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  Domain Name: JmjC
JmjC domain, hydroxylase. The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.
No pairwise interactions found for the domain JmjC

Total Mutations Found: 9
Total Disease Mutations Found: 4
This domain occurred 26 times on human genes (67 proteins).



  KABUKI SYNDROME 2
  MENTAL RETARDATION, X-LINKED, SYNDROMIC, CLAES-JENSEN TYPE
  SIDERIUS X-LINKED MENTAL RETARDATION SYNDROME


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for JmjC








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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