Results for the protein: O43283

Results for the Protein: O43283

68052263

9175

MAP3K13

NCBI, UniProt

M3K13_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase 13; AltName: Full=Leucine zipper-bearing kinase; AltName: Full=Mixed lineage kinase; Short=MLK

			0 5 0 0 5

Tips:

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Swiss-Prot Protein: O43283

Identical to: NP_001229243, NP_004712

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_PDGFR_alpha	cd05105	6.5e-07	52	417
PTKc_PDGFR_beta	cd05107	3.9e-05	52	412
PTKc_VEGFR2	cd05103	3.8e-07	77	413
STKc_myosinIIIB	cd06639	9.8e-09	134	410
PTKc_Kit	cd05104	5.8e-08	138	411
PTKc_CSF-1R	cd05106	3e-05	139	412
STKc_CDKL5	cd07848	2.8e-05	141	433
PTKc_PDGFR	cd05055	2.1e-10	142	411
STKc_myosinIIIA	cd06638	5.9e-09	142	409
PTKc_DDR1	cd05096	5.9e-09	143	411
PTKc_DDR_like	cd05097	2.4e-10	143	410
STKc_PAK	cd06614	3.1e-20	145	415
STKc_TAO3	cd06633	8.1e-09	146	446
STKc_JNK1	cd07875	7.4e-05	146	487
STKc_JNK2	cd07876	3.6e-06	146	507
STKc_TAO1	cd06635	3.3e-10	147	446
STKc_PAK4	cd06657	4.4e-06	147	430
STKc_PAK5	cd06658	1.2e-06	147	424
STKc_PAK6	cd06659	2.2e-09	148	429
STKc_JNK3	cd07874	1.7e-05	150	507
STKc_p38alpha_MAPK14	cd07877	3.7e-05	150	459
PTKc_FGFR1	cd05098	4.5e-20	151	420
STKc_OSR1_SPAK	cd06610	1.2e-15	151	409
STKc_JNK	cd07850	4.6e-08	151	466
STKc_Nek6	cd08228	5.1e-07	151	407
STKc_Nek7	cd08229	1e-08	151	407
PTKc_FGFR2	cd05101	1.7e-19	152	420
STKc_TAO	cd06607	3.3e-09	152	442
STKc_TAO2	cd06634	2.6e-11	152	443
STKc_MAP4K4_6	cd06636	9.4e-07	153	409
STKc_STK10_LOK	cd06644	8.1e-12	153	429
STKc_PAK_I	cd06647	2.2e-13	153	430
STKc_p38	cd07851	3.1e-09	153	442
STKc_p38delta_MAPK13	cd07879	0.001	153	484
STKc_p38gamma_MAPK12	cd07880	1.1e-05	153	491
STKc_p38beta_MAPK11	cd07878	4e-05	153	464
PKc_MKK7	cd06618	6.4e-12	154	443
STKc_PAK_II	cd06648	1.3e-10	154	422
PKc_MEK2	cd06649	2.2e-07	154	481
STKc_PAK1	cd06654	6e-09	154	430
STKc_PAK3	cd06656	6.5e-09	154	427
STKc_PAK2	cd06655	7.3e-09	154	427
PTKc_FGFR	cd05053	6.9e-15	155	412
PTKc_FGFR4	cd05099	6.2e-22	155	425
PTKc_FGFR3	cd05100	6e-10	155	444
STKc_SLK_like	cd06611	9.4e-14	155	417
STKc_SLK	cd06643	2.4e-10	155	427
PTKc_EphR_A10	cd05064	2.3e-26	157	414
STKc_MAP4K3	cd06645	1.8e-09	158	408
STKc_MAP4K5	cd06646	8.1e-09	158	408
STKc_ASK	cd06624	4.8e-26	159	409
PKc_MEK1	cd06650	1.6e-06	159	485
STKc_ERK5	cd07855	2.4e-06	159	453
STKc_CDK9	cd07865	4.5e-10	159	423
PTKc_EGFR_like	cd05057	5.6e-25	160	426
PTKc_VEGFR3	cd05102	7.8e-08	160	413
PKc_STE	cd05122	4.6e-31	160	408
STKc_Sty1_Hog1	cd07856	9.2e-07	160	466
PTKc_InsR_like	cd05032	1.9e-17	161	409
PTKc_Src_like	cd05034	9.4e-32	161	409
