Results for the protein: NP

Results for the Protein: NP_001010938

58331191

10188

TNK2

NCBI

activated CDC42 kinase 1 isoform 2 [Homo sapiens]

Known Diseases associated with this Protein:
VARIANT OF UNKNOWN SIGNIFICANCE

1

3

1

3

0

Tips:

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RefSeq Protein: NP_001010938

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_PDGFR_beta	cd05107	1.3e-08	58	450
PTKc_PDGFR_alpha	cd05105	1.6e-13	63	454
PTKc_Kit	cd05104	5.5e-13	74	453
PTKc_VEGFR	cd05054	1.6e-26	83	455
PTKc_VEGFR3	cd05102	1.5e-17	122	455
PTKc_VEGFR2	cd05103	4.9e-14	123	452
STKc_TAO1	cd06635	2.9e-05	164	478
STKc_TAO3	cd06633	0.00056	170	487
PTKc_FGFR1	cd05098	9.7e-31	172	461
STKc_PAK1	cd06654	0.00016	172	473
STKc_PAK6	cd06659	0.00019	172	473
PKc_MKK7	cd06618	7.2e-07	173	461
STKc_PAK_II	cd06648	2.4e-05	173	460
STKc_PAK3	cd06656	0.00032	173	475
STKc_PAK2	cd06655	0.00075	173	474
STKc_PAK	cd06614	2.9e-11	173	460
STKc_PAK_I	cd06647	0.00012	173	471
PTKc_FGFR2	cd05101	4.7e-29	174	464
STKc_TAO2	cd06634	3.5e-07	174	480
STKc_myosinIIIB	cd06639	7.4e-06	175	451
STKc_CDK10	cd07845	1.1e-06	175	472
PTKc_FGFR4	cd05099	1.5e-40	176	466
PTKc_FGFR3	cd05100	2e-25	176	490
STKc_myosinIIIA	cd06638	2.8e-06	176	448
PTKc_PDGFR	cd05055	2.4e-15	177	452
STKc_STK10_LOK	cd06644	6.6e-07	177	470
PTK_Tyk2_rpt1	cd05076	3.7e-07	178	448
STKc_TAO	cd06607	1.3e-05	178	487
STKc_ASK	cd06624	4.6e-09	178	449
STKc_MAP4K4_6	cd06636	0.00058	178	450
STKc_p38	cd07851	0.00075	178	480
STKc_CDK9	cd07865	0.0001	178	462
STKc_MAP4K3	cd06645	0.00025	179	449
STKc_MAP4K5	cd06646	0.00029	179	449
PTKc_EGFR_like	cd05057	1.5e-81	181	462
PTKc_EGFR	cd05108	1.5e-54	181	489
PTKc_HER4	cd05110	9.8e-51	181	495
PTKc_HER2	cd05109	7.8e-57	181	460
PTK_HER3	cd05111	1.8e-61	181	460
STKc_Sty1_Hog1	cd07856	0.00014	181	480
PTKc_ALK_LTK	cd05036	3.8e-36	182	450
PTKc_FAK	cd05056	1.3e-80	182	456
PTKc_Chk	cd05083	3.9e-61	182	451
PTKc_Tie2	cd05088	1e-25	182	472
PTKc_Csk_like	cd05039	7.6e-37	183	451
PTK_CCK4	cd05046	2.7e-19	183	450
PTKc_Ror	cd05048	4.8e-37	183	447
PTKc_Trk	cd05049	7.3e-54	183	450
PTKc_DDR	cd05051	4.6e-37	183	450
PTK_Ryk	cd05043	8.3e-21	183	451
STKc_SLK	cd06643	9.8e-07	183	453
PTKc_InsR_like	cd05032	2.1e-43	184	450
PTKc_Jak_rpt2	cd05038	4.9e-79	184	451
PTKc_Src_like	cd05034	3e-75	184	451
