07859
STKc_FA2-like - cd08529
STKc_Nek6 - cd08228
STKc_Nek9 - cd08221
STKc_Nek7 - cd08229
STKc_Nek10 - cd08528
STKc_CDKL2_3 - cd07846
STKc_Nek5 - cd08225
STKc_Nek11 - cd08222
STKc_Nek1 - cd08218
STKc_Nek2 - cd08217
STKc_Nek3 - cd08219
STKc_Nek8 - cd08220
STKc_Nek - cd08215
PTKc_RET - cd05045
STKc_MSK1_N - cd05613
STKc_LATS - cd05598
STKc_cPKC_alpha - cd05615
STKc_cPKC_beta - cd05616
STKc_MRCK_alpha - cd05623
STKc_DMPK_like - cd05597
STKc_cPKC - cd05587
STKc_CDK7 - cd07841
PTKc_Musk - cd05050
PTKc_Itk - cd05112
PKc_STE - cd05122
STKc_NDR1 - cd05628
STKc_MSK2_N - cd05614
STKc_MEKK1_plant - cd06632
STKc_YSK4 - cd06631
STKc_MAPKKK - cd06606
STKc_Pho85 - cd07836
STKc_CdkB_plant - cd07837
STKc_MEKK1 - cd06630
STKc_CCRK - cd07832
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MEKK4 - cd06626
STKc_Cdc7_like - cd06627
PKc_MEK - cd06615
STKc_CDK4_6_like - cd07838
STKc_CDK1_like - cd07835
STKc_MOK - cd07831
STKc_CDK9_like - cd07840
Pkinase_Tyr - pfam07714
STKc_MAK_like - cd07830
Pkinase - pfam00069
STYKc - smart00221
TyrKc - smart00219
STKc_SLK_like - cd06611
PTKc_Tyro3 - cd05074
PTKc_Fyn_Yrk - cd05070
STKc_CDK_like - cd07829
PTKc_Axl_like - cd05035
STKc_CMGC - cd05118
PTKc_Srm_Brk - cd05148
STKc_PKN - cd05589
STKc_MST4 - cd06640
STKc_MST3 - cd06641
PKc_MKK3_6 - cd06617
STKc_PKA - cd05580
PKc_MAPKK_plant_like - cd06623
STKc_p70S6K - cd05584
STKc_CRIK - cd05601
STKc_aPKC_iota - cd05618
STKc_aPKC_zeta - cd05617
STKc_PKB_alpha - cd05594
STKc_nPKC_theta - cd05619
STKc_PKB_beta - cd05595
STKc_PKB_gamma - cd05593
STKc_CDKL - cd07833
PKc_MAPKK_PBS2_like - cd06622
STKc_nPKC_epsilon - cd05591
PKc_MAPKK_Pek1_like - cd06621
STKc_OSR1_SPAK - cd06610
PKc_MAPKK - cd06605
STKc_SGK2 - cd05603
PTKc_Aatyk2 - cd05086
PTKc_Met_Ron - cd05058
PTKc_Fes - cd05084
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc - cd00192
STKc_nPKC_theta_delt - cd05592
PTKc_Aatyk - cd05042
PTKc_Fes_like - cd05041
PTKc_Ack_like - cd05040
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_c-ros - cd05044
STKc_SGK - cd05575
STKc_RSK_N - cd05582
STKc_aPKC - cd05588
STKc_nPKC_eta - cd05590
PTKc_Syk_like - cd05060
STKc_PKB - cd05571
PTKc_Fer - cd05085
PTKc_Syk - cd05116
STKc_phototropin_lik - cd05574
STKc_Sid2p_Dbf2p - cd05600
STKc_MST1_2 - cd06612
PTKc_Zap-70 - cd05115
STKc_GRK1 - cd05608
STKc_GRK3 - cd05633
STKc_NDR_like - cd05599
STKc_GRK7 - cd05607
STKc_Rim15_like - cd05611
STKc_AGC - cd05123
STKc_MAST_like - cd05579
STKc_cGK_PKG - cd05572
PKc - cd00180
STKc_beta_ARK - cd05606
STKc_GRK - cd05577
STKc_PKC - cd05570
STKc_Sck1_like - cd05586
STKc_YPK1_like - cd05585
S_TKc - smart00220
PTKc_Tec_like - cd05059
KIND - smart00750


RefSeq Protein: NP_006715
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
STKc_ROCK2cd056213.4e-0512481557
STKc_ROCKcd055961.3e-0512491558
STKc_ROCK1cd056227.7e-0512521558
STKc_TAO1cd066352e-0912631556
STKc_Sty1_Hog1cd078563.9e-0712671558
