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  Domain Name: Filament_head
Intermediate filament head (DNA binding) region. This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.
No pairwise interactions found for the domain Filament_head

Total Mutations Found: 5
Total Disease Mutations Found: 5
This domain occurred 6 times on human genes (11 proteins).



  ALEXANDER DISEASE (ALEXD)
  CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2E


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Filament_head








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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