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  Domain Name: Frizzled
Frizzled/Smoothened family membrane region. This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.
No pairwise interactions found for the domain Frizzled

Total Mutations Found: 6
Total Disease Mutations Found: 5
This domain occurred 9 times on human genes (11 proteins).



  EXUDATIVE VITREORETINOPATHY 1
  EXUDATIVE VITREORETINOPATHY, DIGENIC, INCLUDED
  NAIL DISORDER, NONSYNDROMIC CONGENITAL, 10
  RETINOPATHY OF PREMATURITY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Frizzled















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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