Home News About DMDM Database Statistics Research Publications Contact  

 
  Domain Name: LamG
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 99
Total Disease Mutations Found: 36
This domain occurred 40 times on human genes (88 proteins).



  AUTISM, SUSCEPTIBILITY TO, 15
  EHLERS-DANLOS SYNDROME 1 (EDS1)
  EHLERS-DANLOS SYNDROME 2 (EDS2)
  LEBER CONGENITAL AMAUROSIS 8
  MUSCULAR DYSTROPHY, CONGENITAL MEROSIN-DEFICIENT
  MUSCULAR DYSTROPHY, CONGENITAL, DUE TO PARTIAL LAMA2 DEFICIENCY
  MYASTHENIA, LIMB-GIRDLE, FAMILIAL
  OTOSPONDYLOMEGAEPIPHYSEAL DYSPLASIA
  PITT-HOPKINS-LIKE SYNDROME 2
  RETINITIS PIGMENTOSA 12
  RETINITIS PIGMENTOSA 25
  STICKLER SYNDROME, TYPE II
  THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT
  THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL RECESSIVE


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for LamG












Weblogos are Copyright (c) 2002 Regents of the University of California




Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258