Results for the protein: P35968

Results for the Protein: P35968

9087218

3791

KDR

NCBI, UniProt

VGFR2_HUMAN RecName: Full=Vascular endothelial growth factor receptor 2; Short=VEGFR-2; AltName: Full=Fetal liver kinase 1; Short=FLK-1; AltName: Full=Kinase insert domain receptor; Short=KDR; AltName: Full=Protein-tyrosine kinase receptor flk-1; AltName: CD_antigen=CD309; Flags: Precursor

Known Diseases associated with this Protein:
  HEMANGIOMA, CAPILLARY INFANTILE (HCI)
  HEMANGIOMA, CAPILLARY INFANTILE, SOMATIC
  HEMANGIOMA, CAPILLARY INFANTILE, SUSCEPTIBILITY TO

3

15

2

2

14

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

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Swiss-Prot Protein: P35968

Identical to: NP_002244

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
Ig1_PDGFR-alphabeta	cd05861	0.00052	239	326
Ig1_VEGFR	cd05862	8.3e-61	239	326
Ig	cd00096	9.2e-06	242	322
Ig4_PDGFR-alpha	cd05859	0.00019	329	419
Ig2_FGFR_like	cd05729	0.00013	337	415
Ig_Titin_like	cd05748	6.2e-06	347	417
Ig	cd00096	6.8e-09	348	413
Ig2_VEGFR	cd04976	1.7e-43	348	417
Ig2_VEGFR-3	cd05863	2.3e-09	348	417
Ig2_VEGFR-2	cd05864	2.4e-55	348	417
Ig2_VEGFR-1	cd07702	1.8e-05	348	417
Ig4_PDGFR-alpha	cd05859	0.00022	664	758
Ig5_NCAM-1_like	cd05732	4.8e-08	665	754
Ig5_NCAM-1	cd05869	7.4e-05	665	754
Ig5_NCAM-2	cd05870	0.00066	665	754
Ig3_NCAM-1_like	cd05730	1.2e-05	666	757
Ig_Myomesin_like_C	cd05737	0.00086	666	754
Ig_CEACAM_D4	cd05740	0.00091	666	756
Ig3_Contactin-1	cd05851	3.3e-05	666	755
Ig1_Robo	cd07693	2.8e-05	666	754
Ig3_Contactin_like	cd04968	1.1e-05	667	755
Ig1_NCAM-2	cd05866	0.00078	668	757
Ig_M-protein_C	cd05891	0.00066	668	754
Ig4_Contactin-2-like	cd05728	8.9e-05	670	748
Ig2_Robo	cd05724	1.5e-05	673	754
Ig2_FGFR_like	cd05729	1.9e-06	673	750
Ig2_FGFRL1-like	cd05856	7.1e-06	677	750
Ig5_Contactin_like	cd04969	2.8e-07	681	754
Ig4_L1-NrCAM_like	cd04978	0.00067	681	755
Ig4_Robo	cd05726	0.00011	681	763
Ig3_Peroxidasin	cd05745	7.4e-11	681	754
Ig5_Contactin-1	cd05852	0.00053	681	754
Ig4_Neogenin	cd05723	0.00049	683	754
Ig	cd00096	2.1e-13	684	753
Ig3_Robo	cd05725	0.00012	684	754
Ig2_Follistatin_like	cd05736	0.00048	684	757
Ig_Myotilin_C_like	cd05744	0.00022	684	754
Ig4_Peroxidasin	cd05746	1e-05	684	753
Ig_Pro_neuregulin	cd05750	0.0002	684	752
Ig2_PTK7	cd05760	3e-06	684	759
Ig_1	cd05763	0.00036	684	755
Ig_Myotilin_C	cd05892	0.00072	684	754
Ig3_L1-CAM_like	cd05731	0.00029	688	749
PTKc_PDGFR	cd05055	2.3e-155	784	1164
PTKc_CSF-1R	cd05106	1.4e-136	787	1165
PTKc_PDGFR_alpha	cd05105	9.6e-116	796	1166
PTKc_Kit	cd05104	3.9e-134	796	1164
PTKc_PDGFR_beta	cd05107	3.2e-112	796	1165
PTKc_FGFR1	cd05098	1.8e-110	813	1171
STKc_PAK	cd06614	1.1e-08	814	1176
STKc_STK10_LOK	cd06644	0.00084	815	1183
STKc_p38	cd07851	6.6e-06	817	1212
PTKc_FGFR2	cd05101	2.1e-112	819	1171
PTKc_FGFR	cd05053	5.3e-136	820	1165
PTKc_FGFR4	cd05099	2.6e-109	820	1187
PTKc_FGFR3	cd05100	3.6e-106	820	1205
PTKc_Tie2	cd05088	3.2e-45	822	1191
PTKc_VEGFR	cd05054	9.6e-236	826	1167
PTKc_EGFR_like	cd05057	2.2e-43	826	1179
