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  Domain Name: Cys_knot
Cystine-knot domain. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerisation.
No pairwise interactions found for the domain Cys_knot

Total Mutations Found: 12
Total Disease Mutations Found: 9
This domain occurred 11 times on human genes (21 proteins).



  ARTHROPATHY, PROGRESSIVE PSEUDORHEUMATOID, OF CHILDHOOD
  HYPOGONADISM, MALE
  HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 4
  INFERTILITY, MALE AND FEMALE
  SPONDYLOEPIPHYSEAL DYSPLASIA TARDA WITH PROGRESSIVE ARTHROPATHY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Cys_knot







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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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