PTKc_EphR	cd05033	7.6e-57	184	452
PTKc_Musk	cd05050	1.6e-40	184	450
PTKc_Abl	cd05052	2.2e-69	184	452
PTKc_FGFR	cd05053	2.3e-30	184	454
PTKc_IGF-1R	cd05062	7.2e-31	184	450
PTKc_EphR_A2	cd05063	1.9e-50	184	449
PTKc_EphR_A10	cd05064	3.8e-41	184	452
PTKc_EphR_B	cd05065	9.1e-46	184	449
PTKc_InsR	cd05061	1.7e-37	184	461
PTKc_EphR_A	cd05066	2.8e-54	184	449
PTKc_Tec_like	cd05059	4.4e-65	184	449
PTKc_Lck_Blk	cd05067	2.6e-62	184	451
PTKc_Fyn_Yrk	cd05070	1.2e-59	184	451
PTKc_Frk_like	cd05068	5.1e-81	184	452
PTKc_Hck	cd05073	9.4e-64	184	451
PTKc_Lyn	cd05072	1.2e-64	184	451
PTKc_Jak1_rpt2	cd05079	1e-54	184	452
PTKc_Jak2_Jak3_rpt2	cd05081	1.7e-70	184	452
PTKc_Csk	cd05082	5.2e-55	184	451
PTKc_Ror1	cd05090	2.9e-34	184	447
PTKc_Ror2	cd05091	6.2e-29	184	451
PTKc_TrkA	cd05092	4.7e-43	184	450
PTKc_TrkB	cd05093	6.5e-38	184	457
PTKc_TrkC	cd05094	2.5e-28	184	457
PTKc_DDR2	cd05095	2.6e-38	184	450
PTKc_Src	cd05071	1.1e-55	184	454
PTKc_DDR1	cd05096	1.1e-31	184	450
PTKc_DDR_like	cd05097	1.8e-41	184	450
PTKc_Itk	cd05112	1.7e-60	184	449
PTKc_Btk_Bmx	cd05113	1.7e-67	184	449
PTKc_Tec_Rlk	cd05114	9.6e-67	184	449
PTKc_Yes	cd05069	9.1e-55	184	451
PKc_MKK4	cd06616	3.4e-06	184	459
PKc_MAPKK_Byr1_like	cd06620	2e-07	184	460
STKc_PCTAIRE_like	cd07844	2.5e-06	184	487
STKc_MAPK15	cd07852	1.5e-05	184	489
STKc_MAPK4_6	cd07854	3.1e-06	184	489
STKc_TEY_MAPK_plant	cd07858	2.8e-06	184	530
STKc_PFTAIRE1	cd07869	0.00087	184	491
STKc_PFTAIRE2	cd07870	9.9e-06	184	487
STKc_PCTAIRE3	cd07871	3e-05	184	479
STKc_PCTAIRE1	cd07873	0.00074	184	498
STKc_BUR1	cd07866	1.2e-05	184	441
STKc_MST4	cd06640	5.1e-06	185	467
STKc_STK25-YSK1	cd06642	3.9e-07	185	470
STKc_MST3	cd06641	1.4e-06	185	467
STKc_MST1_2	cd06612	1.5e-10	185	448
STKc_MAP4K3_like	cd06613	4e-09	185	447
STKc_CDK12	cd07864	1e-05	185	468
STKc_TNIK	cd06637	5.1e-05	186	448
STKc_MEKK2	cd06652	3.3e-06	186	443
STKc_MEKK3_like_1	cd06653	1e-07	186	450
STKc_ERK1_2_like	cd07849	2.8e-05	186	477
STKc_CDKL2_3	cd07846	2.4e-05	186	448
PTKc_Tie1	cd05089	2.5e-27	187	471
PTKc_Srm_Brk	cd05148	5.3e-68	187	451
STKc_PKA	cd05580	2e-06	187	462
STKc_PDK1	cd05581	7.5e-11	187	448
STKc_PRKX_like	cd05612	4.4e-05	187	463
PKc_MAPKK	cd06605	1.8e-07	187	453
PKc_MEK	cd06615	1.9e-05	187	470
PKc_MKK3_6	cd06617	1.4e-06	187	465