PTKc_VEGFR2	cd05103	5.2e-299	826	1167
PTKc_VEGFR3	cd05102	1.3e-221	826	1167
PTKc_Src_like	cd05034	4.3e-45	827	1163
PTKc_ALK_LTK	cd05036	1.7e-53	827	1162
PTKc_Csk_like	cd05039	5.3e-35	827	1163
PTKc_Abl	cd05052	6.1e-50	827	1164
PTKc_FAK	cd05056	1.7e-47	827	1168
PTKc_InsR	cd05061	1.1e-42	827	1173
PTKc_IGF-1R	cd05062	1e-40	827	1162
PTKc_Lck_Blk	cd05067	5e-40	827	1163
PTKc_Frk_like	cd05068	3.1e-52	827	1163
PTKc_Yes	cd05069	1.5e-24	827	1163
PTKc_Fyn_Yrk	cd05070	1.1e-27	827	1163
PTKc_Src	cd05071	4e-24	827	1165
PTKc_Hck	cd05073	1e-40	827	1163
PTKc_Csk	cd05082	3.2e-41	827	1163
PTKc_Chk	cd05083	2e-45	827	1163
PTKc_Tie1	cd05089	7.2e-49	827	1193
PTKc_InsR_like	cd05032	5.8e-62	827	1162
PTKc_Lyn	cd05072	1.4e-31	827	1163
PTKc_Srm_Brk	cd05148	8.9e-42	827	1163
STKc_CDK12	cd07864	5.4e-05	827	1160
PTK_CCK4	cd05046	1.9e-29	828	1162
PTKc_Ror	cd05048	4e-42	828	1163
PTKc_Trk	cd05049	1.9e-47	828	1162
PTKc_Musk	cd05050	4.2e-63	828	1162
PTKc_EphR_A2	cd05063	1.5e-27	828	1164
PTKc_EphR_A10	cd05064	7.8e-17	828	1164
PTKc_Ror1	cd05090	4.7e-31	828	1163
PTKc_TrkA	cd05092	7e-36	828	1166
PTKc_TrkB	cd05093	5.3e-28	828	1172
PTKc_TrkC	cd05094	3.9e-16	828	1172
PTKc_DDR2	cd05095	4.7e-32	828	1162
PTKc_DDR1	cd05096	2.5e-28	828	1162
PTKc_Ror2	cd05091	4.2e-27	828	1163
PTKc_DDR	cd05051	2.2e-24	828	1162
PTKc_DDR_like	cd05097	1.4e-28	828	1162
STKc_SLK_like	cd06611	1.5e-05	828	1159
PTKc_EphR	cd05033	1.9e-24	829	1164
PTKc_Jak_rpt2	cd05038	9.2e-44	829	1164
PTKc_EphR_B	cd05065	1.7e-24	829	1164
PTKc_EphR_A	cd05066	2e-30	829	1164
PTKc_Jak1_rpt2	cd05079	6.8e-25	829	1164
PTKc_Tyk2_rpt2	cd05080	1.7e-13	829	1165
PTKc_Jak2_Jak3_rpt2	cd05081	4.6e-22	829	1164
PTK_HER3	cd05111	1.2e-22	829	1179
PTKc_Itk	cd05112	1.9e-30	829	1161
PTKc_Btk_Bmx	cd05113	3.1e-38	829	1161
PTKc_Tec_Rlk	cd05114	1e-33	829	1161
PTKc_EGFR	cd05108	1.5e-20	829	1216
STKc_myosinIII_like	cd06608	9.5e-08	830	1160
STKc_MST1_2	cd06612	4.7e-06	830	1160
STKc_MAP4K3_like	cd06613	8.7e-08	830	1161
PTK_Ryk	cd05043	4.2e-22	831	1163
PKc_MAPKK	cd06605	7.9e-07	832	1168
STKc_MST3_like	cd06609	0.00022	832	1187
PKc_MKK3_6	cd06617	4.7e-06	832	1182
PKc_MAPKK_plant_like	cd06623	9.6e-11	832	1170
SPS1	COG0515	3.7e-22	832	1348
PTKc_RET	cd05045	1.4e-91	833	1167
PKc_STE	cd05122	3.5e-10	833	1161
STKc_MAPKKK	cd06606	1.1e-14	833	1160
STKc_Cdc7_like	cd06627	1.2e-10	833	1160
STKc_MEKK1	cd06630	0.00047	833	1162
STKc_MEKK1_plant	cd06632	1.6e-07	833	1160
STKc_YSK4	cd06631	1.7e-05	833	1160
STKc_CDK7	cd07841	1.3e-05	833	1165
STKc_MPK1	cd07857	0.00019	833	1168
STKc_MAPK	cd07834	6.1e-05	833	1205
STKc_CCRK	cd07832	4e-05	833	1159
STKc_Nek	cd08215	4.3e-08	833	1160
STKc_Nek8	cd08220	0.00047	833	1162
PTKc_Axl_like	cd05035	3.8e-55	834	1164
PTKc_Tec_like	cd05059	7.1e-24	834	1161
PTKc_Tyro3	cd05074	3.8e-44	834	1164
PTKc_Axl	cd05075	5.4e-41	834	1164
STKc_CDK_like	cd07829	1.2e-08	834	1160
STKc_MAK_like	cd07830	2e-06	834	1160
STKc_MAPK4_6	cd07854	0.00018	834	1237
STKc_CMGC	cd05118	2.2e-07	835	1160
STKc_PDK1	cd05581	1.1e-07	835	1160
STKc_MEKK3_like	cd06625	2.1e-05	835	1162
STKc_CDKL	cd07833	6.7e-05	835	1160