STKc_TAO3cd066331.4e-0712711556
STKc_PAK6cd066591.2e-1612711558
STKc_JNK1cd078750.0002812721558
STKc_myosinIIIAcd066381.3e-2012741551
STKc_TAO2cd066341.4e-1012741557
STKc_JNK2cd078762.2e-0512751558
STKc_p38alpha_MAPK14cd078770.0007812751558
STKc_MAP4K4_6cd066363.3e-2112761551
STKc_JNKcd078508.3e-0612761558
PTKc_FGFRcd050530.0005812771551
PTKc_FGFR2cd051010.0002812771558
STKc_myosinIIIBcd066392.2e-1812771552
STKc_PAK4cd066571.3e-1012771556
PTKc_EGFR_likecd050571.4e-0612781557
STKc_STK10_LOKcd066441.3e-2712781558
STKc_PAK1cd066544.8e-2412781558
STKc_p38gamma_MAPK12cd078804.1e-0512781558
STKc_PAKcd066147.7e-2912791558
STKc_PAK_Icd066471.5e-3412791556
STKc_PAK_IIcd066487.4e-2212791558
STKc_PAK2cd066552.9e-2612791557
STKc_PAK3cd066569.2e-2412791557
STKc_JNK3cd078740.0006612791558
PTKc_DDRcd050510.0004112801553
STKc_PAK5cd066582.5e-1112801558
STKc_CDK9cd078652.4e-1112801551
PKc_MKK7cd066181e-1412811558
STKc_p38cd078517.3e-0812811558
PTKc_Csk_likecd050391.3e-0612821552
PTKc_Ablcd050524.6e-0912821550
PTKc_InsRcd050613.4e-0512821555
PTKc_IGF-1Rcd050620.0003312821553
PTKc_EphR_Bcd050652e-0612821554
PTKc_Chkcd050832.2e-0712821552
PTKc_HER2cd051097.9e-0612821554
STKc_MAPK4_6cd078542.5e-0612821558
STKc_ERK5cd078557e-0712821558
PTKc_Trkcd050492.6e-0812831548
PTKc_EphR_A2cd050633.8e-0512831550
PTKc_Ror1cd050902.1e-0512831554
PTKc_Rorcd050482.4e-0512831554
PTKc_TrkBcd050934.8e-0612831556
PTKc_TrkAcd050927.3e-0712831557
PTKc_DDR2cd050957.8e-0512831553
PTKc_Ror2cd050910.0008212831554
PTKc_TrkCcd050940.0008112831556
STKc_TAOcd066071e-0912831556
STKc_MAP4K3cd066456.9e-3312831550
STKc_MAP4K5cd066463.6e-3312831550
STKc_BUR1cd078661.2e-1312831551
PTKc_Jak_rpt2cd050384.3e-0812841554
PTKc_FAKcd050569.5e-1112841558
PTKc_Lck_Blkcd050673.3e-0512841550
PTKc_Frk_likecd050682.1e-1212841548
PTKc_Lyncd050729.3e-0812841548
PTKc_Hckcd050734.9e-0712841548
PTKc_Cskcd050824e-0512841549
PTKc_HER4cd051100.0006312841558
PTKc_Tec_Rlkcd051144.1e-0712841550
PTKc_Btk_Bmxcd051135.2e-0912841550
STKc_CDK10cd078455.3e-1212841558
PTKc_EphR_A10cd050641.7e-0612851553
PKc_MAPKK_Byr1_likecd066201.1e-1212851557
PKc_MEK2cd066491.6e-0512851558
STKc_CDK12cd078643.7e-1312851551
STKc_PCTAIRE2cd078721.3e-0612851557
STKc_PCTAIRE1cd078731.3e-0612851556
PTKc_InsR_likecd050321.2e-0612861552
PTKc_EphR_Acd050662.6e-0512861550
PTKc_Jak1_rpt2cd050794.8e-0612861554
PTKc_Tyk2_rpt2cd050801.1e-0712861555
PTK_HER3cd051112e-0512861558
STKc_myosinIII_likecd066083.5e-1812861551
STKc_TNIKcd066371.6e-1612861551
STKc_SLKcd066435.2e-3212861558
STKc_PCTAIRE3cd078712.1e-0812861551
PTKc_ALK_LTKcd050362e-0812871551
PTKc_Jak2_Jak3_rpt2cd050811e-0812871555
STKc_ASKcd066242.4e-5712871551
STKc_CDC2L1cd078433.2e-1112871551
STKc_MAPK15cd078521.6e-0912871558
PTKc_Src_likecd050341.2e-0812881550
PTKc_Yescd050697e-0612881548
PTKc_Srccd050712.1e-0512881551
STKc_STK25-YSK1cd066422.2e-2012881558
