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  Domain Name: ARF
ARF-like small GTPases; ARF, ADP-ribosylation factor. Ras homologues involved in vesicular transport. Activator of phospholipase D isoforms. Unlike Ras proteins they lack cysteine residues at their C-termini and therefore are unlikely to be prenylated. ARFs are N-terminally myristoylated. Contains ATP/GTP-binding motif (P-loop).
No pairwise interactions found for the domain ARF

Total Mutations Found: 30
Total Disease Mutations Found: 10
This domain occurred 50 times on human genes (81 proteins).



  BARDET-BIEDL SYNDROME 3 (BBS3)
  CHYLOMICRON RETENTION DISEASE
  JOUBERT SYNDROME 8
  WARBURG MICRO SYNDROME 3


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for ARF









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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