STKc_CDK1_like	cd07835	2.6e-05	835	1187
STKc_CDKL2_3	cd07846	1.7e-05	835	1162
STKc_CDK9_like	cd07840	2.3e-06	835	1176
PTKc	cd00192	2.6e-162	838	1161
PTKc_Ack_like	cd05040	2.4e-32	838	1162
PTKc_Fes_like	cd05041	2.5e-36	838	1162
PTKc_Aatyk	cd05042	2.1e-11	838	1162
PTKc_c-ros	cd05044	1.6e-46	838	1162
PTKc_Met_Ron	cd05058	1.1e-49	838	1166
PTKc_Syk_like	cd05060	1.4e-23	838	1165
PTKc_Fes	cd05084	2.1e-34	838	1162
PTKc_Fer	cd05085	7.3e-38	838	1162
PTKc_Aatyk2	cd05086	8.9e-08	838	1162
PTKc_Aatyk1_Aatyk3	cd05087	3e-18	838	1162
PTKc_Syk	cd05116	8.2e-27	838	1165
STKc_Nek2	cd08217	9.7e-07	838	1163
PKc	cd00180	2.3e-46	840	1160
PTKc_Tie	cd05047	2.3e-54	840	1165
PTKc_Zap-70	cd05115	1.4e-23	840	1165
STKc_AGC	cd05123	8.7e-09	840	1159
STKc_TNIK	cd06637	0.00021	877	1162
PKc_MAPKK_PBS2_like	cd06622	2.3e-06	884	1211
PTKc_HER2	cd05109	8.4e-22	886	1179
PTKc_HER4	cd05110	6.9e-13	886	1189
PKc_MKK5	cd06619	0.0004	894	1188
STKc_PAK6	cd06659	6.9e-06	894	1186
STKc_PAK_II	cd06648	2.2e-05	895	1176
STKc_Nek11	cd08222	0.00073	895	1162
STKc_Nek6	cd08228	0.00013	896	1166
STKc_Nek7	cd08229	2.3e-06	898	1166
STKc_MAPKKK_Byr2_lik	cd06628	3.3e-06	899	1162
STKc_MEKK3	cd06651	0.00095	904	1164
STKc_CDK10	cd07845	8e-05	910	1154
STKc_PCTAIRE3	cd07871	0.00087	910	1183
STKc_Nek3	cd08219	0.00055	911	1163
STKc_PKN	cd05589	0.00015	912	1215
STKc_GRK4_like	cd05605	0.00023	912	1210
STKc_nPKC_theta_delt	cd05592	0.0005	914	1247
STKc_nPKC_theta	cd05619	0.00022	914	1236
STKc_GRK1	cd05608	0.00049	916	1186
STKc_BUR1	cd07866	0.0001	921	1159
STKc_MST4	cd06640	0.00052	922	1187
STKc_MST3	cd06641	8.6e-05	922	1187
STKc_STK25-YSK1	cd06642	0.0001	922	1171
STKc_Nek6_Nek7	cd08224	8.6e-05	924	1166
PTK_Jak1_rpt1	cd05077	4.5e-05	925	1161
STKc_NAK1_like	cd06917	6.1e-05	925	1168
PTK_Jak_rpt1	cd05037	1e-05	926	1161
STKc_CDK5	cd07839	0.001	929	1176
PKc_MAPKK_Pek1_like	cd06621	2.6e-05	933	1143
STKc_Nek9	cd08221	0.00022	934	1164
STKc_FA2-like	cd08529	0.00036	934	1163
STKc_CNK2-like	cd08530	3.8e-06	934	1160
PTK_Jak2_Jak3_rpt1	cd05078	3.9e-06	941	1161
STKc_PKC	cd05570	1.7e-06	941	1213
PKc_MKK4	cd06616	0.00015	941	1178
STKc_GRK	cd05577	0.00029	942	1171
STKc_MEKK4	cd06626	7.9e-06	944	1160
STKc_MAPKKK_Bck1_lik	cd06629	1.5e-06	945	1162
STKc_OSR1_SPAK	cd06610	1.4e-07	949	1162
PKc_MKK7	cd06618	4.2e-05	953	1182
STKc_Yank1	cd05578	5.7e-05	976	1163
STKc_MAPK15	cd07852	0.0002	978	1189
ig	pfam00047	3.2e-07	239	309
ig	pfam00047	1.9e-12	681	739
Pkinase	pfam00069	1e-27	834	1160
IG	smart00409	1.4e-11	231	325
IG_like	smart00410	1.4e-11	231	325
V-set	pfam07686	1.1e-06	233	324
I-set	pfam07679	1.4e-10	330	417
IG	smart00409	2e-12	337	418
IG_like	smart00410	2e-12	337	418
IGc2	smart00408	2.7e-05	344	405
IG	smart00409	2.7e-06	556	662
IG_like	smart00410	2.7e-06	556	662
I-set	pfam07679	5.8e-22	667	754
IG	smart00409	1.5e-17	673	755
IG_like	smart00410	1.5e-17	673	755
IGc2	smart00408	1.3e-21	680	744
Pkinase_Tyr	pfam07714	5.5e-160	834	1160
TyrKc	smart00219	3e-143	834	1160
STYKc	smart00221	4.2e-51	834	1133
S_TKc	smart00220	1.7e-25	844	1164
KIND	smart00750	0.00032	1000	1188

