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  Domain Name: FReD
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 35
Total Disease Mutations Found: 18
This domain occurred 20 times on human genes (34 proteins).



  AFIBRINOGENEMIA, CONGENITAL
  FIBRINOGE
  FIBRINOGEN ALES
  FIBRINOGEN ASAHI
  FIBRINOGEN BALTIMORE 1
  FIBRINOGEN BALTIMORE 2
  FIBRINOGEN BALTIMORE 3
  FIBRINOGEN BALTIMORE 4
  FIBRINOGEN BERGAMO 2
  FIBRINOGEN ESSEN 1;;
  FIBRINOGEN GIESSEN 4
  FIBRINOGEN HAIFA 1;;
  FIBRINOGEN HILLSBOROUGH
  FIBRINOGEN KYOTO 1
  FIBRINOGEN KYOTO 3
  FIBRINOGEN MATSUMOTO 1
  FIBRINOGEN MILANO 1
  FIBRINOGEN MORIOKA 1;;
  FIBRINOGEN NAGOYA 1
  FIBRINOGEN OSAKA 2;;
  FIBRINOGEN OSAKA 5
  FIBRINOGEN PERUGIA 1;;
  FIBRINOGEN PONTOISE 2
  FIBRINOGEN SAGA 1;;
  FIBRINOGEN TOCHIGI 1;;
  FIBRINOGEN TOKYO 2
  HYPOBETALIPOPROTEINEMIA, FAMILIAL, 2
  THROMBOPHILIA, DYSFIBRINOGENEMIC;;


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
Ca2+ binding site
polymerization pocket
gamma-gamma dimer interfa
















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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