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  Domain Name: Nedd8
Nebb8-like ubiquitin protein. Nedd8 (also known as Rub1) has a single conserved ubiquitin-like domain that is part of a protein modification pathway similar to that of ubiquitin. Nedd8 modifies a family of molecular scaffold proteins called cullins that are responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 30
Total Disease Mutations Found: 15
This domain occurred 23 times on human genes (38 proteins).



  PARKINSON DISEASE (PARK)
  PARKINSON DISEASE 2 (PARK2)
  PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
hydrophobic patch
charged pocket









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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