PTKc_ALK_LTK	cd05036	2.1e-17	161	409
PTKc_Csk_like	cd05039	5.5e-22	161	410
PTKc_FAK	cd05056	1.1e-28	161	414
PTKc_InsR	cd05061	9.6e-22	161	423
PTKc_IGF-1R	cd05062	7.3e-20	161	409
PTKc_Lck_Blk	cd05067	1.6e-30	161	407
PTKc_Fyn_Yrk	cd05070	3.4e-25	161	410
PTKc_Src	cd05071	2.1e-21	161	412
PTKc_Lyn	cd05072	3.4e-29	161	410
PTKc_Hck	cd05073	5.1e-23	161	410
PTKc_Yes	cd05069	9e-22	161	410
PTKc_Csk	cd05082	3.2e-34	161	410
PTKc_Chk	cd05083	2.1e-30	161	410
PTKc_Abl	cd05052	1.9e-41	161	411
PTKc_Frk_like	cd05068	1.8e-44	161	410
PTKc_Srm_Brk	cd05148	5.5e-19	161	410
STKc_TNIK	cd06637	6.1e-08	161	409
STKc_ERK1_2_like	cd07849	4.3e-07	161	442
STKc_TEY_MAPK_plant	cd07858	2.6e-07	161	476
STKc_CDK12	cd07864	5.9e-10	161	438
PTK_CCK4	cd05046	1.1e-19	162	409
PTKc_Ror	cd05048	3.1e-18	162	410
PTKc_Trk	cd05049	5.6e-18	162	409
PTKc_Musk	cd05050	1.9e-15	162	409
PTKc_DDR	cd05051	2.1e-14	162	409
PTKc_EphR_A2	cd05063	4.7e-26	162	411
PTKc_EphR_B	cd05065	1.7e-28	162	411
PTKc_Ror2	cd05091	9.4e-14	162	410
PTKc_TrkA	cd05092	7.1e-19	162	417
PTKc_TrkB	cd05093	1.6e-10	162	416
PTKc_TrkC	cd05094	1.9e-08	162	451
PTKc_DDR2	cd05095	3.1e-12	162	409
PTKc_Ror1	cd05090	1.6e-15	162	410
PTKc_Jak_rpt2	cd05038	3e-30	163	411
PTKc_EphR	cd05033	5.9e-23	163	411
PTKc_EphR_A	cd05066	3.2e-27	163	411
PTKc_Tie2	cd05088	1.1e-12	163	429
PTKc_EGFR	cd05108	7.7e-16	163	456
PTKc_HER2	cd05109	4.5e-12	163	416
PTKc_HER4	cd05110	6.5e-10	163	445
PTKc_Itk	cd05112	2.5e-41	163	408
PTKc_Btk_Bmx	cd05113	1.4e-38	163	408
PTKc_Tec_Rlk	cd05114	9.1e-38	163	408
PTK_HER3	cd05111	2.7e-12	163	416
STKc_phototropin_lik	cd05574	6.8e-08	163	420
STKc_CDK10	cd07845	2e-10	163	423
STKc_MAP4K3_like	cd06613	2.3e-17	164	408
STKc_MST4	cd06640	5.2e-12	164	430
STKc_MST3	cd06641	1.3e-10	164	430
STKc_STK25-YSK1	cd06642	2.1e-12	164	430
STKc_CDK8_like	cd07842	2.5e-07	164	409
STKc_PCTAIRE_like	cd07844	8.6e-08	164	438
STKc_CDK4	cd07863	9.3e-07	164	438
PTKc_Jak1_rpt2	cd05079	5.8e-21	165	411
PTKc_Tyk2_rpt2	cd05080	1.7e-12	165	412
PTKc_Tie1	cd05089	7.1e-12	165	428
PTKc_Jak2_Jak3_rpt2	cd05081	1.4e-21	165	411
STKc_GRK7	cd05607	2.8e-06	165	426
STKc_MST1_2	cd06612	6.1e-18	165	409
STKc_MAK_like	cd07830	1e-12	165	409
STKc_CDK4_6_like	cd07838	4.7e-11	165	407
STKc_CDK9_like	cd07840	5.1e-13	165	423
STKc_CDK6	cd07862	9.1e-06	165	442
STKc_BUR1	cd07866	1.3e-07	165	423
STKc_PFTAIRE2	cd07870	3.5e-06	165	437
STKc_PCTAIRE3	cd07871	2.1e-06	165	473
STKc_PCTAIRE2	cd07872	1.6e-06	165	459
STKc_PCTAIRE1	cd07873	4.2e-06	165	452
STKc_Nek6_Nek7	cd08224	1.8e-08	165	415
PTK_Ryk	cd05043	1.4e-14	166	409
STKc_ROCK_NDR_like	cd05573	1.5e-07	166	441
STKc_PKA	cd05580	5.2e-09	166	440
