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  Domain Name: Na_H_Exchanger
Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
No pairwise interactions found for the domain Na_H_Exchanger

Total Mutations Found: 14
Total Disease Mutations Found: 2
This domain occurred 14 times on human genes (18 proteins).



  AUTISM, SUSCEPTIBILITY TO, 16 (1 FAMILY)
  MENTAL RETARDATION, X-LINKED, SYNDROMIC, CHRISTIANSON TYPE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Na_H_Exchanger




















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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