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  Domain Name: NK
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 42
Total Disease Mutations Found: 36
This domain occurred 17 times on human genes (34 proteins).



  ADENYLATE KINASE DEFICIENCY, HEMOLYTIC ANEMIA DUE TO
  BRACHYOLMIA TYPE 4 WITH MILD EPIPHYSEAL AND METAPHYSEAL CHANGES
  LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY
  MITOCHONDRIAL DNA DEPLETION SYNDROME 2 (MYOPATHIC TYPE)
  MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE)
  RETICULAR DYSGENESIS


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   Protein ID            Protein Position

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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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