STKc_PDK1	cd05581	1.5e-13	166	410
STKc_LATS	cd05598	0.00096	166	472
STKc_MAST	cd05609	1.1e-08	166	467
STKc_PRKX_like	cd05612	3.6e-09	166	453
PKc_MAPKK	cd06605	6.5e-15	166	414
STKc_MST3_like	cd06609	1.2e-17	166	430
PKc_MEK	cd06615	2.8e-12	166	476
PKc_MKK4	cd06616	8.9e-08	166	427
PKc_MKK3_6	cd06617	6.8e-12	166	428
PKc_MKK5	cd06619	5.3e-06	166	434
PKc_MAPKK_Byr1_like	cd06620	1.2e-11	166	416
PKc_MAPKK_Pek1_like	cd06621	5.1e-14	166	415
PKc_MAPKK_PBS2_like	cd06622	8.8e-10	166	465
PKc_MAPKK_plant_like	cd06623	7e-19	166	414
STKc_MEKK3_like_1	cd06653	2.5e-10	166	409
STKc_CDKL2_3	cd07846	3.6e-08	166	423
STKc_CDKL1_4	cd07847	3e-10	166	438
STKc_MAPK15	cd07852	9.8e-09	166	437
STKc_CdkB_plant	cd07837	1.7e-06	166	408
STKc_MAPK4_6	cd07854	3.1e-05	166	473
STKc_PFTAIRE1	cd07869	0.00027	166	446
SPS1	COG0515	6.6e-40	166	669
PTKc_Tec_like	cd05059	6.2e-23	167	408
STKc_MSK_N	cd05583	5.7e-09	167	443
STKc_cPKC	cd05587	1.3e-08	167	470
STKc_GRK4_like	cd05605	5.7e-07	167	450
STKc_MSK1_N	cd05613	1.4e-07	167	425
STKc_MSK2_N	cd05614	3.4e-07	167	491
STKc_cPKC_alpha	cd05615	8.2e-08	167	485
STKc_GRK6	cd05630	6.1e-05	167	427
STKc_GRK4	cd05631	0.0002	167	427
STKc_GRK5	cd05632	0.00019	167	423
STKc_cPKC_beta	cd05616	3.8e-07	167	485
STKc_myosinIII_like	cd06608	6e-13	167	409
STKc_MAPKKK	cd06606	1.7e-50	167	409
STKc_Cdc7_like	cd06627	2e-22	167	409
STKc_CCRK	cd07832	2.1e-11	167	424
STKc_Pho85	cd07836	4.9e-06	167	438
STKc_CDK5	cd07839	2.4e-06	167	423
STKc_CDK7	cd07841	3.8e-12	167	423
STKc_NLK	cd07853	3.5e-05	167	493
STKc_CDK2_3	cd07860	1.1e-05	167	438
STKc_CDK1_euk	cd07861	9e-06	167	438
STKc_TDY_MAPK_plant	cd07859	6.8e-06	167	476
STKc_Nek2	cd08217	1.4e-11	167	409
STKc_Nek3	cd08219	2.7e-26	167	409
STKc_Nek8	cd08220	7.3e-12	167	409
STKc_Nek4	cd08223	1.2e-21	167	409
STKc_Nek1	cd08218	5.7e-25	167	409
STKc_Nek5	cd08225	5.1e-23	167	409
STKc_Nek10	cd08528	3.2e-08	167	409
PTKc_Axl_like	cd05035	3e-11	168	411
PTKc_Tyro3	cd05074	3.6e-14	168	411
PTKc_Axl	cd05075	1.7e-14	168	411
STKc_PKN	cd05589	2.6e-08	168	469
STKc_CDK1_like	cd07835	1.7e-07	168	438
STKc_CDC2L1	cd07843	9.3e-09	168	409
STKc_CMGC	cd05118	9.3e-15	169	409
STKc_NAK1_like	cd06917	6.3e-14	169	434
PK_STRAD	cd08216	1.5e-05	169	420
PTKc_RET	cd05045	5.7e-10	170	414
STKc_MEKK3	cd06651	1.2e-12	170	412
STKc_MEKK2	cd06652	4e-09	170	410
STKc_Nek	cd08215	7.7e-28	170	405
STKc_FA2-like	cd08529	2.5e-13	170	409
STKc_Yank1	cd05578	1.3e-09	171	407
STKc_RSK_N	cd05582	6.5e-08	171	489
STKc_p70S6K	cd05584	2e-08	171	470
STKc_MEKK3_like	cd06625	3.5e-23	171	409
STKc_MEKK4	cd06626	1.5e-16	171	409
STKc_MAPKKK_Bck1_lik	cd06629	2e-17	171	409
STKc_CDK_like	cd07829	2.8e-15	171	409
