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  Domain Name: MBD
Methyl-CpG binding domain. The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.
No pairwise interactions found for the domain MBD

Total Mutations Found: 18
Total Disease Mutations Found: 18
This domain occurred 9 times on human genes (29 proteins).



  ENCEPHALOPATHY, NEONATAL SEVERE, DUE TO MECP2 MUTATION, INCLUDED
  MENTAL RETARDATION, X-LINKED, SYNDROMIC 13
  RETT SYNDROME
  RETT SYNDROME, ATYPICAL
  RETT SYNDROME, INCLUDED
  RETT SYNDROME, ZAPPELLA VARIANT


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for MBD








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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