STKc_ERK1_2_likecd078491e-0712881558
STKc_TEY_MAPK_plantcd078588.1e-0512881558
PTKc_EphRcd050333.8e-0812891551
PTK_Rykcd050430.00112891551
STKc_PDK1cd055813.1e-1812891551
STKc_MAP4K3_likecd066131.6e-4212891550
STKc_PCTAIRE_likecd078441.3e-1112891551
STKc_PFTAIRE2cd078704.3e-0912891551
PTKc_DDR_likecd050970.0004912901553
STKc_Yank1cd055785.5e-1912901551
STKc_MSK_Ncd055836.3e-1612901558
STKc_GRK4_likecd056051.6e-0912901557
STKc_GRK6cd056301.2e-0612901557
STKc_GRK4cd056315.9e-0712901557
STKc_GRK5cd056325.7e-0712901557
PKc_MEK1cd066507.7e-0612901558
STKc_MEKK2cd066523.6e-4812901552
STKc_MEKK3_like_1cd066535.2e-5112901551
STKc_MEKK3cd066513.6e-5912901553
STKc_CDK8_likecd078427.1e-1212901551
STKc_CDK8cd078680.0002512901551
STKc_CDC2L6cd078670.0001512901551
PK_STRADcd082166.6e-0912901556
STKc_Nek4cd082232.1e-2412901551
STKc_Nek6_Nek7cd082249.6e-2212901554
STKc_CNK2-likecd085301.2e-1512901551
STKc_ROCK_NDR_likecd055733.3e-1012911558
STKc_MASTcd056098.9e-0812911556
STKc_PRKX_likecd056126.4e-1012911558
STKc_MST3_likecd066095.4e-2612911557
PKc_MKK4cd066168.3e-1312911558
PKc_MKK5cd066193e-0712911558
STKc_MEKK3_likecd066251.3e-7112911551
STKc_MAPKKK_Bck1_likcd066295.6e-3812911551
STKc_NAK1_likecd069171.1e-1912911555
SPS1COG05155.7e-3212911557
PTKc_RETcd050450.0008512921553
PTKc_Muskcd050507e-0712921548
PTKc_Itkcd051124.6e-0812921550
PKc_STEcd051221.5e-7112921550
STKc_cPKCcd055870.0002312921552
STKc_DMPK_likecd055970.0004112921556
STKc_LATScd055981e-0512921557
STKc_MSK1_Ncd056137.7e-1112921557
STKc_MSK2_Ncd056141.1e-0912921555
STKc_cPKC_alphacd056150.0001912921552
STKc_cPKC_betacd056160.0007712921558
STKc_MRCK_alphacd056230.0002412921557
STKc_NDR1cd056280.0003312921557
STKc_MAPKKKcd066065.6e-13212921551
STKc_MEKK4cd066264e-19512921551
STKc_Cdc7_likecd066277.3e-6012921551
PKc_MEKcd066152.3e-1312921558
STKc_MAPKKK_Byr2_likcd066281.1e-6112921551
STKc_MEKK1cd066305.4e-4912921552
STKc_YSK4cd066317.9e-5012921551
STKc_MEKK1_plantcd066321.5e-8812921551
STKc_CCRKcd078321.9e-1612921552
STKc_Pho85cd078363.3e-1812921551
STKc_CdkB_plantcd078371.3e-1312921552
STKc_CDK7cd078413.7e-1612921558
STKc_CDKL2_3cd078467.7e-1512921551
STKc_CDKL1_4cd078476.9e-2912921551
STKc_CDKL5cd078481.1e-0612921551
STKc_MAPKcd078346.3e-1012921557
STKc_MPK1cd078572.5e-0712921558
STKc_TDY_MAPK_plantcd078595.7e-0512921558
STKc_CDK2_3cd078601.1e-2112921551
STKc_CDK1_eukcd078616e-1812921551
STKc_CDK6cd078621.1e-0712921551
STKc_CDK4cd078631.5e-0912921551
STKc_PFTAIRE1cd078696.6e-0612921556
STKc_NLKcd078530.0001512921558
STKc_CDK5cd078391.8e-1212921551
STKc_Nekcd082153.9e-4812921551
STKc_Nek1cd082181.9e-3812921551
STKc_Nek2cd082172.6e-2112921551
STKc_Nek3cd082198.2e-3112921551
STKc_Nek8cd082201.2e-2012921551
STKc_Nek11cd082222.1e-2112921551
STKc_Nek5cd082256.9e-3012921551
STKc_Nek9cd082212.3e-2212921551
STKc_Nek6cd082283.1e-2212921553
STKc_Nek7cd082298.4e-1912921554
