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  Domain Name: ML
Domain involved in innate immunity and lipid metabolism. ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.
No pairwise interactions found for the domain ML

Total Mutations Found: 16
Total Disease Mutations Found: 7
This domain occurred 4 times on human genes (9 proteins).



  GM2-GANGLIOSIDOSIS, AB VARIANT
  NIEMANN-PICK DISEASE, TYPE C2


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for ML











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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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