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  Domain Name: DHC_N1
Dynein heavy chain, N-terminal region 1. Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
No pairwise interactions found for the domain DHC_N1

Total Mutations Found: 20
Total Disease Mutations Found: 7
This domain occurred 9 times on human genes (14 proteins).



  CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2O
  CILIARY DYSKINESIA, PRIMARY, 3
  DOMINA
  DOMINANT
  SHORT RIB-POLYDACTYLY SYNDROME, TYPE IIB
  SHORT RIB-POLYDACTYLY SYNDROME, TYPE III
  SPINAL MUSCULAR ATROPHY, LOWER EXTREMITY-PREDOMINANT, 1, AUTOSOMAL


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for DHC_N1
























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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