Results for the protein: NP

Results for the Protein: NP_001012331

59889558

4914

NTRK1

NCBI

high affinity nerve growth factor receptor isoform 1 precursor [Homo sapiens]

Known Diseases associated with this Protein:
INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
THYROID CARCINOMA, FAMILIAL MEDULLARY

7

2

7

2

0

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

RefSeq Protein: NP_001012331

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
Ig_TrKABC_d5	cd04971	9.3e-52	299	379
Ig_TrkB_d5	cd05855	3.1e-34	299	379
PTKc_PDGFR_alpha	cd05105	3.1e-17	458	781
PTKc_PDGFR_beta	cd05107	5e-22	473	780
PTKc_Kit	cd05104	4.2e-30	479	778
PTKc_CSF-1R	cd05106	1.8e-37	479	780
PTKc_PDGFR	cd05055	1.3e-28	480	779
STKc_PAK_I	cd06647	0.00096	481	790
STKc_PAK	cd06614	1.7e-11	485	789
STKc_TAO	cd06607	0.00047	487	786
PTKc_FGFR1	cd05098	6.6e-56	488	783
STKc_PAK_II	cd06648	2.4e-06	488	789
PTKc_FGFR2	cd05101	7.4e-53	489	783
STKc_PAK6	cd06659	5.4e-05	489	789
PTKc_FGFR4	cd05099	2.6e-58	491	788
PTKc_FGFR3	cd05100	2.7e-40	491	788
STKc_myosinIIIA	cd06638	0.00029	491	775
STKc_CDK12	cd07864	2.3e-08	491	786
STKc_BUR1	cd07866	3.3e-07	491	765
PKc_MKK7	cd06618	2.6e-05	493	781
STKc_TAO2	cd06634	0.00047	493	787
PTK_Tyk2_rpt1	cd05076	3.4e-06	494	776
STKc_ASK	cd06624	2.5e-07	495	777
PTKc_VEGFR	cd05054	3.3e-34	496	782
PTKc_Tie2	cd05088	1.1e-42	496	788
PTKc_VEGFR3	cd05102	5.6e-36	496	782
PTKc_VEGFR2	cd05103	1.9e-33	496	782
PTKc_EGFR	cd05108	1.7e-22	496	790
PTKc_HER2	cd05109	9.2e-41	496	789
PTKc_HER4	cd05110	1e-25	496	790
PTK_HER3	cd05111	2e-39	496	789
STKc_SLK	cd06643	5e-06	496	781
STKc_STK10_LOK	cd06644	2.5e-05	496	783
PTKc_InsR_like	cd05032	4.2e-98	497	777
PTKc_Src_like	cd05034	2.9e-67	497	778
PTKc_ALK_LTK	cd05036	2.4e-91	497	777
PTKc_Csk_like	cd05039	3.4e-39	497	778
PTKc_Abl	cd05052	1.2e-72	497	779
PTKc_FAK	cd05056	8.9e-77	497	783
PTKc_InsR	cd05061	8.6e-77	497	790
PTKc_IGF-1R	cd05062	1e-76	497	777
PTKc_Lck_Blk	cd05067	6.5e-49	497	778
PTKc_Frk_like	cd05068	1e-72	497	778
PTKc_Yes	cd05069	2.5e-42	497	778
PTKc_Fyn_Yrk	cd05070	7.4e-49	497	778
PTKc_Src	cd05071	8.6e-44	497	780
PTKc_Lyn	cd05072	2.5e-54	497	778
PTKc_Csk	cd05082	1.7e-51	497	778
PTKc_Chk	cd05083	1.4e-56	497	778
PTKc_Hck	cd05073	1.3e-50	497	778
STKc_Yank1	cd05578	5e-06	497	781
STKc_MAPK15	cd07852	6.7e-05	497	789
STKc_CDK9	cd07865	6.3e-05	497	786
PTKc_Ror	cd05048	2.6e-116	498	778
PTKc_Trk	cd05049	2.3e-219	498	777
PTKc_Musk	cd05050	1.6e-127	498	777
PTKc_DDR	cd05051	4.4e-101	498	777
PTK_CCK4	cd05046	7.8e-72	498	777
PTKc_EGFR_like	cd05057	1.6e-54	498	789
PTKc_EphR_A2	cd05063	3e-63	498	779
PTKc_EphR_A10	cd05064	3.7e-55	498	779
PTKc_Ror1	cd05090	4.7e-92	498	778
PTKc_Ror2	cd05091	3e-78	498	778
PTKc_TrkA	cd05092	2.6e-241	498	777
PTKc_TrkB	cd05093	1e-205	498	787
PTKc_TrkC	cd05094	7.8e-191	498	787
PTKc_DDR1	cd05096	3.7e-80	498	777
