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  Domain Name: ARM
Armadillo/beta-catenin-like repeats. Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.

Total Mutations Found: 13
Total Disease Mutations Found: 10
This domain occurred 34 times on human genes (96 proteins).



  ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 9
  BRAIN TUMOR-POLYPOSIS SYNDROME 2, INCLUDED
  ECTODERMAL DYSPLASIA/SKIN FRAGILITY SYNDROME
  FAMILIAL ADENOMATOUS POLYPOSIS 1
  GARDNER SYNDROME
  MENTAL RETARDATION, AUTOSOMAL DOMINANT 19


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for ARM






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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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