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  Domain Name: LisH
Lissencephaly type-1-like homology motif. Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
No pairwise interactions found for the domain LisH

Total Mutations Found: 23
Total Disease Mutations Found: 6
This domain occurred 25 times on human genes (53 proteins).



  LISSENCEPHALY 1
  LISSENCEPHALY 1 (LIS1)
  SUBCORTICAL BAND HETEROTOPIA (SBH)
  SUBCORTICAL LAMINAR HETEROTOPIA


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for LisH





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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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