PTKc_DDR_like	cd05097	2.3e-83	498	777
PTKc_DDR2	cd05095	2e-87	498	777
PKc_MAPKK_Byr1_like	cd06620	2.7e-08	498	781
STKc_MAP4K3	cd06645	0.00048	498	776
STKc_MAP4K5	cd06646	0.00027	498	776
STKc_PCTAIRE_like	cd07844	0.00016	498	786
STKc_PFTAIRE2	cd07870	0.00025	498	786
STKc_PCTAIRE3	cd07871	0.00024	498	786
PTKc_EphR	cd05033	2.6e-68	499	779
PTKc_Jak_rpt2	cd05038	4e-67	499	779
PTK_Ryk	cd05043	1.6e-25	499	775
PTKc_FGFR	cd05053	2.1e-66	499	776
PTKc_EphR_B	cd05065	3.3e-58	499	779
PTKc_Tec_like	cd05059	2.8e-68	499	776
PTKc_EphR_A	cd05066	4.2e-64	499	779
PTKc_Jak1_rpt2	cd05079	2.6e-42	499	779
PTKc_Jak2_Jak3_rpt2	cd05081	6.4e-50	499	779
PTKc_Tyk2_rpt2	cd05080	7.7e-40	499	780
PTKc_Itk	cd05112	1.5e-64	499	776
PTKc_Btk_Bmx	cd05113	2e-69	499	776
PTKc_Tec_Rlk	cd05114	1.5e-64	499	776
PKc_MKK4	cd06616	0.00026	499	789
STKc_MAP4K3_like	cd06613	7.2e-09	500	772
STKc_MST4	cd06640	0.00038	500	789
STKc_MST3	cd06641	0.00017	500	789
STKc_STK25-YSK1	cd06642	6.5e-05	500	790
STKc_CDK10	cd07845	1e-06	500	752
STKc_CDKL1_4	cd07847	0.00011	500	777
PTKc_Srm_Brk	cd05148	1.2e-64	501	778
STKc_MEKK2	cd06652	5e-06	501	778
STKc_CDK4	cd07863	8.5e-05	501	786
STKc_Nek6_Nek7	cd08224	1.5e-07	501	780
PTKc_Tie1	cd05089	2.8e-48	502	787
STKc_PDK1	cd05581	6.4e-11	502	786
STKc_PKA	cd05580	9e-05	502	788
STKc_PRKX_like	cd05612	9.6e-05	502	790
PKc_MAPKK	cd06605	2.9e-06	502	787
STKc_OSR1_SPAK	cd06610	4.5e-08	502	769
PKc_MEK	cd06615	5.7e-06	502	789
STKc_myosinIII_like	cd06608	1.2e-05	502	775
PKc_MAPKK_Pek1_like	cd06621	1.9e-05	502	758
PKc_MAPKK_PBS2_like	cd06622	7.7e-05	502	789
PKc_MAPKK_plant_like	cd06623	1.2e-13	502	773
PKc_MKK3_6	cd06617	0.00024	502	777
STKc_CDK7	cd07841	1.5e-08	502	779
STKc_CDK6	cd07862	0.00074	502	789
STKc_Nek1	cd08218	3e-06	502	777
STKc_Nek3	cd08219	1.4e-10	502	777
STKc_Nek5	cd08225	1.2e-06	502	777
STKc_Nek6	cd08228	1.9e-06	502	780
STKc_Nek7	cd08229	4.6e-07	502	777
STKc_CNK2-like	cd08530	2.8e-08	502	775
SPS1	COG0515	1.9e-05	502	790
PTKc_RET	cd05045	3.7e-58	503	782
PKc_STE	cd05122	3.2e-13	503	774
STKc_MSK_N	cd05583	0.00062	503	787
STKc_GRK4_like	cd05605	0.00037	503	788
STKc_MST3_like	cd06609	9.1e-08	503	786
STKc_MST1_2	cd06612	2.6e-09	503	768
STKc_Cdc7_like	cd06627	1.5e-13	503	768
STKc_MOK	cd07831	8.6e-05	503	775
STKc_MAPK	cd07834	6.5e-06	503	787
STKc_Pho85	cd07836	5.9e-05	503	775
STKc_CdkB_plant	cd07837	1.9e-07	503	776
STKc_CDK1_euk	cd07861	0.00061	503	786
STKc_Nek	cd08215	1e-13	503	777
STKc_Nek2	cd08217	4.7e-08	503	775
STKc_Nek11	cd08222	3.1e-07	503	777
STKc_Nek4	cd08223	3.3e-07	503	777
STKc_Nek10	cd08528	0.00017	503	777
STKc_FA2-like	cd08529	2.4e-09	503	768
PTKc_Axl_like	cd05035	1.1e-58	504	779
PTKc_Tyro3	cd05074	2.5e-56	504	779
PTKc_Axl	cd05075	1.7e-51	504	779
STKc_CDK2_3	cd07860	0.00064	504	786
STKc_MAK_like	cd07830	4.3e-10	505	777
STKc_CDK1_like	cd07835	7.1e-06	505	786
