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  Domain Name: IVD
Isovaleryl-CoA dehydrogenase. Isovaleryl-CoA dehydrogenase (IVD) is an is an acyl-CoA dehydrogenase, which catalyzes the third step in leucine catabolism, the conversion of isovaleryl-CoA (3-methylbutyryl-CoA) into 3-methylcrotonyl-CoA. IVD is a homotetramer and has the greatest affinity for small branched chain substrates.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 59
Total Disease Mutations Found: 50
This domain occurred 9 times on human genes (19 proteins).



  2-@METHYLBUTYRYL-COA DEHYDROGENASE DEFICIENCY
  ISOVALERIC ACIDEMIA
  ISOVALERIC ACIDEMIA, TYPE I
  SCAD DEFICIENCY
  SCAD DEFICIENCY, MILD
  VLCAD DEFICIENCY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
FAD binding site
substrate binding site
catalytic base


















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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