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  Domain Name: FN3
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 292
Total Disease Mutations Found: 65
This domain occurred 149 times on human genes (318 proteins).



  AMYLOIDOSIS, PRIMARY LOCALIZED CUTANEOUS, 1
  AMYLOIDOSIS, PRIMARY LOCALIZED CUTANEOUS, 2
  ATYPICAL MYCOBACTERIAL INFECTION, FAMILIAL DISSEMINATED
  B CELL-POSITIVE, NK CELL-POSITIVE
  CARDIOMYOPATHY, DILATED, 1MM
  CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 4
  CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 4, INCLUDED
  COLD-INDUCED SWEATING SYNDROME 1
  COMBINED IMMUNODEFICIENCY, X-LINKED
  CRANIOSYNOSTOSIS AND DENTAL ANOMALIES
  EHLERS-DANLOS SYNDROME, HYPERMOBILITY TYPE
  EPIDERMOLYSIS BULLOSA DYSTROPHICA, AUTOSOMAL RECESSIVE
  EPIDERMOLYSIS BULLOSA, JUNCTIONAL, WITH PYLORIC ATRESIA
  GAZE PALSY, FAMILIAL HORIZONTAL, WITH PROGRESSIVE SCOLIOSIS
  GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2
  HOLOPROSENCEPHALY 11
  HYPERPROLACTINEMIA (1 FAMILY)
  HYPOGONADOTROPIC HYPOGONADISM 1 WITH ANOSMIA
  LARON SYNDROME
  LARON SYNDROME WITH UNDETECTABLE SERUM GH-BINDING PROTEIN
  LEFT VENTRICULAR NONCOMPACTION 10
  MULTIPLE FIBROADENOMAS OF THE BREAST
  NEUTROPHILIA, HEREDITARY
  RETINITIS PIGMENTOSA 39
  SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE,
  SHORT STATURE, IDIOPATHIC, AUTOSOMAL
  USHER SYNDROME, TYPE IIA


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
Interdomain contacts
Cytokine receptor motif













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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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