Home News About DMDM Database Statistics Research Publications Contact  

 
  Domain Name: GATA-N
GATA-type transcription activator, N-terminal. GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.
No pairwise interactions found for the domain GATA-N

Total Mutations Found: 23
Total Disease Mutations Found: 18
This domain occurred 3 times on human genes (6 proteins).



  ATRIAL SEPTAL DEFECT 2
  ATRIAL SEPTAL DEFECT 2 (ASD2)
  ATRIAL SEPTAL DEFECT 9
  ATRIOVENTRICULAR SEPTAL DEFECT 4
  ATRIOVENTRICULAR SEPTAL DEFECT 4 (AVSD4)
  ATRIOVENTRICULAR SEPTAL DEFECT 5
  TETRALOGY OF FALLOT
  TETRALOGY OF FALLOT, INCLUDED
  VENTRICULAR SEPTAL DEFECT 1
  VENTRICULAR SEPTAL DEFECT 1 (VSD1)
  VENTRICULAR SEPTAL DEFECT 1, INCLUDED;;


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for GATA-N












Weblogos are Copyright (c) 2002 Regents of the University of California




Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258