STKc_MOK	cd07831	6.3e-07	171	406
STKc_CDKL	cd07833	7.6e-10	171	407
STKc_MAPK	cd07834	1.6e-08	171	436
STKc_MPK1	cd07857	9.4e-07	171	437
STKc_CNK2-like	cd08530	2.6e-12	171	409
PTKc	cd00192	7.7e-51	172	408
PTKc_Ack_like	cd05040	3.3e-20	172	406
PTKc_Fes_like	cd05041	7.7e-23	172	409
PTKc_Aatyk	cd05042	3.2e-10	172	406
PTKc_Tie	cd05047	5.8e-18	172	412
PTKc_c-ros	cd05044	3.2e-14	172	409
PTK_Jak_rpt1	cd05037	1e-09	172	408
PTKc_Met_Ron	cd05058	8.3e-29	172	413
PTKc_Syk_like	cd05060	8.5e-19	172	410
PTK_Tyk2_rpt1	cd05076	5.8e-05	172	408
PTK_Jak1_rpt1	cd05077	1.1e-06	172	408
PTK_Jak2_Jak3_rpt1	cd05078	1.3e-08	172	408
PTKc_Fes	cd05084	1.4e-36	172	411
PTKc_Fer	cd05085	4.8e-29	172	409
PTKc_Aatyk2	cd05086	4e-06	172	409
PTKc_Aatyk1_Aatyk3	cd05087	5.5e-08	172	409
PTKc_Syk	cd05116	2.9e-23	172	412
STKc_PKC	cd05570	3.1e-12	172	468
STKc_PKB	cd05571	1e-11	172	491
STKc_SGK	cd05575	3e-07	172	472
STKc_aPKC	cd05588	7.8e-08	172	516
STKc_nPKC_eta	cd05590	8.5e-07	172	469
STKc_nPKC_epsilon	cd05591	4.8e-08	172	469
STKc_nPKC_theta_delt	cd05592	1.9e-09	172	471
STKc_PKB_gamma	cd05593	7.6e-09	172	477
STKc_PKB_alpha	cd05594	5.8e-10	172	476
STKc_PKB_beta	cd05595	1.4e-08	172	480
STKc_SGK1	cd05602	3.1e-06	172	475
STKc_SGK2	cd05603	9.8e-09	172	490
STKc_SGK3	cd05604	1.4e-05	172	475
STKc_aPKC_zeta	cd05617	4e-08	172	469
STKc_aPKC_iota	cd05618	3.1e-06	172	488
STKc_nPKC_theta	cd05619	2.7e-08	172	471
STKc_nPKC_delta	cd05620	0.00011	172	471
STKc_MAPKKK_Byr2_lik	cd06628	1.5e-31	172	409
STKc_MEKK1	cd06630	5.4e-12	172	410
STKc_YSK4	cd06631	7.2e-14	172	409
STKc_MEKK1_plant	cd06632	4.3e-16	172	409
STKc_Nek11	cd08222	3.4e-15	172	409
PKc	cd00180	2.6e-72	174	407
STKc_AGC	cd05123	4.2e-13	174	410
PTKc_Zap-70	cd05115	1.1e-25	174	412
STKc_cGK_PKG	cd05572	3.2e-10	174	404
STKc_GRK	cd05577	3e-08	174	426
STKc_MAST_like	cd05579	1e-10	174	400
STKc_YPK1_like	cd05585	8.7e-06	174	464
STKc_Sck1_like	cd05586	2e-05	174	515
STKc_beta_ARK	cd05606	4.4e-05	174	442
STKc_GRK1	cd05608	2.2e-08	174	426
STKc_GRK3	cd05633	0.00036	174	458
STKc_Nek9	cd08221	1.9e-12	174	409
STKc_CRIK	cd05601	0.00094	187	455
Pkinase	pfam00069	1.5e-69	168	407
Pkinase_Tyr	pfam07714	8.1e-68	168	407
TyrKc	smart00219	2.5e-62	168	407
STYKc	smart00221	1.3e-57	168	409
S_TKc	smart00220	1.6e-62	178	409
KIND	smart00750	7.1e-05	239	417

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040708	Polymorphism	p.ARG517GLY	N/A
Swiss-Prot	VAR_030577	Polymorphism	p.ARG915HIS	N/A
Swiss-Prot	VAR_051640	Polymorphism	p.GLU44LYS	N/A
Swiss-Prot	VAR_040709	Polymorphism	p.GLU712LYS	N/A
Swiss-Prot	VAR_040710	Polymorphism	p.PRO746LEU	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258