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  Domain Name: ARM
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, the junctional plaque protein plakoglobin, the adenomatous polyposis coli (APC) tumor suppressor protein, and a number of other proteins. ARM has been implicated in mediating protein-protein interactions, but no common features among the target proteins recognized by the ARM repeats have been identified; related to the HEAT domain; three consecutive copies of the repeat are represented by this alignment model.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 36
Total Disease Mutations Found: 21
This domain occurred 44 times on human genes (98 proteins).



  ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 9
  BRAIN TUMOR-POLYPOSIS SYNDROME 2, INCLUDED
  CILIARY DYSKINESIA, PRIMARY, 23
  ECTODERMAL DYSPLASIA/SKIN FRAGILITY SYNDROME
  FAMILIAL ADENOMATOUS POLYPOSIS 1
  GARDNER SYNDROME
  MENTAL RETARDATION, AUTOSOMAL DOMINANT 19


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
protein binding surface













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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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