PKc_MKK5	cd06619	1.4e-05	187	466
PKc_MAPKK_Pek1_like	cd06621	2.7e-05	187	460
PKc_MAPKK_PBS2_like	cd06622	6e-06	187	495
PKc_MAPKK_plant_like	cd06623	3.3e-13	187	456
STKc_MEKK3_like	cd06625	4.3e-12	187	450
STKc_MST3_like	cd06609	9.9e-10	187	468
STKc_OSR1_SPAK	cd06610	3.5e-10	187	441
STKc_NAK1_like	cd06917	2.9e-08	187	452
STKc_CdkB_plant	cd07837	2.2e-07	187	463
STKc_CDC2L1	cd07843	3.8e-05	187	441
STKc_CDKL1_4	cd07847	3.5e-07	187	487
STKc_CDK6	cd07862	0.00049	187	473
STKc_Nek6_Nek7	cd08224	2.8e-09	187	456
STKc_Nek6	cd08228	7.7e-07	187	453
STKc_Nek7	cd08229	4.4e-09	187	451
SPS1	COG0515	4.5e-32	187	637
PTKc_RET	cd05045	2e-30	188	452
PKc_STE	cd05122	2.8e-12	188	447
STKc_Yank1	cd05578	2.5e-06	188	448
STKc_GRK4_like	cd05605	8.5e-05	188	502
STKc_cPKC	cd05587	3.4e-07	188	521
STKc_cPKC_alpha	cd05615	2.8e-05	188	527
STKc_cPKC_beta	cd05616	4.6e-05	188	529
STKc_MAPKKK	cd06606	1.5e-19	188	448
STKc_Cdc7_like	cd06627	2.3e-17	188	442
STKc_MEKK3	cd06651	3.6e-08	188	444
STKc_CCRK	cd07832	2.1e-06	188	473
STKc_MAPK	cd07834	1.3e-05	188	480
STKc_CDK5	cd07839	3.4e-06	188	462
STKc_CDK7	cd07841	3.1e-07	188	460
STKc_CDK8_like	cd07842	1.9e-06	188	449
STKc_Pho85	cd07836	9.4e-07	188	487
STKc_TDY_MAPK_plant	cd07859	4.2e-05	188	535
STKc_CDK2_3	cd07860	3.9e-06	188	487
STKc_CDK1_euk	cd07861	1.2e-05	188	487
STKc_CDK4	cd07863	0.00027	188	487
STKc_NLK	cd07853	5.7e-06	188	515
STKc_MPK1	cd07857	7.8e-05	188	521
STKc_Nek	cd08215	9.2e-13	188	448
STKc_Nek2	cd08217	4.4e-08	188	449
STKc_Nek1	cd08218	2.7e-05	188	449
STKc_Nek3	cd08219	1.3e-07	188	448
STKc_Nek5	cd08225	5.1e-06	188	448
STKc_Nek4	cd08223	9.8e-06	188	449
STKc_Nek10	cd08528	1.2e-07	188	450
STKc_FA2-like	cd08529	1.9e-10	188	449
STKc_CNK2-like	cd08530	4.1e-09	188	444
PTKc_Axl_like	cd05035	5.8e-57	189	452
PTKc_Tyro3	cd05074	1.3e-51	189	452
PTKc_Axl	cd05075	1.5e-43	189	452
PTKc_Tyk2_rpt2	cd05080	3.7e-50	189	453
STKc_CMGC	cd05118	2.7e-09	189	441
STKc_p70S6K	cd05584	0.00022	189	535
STKc_PKN	cd05589	6.2e-06	189	528
STKc_myosinIII_like	cd06608	1.1e-07	189	448
STKc_CDK_like	cd07829	9.4e-11	189	425
STKc_MAK_like	cd07830	1.1e-09	189	449
STKc_CDK1_like	cd07835	8.5e-08	189	487
STKc_CDK4_6_like	cd07838	8.4e-05	189	462
STKc_CDK9_like	cd07840	1e-06	189	462
STKc_MOK	cd07831	7.6e-07	189	441
STKc_MEKK4	cd06626	3.4e-11	191	448