STKc_FA2-likecd085292.9e-1712921551
STKc_Nek10cd085288.5e-1112921547
PTKc_Axl_likecd050350.0001112931554
PTKc_Fyn_Yrkcd050707.8e-0612931554
PTKc_Tyro3cd050748.8e-0512931553
STKc_CMGCcd051181.6e-1912931551
PTKc_Srm_Brkcd051488.5e-0612931549
STKc_PKNcd055896e-0612931558
STKc_SLK_likecd066117.1e-2012931558
STKc_MST4cd066402e-1712931558
STKc_MST3cd066414e-1412931552
STKc_CDK_likecd078295.4e-2112931551
STKc_MAK_likecd078306e-1612931551
STKc_MOKcd078315.1e-1112931551
STKc_CDK1_likecd078355.7e-1912931551
STKc_CDK4_6_likecd078381.5e-1512931551
STKc_CDK9_likecd078401.8e-1612931551
STKc_PKAcd055801.2e-1312941553
PKc_MKK3_6cd066175.3e-1512941558
PKc_MAPKK_plant_likecd066239.1e-4512941556
STKc_p70S6Kcd055842e-0712961558
PTKccd001922.6e-1412971550
PTKc_Ack_likecd050403.6e-1212971552
PTKc_Fes_likecd050412.7e-0712971551
PTKc_Aatykcd050421.3e-0512971548
PTKc_c-roscd050441.2e-0512971547
PTKc_Met_Roncd050581.9e-0512971555
PTKc_Fescd050841.4e-0712971551
PTKc_Aatyk2cd050863.3e-0512971548
PTK_Jak2_Jak3_rpt1cd050781.7e-0512971549
PTKc_Aatyk1_Aatyk3cd050870.0006812971550
PTKc_Syk_likecd050602.7e-0712971556
PTKc_Fercd050856.5e-0612971551
PTKc_Sykcd051161.6e-0612971550
STKc_PKBcd055711.2e-0712971558
STKc_SGKcd055751.9e-0512971558
STKc_RSK_Ncd055822.2e-0612971558
STKc_aPKCcd055887e-0712971558
STKc_nPKC_etacd055900.0002912971558
STKc_nPKC_theta_deltcd055926.8e-0612971558
STKc_nPKC_epsiloncd055919.8e-0512971558
STKc_PKB_alphacd055943.5e-0712971558
STKc_PKB_betacd055957.3e-0612971558
STKc_PKB_gammacd055933.6e-0612971558
STKc_CRIKcd056018.6e-1012971551
STKc_aPKC_zetacd056171.6e-0712971558
STKc_aPKC_iotacd056182.6e-0612971558
STKc_nPKC_thetacd056191.1e-0512971558
STKc_SGK2cd056034.4e-0512971552
PKc_MAPKKcd066054.3e-2012971556
STKc_OSR1_SPAKcd066102.1e-2112971551
PKc_MAPKK_Pek1_likecd066211.1e-1612971558
PKc_MAPKK_PBS2_likecd066223e-1312971557
STKc_CDKLcd078333.2e-1712971551
PTKc_Zap-70cd051150.0001212981550
STKc_phototropin_likcd055742.9e-1012981558
STKc_Sid2p_Dbf2pcd056001.3e-0612981552
STKc_MST1_2cd066121.2e-2712981551
PKccd001805.2e-7612991549
STKc_AGCcd051239.5e-2712991551
STKc_cGK_PKGcd055723.9e-1512991558
STKc_MAST_likecd055791.6e-1812991556
STKc_GRKcd055775.8e-1112991556
STKc_YPK1_likecd055856.5e-0712991558
STKc_Sck1_likecd055867.5e-0512991556
STKc_PKCcd055703.1e-1212991558
STKc_beta_ARKcd056062.5e-0812991558
STKc_GRK7cd056072.9e-0712991553
STKc_GRK1cd056083.3e-0812991558
STKc_GRK3cd056332.7e-0712991558
STKc_Rim15_likecd056117.1e-0712991556
STKc_NDR_likecd055990.0001812991555
PTKc_Tec_likecd050591.4e-1013131550
Pkinasepfam000692.2e-7612931551
Pkinase_Tyrpfam077142.1e-1712931551
STYKcsmart002213.1e-8412931551
TyrKcsmart002191.3e-1512931551
S_TKcsmart002201e-9113031551
KINDsmart007507.6e-0813751558

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs4559074 Polymorphismp.ARG157HISN/A



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