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  Domain Name: IlGF
IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a cellular level they affect cell cycle, apoptosis, cell migration, proliferation, and differentiation. Typically, the active forms of these peptide hormones are single chains cross-linked by three disulfide bonds.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 13
Total Disease Mutations Found: 10
This domain occurred 3 times on human genes (11 proteins).



  DIABETES MELLITUS, INSULIN-DEPENDENT, 2
  DIABETES MELLITUS, PERMANENT NEONATAL
  HYPERPROINSULINEMIA, FAMILIAL
  MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 10
  PROINSULIN KYOTO


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
IGFBP binding surface
type 1 IGF- and insulin-r
type 2 IGF-receptor bindi









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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