STKc_SLK_like	cd06611	4.5e-09	191	464
STKc_CDKL	cd07833	0.00012	191	448
STKc_Nek11	cd08222	1.4e-06	191	449
STKc_RSK_N	cd05582	5.6e-05	192	526
PTKc	cd00192	3.2e-122	193	449
PTK_Jak_rpt1	cd05037	8.5e-13	193	448
PTKc_Fes_like	cd05041	4.1e-48	193	450
PTKc_Aatyk	cd05042	1.1e-15	193	450
PTKc_c-ros	cd05044	1.5e-44	193	450
PTKc_Tie	cd05047	2.8e-32	193	450
PTKc_Met_Ron	cd05058	9.3e-52	193	454
PTKc_Ack_like	cd05040	1.3e-213	193	450
PTKc_Syk_like	cd05060	4.5e-99	193	453
PTK_Jak1_rpt1	cd05077	3.5e-08	193	448
PTK_Jak2_Jak3_rpt1	cd05078	5e-13	193	448
PTKc_Fes	cd05084	1.2e-48	193	450
PTKc_Fer	cd05085	1.7e-52	193	450
PTKc_Aatyk1_Aatyk3	cd05087	9.7e-22	193	450
PTKc_Aatyk2	cd05086	8.7e-17	193	450
PTKc_Syk	cd05116	2.8e-64	193	449
STKc_PKC	cd05570	6.3e-07	193	489
STKc_PKB	cd05571	3.8e-07	193	530
STKc_nPKC_epsilon	cd05591	7.7e-06	193	516
STKc_PKB_gamma	cd05593	0.0002	193	531
STKc_nPKC_theta_delt	cd05592	1.2e-06	193	520
STKc_PKB_alpha	cd05594	0.00014	193	507
STKc_PKB_beta	cd05595	0.00028	193	528
STKc_SGK2	cd05603	2.1e-05	193	527
STKc_nPKC_theta	cd05619	1e-07	193	514
STKc_nPKC_delta	cd05620	0.00091	193	500
STKc_MAPKKK_Bck1_lik	cd06629	2.6e-10	193	442
STKc_MEKK1	cd06630	3.7e-09	193	445
STKc_YSK4	cd06631	6.7e-10	193	448
STKc_MEKK1_plant	cd06632	3.5e-12	193	442
STKc_Nek8	cd08220	0.00013	193	449
PTKc_Zap-70	cd05115	4e-61	194	453
PKc	cd00180	9.7e-58	195	448
STKc_AGC	cd05123	1.4e-08	195	441
STKc_cGK_PKG	cd05572	5.2e-05	195	451
STKc_YPK1_like	cd05585	0.0007	195	488
STKc_GRK1	cd05608	0.00068	195	466
STKc_MAPKKK_Byr2_lik	cd06628	1.3e-10	195	448
STKc_Nek9	cd08221	2.4e-07	195	449
STKc_MAST_like	cd05579	0.00018	213	441
SH3	cd00174	2.9e-13	440	508
Pkinase	pfam00069	4.3e-36	189	448
Pkinase_Tyr	pfam07714	1.4e-133	189	448
TyrKc	smart00219	2.8e-134	189	448
STYKc	smart00221	2.3e-54	189	450
S_TKc	smart00220	9.5e-42	199	449
KIND	smart00750	8.7e-05	274	456
SH3	smart00326	7.3e-15	437	509
GTPase_binding	pfam09027	3e-44	510	577
Inhibitor_Mig-6	pfam11555	1.8e-34	852	919

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs112384084	Polymorphism	p.ARG955HIS	N/A
dbSNP	rs3747673	Polymorphism	p.ARG162TRP	N/A
dbSNP	rs56260729	Polymorphism	p.PRO803LEU	N/A
OMIM	606994.0001	Disease	p.VAL716MET	VARIANT OF UNKNOWN SIGNIFICANCE

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258