STKc_RSK_N	cd05582	0.00014	506	788
STKc_MEKK3_like	cd06625	1.1e-11	506	777
STKc_MAPKKK_Bck1_lik	cd06629	2.8e-11	506	773
STKc_MEKK3	cd06651	3.5e-09	506	779
STKc_MEKK3_like_1	cd06653	3.9e-07	506	778
STKc_MAPKKK	cd06606	6.8e-19	507	775
STKc_MEKK4	cd06626	3.3e-09	507	773
STKc_MAPKKK_Byr2_lik	cd06628	3.6e-12	507	777
STKc_MEKK1	cd06630	1.6e-07	507	776
STKc_YSK4	cd06631	2.8e-09	507	775
STKc_MEKK1_plant	cd06632	1.4e-10	507	771
STKc_NAK1_like	cd06917	2.9e-07	507	776
STKc_CDKL2_3	cd07846	3.4e-05	507	775
STKc_CDK5	cd07839	2.5e-05	507	775
STKc_Nek8	cd08220	1.9e-06	507	779
PTKc	cd00192	8.6e-131	508	776
PTK_Jak_rpt1	cd05037	3.1e-12	508	776
PTKc_Ack_like	cd05040	7.6e-63	508	777
PTKc_Fes_like	cd05041	2.7e-55	508	777
PTKc_Aatyk	cd05042	1.4e-35	508	777
PTKc_Syk_like	cd05060	1.9e-57	508	780
PTKc_Syk	cd05116	7.2e-49	508	780
PTK_Jak1_rpt1	cd05077	5e-08	509	776
PTK_Jak2_Jak3_rpt1	cd05078	1.4e-12	509	772
PTKc_Fes	cd05084	1.8e-64	509	777
PTKc_Aatyk2	cd05086	1.4e-39	509	777
PTKc_Aatyk1_Aatyk3	cd05087	6.9e-45	509	777
PTKc_Zap-70	cd05115	2e-52	509	780
STKc_CMGC	cd05118	1.1e-07	509	775
STKc_SLK_like	cd06611	9.2e-08	509	781
STKc_CDK_like	cd07829	2e-10	509	775
STKc_CDKL	cd07833	9.2e-06	509	775
STKc_CDK4_6_like	cd07838	5.3e-06	509	786
STKc_CDK9_like	cd07840	2.5e-10	509	789
STKc_CDK8_like	cd07842	5.5e-05	509	773
STKc_CDC2L1	cd07843	0.00014	509	786
PKc	cd00180	8.1e-60	510	775
PTKc_c-ros	cd05044	3.8e-83	510	777
PTKc_Tie	cd05047	2.3e-54	510	780
PTKc_Met_Ron	cd05058	8.1e-61	510	781
PTKc_Fer	cd05085	7.5e-54	510	777
STKc_AGC	cd05123	6.2e-08	510	773
STKc_PKC	cd05570	4.3e-05	510	786
STKc_cGK_PKG	cd05572	2.4e-07	510	773
STKc_GRK	cd05577	0.00065	510	787
STKc_MAST_like	cd05579	2.8e-09	510	773
STKc_nPKC_theta	cd05619	0.001	510	788
STKc_CCRK	cd07832	8.8e-09	510	776
STKc_Nek9	cd08221	2.2e-08	510	777
Pkinase	pfam00069	5.8e-43	504	775
LRRCT	smart00082	1.2e-09	148	192
I-set	pfam07679	0.00026	194	282
Pkinase_Tyr	pfam07714	2.1e-138	504	775
TyrKc	smart00219	2e-135	504	775
STYKc	smart00221	1.1e-50	504	786
S_TKc	smart00220	2.8e-44	514	784
KIND	smart00750	0.00014	609	785

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs6339	Polymorphism	p.GLY607VAL	N/A
dbSNP	rs6336	Polymorphism	p.HIS598TYR	N/A
OMIM	191315.0004	Disease	p.ARG768PRO	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0003	Disease	p.GLY565ARG	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0013	Disease	p.MET575VAL	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0011	Disease	p.PRO683LEU	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0012	Disease	p.TYR359CYS	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0008	Disease	p.TYR598HIS	THYROID CARCINOMA, FAMILIAL MEDULLARY
OMIM	191315.0009	Disease	p.VAL607GLY	THYROID CARCINOMA, FAMILIAL MEDULLARY

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258