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_042055	Polymorphism	p.ALA248GLY	N/A
Swiss-Prot	VAR_042061	Polymorphism	p.ALA1065THR	N/A
Swiss-Prot	VAR_036126	Polymorphism	p.ARG275LEU	N/A
Swiss-Prot	VAR_042060	Polymorphism	p.ASP814ASN	N/A
Swiss-Prot	VAR_042057	Polymorphism	p.CYS482ARG	N/A
Swiss-Prot	VAR_042053	Polymorphism	p.GLN2ARG	N/A
dbSNP	rs1870377	Polymorphism	p.GLN472HIS	N/A
Swiss-Prot	VAR_042058	Polymorphism	p.GLY539ARG	N/A
Swiss-Prot	VAR_036127	Polymorphism	p.GLY873ARG	N/A
Swiss-Prot	VAR_042056	Polymorphism	p.LEU462VAL	N/A
Swiss-Prot	VAR_063147	Disease	p.PRO1147SER	Hemangioma, capillary infantile (HCI)
Swiss-Prot	VAR_042059	Polymorphism	p.THR689MET	N/A
Swiss-Prot	VAR_046679	Polymorphism	p.VAL848GLU	N/A
dbSNP	rs2305948	Polymorphism	p.VAL297ILE	N/A
Swiss-Prot	VAR_046680	Polymorphism	p.VAL952ILE	N/A
Swiss-Prot	VAR_042054	Polymorphism	p.VAL136MET	N/A
OMIM	191306.0002	Disease	p.CYS482ARG	HEMANGIOMA, CAPILLARY INFANTILE, SUSCEPTIBILITY TO
OMIM	191306.0001	Disease	p.PRO1147SER	HEMANGIOMA, CAPILLARY INFANTILE, SOMATIC

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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