Home News About DMDM Database Statistics Research Publications Contact  

 
Click for a Larger Image
  Domain Name: FReD
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 35
Total Disease Mutations Found: 18
This domain occurred 20 times on human genes (34 proteins).



  AFIBRINOGENEMIA, CONGENITAL
  FIBRINOGE
  FIBRINOGEN ALES
  FIBRINOGEN ASAHI
  FIBRINOGEN BALTIMORE 1
  FIBRINOGEN BALTIMORE 2
  FIBRINOGEN BALTIMORE 3
  FIBRINOGEN BALTIMORE 4
  FIBRINOGEN BERGAMO 2
  FIBRINOGEN ESSEN 1;;
  FIBRINOGEN GIESSEN 4
  FIBRINOGEN HAIFA 1;;
  FIBRINOGEN HILLSBOROUGH
  FIBRINOGEN KYOTO 1
  FIBRINOGEN KYOTO 3
  FIBRINOGEN MATSUMOTO 1
  FIBRINOGEN MILANO 1
  FIBRINOGEN MORIOKA 1;;
  FIBRINOGEN NAGOYA 1
  FIBRINOGEN OSAKA 2;;
  FIBRINOGEN OSAKA 5
  FIBRINOGEN PERUGIA 1;;
  FIBRINOGEN PONTOISE 2
  FIBRINOGEN SAGA 1;;
  FIBRINOGEN TOCHIGI 1;;
  FIBRINOGEN TOKYO 2
  HYPOBETALIPOPROTEINEMIA, FAMILIAL, 2
  THROMBOPHILIA, DYSFIBRINOGENEMIC;;


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
Ca2+ binding site
polymerization pocket
gamma-gamma dimer interfa
















Weblogos are Copyright (c) 2002 Regents of the University of California




Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258